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Shyamali Mukherjee
Title Associate Professor
Faculty Rank
Degree M.Sc. Ph.D.
Institution Meharry Medical College
Department Professional & Medical Education; Neuroscience & Pharmacology
Clusters Cancer
Cardiovascular and Related Diseases
Gene and Environmental Health/Toxicology
Address
1005 Dr. D. B. Todd Blvd.
West Basic Science Bldg.
Room # 2114
City Nashville
State TN
Postal Code 37208
Telephone 615-327-6299
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Email
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Awards and Honors icon

1975 Government of West Bengal, India DPI Scholarship
1982 Jadavpur and Calcutta University Scholarship
1988 Lalor Foundation Postdoctural Fellowship
2005 ASBMB, ASPECT, MMC and TSU Poster Presentation Judge
2010 Madison Who's Who Roundtable Member at Madison’s
2011 Madison Who's Who Hall of Fame Member of Executives
2011 Indian Physiological Society Silver Medalist and citation

Narrative icon

  I am involved in teaching pharmacology and neuroscience to medical, dental and graduate students. I am also involved in teaching toxicology to Residence of Occupational health, MSPH and graduate students. I have broad background in physiology, endocrinology, biochemistry, pharmacology, cell culture, molecular biology, and environmental toxicology with specific training and expertise in oxidative stress related diseases. My research focuses on reactive oxygen species related inflammatory diseases, such as pulmonary, cardiovascular and reproductive diseases induced by environmental toxicants. Furthermore, I have developed considerable expertise on liposomal preparation for drug delivery. My current research is 1) to examine how mainstream and secondhand cigarette smoke exposure modulates in the function of translocator protein in prostate epithelial cells and effect of PK11195 and 2) to examine whether antioxidant liposome can be used as a therapeutic regimen to control mustard gas-induced COPD associated neurodegenerative disorder, I have been collaborating with Dr. Das for a considerable time and this collaboration has enabled us to publish a significant number of manuscripts on smoke and mustard gas induced lung injury. We have validated translocator protein as biomarker of breast cancer and established that dietary soy protein has a beneficial effect in delaying the development of breast cancer and controlling its aggressiveness. As Co-investigator on several DOD and FAMRI - funded research projects, I have trained a number of postdoctoral (4), graduate (5), medical (6), undergraduate (5) and high school students (6) in my laboratory. I have the expertise, leadership and enthusiasm necessary to participate in the summer research training of medical students as proposed in this project.

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1. Gopal SH, Mukherjee S, Das SK. Direct and Second Hand Cigarette Smoke Exposure and Development of Childhood Asthma. J Environ Health Sci. 2016; 2(6).
2. Roy SS, Mukherjee S, Das SK. Effects of intratracheal exposure of 2-chloroethyl ethyl sulfide (CEES) on the activation of CCAAT-enhancer-binding protein (C/EBP) and its protection by antioxidant liposome. J Biochem Mol Toxicol. 2017 May; 31(5).
3. Roy SS, Mukherjee S, Ballard BR, Das SK. Protection Against Dimethylbenz[a] Anthracene-Induced Breast Cancer in Female Rats by a-Lactalbumin. Int J Cancer Oncol. 2016; 3(1):1-6.
4. Das SK, Roy SS, Mukherjee S, Ong DE. Lung retinoid metabolism and signaling in chronic obstructive pulmonary disease. Indian J Biochem Biophys. 2014 Dec; 51(6):499-505.
5. Mukherjee S, Das SK. Translocator protein (TSPO) in breast cancer. Curr Mol Med. 2012 May; 12(4):443-57.
6. Gadsden-Gray J, Mukherjee S, Ogunkua O, Das SK. Induction of neuronal damage in guinea pig brain by intratracheal infusion of 2-chloroethyl ethyl sulfide, a mustard gas analog. J Biochem Mol Toxicol. 2012 Jan; 26(1):23-30.
7. Schäffer MW, Roy SS, Mukherjee S, Ong DE, Das SK. Uptake of all-trans retinoic acid-containing aerosol by inhalation to lungs in a guinea pig model system--a pilot study. Exp Lung Res. 2010 Dec; 36(10):593-601.
8. Mukhopadhyay S, Mukherjee S, Ray BK, Ray A, Stone WL, Das SK. Antioxidant liposomes protect against CEES-induced lung injury by decreasing SAF-1/MAZ-mediated inflammation in the guinea pig lung. J Biochem Mol Toxicol. 2010 May-Jun; 24(3):187-94.
