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Sergei Nekhai
Title Center for Sickle Cell Disease
Faculty Rank
Degree Ph.D.
Institution Howard University
Department Medicine
Clusters HIV/AIDS
Address
1840 7th street, NW HURB-1, Rm.203_
City Washington
State DC
Postal Code 20001
Telephone (202) 865-4545
Fax
Email
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  Research projects funded by the National Institutes of Health (NIH), the Centers for Disease Control (CDC), the Food and Drug Administration (FDA), and the Department of Veterans Affairs (VA)

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1.
2019Core C: Basic Sciences Core5P30AI117970-05
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2018Inhibition of HIV-1 in Sickle Cell Disease5R01HL125005-05
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2017Inhibition of HIV-1 in Sickle Cell Disease5R01HL125005-04
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2017Inhibition of HIV-1 in Sickle Cell Disease3R01HL125005-03S1
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2017Conference on Physiology and Pathophysiology of Sickle Cell Disease1R13HL138729-01
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2016Inhibition of HIV-1 in Sickle Cell Disease5R01HL125005-03
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2015Inhibition of HIV-1 in Sickle Cell Disease5R01HL125005-02
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2015Inhibition of HIV-1 in Sickle Cell Disease3R01HL125005-02S1
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2014Inhibition of HIV-1 in Sickle Cell Disease1R01HL125005-01
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2011Regulation of HIV-1 Transcription by CDK25SC1GM082325-04
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2010Regulation of HIV-1 Transcription by CDK25SC1GM082325-03
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2009Regulation of HIV-1 Transcription by CDK25SC1GM082325-02
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2009Howard University Research Scientist Award5R25HL003679-12
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2009Regulation of HIV-1 Transcription by CDK23SC1GM082325-02S1
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2008Regulation of HIV-1 Transcription by CDK21SC1GM082325-01
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2007APPLICATION OF CELLULAR KINETICS AND MOLECULAR DYNAMICS5G12RR003048-20
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2004REGULATION OF HIV-1 TRANSCRIPTION BY CDK25R21AI056973-02
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2004REGULATION OF HIV-1 TRANSCRIPTION BY CDK23R21AI056973-01S1
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2003REGULATION OF HIV-1 TRANSCRIPTION BY CDK21R21AI056973-01

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1. Pleet ML, Mathiesen A, DeMarino C, Akpamagbo YA, Barclay RA, Schwab A, Iordanskiy S, Sampey GC, Lepene B, Ilinykh PA, Bukreyev A, Nekhai S, Aman MJ, Kashanchi F. Corrigendum: Ebola VP40 in Exosomes Can Cause Immune Cell Dysfunction. Front Microbiol. 2018; 9:692.
2. Khaibullina A, Adjei EA, Afangbedji N, Ivanov A, Kumari N, Almeida LEF, Quezado ZMN, Nekhai S, Jerebtsova M. RON kinase inhibition reduces renal endothelial injury in sickle cell disease mice. Haematologica. 2018 May; 103(5):787-798.
3. Richard CA, Rincheval V, Lassoued S, Fix J, Cardone C, Esneau C, Nekhai S, Galloux M, Rameix-Welti MA, Sizun C, Eléouët JF. RSV hijacks cellular protein phosphatase 1 to regulate M2-1 phosphorylation and viral transcription. PLoS Pathog. 2018 Mar; 14(3):e1006920.
4. Jerebtsova M, Saraf SL, Soni S, Afangbedji N, Lin X, Raslan R, Gordeuk VR, Nekhai S. Urinary orosomucoid is associated with progressive chronic kidney disease stage in patients with sickle cell anemia. Am J Hematol. 2018 Aug; 93(4):E107-E109.
5. Jerebtsova M, Saraf SL, Lin X, Lee G, Adjei EA, Kumari N, Afangbedji N, Raslan R, McLean C, Gordeuk VR, Nekhai S. Identification of ceruloplasmin as a biomarker of chronic kidney disease in urine of sickle cell disease patients by proteomic analysis. Am J Hematol. 2018 Feb; 93(2):E45-E47.
