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Aramandla Ramesh
Title Dr.
Faculty Rank Associate Professor
Degree Ph.D.
Institution Meharry Medical College
Department Biochemistry & Cancer Biology
Clusters Cancer
Address
1005 D.B. Todd Blvd.
City Nashville
State TN
Postal Code 37208
Telephone 615-327-6486
Fax 615-327-6442
Email
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  Dr. Aramandla Ramesh is an Associate Professor in the Department of Biochemistry & Cancer Biology at Meharry Medical College in Nashville, TN. Dr. Ramesh earned his first Ph.D. in Marine Microbiology from Annamalai University, India in 1986. He earned his second Ph.D. in Environmental Toxicology from Ehime University, Japan in 1992. His areas of expertise are bioavailability, toxicokinetics, and biotransformation, acute and subchronic toxicity of polycyclic aromatic hydrocarbons (PAHs). Current research in Dr. Ramesh’s laboratory focuses on colon cancer caused by benzo(a)pyrene (BaP), a fat-soluble, widely distributed environmental chemical that belongs to the PAH family of compounds. Studies in his laboratory have shown that exposure of rats and mice to BaP and other PAHs through saturated fat cause induction of cytochrome P450 (CYP) family of enzymes resulting in the formation and distribution of reactive metabolites which stay in target tissues for a longer time and cause enhanced DNA damage. Ongoing research in his laboratory will eventually address the issue of how environmental factors (exposure to toxicants) and dietary practices (excessive intake of animal meat and fat products tainted with BaP) contribute to colorectal cancer in African Americans (third leading cause of cancer related mortalities) relative to other racial/ethnic groups.

Before joining the faculty at Meharry in 2001, Dr. Ramesh was a research specialist in the Departments of Family & Preventive Medicine, and Pharmacology at Meharry. His earlier research focused on acute and subchronic toxicity of benzo(a)pyrene and fluoranthene found in hazardous waste sites that were in close proximity to minority communities. Dr. Ramesh’s association with the Meharry Medical College-Vanderbilt University Environmental Health consortium allows him to combine his long standing research experience in classical PAH toxicology and work collaboratively with Vanderbilt colleagues from the Basic Sciences and Community Medicine departments to investigate the interplay between diet and environmental contaminant exposure using state-of-the-art analytical and molecular approaches. As a Robert Wood Johnson Health Policy Associate, his current research is focused on exposure of minority communities to environmental chemicals and health disparities.

Dr. Ramesh has extensively published in environmental chemistry & toxicology (more than 50 peer-reviewed publications, and 6 book chapters). He completed 6 National Institutes of Health (NIH)-funded projects in toxicology & chemical carcinogenesis. Dr. Ramesh served as a consultant to the Common Wealth Foundation, UK, International Development Research Centre, Canada, and Natural Environment Research Council (NERC). He is also serving as a reviewer for research proposals submitted to the NIH, NSF, EPA, Robert Wood Johnson Foundation, and NERC, UK, and Cancer Research Fund, UK. Dr. Ramesh also serves on the editorial boards of Toxicology Mechanisms & Methods, ISRN Toxicology, and Polycyclic Aromatic Compounds.

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  Research projects funded by the National Institutes of Health (NIH), the Centers for Disease Control (CDC), the Food and Drug Administration (FDA), and the Department of Veterans Affairs (VA)

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1.
2013Mechanisms for Benzo(a)pyrene-Induced Colon Cancer Exacerbation by Dietary Fat5R01CA142845-04
2.
2012Mechanisms for Benzo(a)pyrene-Induced Colon Cancer Exacerbation by Dietary Fat5R01CA142845-03
3.
2011Mechanisms for Benzo(a)pyrene-Induced Colon Cancer Exacerbation by Dietary Fat5R01CA142845-02
4.
2010Mechanisms for Benzo(a)pyrene-Induced Colon Cancer Exacerbation by Dietary Fat1R01CA142845-01A1
5.