9. Mukhopadhyay S, Guillory B, Mukherjee S, Das SK. Antiproliferative effect of peripheral benzodiazepine receptor antagonist PK11195 in rat mammary tumor cells. Mol Cell Biochem. 2010 Jul; 340(1-2):203-13.
10. Schäffer MW, Roy SS, Mukherjee S, Nohr D, Wolter M, Biesalski HK, Ong DE, Das SK. Qualitative and quantitative analysis of retinol, retinyl esters, tocopherols and selected carotenoids out of various internal organs form different species by HPLC. Anal Methods. 2010; 2:1320-1332.
11. Mukhopadhyay S, Mukherjee S, Stone WL, Smith M, Das SK. Role of MAPK/AP-1 signaling pathway in the protection of CEES-induced lung injury by antioxidant liposome. Toxicology. 2009 Jul 10; 261(3):143-51.
12. Villalta F, Scharfstein J, Ashton AW, Tyler KM, Guan F, Mukherjee S, Lima MF, Alvarez S, Weiss LM, Huang H, Machado FS, Tanowitz HB. Perspectives on the Trypanosoma cruzi-host cell receptor interactions. Parasitol Res. 2009 Jun; 104(6):1251-60.
13. Mukherjee S, Stone WL, Yang H, Smith MG, Das SK. Protection of half sulfur mustard gas-induced lung injury in guinea pigs by antioxidant liposomes. J Biochem Mol Toxicol. 2009 Mar-Apr; 23(2):143-53.
14. Kabir SM, Mukherjee S, Rajaratnam V, Smith MG, Das SK. Desensitization of beta-adrenergic receptors in lung injury induced by 2-chloroethyl ethyl sulfide, a mustard analog. J Biochem Mol Toxicol. 2009 Jan-Feb; 23(1):59-70.
15. Sinha Roy S, Mukhopadhyay S, Mukherjee S, Das SK. Breast cancer is associated with an increase in the activity and expression of cholinephosphotransferase in rats. Life Sci. 2008 Nov 07; 83(19-20):661-5.
16. Schäffer MW, Sinha Roy S, Mukherjee S, Das SK. Identification of lutein, a dietary antioxidant carotenoid in guinea pig tissues. Biochem Biophys Res Commun. 2008 Sep 19; 374(2):378-81.
17. Mukhopadhyay S, Mukherjee S, Smith M, Das SK. Activation of MAPK/AP-1 signaling pathway in lung injury induced by 2-chloroethyl ethyl sulfide, a mustard gas analog. Toxicol Lett. 2008 Sep 26; 181(2):112-7.
18. Mukhopadhyay S, Rajaratnam V, Mukherjee S, Das SK. Control of peripheral benzodiazepine receptor-mediated breast cancer in rats by soy protein. Mol Carcinog. 2008 Apr; 47(4):310-9.
19. Mills K, Ansah TA, Ali SF, Mukherjee S, Shockley DC. Augmented behavioral response and enhanced synaptosomal calcium transport induced by repeated cocaine administration are decreased by calcium channel blockers. Life Sci. 2007 Jul 26; 81(7):600-8.
20. Miller LR, Mukherjee S, Ansah TA, Das SK. Cigarette smoke and dopaminergic system. J Biochem Mol Toxicol. 2007; 21(6):325-35.
21. Saunders CR, Das SK, Ramesh A, Shockley DC, Mukherjee S. Benzo(a)pyrene-induced acute neurotoxicity in the F-344 rat: role of oxidative stress. J Appl Toxicol. 2006 Sep-Oct; 26(5):427-38.
22. Mukherjee S, Koner BC, Ray S, Ray A. Environmental contaminants in pathogenesis of breast cancer. Indian J Exp Biol. 2006 Aug; 44(8):597-617.
23. Mukhopadhyay S, Ballard BR, Mukherjee S, Kabir SM, Das SK. Beneficial effects of soy protein in the initiation and progression against dimethylbenz [a] anthracene-induced breast tumors in female rats. Mol Cell Biochem. 2006 Oct; 290(1-2):169-76.
24. Mukhopadhyay S, Mukherjee S, Das SK. Increased expression of peripheral benzodiazepine receptor (PBR) in dimethylbenz[a]anthracene-induced mammary tumors in rats. Glycoconj J. 2006 May; 23(3-4):199-207.