6. Lin X, Kumari N, DeMarino C, Kont YS, Ammosova T, Kulkarni A, Jerebtsova M, Vazquez-Meves G, Ivanov A, Dmytro K, Üren A, Kashanchi F, Nekhai S. Inhibition of HIV-1 infection in humanized mice and metabolic stability of protein phosphatase-1-targeting small molecule 1E7-03. Oncotarget. 2017 Sep 29; 8(44):76749-76769.
7. Sergueeva A, Miasnikova G, Shah BN, Song J, Lisina E, Okhotin DJ, Nouraie M, Nekhai S, Ammosova T, Niu XM, Prchal JT, Zhang X, Gordeuk VR. Prospective study of thrombosis and thrombospondin-1 expression in Chuvash polycythemia. Haematologica. 2017 05; 102(5):e166-e169.
8. Lin X, Ammosova T, Kumari N, Nekhai S. Protein Phosphatase-1 -targeted Small Molecules, Iron Chelators and Curcumin Analogs as HIV-1 Antivirals. Curr Pharm Des. 2017; 23(28):4122-4132.
9. Kumari N, Ammosova T, Diaz S, Lin X, Niu X, Ivanov A, Jerebtsova M, Dhawan S, Oneal P, Nekhai S. Increased iron export by ferroportin induces restriction of HIV-1 infection in sickle cell disease. Blood Adv. 2016 Dec 27; 1(3):170-183.
10. Ammosova T, Washington K, Rotimi J, Kumari N, Smith KA, Niu X, Jerebtsova M, Nekhai S. Protein Phosphatase-1 Regulates Expression of Neuregulin-1. Biology (Basel). 2016 Dec 02; 5(4).
11. Dai Y, Sangerman J, Nouraie M, Faller AD, Oneal P, Rock A, Owoyemi O, Niu X, Nekhai S, Maharaj D, Cui S, Taylor R, Steinberg M, Perrine S. Effects of hydroxyurea on F-cells in sickle cell disease and potential impact of a second fetal globin inducer. Am J Hematol. 2017 Jan; 92(1):E10-E11.
12. Fluitt MB, Kumari N, Nunlee-Bland G, Nekhai S, Gambhir KK. miRNA-15a, miRNA-15b, and miRNA-499 are Reduced in Erythrocytes of Pre-Diabetic African-American Adults. Jacobs J Diabetes Endocrinol. 2016 Dec; 2(1).
13. Pleet ML, Mathiesen A, DeMarino C, Akpamagbo YA, Barclay RA, Schwab A, Iordanskiy S, Sampey GC, Lepene B, Nekhai S, Aman MJ, Kashanchi F. Ebola VP40 in Exosomes Can Cause Immune Cell Dysfunction. Front Microbiol. 2016; 7:1765.
14. Zhang X, Shah BN, Zhang W, Saraf SL, Miasnikova G, Sergueeva A, Ammosova T, Niu X, Nouraie M, Nekhai S, Castro O, Gladwin MT, Prchal JT, Garcia JG, Machado RF, Gordeuk VR. A genetic variation associated with plasma erythropoietin and a non-coding transcript of PRKAR1A in sickle cell disease. Hum Mol Genet. 2016 10 15; 25(20):4601-4609.
15. Santos S, Obukhov Y, Nekhai S, Pushkarsky T, Brichacek B, Bukrinsky M, Iordanskiy S. Cellular minichromosome maintenance complex component 5 (MCM5) is incorporated into HIV-1 virions and modulates viral replication in the newly infected cells. Virology. 2016 10; 497:11-22.
16. Ogunwuyi O, Kumari N, Smith KA, Bolshakov O, Adesina S, Gugssa A, Anderson WA, Nekhai S, Akala EO. Antiretroviral Drugs-Loaded Nanoparticles Fabricated by Dispersion Polymerization with Potential for HIV/AIDS Treatment. Infect Dis (Auckl). 2016; 9:21-32.
