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Ketema Paul
Title Dr.
Faculty Rank Associate Professor
Degree Ph.D.
Institution Morehouse School of Medicine
Department Neurobiology
Clusters Other
Morehouse School of Medicine
720 Westview Drive, SW
Multidisciplinary Research Center
City Atlanta
State GA
Postal Code 30310
Telephone 404-756-5785
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  Research projects funded by the National Institutes of Health (NIH), the Centers for Disease Control (CDC), the Food and Drug Administration (FDA), and the Department of Veterans Affairs (VA)

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2016The impact of sex chromosomes on the ability to recover from sleep loss4R01NS078410-05
2016The impact of sex chromosomes on the ability to recover from sleep loss7R01NS078410-06
2015Indentifying New Genetic Targets to Help treat Sleep Disorders5U54NS083932-03
2015The impact of sex chromosomes on the ability to recover from sleep loss5R01NS078410-04
2014Development of a sex specific biomarker for sleep loss3R01NS078410-03S1
2014The impact of sex chromosomes on the ability to recover from sleep loss5R01NS078410-03
2014Indentifying New Genetic Targets to Help treat Sleep Disorders5U54NS083932-02
2013The impact of sex chromosomes on the ability to recover from sleep loss5R01NS078410-02
2013Indentifying New Genetic Targets to Help treat Sleep Disorders1U54NS083932-01
2012Bmal1: a potential homeostatic regulator of the sleep-wake cycle5U54NS060659-05
2012The impact of sex chromosomes on the ability to recover from sleep loss1R01NS078410-01
2011Bmal1: a potential homeostatic regulator of the sleep-wake cycle5U54NS060659-04
2010Bmal1: a potential homeostatic regulator of the sleep-wake cycle5U54NS060659-03
2009Bmal1: a potential homeostatic regulator of the sleep-wake cycle5U54NS060659-02
2008Bmal1: a potential homeostatic regulator of the sleep-wake cycle1U54NS060659-01