25. Mukhopadhyay S, Rajaratnam V, Mukherjee S, Smith M, Das SK. Modulation of the expression of superoxide dismutase gene in lung injury by 2-chloroethyl ethyl sulfide, a mustard analog. J Biochem Mol Toxicol. 2006; 20(3):142-9.
26. Das SK, Chatterjee D, Mukherjee S, Grimes A, Shen Y, Smith M, Ghosh S. Decrease in brain POMC mRNA expression and onset of obesity in guinea pigs exposed to 2-chloroethyl ethyl sulfide, a mustard analogue. Biochem Biophys Res Commun. 2006 Jan 06; 339(1):55-8.
27. Sinha Roy S, Mukherjee S, Kabir S, Rajaratnam V, Smith M, Das SK. Inhibition of cholinephosphotransferase activity in lung injury induced by 2-chloroethyl ethyl sulfide, a mustard analog. J Biochem Mol Toxicol. 2005; 19(5):289-97.
28. Sinha Roy S, Mukherjee S, Mukhopadhyay S, Das SK. Differential effect of cadmium on cholinephosphotransferase activity in normal and cancerous human mammary epithelial cell lines. Mol Cancer Ther. 2004 Feb; 3(2):199-204.
29. Chatterjee D, Mukherjee S, Smith MG, Das SK. Evidence of hair loss after subacute exposure to 2-chloroethyl ethyl sulfide, a mustard analog, and beneficial effects of N-acetyl cysteine. J Biochem Mol Toxicol. 2004; 18(3):150-3.
30. Mukhopadhyay S, Das SK, Mukherjee S. Expression of Mn-Superoxide Dismutase Gene in Nontumorigenic and Tumorigenic Human Mammary Epithelial Cells. J Biomed Biotechnol. 2004; 2004(4):195-202.
31. Chatterjee D, Mukherjee S, Smith MG, Das SK. Signal transduction events in lung injury induced by 2-chloroethyl ethyl sulfide, a mustard analog. J Biochem Mol Toxicol. 2003; 17(2):114-21.
32. Das SK, Mukherjee S, Smith MG, Chatterjee D. Prophylactic protection by N-acetylcysteine against the pulmonary injury induced by 2-chloroethyl ethyl sulfide, a mustard analogue. J Biochem Mol Toxicol. 2003; 17(3):177-84.
33. Ghosh A, Akech J, Mukherjee S, Das SK. Differential expression of cholinephosphotransferase in normal and cancerous human mammary epithelial cells. Biochem Biophys Res Commun. 2002 Oct 04; 297(4):1043-8.
34. Das SK, Tsao FH, Mukherjee S. Mainstream and sidestream cigarette smoke exposure increases Ca2+-dependent phospholipid binding proteins in guinea pig alveolar type II cells. Mol Cell Biochem. 2002 Feb; 231(1-2):37-42.
35. Stone WL, Mukherjee S, Smith M, Das SK. Therapeutic uses of antioxidant liposomes. Methods Mol Biol. 2002; 199:145-61.
36. Mukherjee S, Coaxum SD, Maleque M, Das SK. Effects of oxidized low density lipoprotein on nitric oxide synthetase and protein kinase C activities in bovine endothelial cells. Cell Mol Biol (Noisy-le-grand). 2001 Sep; 47(6):1051-8.
37. Chatterjee D, Mukherjee S, Das SK. Development and characterization of cholinephosphotransferase antibody. Biochem Biophys Res Commun. 2001 Jul 27; 285(4):965-8.
38. Chatterjee D, Mukherjee S, Das SK. Regulation of cholinephosphotransferase by thyroid hormone. Biochem Biophys Res Commun. 2001 Apr 13; 282(4):861-4.
39. Das SK, Mukherjee S. Role of peripheral benzodiazepine receptors on secretion of surfactant in guinea pig alveolar type II cells. Biosci Rep. 1999 Oct; 19(5):461-71.
40. Das SK, Mukherjee S. Heterogeneity of human red blood cell membrane: co-existence of heavy and light membranes. Mol Cell Biochem. 1999 Jun; 196(1-2):141-9.
41. Das SK, Beg O, Mukherjee S. Partial characterization of guinea pig cholinephosphotransferase cDNA. Biochem Biophys Res Commun. 1997 Dec 18; 241(2):504-8.
42. Nayyar T, Mukherjee S, Das SK. Modulation of binding characteristics of peripheral benzodiazepine receptors in vitamin A-deficient guinea pig lung. Biochem Pharmacol. 1996 May 03; 51(9):1203-9.