17. Baer A, Shafagati N, Benedict A, Ammosova T, Ivanov A, Hakami RM, Terasaki K, Makino S, Nekhai S, Kehn-Hall K. Protein Phosphatase-1 regulates Rift Valley fever virus replication. Antiviral Res. 2016 Mar; 127:79-89.
18. Huang H, Konduru K, Solovena V, Zhou ZH, Kumari N, Takeda K, Nekhai S, Bavari S, Kaplan GG, Yamada KM, Dhawan S. Therapeutic potential of the heme oxygenase-1 inducer hemin against Ebola virus infection. Curr Trends Immunol. 2016; 17:117-123.
19. Kumari N, Kulkarni AA, Lin X, McLean C, Ammosova T, Ivanov A, Hipolito M, Nekhai S, Nwulia E. Inhibition of HIV-1 by curcumin A, a novel curcumin analog. Drug Des Devel Ther. 2015; 9:5051-60.
20. Tyagi M, Iordanskiy S, Ammosova T, Kumari N, Smith K, Breuer D, Ilatovskiy AV, Kont YS, Ivanov A, Üren A, Kovalskyy D, Petukhov M, Kashanchi F, Nekhai S. Reactivation of latent HIV-1 provirus via targeting protein phosphatase-1. Retrovirology. 2015 Jul 16; 12:63.
21. Smith KA, Lin X, Bolshakov O, Griffin J, Niu X, Kovalskyy D, Ivanov A, Jerebtsova M, Taylor RE, Akala E, Nekhai S. Activation of HIV-1 with Nanoparticle-Packaged Small-Molecule Protein Phosphatase-1-Targeting Compound. Sci Pharm. 2015 Jul-Sep; 83(3):535-48.
22. Zhang X, Zhang W, Saraf SL, Nouraie M, Han J, Gowhari M, Hassan J, Miasnikova G, Sergueeva A, Nekhai S, Kittles R, Machado RF, Garcia JG, Gladwin MT, Steinberg MH, Sebastiani P, McClain DA, Gordeuk VR. Genetic polymorphism of APOB is associated with diabetes mellitus in sickle cell disease. Hum Genet. 2015 Aug; 134(8):895-904.
23. Jerebtsova M, Nekhai S. Therapeutics for postexposure treatment of Ebola virus infection. Future Virol. 2015 Mar; 10(3):221-232.
24. Kassim OO, Copeland RL, Kenguele HM, Nekhai S, Ako-Nai KA, Kanaan YM. Antiproliferative activities of Fagara xanthoxyloides and Pseudocedrela kotschyi against prostate cancer cell lines. Anticancer Res. 2015 Mar; 35(3):1453-8.
25. Jerebtsova M, Nekhai S. Quantitative mass spectrometry of urinary biomarkers. J Integr OMICS. 2014 Dec 01; 4(2):69-78.
26. van Beers EJ, Yang Y, Raghavachari N, Tian X, Allen DT, Nichols JS, Mendelsohn L, Nekhai S, Gordeuk VR, Taylor JG, Kato GJ. Iron, inflammation, and early death in adults with sickle cell disease. Circ Res. 2015 Jan 16; 116(2):298-306.
27. Ammosova T, Platonov M, Ivanov A, Kont YS, Kumari N, Kehn-Hall K, Jerebtsova M, Kulkarni AA, Uren A, Kovalskyy D, Nekhai S. 1E7-03, a low MW compound targeting host protein phosphatase-1, inhibits HIV-1 transcription. Br J Pharmacol. 2014 Nov; 171(22):5059-75.
28. Kumari N, Iordanskiy S, Kovalskyy D, Breuer D, Niu X, Lin X, Xu M, Gavrilenko K, Kashanchi F, Dhawan S, Nekhai S. Phenyl-1-Pyridin-2yl-ethanone-based iron chelators increase I?B-a expression, modulate CDK2 and CDK9 activities, and inhibit HIV-1 transcription. Antimicrob Agents Chemother. 2014 Nov; 58(11):6558-71.
