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Annabell C. Segarra
Title Dr.
Faculty Rank Professor
Degree Ph.D.
Institution University of Puerto Rico
Department Physiology
Clusters Genes and Environmental Health/Toxicology
Address
University of Puerto Rico
Medical Sciences Campus
P.O. Box 365067
City San Juan
State PR
Postal Code 00936
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  Area of Expertise: Brain development / Epilepsy / Neuroendocrinology / Imaging.

For more information, please visit: http://md.rcm.upr.edu/physiology/dt_team/dr-annabell-c-segarra/ .

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  Research projects funded by the National Institutes of Health (NIH), the Centers for Disease Control (CDC), the Food and Drug Administration (FDA), and the Department of Veterans Affairs (VA)

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1.
2009Estrogenic regulation of cocaine sensitization5U54NS039405-10

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1. Mosquera L, Shepherd L, Torrado AI, Torres-Diaz YM, Miranda JD, Segarra AC. Comparison of Two Methods of Estradiol Replacement: their Physiological and Behavioral Outcomes. J Vet Sci Technol. 2015 Nov 30; 6(6):276.
2. Zenón F, Jorge I, Cruz A, Suárez E, Segarra AC, Vázquez J, Meléndez LM, Serrano H. 18O proteomics reveal increased human apolipoprotein CIII in Hispanic HIV-1+ women with HAART that use cocaine. Proteomics Clin Appl. 2016 Feb; 10(2):144-55.
3. Zenón F, Segarra AC, Gonzalez M, Meléndez LM. Cocaine potentiates cathepsin B secretion and neuronal apoptosis from HIV-infected macrophages. J Neuroimmune Pharmacol. 2014 Dec; 9(5):703-15.
4. Mosquera L, Colón JM, Santiago JM, Torrado AI, Meléndez M, Segarra AC, Rodríguez-Orengo JF, Miranda JD. Tamoxifen and estradiol improved locomotor function and increased spared tissue in rats after spinal cord injury: their antioxidant effect and role of estrogen receptor alpha. Brain Res. 2014 May 02; 1561:11-22.
5. Segarra AC, Torres-Díaz YM, Silva RD, Puig-Ramos A, Menéndez-Delmestre R, Rivera-Bermúdez JG, Amadeo W, Agosto-Rivera JL. Estrogen receptors mediate estradiol's effect on sensitization and CPP to cocaine in female rats: role of contextual cues. Horm Behav. 2014 Feb; 65(2):77-87.
6. Febo M, Segarra AC, Stolberg TL, Ferris CF. BOLD signal response to cocaine varies with sexual receptivity in female rats. Neuroreport. 2011 Jan 05; 22(1):19-22.
7. Menéndez-Delmestre R, Segarra AC. Testosterone is essential for cocaine sensitization in male rats. Physiol Behav. 2011 Jan 10; 102(1):96-104.
8. Segarra AC, Agosto-Rivera JL, Febo M, Lugo-Escobar N, Menéndez-Delmestre R, Puig-Ramos A, Torres-Diaz YM. Estradiol: a key biological substrate mediating the response to cocaine in female rats. Horm Behav. 2010 Jun; 58(1):33-43.
9. Vano E, Segarra A, Fernandez JM, Ordiales JM, Simon R, Gallego JJ, del Cerro J, Casasola E, Verdu JF, Ballester T, Sotil J, Aspiazu A, Garcia MA, Moreno F, Carreras F, Canis M, Soler MM, Palmero J, Ciudad J, Diaz F, Hernandez J, Gonzalez M, Rosales P. A pilot experience launching a national dose protocol for vascular and interventional radiology. Radiat Prot Dosimetry. 2008; 129(1-3):46-9.
10. Puig-Ramos A, Santiago GS, Segarra AC. U-69593, a kappa opioid receptor agonist, decreases cocaine-induced behavioral sensitization in female rats. Behav Neurosci. 2008 Feb; 122(1):151-60.
11. Cruz-Orengo L, Figueroa JD, Velázquez I, Torrado A, Ortíz C, Hernández C, Puig A, Segarra AC, Whittemore SR, Miranda JD. Blocking EphA4 upregulation after spinal cord injury results in enhanced chronic pain. Exp Neurol. 2006 Dec; 202(2):421-33.
12. Febo M, Segarra AC, Nair G, Schmidt K, Duong TQ, Ferris CF. The neural consequences of repeated cocaine exposure revealed by functional MRI in awake rats. Neuropsychopharmacology. 2005 May; 30(5):936-43.
13. Febo M, Ferris CF, Segarra AC. Estrogen influences cocaine-induced blood oxygen level-dependent signal changes in female rats. J Neurosci. 2005 Feb 02; 25(5):1132-6.
14. Febo M, Segarra AC, Tenney JR, Brevard ME, Duong TQ, Ferris CF. Imaging cocaine-induced changes in the mesocorticolimbic dopaminergic system of conscious rats. J Neurosci Methods. 2004 Oct 30; 139(2):167-76.
15. Febo M, Segarra AC. Cocaine alters GABA(B)-mediated G-protein activation in the ventral tegmental area of female rats: modulation by estrogen. Synapse. 2004 Oct; 54(1):30-6.
16. Febo M, González-Rodríguez LA, Capó-Ramos DE, González-Segarra NY, Segarra AC. Estrogen-dependent alterations in D2/D3-induced G protein activation in cocaine-sensitized female rats. J Neurochem. 2003 Jul; 86(2):405-12.
17. Mejías-Aponte CA, Jiménez-Rivera CA, Segarra AC. Sex differences in models of temporal lobe epilepsy: role of testosterone. Brain Res. 2002 Jul 19; 944(1-2):210-8.
18. Febo M, Jiménez-Rivera CA, Segarra AC. Estrogen and opioids interact to modulate the locomotor response to cocaine in the female rat. Brain Res. 2002 Jul 05; 943(1):151-61.
19. Torres G, García V, Sánchez E, Segarra A, Patterson BK, Meléndez-Guerrero LM. Expression of the HIV-1 co-receptors CCR5 and CXCR4 on placental macrophages and the effect of IL-10 on their expression. Placenta. 2001 Apr; 22 Suppl A:S29-33.
20. Segarra AC, Acosta AM, González JL, Angulo JA, McEwen BS. Sex differences in estrogenic regulation of preproenkephalin mRNA levels in the medial preoptic area of prepubertal rats. Brain Res Mol Brain Res. 1998 Sep 18; 60(1):133-9.
21. Hernández C, Simó R, Chacón P, Segarra A, López D, Mesa J. Relationship between lipoprotein(a) phenotypes and albumin excretion rate in non-insulin-dependent diabetes mellitus: protective effect of 'null' phenotype? Eur J Clin Invest. 1997 Jun; 27(6):497-502.
22. Segarra AC, Luine VN, Strand FL. Sexual behavior of male rats is differentially affected by timing of perinatal ACTH administration. Physiol Behav. 1991 Oct; 50(4):689-97.
23. Segarra AC, McEwen BS. Estrogen increases spine density in ventromedial hypothalamic neurons of peripubertal rats. Neuroendocrinology. 1991 Oct; 54(4):365-72.
24. McEwen BS, Coirini H, Danielsson A, Frankfurt M, Gould E, Mendelson S, Schumacher M, Segarra A, Woolley C. Steroid and thyroid hormones modulate a changing brain. J Steroid Biochem Mol Biol. 1991; 40(1-3):1-14.

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Keywords
Cocaine
Estradiol
Dopamine Uptake Inhibitors
Motor Activity
Estrogens
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