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Shishir Shishodia

Faculty RankAssociate Professor
InstitutionTexas Southern University
DepartmentDe[artment of Biology
Address3100 Cleburne Drive
Houston TX 77004
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Bado M, Keita D, Azu N, Shishodia S, Rosenzweig JA. Mixed bacterial responses to dust exposure in an A549 eukaryotic co-culture. Appl Microbiol Biotechnol. 2018 Nov; 102(22):9759-9770. PMID: 30143838.
      Citations:    Fields:    Translation:HumansCells
    2. Bado M, Kwende S, Shishodia S, Rosenzweig JA. Impact of dust exposure on mixed bacterial cultures and during eukaryotic cell co-culture infections. Appl Microbiol Biotechnol. 2017 Sep; 101(18):7027-7039. PMID: 28776099.
      Citations: 2     Fields:    Translation:HumansCellsPHPublic Health
    3. Shishodia S, Azu N, Rosenzweig JA, Jackson DA. Guggulsterone for Chemoprevention of Cancer. Curr Pharm Des. 2016; 22(3):294-306. PMID: 26561056.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    4. Suraju MO, Lalinde-Barnes S, Sanamvenkata S, Esmaeili M, Shishodia S, Rosenzweig JA. The effects of indoor and outdoor dust exposure on the growth, sensitivity to oxidative-stress, and biofilm production of three opportunistic bacterial pathogens. Sci Total Environ. 2015 Dec 15; 538:949-58. PMID: 26363607.
      Citations: 4     Fields:    Translation:PHPublic Health
    5. Shishodia S. Molecular mechanisms of curcumin action: gene expression. Biofactors. 2013 Jan-Feb; 39(1):37-55. PMID: 22996381.
      Citations: 52     Fields:    Translation:HumansAnimals
    6. Tariq MA, Soedipe A, Ramesh G, Wu H, Zhang Y, Shishodia S, Gridley DS, Pourmand N, Jejelowo O. The effect of acute dose charge particle radiation on expression of DNA repair genes in mice. Mol Cell Biochem. 2011 Mar; 349(1-2):213-8. PMID: 21080036.
      Citations: 2     Fields:    Translation:AnimalsCellsPHPublic Health
    7. Shishodia S, Harikumar KB, Dass S, Ramawat KG, Aggarwal BB. The guggul for chronic diseases: ancient medicine, modern targets. Anticancer Res. 2008 Nov-Dec; 28(6A):3647-64. PMID: 19189646.
      Citations: 23     Fields:    Translation:HumansAnimals
    8. Aggarwal BB, Sethi G, Baladandayuthapani V, Krishnan S, Shishodia S. Targeting cell signaling pathways for drug discovery: an old lock needs a new key. J Cell Biochem. 2007 Oct 15; 102(3):580-92. PMID: 17668425.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    9. Shishodia S, Chaturvedi MM, Aggarwal BB. Role of curcumin in cancer therapy. Curr Probl Cancer. 2007 Jul-Aug; 31(4):243-305. PMID: 17645940.
      Citations: 99     Fields:    Translation:HumansAnimalsCells
    10. Sawhney M, Rohatgi N, Kaur J, Shishodia S, Sethi G, Gupta SD, Deo SV, Shukla NK, Aggarwal BB, Ralhan R. Expression of NF-kappaB parallels COX-2 expression in oral precancer and cancer: association with smokeless tobacco. Int J Cancer. 2007 Jun 15; 120(12):2545-56. PMID: 17354234.
      Citations: 33     Fields:    Translation:HumansCells
    11. Shishodia S, Sethi G, Ahn KS, Aggarwal BB. Guggulsterone inhibits tumor cell proliferation, induces S-phase arrest, and promotes apoptosis through activation of c-Jun N-terminal kinase, suppression of Akt pathway, and downregulation of antiapoptotic gene products. Biochem Pharmacol. 2007 Jun 30; 74(1):118-30. PMID: 17475222.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    12. Koul D, Shen R, Shishodia S, Takada Y, Bhat KP, Reddy SA, Aggarwal BB, Yung WK. PTEN down regulates AP-1 and targets c-fos in human glioma cells via PI3-kinase/Akt pathway. Mol Cell Biochem. 2007 Jun; 300(1-2):77-87. PMID: 17235455.
