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Amosy M'Koma
Title Associate Professor/ Physician Scientist
Faculty Rank Tenure-Track
Degree M.D., M.S., Ph.D.
Institution Meharry Medical College
Department Biochemistry, Cancer Biology, Neuroscience and Pharmacology
Clusters Cancer
Infectious and Immunological Diseases
Other
Address
MMC, 1005 Dr. D. B. Todd Jr. Boulevard
VICC, Vanderbilt-Ingram Cancer Center
City Nashville
State TN
Postal Code 37208
Telephone 615-327-6796
Fax 615-327-6442
Email
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Other Positions icon

Title Associate Professor of Surgery
Institution Vanderbilt University Medical Center
Department General Surgery
Division Colon and Rectal Surgery
 
Title Affiliated Scientific Investigator
Institution American Society of Colon and Rectal Surgeons
Department Colon and Rectal Surgery
Division Colon and Rectal Surgery
 
Title Member
Institution American Gastroenterological Association
Department Gastroenterolog
Division Gastroenterology

Awards and Honors icon

1999 Swedish Institute of Public Health Migration and Health issues
1999 European Union, DGV Partenariat Européen entre communautés africaines
1999 Swedish Government Swedish Committee of Inquiry into HIV/AIDS (Statens offentliga utredningar, S 2002:11)
2005 National Institute of Health / NIGMS Institutional Research & Academic Career Development (IRACDA)
2009 American Society of Colon and Rectal Surgeons Affiliated Scientific Investigator
2009 American Society of Colon and Rectal Surgeons Research Foundation’s 2009 LPG Grant
2009 American Society of Colon and Rectal Surgeons The New Jersey Society of Colon and Rectal Surgeons, Best Basic Science Presentation Poster
2010 NIH/CTSA Vanderbilt Institute Clinical and Translational Research (VICTR)
2011 American Association for Cancer Research AACR Minority Serving Institution Faculty Scholar in Cancer Research
2011 National Institute of Health/NCI The Early Detection Research Network (EDRN), Data Management Center (DMCC)
2012 American Association for Cancer Research AACR Minority Serving Institution Faculty Scholar in Cancer Research
2013 National Institute of Health/NIDDK 5R21 DK095186
2014 American Society of Colon and Rectal Surgeons Membership Committee: Recommends member categories and criteria to the Executive Council worldwide
2015 “World Journal of Surgical Procedures” Published by Baishideng Publishing Group Inc. Recognition of Research
2016 American Society of Colon and Rectal Surgeons The New England Society of Colon and Rectal Surgeons, Best Clinical Podium Presentation

Narrative icon

  My laboratory is specialized in inflammatory bowel disease (IBD), ulcerative colitis (UC) and Crohn’s colitis (CC) and IBD-associated colorectal cancer (CRC) research, more focused on the biopathophysiology of IBD. My particular keen specialty is on diagnostic methodologies and surgical management of IBD, specifically as they relate to the physiology of restorative proctocolectomy (RPC) and ileal pouch anal anastomosis (IPAA). In years I have been interested in investigating the biochemical variable events following surgical treatment of the colitides and familial adenomatous polyposis (FAP). The current research efforts in collaboration with Dr. Richard Caprioli are directed towards developing strategic methodologies based on MALDI MS, proteomics approaches to identify fingerprints that can discriminate inflammatory colitides. An accurate diagnosis prior to initiating medical therapy or performing colectomy is of paramount importance in terms of evidenced personalized medical therapy, surgical intervention and prognosis, as well as delineation of IBD by non-invasive, easier, affordable, accurate and faster screening. This project performs proteomic analyses of UC and CC, using human colon mucosal and submucosal layers in order to identify proteins that are unique and characteristic of different IBD phenotype. Based on our current data, using MALDI MS technology, we have identified several protein spectral peaks of interest that may delineate the inflammatory colitides in endoscopic biopsies. In the future, we will explore the use of one or more of these proteins as a serum biomarker if the protein(s) uncovered is/are secretory and transposable. Over the past years we have established a translational research program in biomarker discoveries focused on Early Detection of IBD associated colorectal malignancy. While maintaining a close collaborative relationship with several other investigators and laboratories at Vanderbilt University, I have now set up a translational research laboratory, The Laboratory of Inflammatory Bowel Disease Research (LIBDR), as a faculty member at Meharry Medical College School of Medicine, Department of Biochemistry and Cancer Biology, Division of Biomedical Sciences to continue these objectives.

