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Temesgen Samuel
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Title Dr
Faculty Rank Associate Professor
Degree DVM, PhD
Institution Tuskegee University
Department Pathobiology
Clusters Cancer
Address
Tuskegee University
1200 West Montgomery Road
College of Veterinary Medicine
Patterson Hall Room A408
City Tuskegee
State AL
Postal Code 36088
Telephone 334-724-4547/ -4671
Fax
Email
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Other Positions icon

Title Associate Prof.
Institution Tuskegee University
Department Pathobiology
Division School of Vet Medicine

Awards and Honors icon

AACR AACR Aflac Scholar-in-Training Travel Award
AACR AACR Minority Serving Institution Faculty travel award , AACR
DoD Breast Cancer Research Program fellowship, Burnham Institute
DAAD, Germany The DAAD prize for outstanding students, Hannover, Germany
Tuskegee University Tuskegee University Faculty Senate Research Award,
Zoetis Zoetis award for excellence in research , Zoetis
2008 TU/Morehouse/UAB cancer center partnership Health Disparity Research Training Scholar

Narrative icon

  Samuel Lab Research Interest Areas
1. Enhancing the efficacy of anti-cancer therapy. The efficacy of cancer therapy is severely compromised due to serious side effects and resistance. Our laboratory is interested in improving the outcomes of cancer therapy through:
a. Understanding of the molecular responses in cells exposed to clinically used targeted or broad-acting therapeutic agents. We characterize the activation of critical signaling mechanisms when neoplastic epithelial or stromal cells are exposed to therapeutic drugs.
b. Designing rational combination strategies that will improve the therapeutic index of clinically used drugs. We test natural compounds and novel agents for their enhancing activities when combined with known anti-neoplastic agents. The overarching goal of our research interest in this area is to rationalize the use of combination therapy in cancer management. We employ molecular and cell biology techniques as well as in vitro cell line and in vivo preclinical models to address these questions.
c. Strategies using nanomaterial- or biomimetic vehicles for drug delivery. In collaboration with Material Sciences Engineering department faculty, we formulate and test bio-derived nanomaterials for delivery of drugs that would otherwise be unstable for example in the upper digestive tract or would not reach distal organs such as the large bowel.

2. Collaborative: Development of molecular tools and novel methods for the detection of pathogens. Projects in this area are focused on developing rapid and sensitive strategies to detect pathogens that cause major foodborne diseases. Specifically, we work on establishing molecular and nanotechnology-based tools to reduce the time length for pathogen identification after an outbreak or overt disease.