      Citations: 14     Fields:    Translation:HumansCells
    13. Sandur SK, Ahn KS, Ichikawa H, Sethi G, Shishodia S, Newman RA, Aggarwal BB. Zyflamend, a polyherbal preparation, inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of NF-kappa B activation and NF-kappa B-regulated gene products. Nutr Cancer. 2007; 57(1):78-87. PMID: 17516865.
      Citations: 14     Fields:    Translation:HumansCells
    14. Shishodia S, Singh T, Chaturvedi MM. Modulation of transcription factors by curcumin. Adv Exp Med Biol. 2007; 595:127-48. PMID: 17569208.
      Citations: 52     Fields:    Translation:HumansAnimals
    15. Aggarwal BB, Banerjee S, Bharadwaj U, Sung B, Shishodia S, Sethi G. Curcumin induces the degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 and p27 in multiple human tumor cell lines. Biochem Pharmacol. 2007 Apr 01; 73(7):1024-32. PMID: 17240359.
      Citations: 34     Fields:    Translation:HumansCells
    16. Bhardwaj A, Sethi G, Vadhan-Raj S, Bueso-Ramos C, Takada Y, Gaur U, Nair AS, Shishodia S, Aggarwal BB. Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-kappaB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells. Blood. 2007 Mar 15; 109(6):2293-302. PMID: 17164350.
      Citations: 124     Fields:    Translation:HumansCells
    17. Tang X, Liu D, Shishodia S, Ozburn N, Behrens C, Lee JJ, Hong WK, Aggarwal BB, Wistuba II. Nuclear factor-kappaB (NF-kappaB) is frequently expressed in lung cancer and preneoplastic lesions. Cancer. 2006 Dec 01; 107(11):2637-46. PMID: 17078054.
      Citations: 66     Fields:    Translation:Humans
    18. Nair AS, Shishodia S, Ahn KS, Kunnumakkara AB, Sethi G, Aggarwal BB. Deguelin, an Akt inhibitor, suppresses IkappaBalpha kinase activation leading to suppression of NF-kappaB-regulated gene expression, potentiation of apoptosis, and inhibition of cellular invasion. J Immunol. 2006 Oct 15; 177(8):5612-22. PMID: 17015749.
      Citations: 39     Fields:    Translation:HumansCells
    19. Ahn KS, Sethi G, Shishodia S, Sung B, Arbiser JL, Aggarwal BB. Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-kappaB activation pathway. Mol Cancer Res. 2006 Sep; 4(9):621-33. PMID: 16966432.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    20. Sharma C, Kaur J, Shishodia S, Aggarwal BB, Ralhan R. Curcumin down regulates smokeless tobacco-induced NF-kappaB activation and COX-2 expression in human oral premalignant and cancer cells. Toxicology. 2006 Nov 10; 228(1):1-15. PMID: 16996673.
      Citations: 30     Fields:    Translation:HumansCells
    21. Aggarwal BB, Shishodia S, Sandur SK, Pandey MK, Sethi G. Inflammation and cancer: how hot is the link? Biochem Pharmacol. 2006 Nov 30; 72(11):1605-21. PMID: 16889756.
      Citations: 401     Fields:    Translation:Humans
    22. Ichikawa H, Takada Y, Shishodia S, Jayaprakasam B, Nair MG, Aggarwal BB. Withanolides potentiate apoptosis, inhibit invasion, and abolish osteoclastogenesis through suppression of nuclear factor-kappaB (NF-kappaB) activation and NF-kappaB-regulated gene expression. . 2006 Jun; 5(6):1434-45. PMID: 16818501.
    23. Manna SK, Rangasamy T, Wise K, Sarkar S, Shishodia S, Biswal S, Ramesh GT. Long term environmental tobacco smoke activates nuclear transcription factor-kappa B, activator protein-1, and stress responsive kinases in mouse brain. Biochem Pharmacol. 2006 May 28; 71(11):1602-9. PMID: 16569398.
