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Hassan Brim
Title Assistant Professor
Faculty Rank Research Assistant Professor
Degree PhD
Institution Howard University
Department Pathology/ Cancer Center
Clusters Cancer
Address
2041 Georgia Avenue, NW
Suite 220, NW
City Washington
State DC
Postal Code 20060
Telephone 202-806-4198
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Email
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  Research Interests: Genetics, Epigenetics and environmental factors in African American Colon Cancer

Dr. Hassan Brim earned his PhD from the Free University of Brussels in the field of "Molecular Biology, Genetic Engineering and Environmental Microbiology." He then moved to the Naval Medical Center in Bethesda where he worked on the degradation and transformation of carcinogenic products in radioactive environments. This work was implemented in a radio resistant bacterium equipped with particular DNA repair mechanisms. This work has led to high profile publications in Nature Biotechnology and cited in Science Magazine. From there, Dr. Brim moved to study DNA repair in colon cancer specimens. He analyzed microsatellite instability, DNA methylation and chromosomal instability in colon cancer cases. He is currently addressing environmental factors that trigger and/or promote colon cancer among which the gut flora is a major player of which the role is yet to be defined. Dr. Brim is currently an Assistant professor at the Department of Pathology and has more than 30 publications.

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1. Ashktorab H, Soleimani A, Nichols A, Sodhi K, Laiyemo AO, Nunlee-Bland G, Nouraie SM, Brim H. Adiponectin, Leptin, IGF-1, and Tumor Necrosis Factor Alpha As Potential Serum Biomarkers for Non-Invasive Diagnosis of Colorectal Adenoma in African Americans. Front Endocrinol (Lausanne). 2018; 9:77.
2. Brim H, Yooseph S, Lee E, Sherif ZA, Abbas M, Laiyemo AO, Varma S, Torralba M, Dowd SE, Nelson KE, Pathmasiri W, Sumner S, de Vos W, Liang Q, Yu J, Zoetendal E, Ashktorab H. A Microbiomic Analysis in African Americans with Colonic Lesions Reveals Streptococcus sp.VT162 as a Marker of Neoplastic Transformation. Genes (Basel). 2017 11 09; 8(11).
3. Ashktorab H, Azimi H, Varma S, Tavakoli P, Nickerson ML, Brim H. Distinctive DNA mismatch repair and APC rare variants in African Americans with colorectal neoplasia. Oncotarget. 2017 Nov 21; 8(59):99966-99977.
4. Ashktorab H, Kupfer SS, Brim H, Carethers JM. Racial Disparity in Gastrointestinal Cancer Risk. Gastroenterology. 2017 10; 153(4):910-923.
5. Afsari A, Lee E, Shokrani B, Boortalary T, Sherif ZA, Nouraie M, Laiyemo AO, Alkhalloufi K, Brim H, Ashktorab H. Clinical and Pathological Risk Factors Associated with Liver Fibrosis and Steatosis in African-Americans with Chronic Hepatitis C. Dig Dis Sci. 2017 08; 62(8):2159-2165.
6. Sanabria-Salas MC, Hernández-Suárez G, Umaña-Pérez A, Rawlik K, Tenesa A, Serrano-López ML, Sánchez de Gómez M, Rojas MP, Bravo LE, Albis R, Plata JL, Green H, Borgovan T, Li L, Majumdar S, Garai J, Lee E, Ashktorab H, Brim H, Li L, Margolin D, Fejerman L, Zabaleta J. IL1B-CGTC haplotype is associated with colorectal cancer in admixed individuals with increased African ancestry. Sci Rep. 2017 Feb 03; 7:41920.
7. Ashktorab H, Mokarram P, Azimi H, Olumi H, Varma S, Nickerson ML, Brim H. Targeted exome sequencing reveals distinct pathogenic variants in Iranians with colorectal cancer. Oncotarget. 2017 Jan 31; 8(5):7852-7866.
8. Liang Q, Chiu J, Chen Y, Huang Y, Higashimori A, Fang J, Brim H, Ashktorab H, Ng SC, Ng SSM, Zheng S, Chan FKL, Sung JJY, Yu J. Fecal Bacteria Act as Novel Biomarkers for Noninvasive Diagnosis of Colorectal Cancer. Clin Cancer Res. 2017 04 15; 23(8):2061-2070.