2008Chemoprevention of colon cancer via neonatal imprinting5R03CA130112-02
6.
2007Chemoprevention of colon cancer via neonatal imprinting1R03CA130112-01
7.
2003Dietary fat modulated metabolic fate of fluoranthene1R15ES012168-01

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1. Yang F, Yang H, Ramesh A, Goodwin JS, Okoro EU, Guo Z. Overexpression of Catalase Enhances Benzo(a)pyrene Detoxification in Endothelial Microsomes. PLoS One. 2016; 11(9):e0162561.
2. Harris KL, Pulliam SR, Okoro E, Guo Z, Washington MK, Adunyah SE, Amos-Landgraf JM, Ramesh A. Western diet enhances benzo(a)pyrene-induced colon tumorigenesis in a polyposis in rat coli (PIRC) rat model of colon cancer. Oncotarget. 2016 May 17; 7(20):28947-60.
3. Clark RS, Pellom ST, Booker B, Ramesh A, Zhang T, Shanker A, Maguire M, Juarez PD, Patricia MJ, Langston MA, Lichtveld MY, Hood DB. Validation of research trajectory 1 of an Exposome framework: Exposure to benzo(a)pyrene confers enhanced susceptibility to bacterial infection. Environ Res. 2016 Apr; 146:173-84.
4. Ramesh A, Prins PA, Perati PR, Rekhadevi PV, Sampson UK. Metabolism of benzo(a)pyrene by aortic subcellular fractions in the setting of abdominal aortic aneurysms. Mol Cell Biochem. 2016 Jan; 411(1-2):383-91.
5. Banks LD, Amoah P, Niaz MS, Washington MK, Adunyah SE, Ramesh A. Olive oil prevents benzo(a)pyrene [B(a)P]-induced colon carcinogenesis through altered B(a)P metabolism and decreased oxidative damage in Apc(Min) mouse model. J Nutr Biochem. 2016 Feb; 28:37-50.
6. McCallister MM, Li Z, Zhang T, Ramesh A, Clark RS, Maguire M, Hutsell B, Newland MC, Hood DB. Revealing Behavioral Learning Deficit Phenotypes Subsequent to In Utero Exposure to Benzo(a)pyrene. Toxicol Sci. 2016 Jan; 149(1):42-54.
7. Laknaur A, Foster TL, Bobb LE, Ramesh A, Ladson GM, Hood DB, Al-Hendy A, Thota C. Altered expression of histone deacetylases, inflammatory cytokines and contractile-associated factors in uterine myometrium of Long Evans rats gestationally exposed to benzo[a]pyrene. J Appl Toxicol. 2016 Jun; 36(6):827-35.
8. Ramesh A, Kumar A, Aramandla MP, Nyanda AM. Polycyclic aromatic hydrocarbon residues in serum samples of autopsied individuals from Tennessee. Int J Environ Res Public Health. 2014 Dec 25; 12(1):322-34.
9. Mantey JA, Rekhadevi PV, Diggs DL, Ramesh A. Metabolism of benzo(a)pyrene by subcellular fractions of gastrointestinal (GI) tract and liver in Apc(Min) mouse model of colon cancer. Tumour Biol. 2014 May; 35(5):4929-35.
10. Diggs DL, Myers JN, Banks LD, Niaz MS, Hood DB, Roberts LJ, Ramesh A. Influence of dietary fat type on benzo(a)pyrene [B(a)P] biotransformation in a B(a)P-induced mouse model of colon cancer. J Nutr Biochem. 2013 Dec; 24(12):2051-63.
11. Harris KL, Banks LD, Mantey JA, Huderson AC, Ramesh A. Bioaccessibility of polycyclic aromatic hydrocarbons: relevance to toxicity and carcinogenesis. Expert Opin Drug Metab Toxicol. 2013 Nov; 9(11):1465-80.