Mentorship icon

 
Availability Date:
Friday, January 01, 2016

I am recognized for my expertise in inflammatory bowel disease (IBD) diagnostics, as well as my expertise in the improvement of diagnostic assessments of disease activity and surgical management of ulcerative colitis and familial adenomatous polyposis. I have basic, clinical, and translational research expertise in these areas. In addition, I have the leadership, training expertise, motivation and infrastructure necessary to successfully carry out mentorship in innovative strategic diagnostic studies based on MALDI-mass spectrometry, proteomics, bioinformatics and recombinant single-chain antibody development to identify proteomic patterns that delineate ulcerative colitis (UC) and Crohn’s colitis (CC) with precision from indeterminate colitis. I am particularly focused on improving the diagnostic accuracy and understanding the biopathophysiologic mechanisms of IBD with a particular emphasis on diagnostic precision. Our objective is to identify unique, phenotype-specific molecular biometric tools that will help clinicians more accurately differentiate ulcerative colitis and Crohn’s colitis and be able to predict indeterminate colitis as being either an undefined ulcerative colitis or Crohn’s colitis at a patient’s first clinic visit.

I am available to mentor as:
Principal Investigator [PI]

Contact Information for Mentoring:
amkoma@mmc.edu

Preferred Methods of Mentoring:
  • Email
  • In Person
  • Online Meetings

Programs, Membership, and Biomedical Research icon

Mentoring Mentor

Publications icon

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1. Hawkins AT, Um JW, M'Koma AE. Adaptive Returns of Deficient Systemic Plasma Immunoglobulin G Levels as Rehabilitation Biomarker After Emergency Colectomy for Fulminant Ulcerative Colitis. Clin Med Insights Gastroenterol. 2017; 10:1179552217746692.
2. Williams AD, Korolkova OY, Sakwe AM, Geiger TM, James SD, Muldoon RL, Herline AJ, Goodwin JS, Izban MG, Washington MK, Smoot DT, Ballard BR, Gazouli M, M'Koma AE. Correction: Human alpha defensin 5 is a candidate biomarker to delineate inflammatory bowel disease. PLoS One. 2017; 12(12):e0189551.
3. Williams AD, Korolkova OY, Sakwe AM, Geiger TM, James SD, Muldoon RL, Herline AJ, Goodwin JS, Izban MG, Washington MK, Smoot DT, Ballard BR, Gazouli M, M'Koma AE. Human alpha defensin 5 is a candidate biomarker to delineate inflammatory bowel disease. PLoS One. 2017; 12(8):e0179710.
4. Ballard BR, M'Koma AE. Gastrointestinal endoscopy biopsy derived proteomic patterns predict indeterminate colitis into ulcerative colitis and Crohn's colitis. World J Gastrointest Endosc. 2015 Jun 25; 7(7):670-4.
5. Korolkova OY, Myers JN, Pellom ST, Wang L, M'Koma AE. Characterization of Serum Cytokine Profile in Predominantly Colonic Inflammatory Bowel Disease to Delineate Ulcerative and Crohn's Colitides. Clin Med Insights Gastroenterol. 2015; 8:29-44.
6. Vaiopoulou A, Gazouli M, Papadopoulou A, Anagnostopoulos AK, Karamanolis G, Theodoropoulos GE, M'Koma A, Tsangaris GT. Serum protein profiling of adults and children with Crohn disease. J Pediatr Gastroenterol Nutr. 2015 Jan; 60(1):42-7.
7. M'Koma AE. Diagnosis of inflammatory bowel disease: Potential role of molecular biometrics. World J Gastrointest Surg. 2014 Nov 27; 6(11):208-19.
8. Myers JN, Schäffer MW, Korolkova OY, Williams AD, Gangula PR, M'Koma AE. Implications of the colonic deposition of free hemoglobin-a chain: a previously unknown tissue by-product in inflammatory bowel disease. Inflamm Bowel Dis. 2014 Sep; 20(9):1530-47.
9. M'Koma AE. Inflammatory bowel disease: an expanding global health problem. Clin Med Insights Gastroenterol. 2013; 6:33-47.
10. Seeley EH, Washington MK, Caprioli RM, M'Koma AE. Proteomic patterns of colonic mucosal tissues delineate Crohn's colitis and ulcerative colitis. Proteomics Clin Appl. 2013 Aug; 7(7-8):541-9.
11. Smith JC, Schäffer MW, Ballard BR, Smoot DT, Herline AJ, Adunyah SE, M'Koma AE. Adenocarcinomas After Prophylactic Surgery For Familial Adenomatous Polyposis. J Cancer Ther. 2013; 4(1):260-270.
12. M'Koma AE, Herline AJ, Adunyah SE. Subsequent Adenomas of Ileal Pouch and Anorectal Segment after Prophylactic Surgery for Familial Adenomatous Polyposis. World J Colorectal Surg. 2013; 3(2).
13. M'Koma AE. Letter to Editor. Adv Enzyme Res. 2013; 1(4):77-78.
14. M'Koma AE, Moses HL, Adunyah SE. Inflammatory bowel disease-associated colorectal cancer: proctocolectomy and mucosectomy do not necessarily eliminate pouch-related cancer incidences. Int J Colorectal Dis. 2011 May; 26(5):533-52.
15. Um JW, M'Koma AE. Pouch-related dysplasia and adenocarcinoma following restorative proctocolectomy for ulcerative colitis. Tech Coloproctol. 2011 Mar; 15(1):7-16.
16. M'Koma AE, Seeley EH, Washington MK, Schwartz DA, Muldoon RL, Herline AJ, Wise PE, Caprioli RM. Proteomic profiling of mucosal and submucosal colonic tissues yields protein signatures that differentiate the inflammatory colitides. Inflamm Bowel Dis. 2011 Apr; 17(4):875-83.
17. M'Koma AE, Wise PE, Schwartz DA, Muldoon RL, Herline AJ. Prevalence and outcome of anemia after restorative proctocolectomy: a clinical literature review. Dis Colon Rectum. 2009 Apr; 52(4):726-39.
18. Blum DL, Koyama T, M'Koma AE, Iturregui JM, Martinez-Ferrer M, Uwamariya C, Smith JA, Clark PE, Bhowmick NA. Chemokine markers predict biochemical recurrence of prostate cancer following prostatectomy. Clin Cancer Res. 2008 Dec 01; 14(23):7790-7.
19. M'Koma AE, Wise PE, Muldoon RL, Schwartz DA, Washington MK, Herline AJ. Evolution of the restorative proctocolectomy and its effects on gastrointestinal hormones. Int J Colorectal Dis. 2007 Oct; 22(10):1143-63.
20. M'Koma AE, Blum DL, Norris JL, Koyama T, Billheimer D, Motley S, Ghiassi M, Ferdowsi N, Bhowmick I, Chang SS, Fowke JH, Caprioli RM, Bhowmick NA. Detection of pre-neoplastic and neoplastic prostate disease by MALDI profiling of urine. Biochem Biophys Res Commun. 2007 Feb 16; 353(3):829-34.
21. M'Koma AE, Longo WE. Postoperative liver enzyme abnormalities are related to staged restorative proctocolectomy. Int J Colorectal Dis. 2007 Mar; 22(3):283-8.
22. M'Koma AE. Serum biochemical evaluation of patients with functional pouches ten to 20 years after restorative proctocolectomy. Int J Colorectal Dis. 2006 Oct; 21(7):711-20.
23. M'Koma AE, Lindquist K, Liljeqvist L. A study of plasma immunoglobulins profile in connection with restorative proctocolectomy. Int J Surg Investig. 2000; 2(2):125-31.
24. M'Koma AE, Lindquist K, Liljeqvist L. Observations in the blood lipid profile in patients undergoing restorative proctocolectomy. Int J Surg Investig. 2000; 2(3):227-35.
25. M'Koma AE, Lindquist K, Liljeqvist L. Effect of restorative proctocolectomy on gastric acid secretion and serum gastrin levels: a prospective study. Dis Colon Rectum. 1999 Mar; 42(3):398-402.
26. M'Koma AE. Follow-up results of hematology data before and after restorative proctocolectomy. Clinical outcome. Dis Colon Rectum. 1994 Sep; 37(9):932-7.
27. M'Koma AE, Lindquist K, Liljeqvist L. Biochemical laboratory data in patients before and after restorative proctocolectomy. A study on 83 patients with a follow-up of 36 months. Ann Chir. 1994; 48(6):525-34.