Publications icon

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1. Chowdhury R, Gales D, Valenzuela P, Miller S, Yehualaeshet T, Manne U, Francia G, Samuel T. Bromoethylindole (BEI-9) redirects NF-?B signaling induced by camptothecin and TNFa to promote cell death in colon cancer cells. Apoptosis. 2017 Dec; 22(12):1553-1563.
2. Miller SA, White JA, Chowdhury R, Gales DN, Tameru B, Tiwari AK, Samuel T. Effects of consumption of whole grape powder on basal NF-?B signaling and inflammatory cytokine secretion in a mouse model of inflammation. J Nutr Intermed Metab. 2018 Mar; 11:1-8.
3. Afroj S, Aldahami K, Reddy G, Guard J, Adesiyun A, Samuel T, Abdela W. Simultaneous Detection of Multiple Salmonella Serovars from Milk and Chicken Meat by Real-Time PCR Using Unique Genomic Target Regions. J Food Prot. 2017 Oct 23; 1944-1957.
4. Amawi H, Ashby CR, Samuel T, Peraman R, Tiwari AK. Polyphenolic Nutrients in Cancer Chemoprevention and Metastasis: Role of the Epithelial-to-Mesenchymal (EMT) Pathway. Nutrients. 2017 Aug 21; 9(8).
5. Amawi H, Hussein NA, Karthikeyan C, Manivannan E, Wisner A, Williams FE, Samuel T, Trivedi P, Ashby CR, Tiwari AK. HM015k, a Novel Silybin Derivative, Multi-Targets Metastatic Ovarian Cancer Cells and Is Safe in Zebrafish Toxicity Studies. Front Pharmacol. 2017; 8:498.
6. Jia X, Shanmugam C, Paluri RK, Jhala NC, Behring MP, Katkoori VR, Sugandha SP, Bae S, Samuel T, Manne U. Prognostic value of loss of heterozygosity and sub-cellular localization of SMAD4 varies with tumor stage in colorectal cancer. Oncotarget. 2017 Mar 21; 8(12):20198-20212.
7. Tiimob BJ, Mwinyelle G, Abdela W, Samuel T, Jeelani S, Rangari VK. Nanoengineered Eggshell-Silver Tailored Copolyester Polymer Blend Film with Antimicrobial Properties. J Agric Food Chem. 2017 Mar 08; 65(9):1967-1976.
8. Manne U, Jadhav T, Putcha BK, Samuel T, Soni S, Shanmugam C, Suswam EA. Molecular Biomarkers of Colorectal Cancer and Cancer Disparities: Current Status and Perspective. Curr Colorectal Cancer Rep. 2016 Dec; 12(6):332-344.
9. Fadlalla K, Elgendy R, Gilbreath E, Pondugula SR, Yehualaeshet T, Mansour M, Serbessa T, Manne U, Samuel T. 3-(2-Bromoethyl)-indole inhibits the growth of cancer cells and NF-?B activation. Oncol Rep. 2015 Jul; 34(1):495-503.
10. Pondugula SR, Flannery PC, Abbott KL, Coleman ES, Mani S, Samuel T, Xie W. Diindolylmethane, a naturally occurring compound, induces CYP3A4 and MDR1 gene expression by activating human PXR. Toxicol Lett. 2015 Feb 03; 232(3):580-9.
11. Samuel T, Fadlalla K, Gales DN, Putcha BD, Manne U. Variable NF-?B pathway responses in colon cancer cells treated with chemotherapeutic drugs. BMC Cancer. 2014 Aug 18; 14:599.
12. Delesa EK, Yohannes A, Alemayehu M, Samuel T, Yehualaeshet T. Calves' sex ratio in naturally and artificially bred cattle in central Ethiopia. Theriogenology. 2014 Aug; 82(3):433-9.
13. Woubit A, Yehualaeshet T, Roberts S, Graham M, Kim M, Samuel T. Customizable PCR-microplate array for differential identification of multiple pathogens. J Food Prot. 2013 Nov; 76(11):1948-57.
14. Gales D, Clark C, Manne U, Samuel T. The Chemokine CXCL8 in Carcinogenesis and Drug Response. ISRN Oncol. 2013 Oct 09; 2013:859154.
15. Khazal KF, Samuel T, Hill DL, Grubbs CJ. Effect of an extract of Withania somnifera root on estrogen receptor-positive mammary carcinomas. Anticancer Res. 2013 Apr; 33(4):1519-23.
16. Woubit A, Yehualaeshet T, Habtemariam T, Samuel T. Novel genomic tools for specific and real-time detection of biothreat and frequently encountered foodborne pathogens. J Food Prot. 2012 Apr; 75(4):660-70.
17. Rodriguez S, Fadlalla K, Graham T, Tameru B, Fermin CD, Samuel T. Immunohistochemical evaluation of AKT protein activation in canine mast cell tumours. J Comp Pathol. 2012 Aug-Oct; 147(2-3):171-6.
18. Katkoori VR, Shanmugam C, Jia X, Vitta SP, Sthanam M, Callens T, Messiaen L, Chen D, Zhang B, Bumpers HL, Samuel T, Manne U. Prognostic significance and gene expression profiles of p53 mutations in microsatellite-stable stage III colorectal adenocarcinomas. PLoS One. 2012; 7(1):e30020.
19. Samuel T, Fadlalla K, Mosley L, Katkoori V, Turner T, Manne U. Dual-mode interaction between quercetin and DNA-damaging drugs in cancer cells. Anticancer Res. 2012 Jan; 32(1):61-71.
20. Fadlalla K, Watson A, Yehualaeshet T, Turner T, Samuel T. Ruta graveolens extract induces DNA damage pathways and blocks Akt activation to inhibit cancer cell proliferation and survival. Anticancer Res. 2011 Jan; 31(1):233-41.
21. Samuel T, Fadlalla K, Turner T, Yehualaeshet TE. The flavonoid quercetin transiently inhibits the activity of taxol and nocodazole through interference with the cell cycle. Nutr Cancer. 2010; 62(8):1025-35.
22. Santoro MM, Samuel T, Mitchell T, Reed JC, Stainier DY. Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis. Nat Genet. 2007 Nov; 39(11):1397-402.
23. Hyer ML, Samuel T, Reed JC. The FLIP-side of Fas signaling. Clin Cancer Res. 2006 Oct 15; 12(20 Pt 1):5929-31.
24. Samuel T, Welsh K, Lober T, Togo SH, Zapata JM, Reed JC. Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspases. J Biol Chem. 2006 Jan 13; 281(2):1080-90.
25. Samuel T, Okada K, Hyer M, Welsh K, Zapata JM, Reed JC. cIAP1 Localizes to the nuclear compartment and modulates the cell cycle. Cancer Res. 2005 Jan 01; 65(1):210-8.
26. Wang Z, Cuddy M, Samuel T, Welsh K, Schimmer A, Hanaii F, Houghten R, Pinilla C, Reed JC. Cellular, biochemical, and genetic analysis of mechanism of small molecule IAP inhibitors. J Biol Chem. 2004 Nov 12; 279(46):48168-76.
27. Dohi T, Okada K, Xia F, Wilford CE, Samuel T, Welsh K, Marusawa H, Zou H, Armstrong R, Matsuzawa S, Salvesen GS, Reed JC, Altieri DC. An IAP-IAP complex inhibits apoptosis. J Biol Chem. 2004 Aug 13; 279(33):34087-90.
28. Pedersen IM, Zapata JM, Samuel T, Scott FL, Salvesen GS, Honda T, Gribble GW, Suh N, Sporn MB, Kipps TJ, Reed JC. Retraction: The triterpenoid CDDO-Imidazolide induces apoptosis and enhances fludarabine-induced apoptosis of CLL B-cells. Blood. 2004 Aug 15; 104(4):932.
29. Weber HO, Samuel T, Rauch P, Funk JO. Human p14(ARF)-mediated cell cycle arrest strictly depends on intact p53 signaling pathways. Oncogene. 2002 May 09; 21(20):3207-12.
30. Samuel T, Weber HO, Funk JO. Linking DNA damage to cell cycle checkpoints. Cell Cycle. 2002 May-Jun; 1(3):162-8.

