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Marian Sepulveda

Faculty RankAssistant Professor
InstitutionPonce Health Sciences University
DepartmentBasic Sciences
AddressP.O. Box 7034
Ponce PR 00746
ORCID ORCID Icon0000-0002-8970-9328 Additional info
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    Collapse Biography 
    Collapse education and training
    University of Puerto Rico, Mayaguez/Puerto RicoBS1997Industrial Biotechnology
    Ponce School of Medicine, Ponce/Puerto RicoPh.D.2013Doctor of Philosophy Biomedical Sciences/ Neuroscience
    University of North Carolina, Chapel Hill/North CarolinaC2018Post-doctoral trainee/Cocaine Addiction in animal model
    Collapse awards and honors
    2021Award to participate in The Art of Grantsmanship: A comprehensive online course, Hispanic Alliance for Clinical and Translational Research (ALLIANCE).
    2017Travel Award Winner: Neuroscience Scholars Program Professional Development Award, Society of Neuroscience
    2017Travel Award Winner, Poster presentation: Annual Spring Neuroscience Meeting, Triangle Chapter, NC
    2016 - 2018Society for Neuroscience (SfN) Neuroscience Scholars Program (NSP) Associate , Society of Neurosciences
    2016 - 2018Broadening the Representation of Academic Investigators in NeuroScience Affiliates Program, BRAINS
    2016Award to attend the Cold Spring Harbor Laboratory course: Cellular Biology of Addiction, Cold Spring Harbor Laboratory, Cambridge, UK
    2015NIDA Diversity Scholar Travel Award , NIDA-Annual Society for Neuroscience
    2015Travel Award to attend American Psychological Association Convention, Toronto, CA, American Psychological Association
    2014Two-day workshop for 2014 recipients of NIDA’s diversity supplements program. Bethesda, MD, NIDA
    2015 - 2016Post-doctoral Fellow, NIDA Diversity Supplement., NIDA

    Collapse Overview 
    Collapse overview
    I am currently an Assistant Professor at Ponce Health Sciences University/Ponce Research Institute, investigating cellular mechanisms of cocaine reward and addiction. I am developing a research program with clinical application, as well as provide scientific education to both university students and the greater community. One of my long-term goals includes providing academic, educational, and research opportunities to underrepresented groups. During my postdoctoral training in Dr. Reissner’s laboratory at University of North Carolina, Chapel Hill, I found that riluzole, a drug for Amyotrophic Lateral Sclerosis, decreases cue- and cocaine primed reinstatement and prevents the changes in excitability induced by cocaine in medial prefrontal cortex neurons (Sepulveda-Orengo et al., 2018). Looking toward treatments to prevent relapse of cocaine, I am investigating the effects of aerobic exercise in cocaine-induced neurophysiological changes. As exercise represents an important candidate therapy currently under investigation for substance use disorders, it is important to understand the cellular mechanism(s) by which effects on measures of drug craving and seeking are exerted. This will accordingly allow for more effective treatment avenues, at the levels of both behavior and pharmacotherapy, and will inform whether and how exercise may also have benefit for other psychiatric conditions.

    Collapse Research 
    Collapse research activities and funding
    CRG-2020-00114     (Marian T. Sepulveda Orengo)Oct 14, 2019 - Sep 30, 2021
    Puerto Rico Science, Technology and Research Trust
    The effects of aerobic exercise on cocaine-induced cellular adaptation in the reward circuitry
    Role Description: To determine the physiological and molecular effects of aerobic exercise on fundamental cellular features of the reward circuitry known to be affected by cocaine addiction in a rat model of short-access self-administration paradigm. Particularly, to examine the effects of exercise in male and female rats on expression of astroglial proteins (GLT1, GFAP and AQP4) that are altered by cocaine. In addition, to determine the effects of aerobic exercise on the cocaine-induced increase in intrinsic excitability of PL neurons.
    Role: PI