Books/Monographs/Textbooks icon

 

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1. Amosy E. M'Koma. Inflammatory Bowel Disease. State-of-the-Art Performance Improvements After Restorative Proctocolectomy for Ulcerative Colitis: Thirty-Year-Benchmark Evaluation. 2017; 1-45.
2. M'Koma AE. Diagnosis of inflammatory bowel disease: Potential role of molecular biometrics. e-Book: World Clinical Inflammatory Bowel Disease. 2015; 1-1215.

Original Articles icon

 

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1. Williams AD, Korolkova OY, Sakwe AM, Geiger TM, James SD, Muldoon RL, Herline AJ, Goodwin JF, Izban MG, Washington MK, Smoot DT, Ballard BR, Gazouli M, M'Koma AE. . Original Resarch. Human Alpha Defensin-5 is a Candidate Biomarker to Delineate Inflammatory Bowel Disease. 2017; 8(12):e017910.
2. Hawkins AT, Um JW, M'Koma AE. Adaptive Returns of Deficient Systemic Plasma Immunoglobulin G Levels as Rehabilitation Biomarker After Emergency Colectomy for Fulminant Ulcerative Colitis. Original Article. 2017; 1179552217746692.
3. Korolkova OY, Myers JN, Pellom ST, Wang L, M'Koma AE. Characterization of Serum Cytokine Profile in Predominantly Colonic Inflammatory Bowel Disease to Delineate Ulcerative and Crohn's Colitides. Clin Med Insights Gastroenterol. 2015; 8:29-44.
4. Seeley EH, Washington MK, Caprioli RM, M'Koma AE. Proteomic patterns of colonic mucosal tissues delineate Crohn's colitis and ulcerative colitis. Proteomics Clin Appl. 2013; 7-8(7):541-9.
5. Um JW, M'Koma AE. Dysplasie und Adenokarzinome im Ileum-Pouch nach restaurativer Proctokolectomie wegen Colitis ulcerosa. Coloproctology. 2011; 33(5): 273-282.