29. Ilinykh PA, Tigabu B, Ivanov A, Ammosova T, Obukhov Y, Garron T, Kumari N, Kovalskyy D, Platonov MO, Naumchik VS, Freiberg AN, Nekhai S, Bukreyev A. Role of protein phosphatase 1 in dephosphorylation of Ebola virus VP30 protein and its targeting for the inhibition of viral transcription. J Biol Chem. 2014 Aug 15; 289(33):22723-38.
30. Chasnyk V, Fedorova E, Egorov A, Ammosova T, Nekhai S, Kostik M, Santimov A, Dubko M, Kalashnikova O, Masalova V, Likhacheva T, Snegireva L, Grom A. A130: Is the CCR5-delta32 Mutation Protective Against Systemic-Onset Juvenile Idiopathic Arthritis? Arthritis Rheumatol. 2014 Mar; 66 Suppl 3:S171.
31. Zhang X, Zhang W, Ma SF, Desai AA, Saraf S, Miasniakova G, Sergueeva A, Ammosova T, Xu M, Nekhai S, Abbasi T, Casanova NG, Steinberg MH, Baldwin CT, Sebastiani P, Prchal JT, Kittles R, Garcia JG, Machado RF, Gordeuk VR. Hypoxic response contributes to altered gene expression and precapillary pulmonary hypertension in patients with sickle cell disease. Circulation. 2014 Apr 22; 129(16):1650-8.
32. Nekhai S, Petukhov M, Breuer D. Regulation of CDK9 activity by phosphorylation and dephosphorylation. Biomed Res Int. 2014; 2014:964964.
33. Ashenafi M, Ammosova T, Nekhai S, Byrnes WM. Purification and characterization of aminoglycoside phosphotransferase APH(6)-Id, a streptomycin-inactivating enzyme. Mol Cell Biochem. 2014 Feb; 387(1-2):207-16.
34. Salomon-Andonie J, Miasnikova G, Sergueeva A, Polyakova LA, Niu X, Nekhai S, Gordeuk VR. Effect of congenital upregulation of hypoxia inducible factors on percentage of fetal hemoglobin in the blood. Blood. 2013 Oct 24; 122(17):3088-9.
35. Zhang X, Zhang W, Ma SF, Miasniakova G, Sergueeva A, Ammosova T, Xu M, Nekhai S, Nourai M, Wade MS, Prchal JT, Garcia JGN, Machado RF, Gordeuk VR. Iron deficiency modifies gene expression variation induced by augmented hypoxia sensing. Blood Cells Mol Dis. 2014 Jan; 52(1):35-45.
36. Zhou ZH, Kumari N, Nekhai S, Clouse KA, Wahl LM, Yamada KM, Dhawan S. Heme oxygenase-1 induction alters chemokine regulation and ameliorates human immunodeficiency virus-type-1 infection in lipopolysaccharide-stimulated macrophages. Biochem Biophys Res Commun. 2013 Jun 07; 435(3):373-7.
37. Nekhai S, Kumari N, Dhawan S. Role of cellular iron and oxygen in the regulation of HIV-1 infection. Future Virol. 2013 Mar; 8(3):301-311.
38. Tomasic NL, Piterkova L, Huff C, Bilic E, Yoon D, Miasnikova GY, Sergueeva AI, Niu X, Nekhai S, Gordeuk V, Prchal JT. The phenotype of polycythemia due to Croatian homozygous VHL (571C>G:H191D) mutation is different from that of Chuvash polycythemia (VHL 598C>T:R200W). Haematologica. 2013 Apr; 98(4):560-7.
39. Zhou ZH, Kumari N, Catalano J, Nekhai S, Wise J, Yamada KM, Dhawan S. Heme oxygenase-1-mediated host cell response inhibits the susceptibility of prostate cancer cells to retroviral infection and retards their proliferation. Curr Trends Immunol. 2013 Jan; 14:53-56.