9. Brim H, Ashktorab H. Genomics of Colorectal Cancer in African Americans. Next Gener Seq Appl. 2016 Sep; 3(2).
10. Ashktorab H, Shakoori A, Zarnogi S, Sun X, Varma S, Lee E, Shokrani B, Laiyemo AO, Washington K, Brim H. Reduced Representation Bisulfite Sequencing Determination of Distinctive DNA Hypermethylated Genes in the Progression to Colon Cancer in African Americans. Gastroenterol Res Pract. 2016; 2016:2102674.
11. Ashktorab H, Etaati F, Rezaeean F, Nouraie M, Paydar M, Namin HH, Sanderson A, Begum R, Alkhalloufi K, Brim H, Laiyemo AO. Can optical diagnosis of small colon polyps be accurate? Comparing standard scope without narrow banding to high definition scope with narrow banding. World J Gastroenterol. 2016 Jul 28; 22(28):6539-46.
12. Ashktorab H, Hermann P, Nouraie M, Shokrani B, Lee E, Haidary T, Brim H, Stein U. Increased MACC1 levels in tissues and blood identify colon adenoma patients at high risk. J Transl Med. 2016 07 20; 14(1):215.
13. Ashktorab H, Vilmenay K, Brim H, Laiyemo AO, Kibreab A, Nouraie M. Colorectal Cancer in Young African Americans: Is It Time to Revisit Guidelines and Prevention? Dig Dis Sci. 2016 10; 61(10):3026-3030.
14. Abbas M, Berka N, Khraiwesh M, Ramadan A, Apprey V, Furbert-Harris P, Quinn T, Brim H, Dunston G. Genetic Polymorphisms of TLR4 and MICA are Associated with Severity of Trachoma Disease in Tanzania. Autoimmune Infect Dis. 2016 Jun; 2(3).
15. Ashktorab H, Ahuja S, Kannan L, Llor X, Ellis NA, Xicola RM, Laiyemo AO, Carethers JM, Brim H, Nouraie M. A meta-analysis of MSI frequency and race in colorectal cancer. Oncotarget. 2016 Apr 23; 7(23):34546-57.
16. Sherif ZA, Saeed A, Ghavimi S, Nouraie SM, Laiyemo AO, Brim H, Ashktorab H. Global Epidemiology of Nonalcoholic Fatty Liver Disease and Perspectives on US Minority Populations. Dig Dis Sci. 2016 May; 61(5):1214-25.
17. Shahnazi A, Sanderson AK, Laiyemo AO, Nouraie M, Haidary T, Brim H, Geramfard S, Afsari A, Ashktorab H. Diabetes Mellitus and Pancreatic Cysts in African Americans. Pancreas. 2016 Apr; 45(4):e14-5.
18. Ashktorab H, Azimi H, Nickerson ML, Bass S, Varma S, Brim H. Targeted Exome Sequencing Outcome Variations of Colorectal Tumors within and across Two Sequencing Platforms. Next Gener Seq Appl. 2016 Jun; 3(1).
19. Ashktorab H, Ogundipe T, Brim H, Shahnazi A, Laiyemo AO, Lee E, Shokrani B, Nouraie M. Lymph nodes' evaluation in relation to colorectal cancer staging among African Americans. BMC Cancer. 2015 Dec 16; 15:976.
20. Ashktorab H, Laiyemo AO, Lee E, Cruz-Correa M, Ghuman A, Nouraie M, Brim H. Prevalence and features of colorectal lesions among Hispanics: A hospital-based study. World J Gastroenterol. 2015 Dec 14; 21(46):13095-100.
21. Laiyemo AO, Thompson N, Williams CD, Idowu KA, Bull-Henry K, Sherif ZA, Lee EL, Brim H, Ashktorab H, Platz EA, Smoot DT. Race and colorectal cancer screening compliance among persons with a family history of cancer. World J Gastrointest Endosc. 2015 Dec 10; 7(18):1300-5.
22. Nayani R, Ashktorab H, Brim H, Laiyemo AO. Genetic Basis for Colorectal Cancer Disparities. Curr Colorectal Cancer Rep. 2015 Dec 01; 11(6):408-413.
23. Nouraie M, Kansal V, Belfonte C, Ghazvini M, Haidari T, Shahnazi A, Brim H, Soliman EZ, Ashktorab H. Atrial Fibrillation and Colonic Neoplasia in African Americans. PLoS One. 2015; 10(8):e0135609.