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1. Tiimob BJ, Mwinyelle G, Abdela W, Samuel T, Jeelani S, Rangari VK. J Agric Food Chem. 2017 Mar 8;65(9):1967-1976. . J Agric Food Chem. Nanoengineered Eggshell-Silver Tailored Copolyester Polymer Blend Film with Antimicrobial Properties. 2017; 65:1967-1976.
2. Render, D., Samuel, T., King, H., Vig, M., Jeelani, S., Jayachandra, R. B. and Rangari, V. Journal of Nanomaterials (Open Access). Biomaterial-Derived Calcium Carbonate Nanoparticles for Enteric Drug Delivery. 2016; 2016 :Article ID 3170248.
3. Abdelrahman Mohamed, Gopal P. Reddy, Temesgen Samuel, Mahmoud Mansour, Abdela Woubit. . SOJ Veterinary Sciences. Clostridium difficile (Cd) in Shelter Dogs: Rationale for Screening of Pets Slated for Adoption. 2016; 2(1):1-6.
4. Tiimob, B., Apalangya, V., Samuel, T., Jeelani, S., Vijaya, R. British Journal of Applied Science & Technology. Synthesis, Characterization and In vitro Cytotoxicity Assessment of Eggshell-derived β-CaSiO3 Nano Biomaterial. 2015; 8(2):180 -192.
5. Render, D.; Fadlalla, K.; Rangari, V.; Samuel, T.; and Jeelani, S. . Int. J. of Biomedical Nanoscience and Nanotechnology. Bio-based calcium carbonate (CaCO3) nanoparticles for drug delivery applications. 2014; 3(3):221 - 235.

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Cell Cycle
NF-kappa B
Colonic Neoplasms
DNA Damage
Antineoplastic Agents
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