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Chandrasekhar Thota
Title Assistant Professor
Faculty Rank
Degree PhD
Institution Meharry Medical College
Department Obstetrics and Gynecology
Clusters Genes and Environmental Health/Toxicology
Women's Health and Reproductive Biology
Address
1005 Dr.DB Todd Jr Blvd
Meharry Medical College
City Nashville
State TN
Postal Code 37208
Telephone 6159633109
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  Dr. Chandrasekhar Thota graduated from National Dairy Research Institute, India. As a senior scientist in the Indian Council of Agricultural Research he assessed the role of steroid hormones and opiates on circulatory profiles of luteinizing and follicle stimulating hormones in sub fertile dairy animals. At University of Texas, Medical Branch Galveston he conducted studies to assess the role of peptide hormones in regulation of pregnancy. Dr. Thota joined Meharry Medical College, Nashville, TN in 2008 as an Assistant Professor in the Department of Obstetrics and Gynecology. At Meharry his research is focused on developing novel therapies for conditions like preterm birth and poor menopausal health. Dr. Thota‚Äôs group has some significant findings in women health. They identified that Catechol-O-methyl transferase enzyme involved in estrogen metabolism is considerably altered in African American women and a single nucleotide polymorphism in this enzyme is associated with preterm birth in African Americans. Dr. Thota and his group have also demonstrated that levels of serum 1, 25 (OH)2D, the active form of vitamin D, are lower in women who deliver preterm compared to term both in African Americans and Caucasians suggesting an important role for vitamin D in the maintenance of pregnancy. His lab is currently engaged in delineating the role of vitamin D and polymorphisms in the enzymes involved in estrogen and vitamin D metabolism in infection induced preterm deliveries. At present his lab is also assessing the role of Benzo(a)pyrene a component of industrial and environmental toxicant in the incidence of preterm birth in rodents and correlate the results to those in African Americans and Hispanics as they tend to live in areas where toxic levels of chemicals including Benzo(a)pyrene can accumulate in a short period of time. They plan to conduct studies to assess developmental reprogramming and increased risk of preterm delivery after early life exposure to Benzo (a) pyrene in rats. He published 24 research articles in peer reviewed journals. He is a reviewer for the journals, Reproductive Sciences, The Journal of Nutrition and Experimental lung research. He is a member of editorial board for Clinical Medicine Insights: Women's Health today and Clinical Medicine Insights: Reproductive Health.

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  Research projects funded by the National Institutes of Health (NIH), the Centers for Disease Control (CDC), the Food and Drug Administration (FDA), and the Department of Veterans Affairs (VA)

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1.
2011GENE POLYMORPHISM AND HYPOVITAMINOSIS D IN HEALTH DISPARITY OF PRETERM BIRTH5G12RR003032-27

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1. Laknaur A, Foster TL, Bobb LE, Ramesh A, Ladson GM, Hood DB, Al-Hendy A, Thota C. Altered expression of histone deacetylases, inflammatory cytokines and contractile-associated factors in uterine myometrium of Long Evans rats gestationally exposed to benzo[a]pyrene. J Appl Toxicol. 2016 Jun; 36(6):827-35.
2. Thota C, Laknaur A, Farmer T, Ladson G, Al-Hendy A, Ismail N. Vitamin D regulates contractile profile in human uterine myometrial cells via NF-?B pathway. Am J Obstet Gynecol. 2014 Apr; 210(4):347.e1-347.e10.
3. Nair S, Curiel DT, Rajaratnam V, Thota C, Al-Hendy A. Targeting adenoviral vectors for enhanced gene therapy of uterine leiomyomas. Hum Reprod. 2013 Sep; 28(9):2398-406.
4. Thota C, Menon R, Fortunato SJ, Brou L, Lee JE, Al-Hendy A. 1,25-Dihydroxyvitamin D deficiency is associated with preterm birth in African American and Caucasian women. Reprod Sci. 2014 Feb; 21(2):244-50.
5. Thota C, Farmer T, Garfield RE, Menon R, Al-Hendy A. Vitamin D elicits anti-inflammatory response, inhibits contractile-associated proteins, and modulates Toll-like receptors in human myometrial cells. Reprod Sci. 2013 Apr; 20(4):463-75.
6. Thota C, Menon R, Wentz MJ, Fortunato SJ, Bartlett J, Drobek CO, Nair S, Al-Hendy A. A single-nucleotide polymorphism in the fetal catechol-O-methyltransferase gene is associated with spontaneous preterm birth in African Americans. Reprod Sci. 2012 Feb; 19(2):135-42.
7. Sharan C, Halder SK, Thota C, Jaleel T, Nair S, Al-Hendy A. Vitamin D inhibits proliferation of human uterine leiomyoma cells via catechol-O-methyltransferase. Fertil Steril. 2011 Jan; 95(1):247-53.
8. Harirah H, Thota C, Wentz MJ, Zaman W, Al-Hendy A. Elevated expression of catechol-O-methyltransferase is associated with labor and increased prostaglandin E(2) production by human fetal membranes. Am J Obstet Gynecol. 2009 Nov; 201(5):496.e1-7.
9. Ross GR, Chauhan M, Gangula PR, Reed L, Thota C, Yallampalli C. Female sex steroids increase adrenomedullin-induced vasodilation by increasing the expression of adrenomedullin2 receptor components in rat mesenteric artery. Endocrinology. 2006 Jan; 147(1):389-96.
10. Thota CS, Reed LC, Yallampalli C. Effects of parathyroid hormone like hormone (PTHLH) antagonist, PTHLH(7-34), on fetoplacental development and growth during midgestation in rats. Biol Reprod. 2005 Dec; 73(6):1191-8.
11. Dong YL, Green KE, Vegiragu S, Hankins GD, Martin E, Chauhan M, Thota C, Yallampalli C. Evidence for decreased calcitonin gene-related peptide (CGRP) receptors and compromised responsiveness to CGRP of fetoplacental vessels in preeclamptic pregnancies. J Clin Endocrinol Metab. 2005 Apr; 90(4):2336-43.
12. Thota C, Yallampalli C. Progesterone upregulates calcitonin gene-related peptide and adrenomedullin receptor components and cyclic adenosine 3'5'-monophosphate generation in Eker rat uterine smooth muscle cell line. Biol Reprod. 2005 Feb; 72(2):416-22.
13. Chauhan M, Thota CS, Kondapaka S, Wimalawansa S, Yallampalli C. Evidence for the existence of a new receptor for CGRP, which is not CRLR. Peptides. 2003 Jan; 24(1):65-71.
14. Yallampalli C, Chauhan M, Thota CS, Kondapaka S, Wimalawansa SJ. Calcitonin gene-related peptide in pregnancy and its emerging receptor heterogeneity. Trends Endocrinol Metab. 2002 Aug; 13(6):263-9.
15. Halhali A, Wimalawansa SJ, Berentsen V, Avila E, Thota CS, Larrea F. Calcitonin gene- and parathyroid hormone-related peptides in preeclampsia: effects of magnesium sulfate. Obstet Gynecol. 2001 Jun; 97(6):893-7.

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