      Citations: 14     Fields:    Translation:AnimalsCellsPHPublic Health
    24. Shishodia S, Sethi G, Konopleva M, Andreeff M, Aggarwal BB. A synthetic triterpenoid, CDDO-Me, inhibits IkappaBalpha kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor kappaB-regulated gene products in human leukemic cells. Clin Cancer Res. 2006 Mar 15; 12(6):1828-38. PMID: 16551868.
      Citations: 77     Fields:    Translation:HumansCells
    25. Koul D, Shen R, Bergh S, Sheng X, Shishodia S, Lafortune TA, Lu Y, de Groot JF, Mills GB, Yung WK. Inhibition of Akt survival pathway by a small-molecule inhibitor in human glioblastoma. . 2006 Mar; 5(3):637-44. PMID: 16546978.
    26. Aggarwal BB, Shishodia S. Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol. 2006 May 14; 71(10):1397-421. PMID: 16563357.
      Citations: 336     Fields:    Translation:HumansAnimalsCells
    27. Aggarwal BB, Ichikawa H, Garodia P, Weerasinghe P, Sethi G, Bhatt ID, Pandey MK, Shishodia S, Nair MG. From traditional Ayurvedic medicine to modern medicine: identification of therapeutic targets for suppression of inflammation and cancer. Expert Opin Ther Targets. 2006 Feb; 10(1):87-118. PMID: 16441231.
      Citations: 44     Fields:    Translation:HumansAnimals
    28. Shishodia S, Sethi G, Aggarwal BB. Curcumin: getting back to the roots. Ann N Y Acad Sci. 2005 Nov; 1056:206-17. PMID: 16387689.
      Citations: 133     Fields:    Translation:HumansCells
    29. Shishodia S, Gutierrez AM, Lotan R, Aggarwal BB. N-(4-hydroxyphenyl)retinamide inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of I(kappa)B(alpha) kinase and nuclear factor-kappaB-regulated gene products. Cancer Res. 2005 Oct 15; 65(20):9555-65. PMID: 16230421.
      Citations: 15     Fields:    Translation:HumansCells
    30. Aggarwal BB, Shishodia S, Takada Y, Banerjee S, Newman RA, Bueso-Ramos CE, Price JE. Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice. Clin Cancer Res. 2005 Oct 15; 11(20):7490-8. PMID: 16243823.
      Citations: 142     Fields:    Translation:HumansAnimalsCells
    31. Aggarwal S, Ichikawa H, Takada Y, Sandur SK, Shishodia S, Aggarwal BB. Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt activation. Mol Pharmacol. 2006 Jan; 69(1):195-206. PMID: 16219905.
      Citations: 139     Fields:    Translation:HumansCells
    32. Shishodia S, Amin HM, Lai R, Aggarwal BB. Curcumin (diferuloylmethane) inhibits constitutive NF-kappaB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma. Biochem Pharmacol. 2005 Sep 01; 70(5):700-13. PMID: 16023083.
      Citations: 119     Fields:    Translation:HumansCells
    33. Siwak DR, Shishodia S, Aggarwal BB, Kurzrock R. Curcumin-induced antiproliferative and proapoptotic effects in melanoma cells are associated with suppression of IkappaB kinase and nuclear factor kappaB activity and are independent of the B-Raf/mitogen-activated/extracellular signal-regulated protein kinase pathway and the Akt pathway. Cancer. 2005 Aug 15; 104(4):879-90. PMID: 16007726.
      Citations: 52     Fields:    Translation:HumansCells
    34. Aggarwal BB, Shishodia S. Suppression of the nuclear factor-kappaB activation pathway by spice-derived phytochemicals: reasoning for seasoning. Ann N Y Acad Sci. 2004 Dec; 1030:434-41. PMID: 15659827.