40. Van Duyne R, Guendel I, Jaworski E, Sampey G, Klase Z, Chen H, Zeng C, Kovalskyy D, El Kouni MH, Lepene B, Patanarut A, Nekhai S, Price DH, Kashanchi F. Effect of mimetic CDK9 inhibitors on HIV-1-activated transcription. J Mol Biol. 2013 Feb 22; 425(4):812-29.
41. Breuer D, Kotelkin A, Ammosova T, Kumari N, Ivanov A, Ilatovskiy AV, Beullens M, Roane PR, Bollen M, Petukhov MG, Kashanchi F, Nekhai S. CDK2 regulates HIV-1 transcription by phosphorylation of CDK9 on serine 90. Retrovirology. 2012 Nov 09; 9:94.
42. Nekhai S, Xu M, Foster A, Kasvosve I, Diaz S, Machado RF, Castro OL, Kato GJ, Taylor JG, Gordeuk VR. Reduced sensitivity of the ferroportin Q248H mutant to physiological concentrations of hepcidin. Haematologica. 2013 Mar; 98(3):455-63.
43. Jerebtsova M, Kumari N, Obuhkov Y, Nekhai S. Adenoviral E4 gene stimulates secretion of pigmental epithelium derived factor (PEDF) that maintains long-term survival of human glomerulus-derived endothelial cells. Mol Cell Proteomics. 2012 Nov; 11(11):1378-88.
44. Debebe Z, Nekhai S, Ashenafi M, Lovejoy DB, Kalinowski DS, Gordeuk VR, Byrnes WM, Richardson DR, Karla PK. Development of a sensitive HPLC method to measure in vitro permeability of E- and Z-isomeric forms of thiosemicarbazones in Caco-2 monolayers. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Oct 01; 906:25-32.
45. Santos S, Obukhov Y, Nekhai S, Bukrinsky M, Iordanskiy S. Virus-producing cells determine the host protein profiles of HIV-1 virion cores. Retrovirology. 2012 Aug 13; 9:65.
46. Jerebtsova M, Kumari N, Xu M, de Melo GB, Niu X, Jeang KT, Nekhai S. HIV-1 Resistant CDK2-Knockdown Macrophage-Like Cells Generated from 293T Cell-Derived Human Induced Pluripotent Stem Cells. Biology (Basel). 2012 Jul 26; 1(2):175-195.
47. Narayanan A, Sampey G, Van Duyne R, Guendel I, Kehn-Hall K, Roman J, Currer R, Galons H, Oumata N, Joseph B, Meijer L, Caputi M, Nekhai S, Kashanchi F. Use of ATP analogs to inhibit HIV-1 transcription. Virology. 2012 Oct 10; 432(1):219-31.
48. Ammosova T, Platonov M, Yedavalli VR, Obukhov Y, Gordeuk VR, Jeang KT, Kovalskyy D, Nekhai S. Small molecules targeted to a non-catalytic "RVxF" binding site of protein phosphatase-1 inhibit HIV-1. PLoS One. 2012; 7(6):e39481.
49. Nouraie M, Nekhai S, Gordeuk VR. Sickle cell disease is associated with decreased HIV but higher HBV and HCV comorbidities in U.S. hospital discharge records: a cross-sectional study. Sex Transm Infect. 2012 Nov; 88(7):528-33.
50. Gordeuk VR, Miasnikova GY, Sergueeva AI, Niu X, Nouraie M, Okhotin DJ, Polyakova LA, Ammosova T, Nekhai S, Ganz T, Prchal JT. Chuvash polycythemia VHLR200W mutation is associated with down-regulation of hepcidin expression. Blood. 2011 Nov 10; 118(19):5278-82.
51. Van Duyne R, Guendel I, Narayanan A, Gregg E, Shafagati N, Tyagi M, Easley R, Klase Z, Nekhai S, Kehn-Hall K, Kashanchi F. Varying modulation of HIV-1 LTR activity by Baf complexes. J Mol Biol. 2011 Aug 19; 411(3):581-96.