24. Ashktorab H, Panchal H, Shokrani B, Paydar M, Sanderson A, Lee EL, Begum R, Haidary T, Laiyemo AO, McDonald-Pinkett S, Brim H, Nouraie M. Association between Diverticular Disease and Pre-Neoplastic Colorectal Lesions in an Urban African-American Population. Digestion. 2015; 92(2):60-5.
25. Ashktorab H, Varma S, Brim H. Next-generation sequencing in African Americans with colorectal cancer. Proc Natl Acad Sci U S A. 2015 Jun 02; 112(22):E2852.
26. Ashktorab H, Brim H. DNA Methylation and Colorectal Cancer. Curr Colorectal Cancer Rep. 2014 Dec 01; 10(4):425-430.
27. Ashktorab H, Daremipouran M, Devaney J, Varma S, Rahi H, Lee E, Shokrani B, Schwartz R, Nickerson ML, Brim H. Identification of novel mutations by exome sequencing in African American colorectal cancer patients. Cancer. 2015 Jan 01; 121(1):34-42.
28. Laiyemo AO, Williams CD, Burnside C, Moghadam S, Sanasi-Bhola KD, Kwagyan J, Brim H, Ashktorab H, Scott VF, Smoot DT. Factors associated with attendance to scheduled outpatient endoscopy. Postgrad Med J. 2014 Oct; 90(1068):571-5.
29. Brim H, Zahaf M, Laiyemo AO, Nouraie M, Pérez-Pérez GI, Smoot DT, Lee E, Razjouyan H, Ashktorab H. Gastric Helicobacter pylori infection associates with an increased risk of colorectal polyps in African Americans. BMC Cancer. 2014 Apr 28; 14:296.
30. Ashktorab H, Paydar M, Yazdi S, Namin HH, Sanderson A, Begum R, Semati M, Etaati F, Lee E, Brim H, Zenebe A, Nunlee-Bland G, Laiyemo AO, Nouraie M. BMI and the risk of colorectal adenoma in African-Americans. Obesity (Silver Spring). 2014 May; 22(5):1387-91.
31. Brim H, Abu-Asab MS, Nouraie M, Salazar J, Deleo J, Razjouyan H, Mokarram P, Schaffer AA, Naghibhossaini F, Ashktorab H. An integrative CGH, MSI and candidate genes methylation analysis of colorectal tumors. PLoS One. 2014; 9(1):e82185.
32. Ashktorab H, Daremipouran M, Goel A, Varma S, Leavitt R, Sun X, Brim H. DNA methylome profiling identifies novel methylated genes in African American patients with colorectal neoplasia. Epigenetics. 2014 Apr; 9(4):503-12.
33. Brim H, Yooseph S, Zoetendal EG, Lee E, Torralbo M, Laiyemo AO, Shokrani B, Nelson K, Ashktorab H. Microbiome analysis of stool samples from African Americans with colon polyps. PLoS One. 2013; 8(12):e81352.
34. Fatemi M, Paul TA, Brodeur GM, Shokrani B, Brim H, Ashktorab H. Epigenetic silencing of CHD5, a novel tumor-suppressor gene, occurs in early colorectal cancer stages. Cancer. 2014 Jan 15; 120(2):172-80.
35. Ashktorab H, Paydar M, Namin HH, Sanderson A, Begum R, Brim H, Panchal H, Lee E, Kibreab A, Nouraie M, Laiyemo AO. Prevalence of colorectal neoplasia among young African Americans and Hispanic Americans. Dig Dis Sci. 2014 Feb; 59(2):446-50.
36. Ashktorab H, Rahi H, Wansley D, Varma S, Shokrani B, Lee E, Daremipouran M, Laiyemo A, Goel A, Carethers JM, Brim H. Toward a comprehensive and systematic methylome signature in colorectal cancers. Epigenetics. 2013 Aug; 8(8):807-15.
37. Ashktorab H, Hassanzadeh Namin H, Taylor T, Williams C, Brim H, Mellman T, Shokrani B, Holt CL, Laiyemo AO, Nouraie M. Role of life events in the presence of colon polyps among African Americans. BMC Gastroenterol. 2013 Jun 12; 13:101.
38. Errami Y, Brim H, Oumouna-Benachour K, Oumouna M, Naura AS, Kim H, Ju J, Davis CJ, Kim JG, Ashktorab H, Fallon K, Xu M, Zhang J, Del Valle L, Boulares AH. ICAD deficiency in human colon cancer and predisposition to colon tumorigenesis: linkage to apoptosis resistance and genomic instability. PLoS One. 2013; 8(2):e57871.