Proceedings of Meetings icon

 

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1. M'Koma AE. Mucosal Derived Proteomic Patterns Predict Indeterminate into Ulcerative and Crohn’s Colitides. 3rd International Conference on Predictive, Preventive and Personalized Medicine & Molecular Diagnostics. 2015.
2. M'Koma AE, Wise PE, Seeley EH, Schwartz DA, Washington MK, Muldoon RL, El-Rifai WM, Herline AJ. Gene Expression of Colonic Submucosa Differs Between the Inflammatory Colitides. Annual Congress - The American Society of Colon and Rectal Surgeons. 2010; 117.
3. M'Koma AE, Wise PE, Seeley EH, Washington MK, Schwartz DA, Muldoon RL, Herline AJ, Caprioli RM. Human Alpha-Defensins are Differentially Expressed Between the Inflammatory Colitides. Gastroenterology. 2010; 138:S-525.
4. M'Koma AE, Seeley EH, Wise PE, Washington MK, Schwartz DA, Caprioli RM, Muldoon RL, Herline AJ. Proteomic Patterns of Colonic Submucosa Discriminates Inflammatory Colitides. Annual Congress - The American Society of Colon and Rectal Surgeons. 2009; 166.
5. M'Koma AE, Seeley EH, Wise PE, Washington MK, Schwartz DA, Herline AJ, Muldoon RL, Caprioli RM. Proteomic analysis of colonic submucosa differentiates Crohn's and ulcerative colitis. Annual Congress - Digestive Disease Week. 2009; P600:M1096.

Reviews/Chapters/Editorials icon

 

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1. James SD, Hawkins AT, M'Koma AE. Adenocarcinoma at the Ileostomy Site After a Proctocolectomy for Ulcerative Colitis and/or Familial Adenomatous Polyposis: An Overview. 2018; 6(64):30-40.
2. M'Koma AE. Editorial. Editorial Policies and Skills to Solving Diagnostic Delay in Inflammatory Bowel Disease. 2017; 1(1):1.
3. Williams AD, M'Koma AE. Clinics in Surgery. Delineation of inflammatory bowel disease by molecular biometrics: verification versus validation. 2017; (2):1408.
4. Ballard BR, M'Koma AE. Gastrointestinal endoscopy biopsy derived proteomic patterns predict indeterminate colitis into ulcerative colitis and Crohn’s colitis. World J Gastrointest Endosc. 2015; 7(7):670-674.
5. M'Koma AE. Diagnosis of inflammatory bowel disease: Potential role of molecular biometrics. World J Gastrointest Surg. 2014; 6(11):208-219.
6. M'Koma AE, Moses HL, Adunyah SE. Inflammatory bowel disease-associated colorectal cancer: proctocolectomy and mucosectomy do not necessarily eliminate pouch-related cancer incidences. Int J Colorectal Dis. 2014; 5(26):533-552.
7. M'Koma AE. Inflammatory Bowel Disease: An Expanding Global Health Problem. Clin Med Insights. 2013; 6:33-47.
8. M'Koma AE, Herline AJ, Adunyah SE. Subsequent Adenomas of Ileal Pouch and Anorectal Segment after Prophylactic Surgery for Familial Adenomatous Polyposis. World Journal of Colorectal Surgery. 2013; 3(2):1.
9. Smith JC, Schäffer MW, Ballard BR, Smoot DT, Herline AJ, Adunyah SE, M'Koma AE. Adenocarcinomas after Prophylactic Surgery for Familial Adenomatous Polyposis. Journal of Cancer Research. 2013; 4(1):260-270.
10. M'Koma AE. Biochemical Laboratory Data Following Restorative Proctocolectomy: Observations on Essential Biochemical Data Profile in Connection with Restorative Proctocolectomy in Humans. LAP Lambert Academic Publishing. 2010; 140.

Thesis icon

 

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1. M'Koma AE. Observations on Essential Biochemical Data Profile in Connection with Restorative Proctocolectomy in Humans. 2001.
2. Amosy E. M'Koma . Original Resarch. Observations on Biochemical Data in Connection with Restorative Proctocolectomy [An analysis with specific reference to lipoproteins and gastric acids]. 1999; 8(12):e017910.

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