52. Ammosova T, Obukhov Y, Kotelkin A, Breuer D, Beullens M, Gordeuk VR, Bollen M, Nekhai S. Protein phosphatase-1 activates CDK9 by dephosphorylating Ser175. PLoS One. 2011 Apr 21; 6(4):e18985.
53. Thuma PE, van Dijk J, Bucala R, Debebe Z, Nekhai S, Kuddo T, Nouraie M, Weiss G, Gordeuk VR. Distinct clinical and immunologic profiles in severe malarial anemia and cerebral malaria in Zambia. J Infect Dis. 2011 Jan 15; 203(2):211-9.
54. Xu M, Kashanchi F, Foster A, Rotimi J, Turner W, Gordeuk VR, Nekhai S. Hepcidin induces HIV-1 transcription inhibited by ferroportin. Retrovirology. 2010 Dec 02; 7:104.
55. Ammosova T, Yedavalli VR, Niu X, Jerebtsova M, Van Eynde A, Beullens M, Bollen M, Jeang KT, Nekhai S. Expression of a protein phosphatase 1 inhibitor, cdNIPP1, increases CDK9 threonine 186 phosphorylation and inhibits HIV-1 transcription. J Biol Chem. 2011 Feb 04; 286(5):3798-804.
56. Debebe Z, Ammosova T, Breuer D, Lovejoy DB, Kalinowski DS, Kumar K, Jerebtsova M, Ray P, Kashanchi F, Gordeuk VR, Richardson DR, Nekhai S. Iron chelators of the di-2-pyridylketone thiosemicarbazone and 2-benzoylpyridine thiosemicarbazone series inhibit HIV-1 transcription: identification of novel cellular targets--iron, cyclin-dependent kinase (CDK) 2, and CDK9. Mol Pharmacol. 2011 Jan; 79(1):185-96.
57. Jerebtsova M, Klotchenko SA, Artamonova TO, Ammosova T, Washington K, Egorov VV, Shaldzhyan AA, Sergeeva MV, Zatulovskiy EA, Temkina OA, Petukhov MG, Vasin AV, Khodorkovskii MA, Orlov YN, Nekhai S. Mass spectrometry and biochemical analysis of RNA polymerase II: targeting by protein phosphatase-1. Mol Cell Biochem. 2011 Jan; 347(1-2):79-87.
58. Kasvosve I, Debebe Z, Nekhai S, Gordeuk VR. Ferroportin (SLC40A1) Q248H mutation is associated with lower circulating plasma tumor necrosis factor-alpha and macrophage migration inhibitory factor concentrations in African children. Clin Chim Acta. 2010 Sep 06; 411(17-18):1248-52.
59. Charles S, Ammosova T, Cardenas J, Foster A, Rotimi J, Jerebtsova M, Ayodeji AA, Niu X, Ray PE, Gordeuk VR, Kashanchi F, Nekhai S. Regulation of HIV-1 transcription at 3% versus 21% oxygen concentration. J Cell Physiol. 2009 Nov; 221(2):469-79.
60. Gordeuk VR, Campbell A, Rana S, Nouraie M, Niu X, Minniti CP, Sable C, Darbari D, Dham N, Onyekwere O, Ammosova T, Nekhai S, Kato GJ, Gladwin MT, Castro OL. Relationship of erythropoietin, fetal hemoglobin, and hydroxyurea treatment to tricuspid regurgitation velocity in children with sickle cell disease. Blood. 2009 Nov 19; 114(21):4639-44.
61. Niu X, Miasnikova GY, Sergueeva AI, Polyakova LA, Okhotin DJ, Tuktanov NV, Nouraie M, Ammosova T, Nekhai S, Gordeuk VR. Altered cytokine profiles in patients with Chuvash polycythemia. Am J Hematol. 2009 Feb; 84(2):74-8.