39. Laiyemo AO, Doubeni C, Brim H, Ashktorab H, Schoen RE, Gupta S, Charabaty A, Lanza E, Smoot DT, Platz E, Cross AJ. Short- and long-term risk of colorectal adenoma recurrence among whites and blacks. Gastrointest Endosc. 2013 Mar; 77(3):447-54.
40. Errami Y, Naura AS, Kim H, Ju J, Suzuki Y, El-Bahrawy AH, Ghonim MA, Hemeida RA, Mansy MS, Zhang J, Xu M, Smulson ME, Brim H, Boulares AH. Apoptotic DNA fragmentation may be a cooperative activity between caspase-activated deoxyribonuclease and the poly(ADP-ribose) polymerase-regulated DNAS1L3, an endoplasmic reticulum-localized endonuclease that translocates to the nucleus during apoptosis. J Biol Chem. 2013 Feb 01; 288(5):3460-8.
41. Ashktorab H, Entezari O, Nouraie M, Dowlati E, Frederick W, Woods A, Lee E, Brim H, Smoot DT, Ghadyari F, Kamangar F, Razjouyan H. Helicobacter pylori protection against reflux esophagitis. Dig Dis Sci. 2012 Nov; 57(11):2924-8.
42. Brim H, Lee E, Abu-Asab MS, Chaouchi M, Razjouyan H, Namin H, Goel A, Schäffer AA, Ashktorab H. Genomic aberrations in an African American colorectal cancer cohort reveals a MSI-specific profile and chromosome X amplification in male patients. PLoS One. 2012; 7(8):e40392.
43. Ashktorab H, Green W, Finzi G, Sessa F, Nouraie M, Lee EL, Morgano A, Moschetta A, Cattaneo M, Mariani-Costantini R, Brim H, Biunno I. SEL1L, an UPR response protein, a potential marker of colonic cell transformation. Dig Dis Sci. 2012 Apr; 57(4):905-12.
44. Ashktorab H, Nguza B, Fatemi M, Nouraie M, Smoot DT, Schäffer AA, Kupfer SS, Camargo CA, Brim H. Case-control study of vitamin D, dickkopf homolog 1 (DKK1) gene methylation, VDR gene polymorphism and the risk of colon adenoma in African Americans. PLoS One. 2011; 6(10):e25314.
45. Ashktorab H, Nouri Z, Nouraie M, Razjouyan H, Lee EE, Dowlati E, El-Seyed el-W, Laiyemo A, Brim H, Smoot DT. Esophageal carcinoma in African Americans: a five-decade experience. Dig Dis Sci. 2011 Dec; 56(12):3577-82.
46. Brim H, Kumar K, Nazarian J, Hathout Y, Jafarian A, Lee E, Green W, Smoot D, Park J, Nouraie M, Ashktorab H. SLC5A8 gene, a transporter of butyrate: a gut flora metabolite, is frequently methylated in African American colon adenomas. PLoS One. 2011; 6(6):e20216.
47. Nouraie M, Hosseinkhah F, Brim H, Zamanifekri B, Smoot DT, Ashktorab H. Clinicopathological features of colon polyps from African-Americans. Dig Dis Sci. 2010 May; 55(5):1442-9.
48. Ashktorab H, Schäffer AA, Daremipouran M, Smoot DT, Lee E, Brim H. Distinct genetic alterations in colorectal cancer. PLoS One. 2010 Jan 26; 5(1):e8879.
49. Mokarram P, Kumar K, Brim H, Naghibalhossaini F, Saberi-firoozi M, Nouraie M, Green R, Lee E, Smoot DT, Ashktorab H. Distinct high-profile methylated genes in colorectal cancer. PLoS One. 2009 Sep 11; 4(9):e7012.
50. Kumar K, Brim H, Giardiello F, Smoot DT, Nouraie M, Lee EL, Ashktorab H. Distinct BRAF (V600E) and KRAS mutations in high microsatellite instability sporadic colorectal cancer in African Americans. Clin Cancer Res. 2009 Feb 15; 15(4):1155-61.
51. Ashktorab H, Belgrave K, Hosseinkhah F, Brim H, Nouraie M, Takkikto M, Hewitt S, Lee EL, Dashwood RH, Smoot D. Global histone H4 acetylation and HDAC2 expression in colon adenoma and carcinoma. Dig Dis Sci. 2009 Oct; 54(10):2109-17.