12. Rekhadevi PV, Diggs DL, Huderson AC, Harris KL, Archibong AE, Ramesh A. Metabolism of the environmental toxicant benzo(a)pyrene by subcellular fractions of human ovary. Hum Exp Toxicol. 2014 Feb; 33(2):196-202.
13. Harris KL, Myers JN, Ramesh A. Benzo(a)pyrene modulates fluoranthene-induced cellular responses in HT-29 colon cells in a dual exposure system. Environ Toxicol Pharmacol. 2013 Sep; 36(2):358-67.
14. Archibong AE, Ramesh A, Inyang F, Niaz MS, Hood DB, Kopsombut P. Endocrine disruptive actions of inhaled benzo(a)pyrene on ovarian function and fetal survival in fisher F-344 adult rats. Reprod Toxicol. 2012 Dec; 34(4):635-43.
15. Huderson AC, Myers JN, Niaz MS, Washington MK, Ramesh A. Chemoprevention of benzo(a)pyrene-induced colon polyps in ApcMin mice by resveratrol. J Nutr Biochem. 2013 Apr; 24(4):713-24.
16. Diggs DL, Harris KL, Rekhadevi PV, Ramesh A. Tumor microsomal metabolism of the food toxicant, benzo(a)pyrene, in ApcMin mouse model of colon cancer. Tumour Biol. 2012 Aug; 33(4):1255-60.
17. Prins PA, Perati PR, Kon V, Guo Z, Ramesh A, Linton MF, Fazio S, Sampson UK. Benzo[a]pyrene potentiates the pathogenesis of abdominal aortic aneurysms in apolipoprotein E knockout mice. Cell Physiol Biochem. 2012; 29(1-2):121-30.
18. Jules GE, Pratap S, Ramesh A, Hood DB. In utero exposure to benzo(a)pyrene predisposes offspring to cardiovascular dysfunction in later-life. Toxicology. 2012 May 16; 295(1-3):56-67.
19. Li Z, Chadalapaka G, Ramesh A, Khoshbouei H, Maguire M, Safe S, Rhoades RE, Clark R, Jules G, McCallister M, Aschner M, Hood DB. PAH particles perturb prenatal processes and phenotypes: protection from deficits in object discrimination afforded by dampening of brain oxidoreductase following in utero exposure to inhaled benzo(a)pyrene. Toxicol Sci. 2012 Jan; 125(1):233-47.
20. Diggs DL, Huderson AC, Harris KL, Myers JN, Banks LD, Rekhadevi PV, Niaz MS, Ramesh A. Polycyclic aromatic hydrocarbons and digestive tract cancers: a perspective. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2011 Oct; 29(4):324-57.
21. Myers JN, Rekhadevi PV, Ramesh A. Comparative evaluation of different cell lysis and extraction methods for studying benzo(a)pyrene metabolism in HT-29 colon cancer cell cultures. Cell Physiol Biochem. 2011; 28(2):209-18.
22. Sheng L, Ding X, Ferguson M, McCallister M, Rhoades R, Maguire M, Ramesh A, Aschner M, Campbell D, Levitt P, Hood DB. Prenatal polycyclic aromatic hydrocarbon exposure leads to behavioral deficits and downregulation of receptor tyrosine kinase, MET. Toxicol Sci. 2010 Dec; 118(2):625-34.
23. Huderson AC, Harris DL, Niaz MS, Ramesh A. Effect of benzo(a)pyrene exposure on fluoranthene metabolism by mouse adipose tissue microsomes. Toxicol Mech Methods. 2010 Feb; 20(2):53-8.
24. Ramesh A, Archibong AE, Niaz MS. Ovarian susceptibility to benzo[a]pyrene: tissue burden of metabolites and DNA adducts in F-344 rats. J Toxicol Environ Health A. 2010; 73(23):1611-25.