62. Gordeuk VR, Diaz SF, Onojobi GO, Kasvosve I, Debebe Z, Edossa A, Pantin JM, Xiong S, Nekhai S, Nouraie M, Tsukamoto H, Taylor RE. Ferroportin Q248h, dietary iron, and serum ferritin in community African-Americans with low to high alcohol consumption. Alcohol Clin Exp Res. 2008 Nov; 32(11):1947-53.
63. Berro R, Pedati C, Kehn-Hall K, Wu W, Klase Z, Even Y, Genevière AM, Ammosova T, Nekhai S, Kashanchi F. CDK13, a new potential human immunodeficiency virus type 1 inhibitory factor regulating viral mRNA splicing. J Virol. 2008 Jul; 82(14):7155-66.
64. Sergueeva AI, Miasnikova GY, Okhotin DJ, Levina AA, Debebe Z, Ammosova T, Niu X, Romanova EA, Nekhai S, DiBello PM, Jacobsen DW, Prchal JT, Gordeuk VR. Elevated homocysteine, glutathione and cysteinylglycine concentrations in patients homozygous for the Chuvash polycythemia VHL mutation. Haematologica. 2008 Feb; 93(2):279-82.
65. Debebe Z, Ammosova T, Jerebtsova M, Kurantsin-Mills J, Niu X, Charles S, Richardson DR, Ray PE, Gordeuk VR, Nekhai S. Iron chelators ICL670 and 311 inhibit HIV-1 transcription. Virology. 2007 Oct 25; 367(2):324-33.
66. Berro R, de la Fuente C, Klase Z, Kehn K, Parvin L, Pumfery A, Agbottah E, Vertes A, Nekhai S, Kashanchi F. Identifying the membrane proteome of HIV-1 latently infected cells. J Biol Chem. 2007 Mar 16; 282(11):8207-18.
67. Nekhai S, Jerebtsova M, Jackson A, Southerland W. Regulation of HIV-1 transcription by protein phosphatase 1. Curr HIV Res. 2007 Jan; 5(1):3-9.
68. Nekhai S, Bhat UG, Ammosova T, Radhakrishnan SK, Jerebtsova M, Niu X, Foster A, Layden TJ, Gartel AL. A novel anticancer agent ARC antagonizes HIV-1 and HCV. Oncogene. 2007 May 31; 26(26):3899-903.
69. Nekhai S, Jeang KT. Transcriptional and post-transcriptional regulation of HIV-1 gene expression: role of cellular factors for Tat and Rev. Future Microbiol. 2006 Dec; 1(4):417-26.
70. Ammosova T, Berro R, Jerebtsova M, Jackson A, Charles S, Klase Z, Southerland W, Gordeuk VR, Kashanchi F, Nekhai S. Phosphorylation of HIV-1 Tat by CDK2 in HIV-1 transcription. Retrovirology. 2006 Nov 03; 3:78.
71. Epie N, Ammosova T, Turner W, Nekhai S. Inhibition of PP2A by LIS1 increases HIV-1 gene expression. Retrovirology. 2006 Oct 02; 3:65.
72. Bushuev VI, Miasnikova GY, Sergueeva AI, Polyakova LA, Okhotin D, Gaskin PR, Debebe Z, Nekhai S, Castro OL, Prchal JT, Gordeuk VR. Endothelin-1, vascular endothelial growth factor and systolic pulmonary artery pressure in patients with Chuvash polycythemia. Haematologica. 2006 Jun; 91(6):744-9.
73. Kasvosve I, Gomo ZA, Nathoo KJ, Matibe P, Mudenge B, Loyevsky M, Nekhai S, Gordeuk VR. Association of serum transferrin receptor concentration with markers of inflammation in Zimbabwean children. Clin Chim Acta. 2006 Sep; 371(1-2):130-6.
74. Nekhai S, Jerebtsova M. Therapies for HIV with RNAi. Curr Opin Mol Ther. 2006 Feb; 8(1):52-61.
75. Pumfery A, de la Fuente C, Berro R, Nekhai S, Kashanchi F, Chao SH. Potential use of pharmacological cyclin-dependent kinase inhibitors as anti-HIV therapeutics. Curr Pharm Des. 2006; 12(16):1949-61.