52. Brim H, Mokarram P, Naghibalhossaini F, Saberi-Firoozi M, Al-Mandhari M, Al-Mawaly K, Al-Mjeni R, Al-Sayegh A, Raeburn S, Lee E, Giardiello F, Smoot DT, Vilkin A, Boland CR, Goel A, Hafezi M, Nouraie M, Ashktorab H. Impact of BRAF, MLH1 on the incidence of microsatellite instability high colorectal cancer in populations based study. Mol Cancer. 2008 Aug 21; 7:68.
53. Ashktorab H, Brim H, Al-Riyami M, Date A, Al-Mawaly K, Kashoub M, Al-Mjeni R, Smoot DT, Al-Moundhri M, Al-Hashemi S, Ganguly SS, Raeburn S. Sporadic colon cancer: mismatch repair immunohistochemistry and microsatellite instability in Omani subjects. Dig Dis Sci. 2008 Oct; 53(10):2723-31.
54. Sultan AS, Brim H, Sherif ZA. Co-overexpression of Janus kinase 2 and signal transducer and activator of transcription 5a promotes differentiation of mammary cancer cells through reversal of epithelial-mesenchymal transition. Cancer Sci. 2008 Feb; 99(2):272-9.
55. Saleem M, Brim H, Hussain S, Arshad M, Leigh MB. Perspectives on microbial cell surface display in bioremediation. Biotechnol Adv. 2008 Mar-Apr; 26(2):151-61.
56. Brim H, Osborne JP, Kostandarithes HM, Fredrickson JK, Wackett LP, Daly MJ. Deinococcus radiodurans engineered for complete toluene degradation facilitates Cr(VI) reduction. Microbiology. 2006 Aug; 152(Pt 8):2469-77.
57. Qin J, Song L, Brim H, Daly MJ, Summers AO. Hg(II) sequestration and protection by the MerR metal-binding domain (MBD). Microbiology. 2006 Mar; 152(Pt 3):709-19.
58. Ghosal D, Omelchenko MV, Gaidamakova EK, Matrosova VY, Vasilenko A, Venkateswaran A, Zhai M, Kostandarithes HM, Brim H, Makarova KS, Wackett LP, Fredrickson JK, Daly MJ. How radiation kills cells: survival of Deinococcus radiodurans and Shewanella oneidensis under oxidative stress. FEMS Microbiol Rev. 2005 Apr; 29(2):361-75.
59. Brim H, Venkateswaran A, Kostandarithes HM, Fredrickson JK, Daly MJ. Engineering Deinococcus geothermalis for bioremediation of high-temperature radioactive waste environments. Appl Environ Microbiol. 2003 Aug; 69(8):4575-82.
60. Goris J, De Vos P, Coenye T, Hoste B, Janssens D, Brim H, Diels L, Mergeay M, Kersters K, Vandamme P. Classification of metal-resistant bacteria from industrial biotopes as Ralstonia campinensis sp. nov., Ralstonia metallidurans sp. nov. and Ralstonia basilensis Steinle et al. 1998 emend. Int J Syst Evol Microbiol. 2001 Sep; 51(Pt 5):1773-82.
61. Brim H, McFarlan SC, Fredrickson JK, Minton KW, Zhai M, Wackett LP, Daly MJ. Engineering Deinococcus radiodurans for metal remediation in radioactive mixed waste environments. Nat Biotechnol. 2000 Jan; 18(1):85-90.
62. Sekkali B, Brim H, Muller M, Argenton F, Bortolussi M, Colombo L, Belayew A, Martial JA. Structure and functional analysis of a tilapia (Oreochromis mossambicus) growth hormone gene: activation and repression by pituitary transcription factor Pit-1. DNA Cell Biol. 1999 Jun; 18(6):489-502.
63. Brim H, Heyndrickx M, de Vos P, Wilmotte A, Springael D, Schlegel HG, Mergeay M. Amplified rDNA restriction analysis and further genotypic characterisation of metal-resistant soil bacteria and related facultative hydrogenotrophs. Syst Appl Microbiol. 1999 May; 22(2):258-68.
64. Brim H, Heuer H, Krögerrecklenfort E, Mergeay M, Smalla K. Characterization of the bacterial community of a zinc-polluted soil. Can J Microbiol. 1999 Apr; 45(4):326-38.

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Colorectal Neoplasms
African Americans
Colonic Polyps
Adenoma
DNA Methylation
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