25. Harris DL, Huderson AC, Niaz MS, Ford JJ, Archibong AE, Ramesh A. Comparative metabolism of benzo(a)pyrene by ovarian microsomes of various species. Environ Toxicol. 2009 Dec; 24(6):603-9.
26. Harris DL, Washington MK, Hood DB, Roberts LJ, Ramesh A. Dietary fat-influenced development of colon neoplasia in Apc Min mice exposed to benzo(a)pyrene. Toxicol Pathol. 2009 Dec; 37(7):938-46.
27. Wang Z, Yang H, Ramesh A, Roberts LJ, Zhou L, Lin X, Zhao Y, Guo Z. Overexpression of Cu/Zn-superoxide dismutase and/or catalase accelerates benzo(a)pyrene detoxification by upregulation of the aryl hydrocarbon receptor in mouse endothelial cells. Free Radic Biol Med. 2009 Oct 15; 47(8):1221-9.
28. McCallister MM, Maguire M, Ramesh A, Aimin Q, Liu S, Khoshbouei H, Aschner M, Ebner FF, Hood DB. Prenatal exposure to benzo(a)pyrene impairs later-life cortical neuronal function. Neurotoxicology. 2008 Sep; 29(5):846-54.
29. Ramesh A, Inyang F, Lunstra DD, Niaz MS, Kopsombut P, Jones KM, Hood DB, Hills ER, Archibong AE. Alteration of fertility endpoints in adult male F-344 rats by subchronic exposure to inhaled benzo(a)pyrene. Exp Toxicol Pathol. 2008 Aug; 60(4-5):269-80.
30. Archibong AE, Ramesh A, Niaz MS, Brooks CM, Roberson SI, Lunstra DD. Effects of benzo(a)pyrene on intra-testicular function in F-344 rats. Int J Environ Res Public Health. 2008 Mar; 5(1):32-40.
31. Harris DL, Hood DB, Ramesh A. Vehicle-dependent disposition kinetics of fluoranthene in Fisher-344 rats. Int J Environ Res Public Health. 2008 Mar; 5(1):41-8.
32. Brown LA, Khousbouei H, Goodwin JS, Irvin-Wilson CV, Ramesh A, Sheng L, McCallister MM, Jiang GC, Aschner M, Hood DB. Down-regulation of early ionotrophic glutamate receptor subunit developmental expression as a mechanism for observed plasticity deficits following gestational exposure to benzo(a)pyrene. Neurotoxicology. 2007 Sep; 28(5):965-78.
33. Smith TL, Merry ST, Harris DL, Joe Ford J, Ike J, Archibong AE, Ramesh A. Species-specific testicular and hepatic microsomal metabolism of benzo(a)pyrene, an ubiquitous toxicant and endocrine disruptor. Toxicol In Vitro. 2007 Jun; 21(4):753-8.
34. Saunders CR, Das SK, Ramesh A, Shockley DC, Mukherjee S. Benzo(a)pyrene-induced acute neurotoxicity in the F-344 rat: role of oxidative stress. J Appl Toxicol. 2006 Sep-Oct; 26(5):427-38.
35. Walker SA, Addai AB, Mathis M, Ramesh A. Effect of dietary fat on metabolism and DNA adduct formation after acute oral exposure of F-344 rats to fluoranthene. J Nutr Biochem. 2007 Apr; 18(4):236-49.
36. Ramesh A, Knuckles ME. Dose-dependent benzo(a)pyrene [B(a)P]-DNA adduct levels and persistence in F-344 rats following subchronic dietary exposure to B(a)P. Cancer Lett. 2006 Aug 28; 240(2):268-78.
37. Walker SA, Whitten LB, Seals GB, Lee WE, Archibong AE, Ramesh A. Inter-species comparison of liver and small intestinal microsomal metabolism of fluoranthene. Food Chem Toxicol. 2006 Mar; 44(3):380-7.