76. Ammosova T, Jerebtsova M, Beullens M, Lesage B, Jackson A, Kashanchi F, Southerland W, Gordeuk VR, Bollen M, Nekhai S. Nuclear targeting of protein phosphatase-1 by HIV-1 Tat protein. J Biol Chem. 2005 Oct 28; 280(43):36364-71.
77. Ammosova T, Berro R, Kashanchi F, Nekhai S. RNA interference directed to CDK2 inhibits HIV-1 transcription. Virology. 2005 Oct 25; 341(2):171-8.
78. Ammosova T, Washington K, Debebe Z, Brady J, Nekhai S. Dephosphorylation of CDK9 by protein phosphatase 2A and protein phosphatase-1 in Tat-activated HIV-1 transcription. Retrovirology. 2005 Jul 27; 2:47.
79. Epie N, Ammosova T, Sapir T, Voloshin Y, Lane WS, Turner W, Reiner O, Nekhai S. HIV-1 Tat interacts with LIS1 protein. Retrovirology. 2005 Feb 07; 2:6.
80. Ammosova T, Jerebtsova M, Beullens M, Voloshin Y, Ray PE, Kumar A, Bollen M, Nekhai S. Nuclear protein phosphatase-1 regulates HIV-1 transcription. J Biol Chem. 2003 Aug 22; 278(34):32189-94.
81. Washington K, Ammosova T, Beullens M, Jerebtsova M, Kumar A, Bollen M, Nekhai S. Protein phosphatase-1 dephosphorylates the C-terminal domain of RNA polymerase-II. J Biol Chem. 2002 Oct 25; 277(43):40442-8.
82. Deng L, Ammosova T, Pumfery A, Kashanchi F, Nekhai S. HIV-1 Tat interaction with RNA polymerase II C-terminal domain (CTD) and a dynamic association with CDK2 induce CTD phosphorylation and transcription from HIV-1 promoter. J Biol Chem. 2002 Sep 13; 277(37):33922-9.
83. Nekhai S, Zhou M, Fernandez A, Lane WS, Lamb NJ, Brady J, Kumar A. HIV-1 Tat-associated RNA polymerase C-terminal domain kinase, CDK2, phosphorylates CDK7 and stimulates Tat-mediated transcription. Biochem J. 2002 Jun 15; 364(Pt 3):649-57.
84. Bharucha DC, Zhou M, Nekhai S, Brady JN, Shukla RR, Kumar A. A protein phosphatase from human T cells augments tat transactivation of the human immunodeficiency virus type 1 long-terminal repeat. Virology. 2002 Apr 25; 296(1):6-16.
85. Nekhai SA, Beletzkij VE, Graifer DM. Influence of systematic error on the shape of the scatchard plot of tRNAPhe binding to eukaryotic ribosomes. Biochem J. 1997 Jul 15; 325 ( Pt 2):401-4.
86. Nekhai SA, Parfenov DV, Saminsky EM. tRNA regions which contact with the ribosomal poly(U)-programmed P-site. Biochim Biophys Acta. 1994 Aug 02; 1218(3):481-4.
87. Nekhai SA, Saminskii EM. [Study of the poly(U)-dependent interaction of tRNA(Phe) with the P-site of Escherichia coli ribosomes by chemical modification with nitrosoethylurea]. Mol Biol (Mosk). 1994 Jul-Aug; 28(4):926-31.
88. Nekhai SA, Saminsky EM. On the binding of isolated yeast tRNA(Phe) anticodon arm to Escherichia coli 30S and 70S ribosomes. Guanosine-42 is important for the binding. Biochim Biophys Acta. 1994 May 17; 1218(1):21-6.
89. Nekhai SA, Saminskii EM. [Binding of a fragment of yeast phenylalanyl tRNA containing an anticodon loop with 30S and 70S ribosomes from Escherichia coli. The role of guanosine-42 in this interaction]. Mol Biol (Mosk). 1994 May-Jun; 28(3):658-64.

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