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Kathryn J. Schunke, PhD

Faculty RankAssistant Professor
InstitutionUniversity of Hawaii
DepartmentAnatomy, Biochemistry & Physiology
AddressJohn A. Burns School of Medicine
University of Hawaii at Manoa
651 Ilalo Street
Honolulu HI 96813
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    Collapse Biography 
    Collapse education and training
    University of California, DavisBS03/2005Neurobiology, Physiology and Behavior
    Rutgers University, PiscatawayPhD05/2010Integrative Physiology
    Johns Hopkins University, BaltimorePostdoctoral07/2015Neuroscience/ Vascular Disease

    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
    17ADVC-86291     (Kathryn Schunke)May 1, 2017 - Nov 30, 2018
    Hawaii Community Foundation
    A Novel Inhibitor of HIF-1 Action in the Heart

    18CDA34080353     (Kathryn Schunke)Jul 1, 2017 - Nov 30, 2021
    American Heart Association
    HIF-1 Activity can be Inhibited by PRKCBP1 in the Heart
    Role Description: We will demonstrate that PRKCBP1 is a regulator of HIF-1 activity, likely through chromatin remodeling. Our goals in this project are to identify the mechanisms by which PRKCBP1 modulates the HIF response and define its role in ischemic heart disease. Our identification of a new oxygen-dependent and previously unsuspected regulator of HIF may provide a target for new therapeutic approaches to ischemic heart disease.
    Role: PI

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Dyavanapalli J, Rodriguez J, Rocha Dos Santos C, Escobar JB, Dwyer MK, Schloen J, Lee KM, Wolaver W, Wang X, Dergacheva O, Michelini LC, Schunke KJ, Spurney CF, Kay MW, Mendelowitz D. Activation of Oxytocin Neurons Improves Cardiac Function in a Pressure-Overload Model of Heart Failure. JACC Basic Transl Sci. 2020 May; 5(5):484-497. PMID: 32478209.
    2. Schunke KJ, Walton CB, Veal DR, Mafnas CT, Anderson CD, Williams AL, Shohet RV. Protein kinase C binding protein 1 inhibits hypoxia-inducible factor-1 in the heart. Cardiovasc Res. 2019 07 01; 115(8):1332-1342. PMID: 30395227.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    3. Williams AL, Khadka V, Tang M, Avelar A, Schunke KJ, Menor M, Shohet RV. HIF1 mediates a switch in pyruvate kinase isoforms after myocardial infarction. Physiol Genomics. 2018 07 01; 50(7):479-494. PMID: 29652636.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    4. Chen L, Xu X, Zeng H, Chan KWY, Yadav N, Cai S, Schunke KJ, Faraday N, van Zijl PCM, Xu J. Separating fast and slow exchange transfer and magnetization transfer using off-resonance variable-delay multiple-pulse (VDMP) MRI. Magn Reson Med. 2018 10; 80(4):1568-1576. PMID: 29405374.
    5. Schunke KJ, Rosati LM, Zahurak M, Herman JM, Narang AK, Usach I, Klein AP, Yeo CJ, Korman LT, Hruban RH, Cameron JL, Laheru DA, Abrams RA. Long-term analysis of 2 prospective studies that incorporate mitomycin C into an adjuvant chemoradiation regimen for pancreatic and periampullary cancers. Adv Radiat Oncol. 2018 Jan-Mar; 3(1):42-51. PMID: 29556579.
    6. Schunke KJ, Toung TK, Zhang J, Pathak AP, Xu J, Zhang J, Koehler RC, Faraday N. A novel atherothrombotic model of ischemic stroke induced by injection of collagen into the cerebral vasculature. J Neurosci Methods. 2015 Jan 15; 239:65-74. PMID: 25314906.
    7. Schunke KJ, Coyle L, Merrill GF, Denhardt DT. Acetaminophen attenuates doxorubicin-induced cardiac fibrosis via osteopontin and GATA4 regulation: reduction of oxidant levels. J Cell Physiol. 2013 Oct; 228(10):2006-14. PMID: 23526585.
    8. Faraday N, Schunke K, Saleem S, Fu J, Wang B, Zhang J, Morrell C, Dore S. Cathepsin G-dependent modulation of platelet thrombus formation in vivo by blood neutrophils. PLoS One. 2013; 8(8):e71447. PMID: 23940756.
    9. Baliga SS, Jaques-Robinson KM, Hadzimichalis NM, Golfetti R, Merrill GF. Acetaminophen reduces mitochondrial dysfunction during early cerebral postischemic reperfusion in rats. Brain Res. 2010 Mar 10; 1319:142-54. PMID: 20079345.
    10. Chakir K, Daya SK, Aiba T, Tunin RS, Dimaano VL, Abraham TP, Jaques-Robinson KM, Jacques K, Lai EW, Pacak K, Zhu WZ, Xiao RP, Tomaselli GF, Kass DA. Mechanisms of enhanced beta-adrenergic reserve from cardiac resynchronization therapy. Circulation. 2009 Mar 10; 119(9):1231-40. PMID: 19237665.
    11. Jaques-Robinson KM, Golfetti R, Baliga SS, Hadzimichalis NM, Merrill GF. Acetaminophen is cardioprotective against H2O2-induced injury in vivo. Exp Biol Med (Maywood). 2008 Oct; 233(10):1315-22. PMID: 18703752.
    12. Hadzimichalis NM, Baliga SS, Golfetti R, Jaques KM, Firestein BL, Merrill GF. Acetaminophen-mediated cardioprotection via inhibition of the mitochondrial permeability transition pore-induced apoptotic pathway. Am J Physiol Heart Circ Physiol. 2007 Dec; 293(6):H3348-55. PMID: 17921323.
    13. Merrill GF, Merrill JH, Golfetti R, Jaques KM, Hadzimichalis NS, Baliga SS, Rork TH. Antiarrhythmic properties of acetaminophen in the dog. Exp Biol Med (Maywood). 2007 Oct; 232(9):1245-52. PMID: 17895533.
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