38. Ramesh A, Inyang F, Knuckles ME. Modulation of adult rat benzo(a)pyrene (BaP) metabolism and DNA adduct formation by neonatal diethylstilbestrol (DES) exposure. Exp Toxicol Pathol. 2004 Dec; 56(3):129-38.
39. Knuckles ME, Inyang F, Ramesh A. Acute and subchronic oral toxicity of fluoranthene in F-344 rats. Ecotoxicol Environ Saf. 2004 Sep; 59(1):102-8.
40. Wormley DD, Ramesh A, Hood DB. Environmental contaminant-mixture effects on CNS development, plasticity, and behavior. Toxicol Appl Pharmacol. 2004 May 15; 197(1):49-65.
41. Ramesh A, Walker SA, Hood DB, Guillén MD, Schneider K, Weyand EH. Bioavailability and risk assessment of orally ingested polycyclic aromatic hydrocarbons. Int J Toxicol. 2004; 23(5):301-33.
42. Wu J, Ramesh A, Nayyar T, Hood DB. Assessment of metabolites and AhR and CYP1A1 mRNA expression subsequent to prenatal exposure to inhaled benzo(a)pyrene. Int J Dev Neurosci. 2003 Oct; 21(6):333-46.
43. Inyang F, Ramesh A, Kopsombut P, Niaz MS, Hood DB, Nyanda AM, Archibong AE. Disruption of testicular steroidogenesis and epididymal function by inhaled benzo(a)pyrene. Reprod Toxicol. 2003 Sep-Oct; 17(5):527-37.
44. Archibong AE, Inyang F, Ramesh A, Greenwood M, Nayyar T, Kopsombut P, Hood DB, Nyanda AM. Alteration of pregnancy related hormones and fetal survival in F-344 rats exposed by inhalation to benzo(a)pyrene. Reprod Toxicol. 2002 Nov-Dec; 16(6):801-8.
45. Saunders CR, Ramesh A, Shockley DC. Modulation of neurotoxic behavior in F-344 rats by temporal disposition of benzo(a)pyrene. Toxicol Lett. 2002 Mar 24; 129(1-2):33-45.
46. Ramesh A, Inyang F, Hood DB, Archibong AE, Knuckles ME, Nyanda AM. Metabolism, bioavailability, and toxicokinetics of benzo(alpha)pyrene in F-344 rats following oral administration. Exp Toxicol Pathol. 2001 Sep; 53(4):275-90.
47. Ramesh A, Greenwood M, Inyang F, Hood DB. Toxicokinetics of inhaled benzo[a]pyrene: plasma and lung bioavailability. Inhal Toxicol. 2001 Jun; 13(6):533-55.
48. Hood DB, Nayyar T, Ramesh A, Greenwood M, Inyang F. Modulation in the developmental expression profile of Sp1 subsequent to transplacental exposure of fetal rats to desorbed benzo[a]pyrene following maternal inhalation. Inhal Toxicol. 2000 Jun; 12(6):511-35.
49. Nyanda AM, Nunes MG, Ramesh A. A simple high-performance liquid chromatography method for the quantitation of tricyclic antidepressant drugs in human plasma or serum. J Toxicol Clin Toxicol. 2000; 38(6):631-6.
50. Ramesh A, Inyang F, Hood DB, Knuckles ME. Aryl hydrocarbon hydroxylase activity in F-344 rats subchronically exposed to benzo(a)pyrene and fluoranthene through diet. J Biochem Mol Toxicol. 2000; 14(3):155-61.
51. Hilliard A, Ramesh A, Zawia NH. Correlation between lead-induced changes in cerebral ornithine decarboxylase and protein kinase C activities during development and in cultured PC 12 cells. Int J Dev Neurosci. 1999 Dec; 17(8):777-85.
52. Hilliard AL, Ramesh A, Zawia NH. Regional variations in spermine levels in the developing rat brain following exposure to lead. Brain Res Bull. 1999 Jul 15; 49(5):349-53.

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Colonic Neoplasms
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