      Citations: 62     Fields:    
    35. Li L, Aggarwal BB, Shishodia S, Abbruzzese J, Kurzrock R. Nuclear factor-kappaB and IkappaB kinase are constitutively active in human pancreatic cells, and their down-regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis. Cancer. 2004 Nov 15; 101(10):2351-62. PMID: 15476283.
      Citations: 93     Fields:    Translation:HumansCells
    36. Shishodia S, Aggarwal BB. Nuclear factor-kappaB: a friend or a foe in cancer? Biochem Pharmacol. 2004 Sep 15; 68(6):1071-80. PMID: 15313403.
      Citations: 58     Fields:    Translation:HumansAnimals
    37. Aggarwal BB, Bhardwaj A, Aggarwal RS, Seeram NP, Shishodia S, Takada Y. Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Res. 2004 Sep-Oct; 24(5A):2783-840. PMID: 15517885.
      Citations: 307     Fields:    Translation:HumansAnimals
    38. Shishodia S, Aggarwal BB. Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis. J Biol Chem. 2004 Nov 05; 279(45):47148-58. PMID: 15322087.
      Citations: 46     Fields:    Translation:HumansCells
    39. Shishodia S, Koul D, Aggarwal BB. Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates TNF-induced NF-kappa B activation through inhibition of activation of I kappa B alpha kinase and Akt in human non-small cell lung carcinoma: correlation with suppression of COX-2 synthesis. J Immunol. 2004 Aug 01; 173(3):2011-22. PMID: 15265936.
      Citations: 50     Fields:    Translation:HumansCells
    40. Shishodia S, Aggarwal BB. Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates activation of cigarette smoke-induced nuclear factor (NF)-kappaB by suppressing activation of IkappaBalpha kinase in human non-small cell lung carcinoma: correlation with suppression of cyclin D1, COX-2, and matrix metalloproteinase-9. Cancer Res. 2004 Jul 15; 64(14):5004-12. PMID: 15256475.
      Citations: 23     Fields:    Translation:HumansCells
    41. Aggarwal BB, Takada Y, Shishodia S, Gutierrez AM, Oommen OV, Ichikawa H, Baba Y, Kumar A. Nuclear transcription factor NF-kappa B: role in biology and medicine. Indian J Exp Biol. 2004 Apr; 42(4):341-53. PMID: 15088683.
      Citations: 34     Fields:    Translation:HumansAnimals
    42. Bueso-Ramos CE, Rocha FC, Shishodia S, Medeiros LJ, Kantarjian HM, Vadhan-Raj S, Estrov Z, Smith TL, Nguyen MH, Aggarwal BB. Expression of constitutively active nuclear-kappa B RelA transcription factor in blasts of acute myeloid leukemia. Hum Pathol. 2004 Feb; 35(2):246-53. PMID: 14991544.
      Citations: 20     Fields:    Translation:Humans
    43. Ashikawa K, Shishodia S, Fokt I, Priebe W, Aggarwal BB. Evidence that activation of nuclear factor-kappaB is essential for the cytotoxic effects of doxorubicin and its analogues. Biochem Pharmacol. 2004 Jan 15; 67(2):353-64. PMID: 14698047.
      Citations: 20     Fields:    Translation:HumansCells
    44. Donato NJ, Wu JY, Stapley J, Lin H, Arlinghaus R, Aggarwal BB, Shishodia S, Albitar M, Hayes K, Kantarjian H, Talpaz M, Shishodin S. Imatinib mesylate resistance through BCR-ABL independence in chronic myelogenous leukemia. Cancer Res. 2004 Jan 15; 64(2):672-7. PMID: 14744784.
      Citations: 64     Fields:    Translation:HumansCells
    45. Shishodia S, Aggarwal BB. Nuclear factor-kappaB activation mediates cellular transformation, proliferation, invasion angiogenesis and metastasis of cancer. Cancer Treat Res. 2004; 119:139-73. PMID: 15164877.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    46. Bharti AC, Shishodia S, Reuben JM, Weber D, Alexanian R, Raj-Vadhan S, Estrov Z, Talpaz M, Aggarwal BB. Nuclear factor-kappaB and STAT3 are constitutively active in CD138+ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis. Blood. 2004 Apr 15; 103(8):3175-84. PMID: 15070700.