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1. Nichols IS, Jones MI, Okere C, Ananaba G, Bush B, Gray C, Brager A, Ehlen JC, Paul K. Nitrergic neurons of the dorsal raphe nucleus encode information about stress duration. PLoS One. 2017; 12(11):e0187071.
2. Ehlen JC, Brager AJ, Baggs J, Pinckney L, Gray CL, DeBruyne JP, Esser KA, Takahashi JS, Paul KN. Bmal1 function in skeletal muscle regulates sleep. Elife. 2017 Jul 20; 6.
3. Brager AJ, Heemstra L, Bhambra R, Ehlen JC, Esser KA, Paul KN, Novak CM. Homeostatic effects of exercise and sleep on metabolic processes in mice with an overexpressed skeletal muscle clock. Biochimie. 2017 Jan; 132:161-165.
4. Brager AJ, Yang T, Ehlen JC, Simon RP, Meller R, Paul KN. Sleep Is Critical for Remote Preconditioning-Induced Neuroprotection. Sleep. 2016 11 01; 39(11):2033-2040.
5. Ehlen JC, Jones KA, Pinckney L, Gray CL, Burette S, Weinberg RJ, Evans JA, Brager AJ, Zylka MJ, Paul KN, Philpot BD, DeBruyne JP. Maternal Ube3a Loss Disrupts Sleep Homeostasis But Leaves Circadian Rhythmicity Largely Intact. J Neurosci. 2015 Oct 07; 35(40):13587-98.
6. Evans JA, Suen TC, Callif BL, Mitchell AS, Castanon-Cervantes O, Baker KM, Kloehn I, Baba K, Teubner BJ, Ehlen JC, Paul KN, Bartness TJ, Tosini G, Leise T, Davidson AJ. Shell neurons of the master circadian clock coordinate the phase of tissue clocks throughout the brain and body. BMC Biol. 2015 Jun 23; 13:43.
7. Jefferson F, Ehlen JC, Williams NS, Montemarano JJ, Paul KN. A dopamine receptor d2-type agonist attenuates the ability of stress to alter sleep in mice. Endocrinology. 2014 Nov; 155(11):4411-21.
8. Ehlen JC, Jefferson F, Brager AJ, Benveniste M, Paul KN. Period-amplitude analysis reveals wake-dependent changes in the electroencephalogram during sleep deprivation. Sleep. 2013 Nov 01; 36(11):1723-35.
9. Brager AJ, Ehlen JC, Castanon-Cervantes O, Natarajan D, Delisser P, Davidson AJ, Paul KN. Sleep loss and the inflammatory response in mice under chronic environmental circadian disruption. PLoS One. 2013; 8(5):e63752.
10. Ehlen JC, Hesse S, Pinckney L, Paul KN. Sex chromosomes regulate nighttime sleep propensity during recovery from sleep loss in mice. PLoS One. 2013; 8(5):e62205.
11. Papale LA, Makinson CD, Christopher Ehlen J, Tufik S, Decker MJ, Paul KN, Escayg A. Altered sleep regulation in a mouse model of SCN1A-derived genetic epilepsy with febrile seizures plus (GEFS+). Epilepsia. 2013 Apr; 54(4):625-34.
12. Paul KN. Serotonin and sleep: breaking the cycle (Commentary on Nakamaru-Ogiso et al.). Eur J Neurosci. 2012 Jun; 35(11):1761.
13. Mong JA, Baker FC, Mahoney MM, Paul KN, Schwartz MD, Semba K, Silver R. Sleep, rhythms, and the endocrine brain: influence of sex and gonadal hormones. J Neurosci. 2011 Nov 09; 31(45):16107-16.
14. Sompol P, Liu X, Baba K, Paul KN, Tosini G, Iuvone PM, Ye K. N-acetylserotonin promotes hippocampal neuroprogenitor cell proliferation in sleep-deprived mice. Proc Natl Acad Sci U S A. 2011 May 24; 108(21):8844-9.
15. Castanon-Cervantes O, Wu M, Ehlen JC, Paul K, Gamble KL, Johnson RL, Besing RC, Menaker M, Gewirtz AT, Davidson AJ. Dysregulation of inflammatory responses by chronic circadian disruption. J Immunol. 2010 Nov 15; 185(10):5796-805.
16. Pinotti M, Bertolucci C, Frigato E, Branchini A, Cavallari N, Baba K, Contreras-Alcantara S, Ehlen JC, Bernardi F, Paul KN, Tosini G. Chronic sleep deprivation markedly reduces coagulation factor VII expression. Haematologica. 2010 Aug; 95(8):1429-32.
17. Papale LA, Paul KN, Sawyer NT, Manns JR, Tufik S, Escayg A. Dysfunction of the Scn8a voltage-gated sodium channel alters sleep architecture, reduces diurnal corticosterone levels, and enhances spatial memory. J Biol Chem. 2010 May 28; 285(22):16553-61.
18. Paul KN, Saafir TB, Tosini G. The role of retinal photoreceptors in the regulation of circadian rhythms. Rev Endocr Metab Disord. 2009 Dec; 10(4):271-8.
19. Paul KN, Losee-Olson S, Pinckney L, Turek FW. The ability of stress to alter sleep in mice is sensitive to reproductive hormones. Brain Res. 2009 Dec 11; 1305:74-85.
20. Paul KN, Laposky AD, Turek FW. Reproductive hormone replacement alters sleep in mice. Neurosci Lett. 2009 Oct 09; 463(3):239-43.
21. Ehlen JC, Paul KN. Regulation of light's action in the mammalian circadian clock: role of the extrasynaptic GABAA receptor. Am J Physiol Regul Integr Comp Physiol. 2009 May; 296(5):R1606-12.
22. Paul KN, Turek FW, Kryger MH. Influence of sex on sleep regulatory mechanisms. J Womens Health (Larchmt). 2008 Sep; 17(7):1201-8.
23. Novak CM, Ehlen JC, Paul KN, Fukuhara C, Albers HE. Light and GABA)(A) receptor activation alter period mRNA levels in the SCN of diurnal Nile grass rats. Eur J Neurosci. 2006 Nov; 24(10):2843-52.
24. Paul KN, Dugovic C, Turek FW, Laposky AD. Diurnal sex differences in the sleep-wake cycle of mice are dependent on gonadal function. Sleep. 2006 Sep; 29(9):1211-23.
25. Ehlen JC, Novak CM, Karom MC, Gamble KL, Paul KN, Albers HE. GABAA receptor activation suppresses Period 1 mRNA and Period 2 mRNA in the suprachiasmatic nucleus during the mid-subjective day. Eur J Neurosci. 2006 Jun; 23(12):3328-36.
26. Gamble KL, Paul KN, Karom MC, Tosini G, Albers HE. Paradoxical effects of NPY in the suprachiasmatic nucleus. Eur J Neurosci. 2006 May; 23(9):2488-94.
27. Paul KN, Fukuhara C, Karom M, Tosini G, Albers HE. AMPA/kainate receptor antagonist DNQX blocks the acute increase of Per2 mRNA levels in most but not all areas of the SCN. Brain Res Mol Brain Res. 2005 Sep 13; 139(1):129-36.
28. Paul KN, Gamble KL, Fukuhara C, Novak CM, Tosini G, Albers HE. Tetrodotoxin administration in the suprachiasmatic nucleus prevents NMDA-induced reductions in pineal melatonin without influencing Per1 and Per2 mRNA levels. Eur J Neurosci. 2004 May; 19(10):2808-14.
29. Gamble KL, Novak CM, Paul KN, Albers HE. Tetrodotoxin blocks the circadian effects of NMDA during the day but not at night. Neuroreport. 2003 Mar 24; 14(4):641-4.
30. Paul KN, Fukuhara C, Tosini G, Albers HE. Transduction of light in the suprachiasmatic nucleus: evidence for two different neurochemical cascades regulating the levels of Per1 mRNA and pineal melatonin. Neuroscience. 2003; 119(1):137-44.
31. Mann DR, Akinbami MA, Gould KG, Paul K, Wallen K. Sexual maturation in male rhesus monkeys: importance of neonatal testosterone exposure and social rank. J Endocrinol. 1998 Mar; 156(3):493-501.

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