43. Mukherjee S, Nayyar T, Chytil F, Das SK. Mainstream and sidestream cigarette smoke exposure increases retinol in guinea pig lungs. Free Radic Biol Med. 1995 Mar; 18(3):507-14.
44. Das SK, Mukherjee S, Banerjee DK. Beta-adrenoreceptors of multiple affinities in a clonal capillary endothelial cell line and its functional implication. Mol Cell Biochem. 1994 Nov 09; 140(1):49-54.
45. Mukherjee S, Ghosh S, Rodgers L, Nayyar T, Desai U, Das SK. Toxic effects of fatty acid anilides on the oxygen defense systems of guinea pig lungs and erythrocytes. J Biochem Toxicol. 1994 Feb; 9(1):1-7.
46. Das SK, Mukherjee S, Desai U. Development of pancellular toxicity in guinea pig lung by ingestion of oleylanilide. J Biochem Toxicol. 1994 Feb; 9(1):41-9.
47. Das SK, Ghosh S, Mukherjee S. Role of thyroid hormone in de novo synthesis of cholinephosphotransferase in guinea pig lung mitochondria and microsomes. Exp Lung Res. 1993 Nov-Dec; 19(6):685-97.
48. Mukherjee S, Woods L, Weston Z, Williams AB, Das SK. The effect of mainstream and sidestream cigarette smoke exposure on oxygen defense mechanisms of guinea pig erythrocytes. J Biochem Toxicol. 1993 Sep; 8(3):119-25.
49. Das SK, Chakrabarti P, Mukherjee S. Effects of aging on cholinephosphotransferase activity on guinea pig lung mitochondria and microsomes. Mol Cell Biochem. 1993 Apr 07; 121(1):31-6.
50. Das SK, Hinds JE, Hardy RE, Collins JC, Mukherjee S. Effects of physical stress on peroxide scavengers in normal and sickle cell trait erythrocytes. Free Radic Biol Med. 1993 Feb; 14(2):139-47.
51. Das SK, Chakrabarti P, Tsao FH, Nayyar T, Mukherjee S. Identification of calcium-dependent phospholipid-binding proteins (annexins) from guinea pig alveolar type II cells. Mol Cell Biochem. 1992 Sep 22; 115(1):79-84.
52. Hardy RE, Mukherjee S, Hinds JE, Weaver C, Childs K, Patterson P, Talley PA, South MA, Collins JC, Das SK. Effects of physical stress on complete blood count and venous blood gas profile of individuals with sickle cell trait. Acta Haematol. 1992; 88(2-3):114-9.
53. Ghosh S, Oten PW, Mukherjee S, Das SK. Study of properties of cholinephosphotransferase from fetal guinea pig lung mitochondria and microsomes. Mol Cell Biochem. 1991 Mar 13; 101(2):157-66.
54. Mukherjee S, Mohammad AR, Das SK. Effects of dimethylbenz[a]anthracene-induced malignancy on the subcellular distribution of peripheral benzodiazepine receptors in submandibular glands of rats. Biochem Pharmacol. 1990 Oct 01; 40(7):1589-94.
55. Mukherjee S, Nag S, Das SK. Gestational variation of glycerophosphate acyltransferase activity in maternal guinea pig lung and possible role of thyroid hormone in its de novo synthesis. Exp Lung Res. 1990 Sep-Oct; 16(5):481-8.
56. Ghosh S, Mukherjee S, Das SK. Existence of cholinephosphotransferase in mitochondria and microsomes of liver and lung of guinea pig and rat. Lipids. 1990 May; 25(5):296-300.
57. Mukherjee S, Das SK. Subcellular distribution of "peripheral type" binding sites for [3H]Ro5-4864 in guinea pig lung. Localization to the mitochondrial inner membrane. J Biol Chem. 1989 Oct 05; 264(28):16713-8.
58. Stith IE, Nag S, Mukherjee S, Das SK. Effects of centrophenoxine on cholinephosphotransferase activity in maternal and fetal guinea pig lung. Exp Lung Res. 1989 Jul; 15(4):587-96.

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1. Mukherjee, S. and Das, S.K. . “Current Molecular Medicine- Special Issue on TSPO”. Translocator protein (TSPO) in Breast Cancer. 12:443-457 .

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Diacylglycerol Cholinephosphotransferase
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