      Citations: 106     Fields:    Translation:HumansCells
    47. Bharti AC, Takada Y, Shishodia S, Aggarwal BB. Evidence that receptor activator of nuclear factor (NF)-kappaB ligand can suppress cell proliferation and induce apoptosis through activation of a NF-kappaB-independent and TRAF6-dependent mechanism. J Biol Chem. 2004 Feb 13; 279(7):6065-76. PMID: 14645259.
      Citations: 32     Fields:    Translation:AnimalsCells
    48. Shishodia S, Majumdar S, Banerjee S, Aggarwal BB. Ursolic acid inhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1. Cancer Res. 2003 Aug 01; 63(15):4375-83. PMID: 12907607.
      Citations: 102     Fields:    Translation:HumansCells
    49. Shishodia S, Potdar P, Gairola CG, Aggarwal BB. Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1. Carcinogenesis. 2003 Jul; 24(7):1269-79. PMID: 12807725.
      Citations: 72     Fields:    Translation:HumansCells
    50. Estrov Z, Shishodia S, Faderl S, Harris D, Van Q, Kantarjian HM, Talpaz M, Aggarwal BB. Resveratrol blocks interleukin-1beta-induced activation of the nuclear transcription factor NF-kappaB, inhibits proliferation, causes S-phase arrest, and induces apoptosis of acute myeloid leukemia cells. Blood. 2003 Aug 01; 102(3):987-95. PMID: 12689943.
      Citations: 71     Fields:    Translation:HumansCells
    51. Aggarwal BB, Shishodia S, Ashikawa K, Bharti AC. The role of TNF and its family members in inflammation and cancer: lessons from gene deletion. Curr Drug Targets Inflamm Allergy. 2002 Dec; 1(4):327-41. PMID: 14561180.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    52. Ashikawa K, Majumdar S, Banerjee S, Bharti AC, Shishodia S, Aggarwal BB. Piceatannol inhibits TNF-induced NF-kappaB activation and NF-kappaB-mediated gene expression through suppression of IkappaBalpha kinase and p65 phosphorylation. J Immunol. 2002 Dec 01; 169(11):6490-7. PMID: 12444159.
      Citations: 47     Fields:    Translation:HumansCells
    53. Anto RJ, Mukhopadhyay A, Shishodia S, Gairola CG, Aggarwal BB. Cigarette smoke condensate activates nuclear transcription factor-kappaB through phosphorylation and degradation of IkappaB(alpha): correlation with induction of cyclooxygenase-2. Carcinogenesis. 2002 Sep; 23(9):1511-8. PMID: 12189195.
      Citations: 71     Fields:    Translation:HumansCells
    54. Mukhopadhyay A, Shishodia S, Suttles J, Brittingham K, Lamothe B, Nimmanapalli R, Bhalla KN, Aggarwal BB. Ectopic expression of protein-tyrosine kinase Bcr-Abl suppresses tumor necrosis factor (TNF)-induced NF-kappa B activation and IkappaBalpha phosphorylation. Relationship with down-regulation of TNF receptors. J Biol Chem. 2002 Aug 23; 277(34):30622-8. PMID: 12060665.
      Citations: 4     Fields:    Translation:HumansCells
    55. Shishodia S, Aggarwal BB. Nuclear factor-kappaB activation: a question of life or death. J Biochem Mol Biol. 2002 Jan 31; 35(1):28-40. PMID: 16248967.
      Citations: 65     Fields:    Translation:HumansAnimalsCells
    56. Mukhopadhyay A, Shishodia S, Fu XY, Aggarwal BB. Lack of requirement of STAT1 for activation of nuclear factor-kappaB, c-Jun NH2-terminal protein kinase, and apoptosis by tumor necrosis factor-alpha. J Cell Biochem. 2002; 84(4):803-15. PMID: 11835405.
      Citations: 1     Fields:    Translation:HumansCells
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