    P20 GM103475-15     (Jose R. Rodriguez Medina)Jan 1, 2020 - Jun 30, 2021
    National Institute of General Medical Sciences of the National Institutes of Health [Institutional Development Award (IDeA)]
    Effects of aerobic exercise on cocaine-induced neuroadaptations in the nucleus accumbens
    Role Description: To determine the physiological and molecular effects of aerobic exercise on fundamental cellular features of the reward circuitry known to be affected by cocaine addiction in a rat model of long-access self-administration paradigm. Particularly, to examine the effects of exercise in male and female rats on expression of proteins (BDNF and TrkB) that are altered by cocaine in the nucleus accumbens (NAc). In addition, to determine the effects of aerobic exercise on the cocaine-induced increase in intrinsic excitability of NAc neurons.
    Role: PI of Pilot project

    NMHHD U54 MD007579     (Jose Torres)Jul 1, 2020 - Feb 28, 2022
    Ponce School of Medicine Research Centers of Minority Institutions Program (RCMI)- Strategic Academic Research Training (START) program
    Role of BDNF-TrkB signaling in exercise-induced attenuation of cocaine seeking
    Role Description: To determine the role of BDNF-TrkB signaling in the aerobic exercise-induced reduction of cue-primed reinstatement from male and female rats with cocaine history in molecular (Aim 1), and neurophysiological changes (Aim 2) of neurons of the NAc core, an important structure in cocaine reward in a rat model of short-access self-administration paradigm.
    Role: PI of Pilot project

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Porter JT, Sepulveda-Orengo MT. Learning-induced intrinsic and synaptic plasticity in the rodent medial prefrontal cortex. Neurobiol Learn Mem. 2020 03; 169:107117. PMID: 31765801.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Robinson SL, Marrero IM, Perez-Heydrich CA, Sepulveda-Orengo MT, Reissner KJ, Thiele TE. Medial prefrontal cortex neuropeptide Y modulates binge-like ethanol consumption in C57BL/6J mice. Neuropsychopharmacology. 2019 05; 44(6):1132-1140. PMID: 30647448.
    3. Testen A, Sepulveda-Orengo MT, Gaines CH, Reissner KJ. Region-Specific Reductions in Morphometric Properties and Synaptic Colocalization of Astrocytes Following Cocaine Self-Administration and Extinction. Front Cell Neurosci. 2018; 12:246. PMID: 30147645.
    4. Sepulveda-Orengo MT, Healey KL, Kim R, Auriemma AC, Rojas J, Woronoff N, Hyppolite R, Reissner KJ. Riluzole Impairs Cocaine Reinstatement and Restores Adaptations in Intrinsic Excitability and GLT-1 Expression. Neuropsychopharmacology. 2018 05; 43(6):1212-1223. PMID: 28990593.
    5. Kim R, Healey KL, Sepulveda-Orengo MT, Reissner KJ. Astroglial correlates of neuropsychiatric disease: From astrocytopathy to astrogliosis. Prog Neuropsychopharmacol Biol Psychiatry. 2018 12 20; 87(Pt A):126-146. PMID: 28989099.
    6. Kim R, Sepulveda-Orengo MT, Healey KL, Williams EA, Reissner KJ. Regulation of glutamate transporter 1 (GLT-1) gene expression by cocaine self-administration and withdrawal. Neuropharmacology. 2018 Jan; 128:1-10. PMID: 28919080.
    7. LaCrosse AL, O'Donovan SM, Sepulveda-Orengo MT, McCullumsmith RE, Reissner KJ, Schwendt M, Knackstedt LA. Contrasting the Role of xCT and GLT-1 Upregulation in the Ability of Ceftriaxone to Attenuate the Cue-Induced Reinstatement of Cocaine Seeking and Normalize AMPA Receptor Subunit Expression. J Neurosci. 2017 06 14; 37(24):5809-5821. PMID: 28495973.
    8. Sepulveda-Orengo MT, Lopez AV, Soler-Cedeño O, Porter JT. Fear extinction induces mGluR5-mediated synaptic and intrinsic plasticity in infralimbic neurons. J Neurosci. 2013 Apr 24; 33(17):7184-93. PMID: 23616528.
      Citations: 36     Fields:    Translation:AnimalsCells
    9. Santini E, Sepulveda-Orengo M, Porter JT. Muscarinic receptors modulate the intrinsic excitability of infralimbic neurons and consolidation of fear extinction. Neuropsychopharmacology. 2012 Aug; 37(9):2047-56. PMID: 22510723.
      Citations: 37     Fields:    Translation:AnimalsCells
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