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Loyda M. Meléndez
Title Dr
Faculty Rank Professor
Degree Ph.D.
Institution University of Puerto Rico
Department Microbiology and Medical Zoology
Clusters HIV/AIDS
Address
UPR-Medical Sciences Campus
School of Medicine
P.O. Box 365067
City San Juan
State PR
Postal Code 00936-5067
Telephone 787-758-2525 xt 2816
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Email
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Title Director
Institution University of Puerto Rico-Medical Sciences Campus
Department HIV Neuroimmunology Laboratory
 
Title Director
Institution University of Puerto Rico-Medical Sciences Campus
Department RCMI Translational Proteomics Center

Awards and Honors icon

1979 PR Development Company -PRIDCO Award for MS degree studies
1985 NIH MARC Award for pre-doctoral studies
1996 School of Allied Health Professional Excellence Award
1999 Glaxo-Wellcome Research Award
2001 NIH Research article in the NIH news
2009 NIH ARRA Award for research
2011 International Society for Neurovirology Research Work Highlighted ISNV Newsletter
2012 Society for Neuroimmune Pharmacology Member of the local organizing committee of the 19th Society for Neuroimmune Pharmacology meeting

Narrative icon

  Dr. Loyda M. Meléndez is Professor in the Department of Microbiology, School of Medicine and directs the RCMI Clinical Proteomics Discovery Core Facility at the University of Puerto Rico Medical Sciences Campus (UPR-MSC). The Facility provides clinical and basic researchers the proteomics instrumentation and ser-vices necessary to determine biomarkers for diseases that involve health disparities. Dr. Meléndez earned her Ph.D. degree in Experimental Pathology & Immunology cum laude from Emory University School of Medicine, where she also completed post-doctoral training in Hematology and Pediatric Infectious Diseas-es in collaboration with the Centers for Disease Control. She also has a M.S. degree magna cum laude in Microbiology from University of Georgia, Athens, and a Medical Technology degree magna cum laude from University of Puerto Rico Medical Sciences Campus. She worked in the industry from 1981-82 as Quality Control Microbiologist, and thereafter joined the UPR-MSC as Professor of Microbiologist in the School of Allied Health. After three years of teaching (1982-85), she was awarded a pre-doctoral MARC faculty fel-lowship. After completion of her PhD and Post-doctoral experience, she joined the Department of Microbi-ology and Medical Zoology of the School of Medicine at the UPR-MSC. She was Director of the Biosafety Committee at this Institution for six years. She is currently Professor of Virology and Principal Investigator of and NIH funded study to understand the mechanisms of macrophage-induced HIV neuropathogenesis using proteomics approaches. Dr. Meléndez has been a mentor of more than 30 graduate and undergrad-uate students in the field of HIV, macrophages, and vertical transmission with active funding from NIH-NCRR-RCMI (Role of HIV variants in vertical transmission), MBRS (Role of the placenta in vertical transmis-sion and protein profiling of “putative” anti-retroviral factors in placental macrophages). Since 2001 she joined the Specialized Neuroscience Program in NeuroAIDS sponsored by NIH-NINDS as a PI in the project entitled: Monocyte immunity and HIV Dementia. With this interdisciplinary project, knowledge transfer of proteomic technology was achieved from her collaborator, Dr. Howard Gendelman’s Laboratory at Univer-sity of Nebraska Medical Center. The development of five publications in the field of NeuroAIDS and prote-omics was instrumental in obtaining funding for an RCMI Core in Proteomics at UPR-MSC and subsequent R01 funding from NIHMH for the study entitled Cystatins and Cathepsins in HIV Neuropathogenesis. Dr. Meléndez is a co-inventor of one patent, has written two book chapters, and is an ad hoc reviewer for NIDA, NIMH, and NIAID and the Journals of PlosONE, Leukocyte Biology, and Placenta. She has published 43 manuscripts in National and International Journals in the areas of HIV and macrophages, and NeuroAIDS.

Mentorship icon

 
Availability Date:
Friday, February 17, 2017

I have been a mentor fro graduate and undergraduate students in research for 25 years. I also mentor young faculty in research at my institution. I can advice young faculty at external institutions.

I am available to mentor as:
HIV, NeuroAIDS, proteomics, and macrophages researcher

Programs, Membership, and Biomedical Research icon

Mentoring Mentor

Publications icon

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1. Cantres-Rosario YM, Acevedo-Mariani FM, Pérez-Laspiur J, Haskins WE, Plaud M, Cantres-Rosario YM, Skolasky R, Méndez-Bermúdez I, Wojna V, Meléndez LM. Microwave & magnetic proteomics of macrophages from patients with HIV-associated cognitive impairment. PLoS One. 2017; 12(7):e0181779.
2. Martínez-Rivera FJ, Pérez-Laspiur J, Santiago-Gascot ME, Alemán-Reyes AG, García-Santiago E, Rodríguez-Pérez Y, Calo-Guadalupe C, Otero-Pagán I, Ayala-Pagán RN, Martínez M, Cantres-Rosario YM, Meléndez LM, Barreto-Estrada JL. Differential protein expression profile in the hypothalamic GT1-7 cell line after exposure to anabolic androgenic steroids. PLoS One. 2017; 12(7):e0180409.
3. Rivera LE, Kraiselburd E, Meléndez LM. Cystatin B and HIV regulate the STAT-1 signaling circuit in HIV-infected and INF-ß-treated human macrophages. J Neurovirol. 2016 10; 22(5):666-673.
4. Delgado-Vélez M, Báez-Pagán CA, Gerena Y, Quesada O, Santiago-Pérez LI, Capó-Vélez CM, Wojna V, Meléndez L, León-Rivera R, Silva W, Lasalde-Dominicci JA. The a7-nicotinic receptor is upregulated in immune cells from HIV-seropositive women: consequences to the cholinergic anti-inflammatory response. Clin Transl Immunology. 2015 Dec; 4(12):e53.
5. Zenón F, Jorge I, Cruz A, Suárez E, Segarra AC, Vázquez J, Meléndez LM, Serrano H. 18O proteomics reveal increased human apolipoprotein CIII in Hispanic HIV-1+ women with HAART that use cocaine. Proteomics Clin Appl. 2016 Feb; 10(2):144-55.
6. Cantres-Rosario YM, Hernandez N, Negron K, Perez-Laspiur J, Leszyk J, Shaffer SA, Meléndez LM. Interacting partners of macrophage-secreted cathepsin B contribute to HIV-induced neuronal apoptosis. AIDS. 2015 Oct 23; 29(16):2081-92.
7. Colón K, Vázquez-Santiago F, Rivera-Amill V, Delgado G, Massey SE, Wojna V, Noel RJ, Meléndez LM. HIV gp120 sequence variability associated with HAND in Hispanic Women. J Virol Antivir Res. 2015; 4(3).
8. Vázquez-Santiago F, García Y, Rivera-Román I, Noel RJ, Wojna V, Meléndez LM, Rivera-Amill V. Longitudinal Analysis of Cerebrospinal Fluid and Plasma HIV-1 Envelope Sequences Isolated From a Single Donor with HIV Asymptomatic Neurocognitive Impairment. J Virol Antivir Res. 2015; 4(1).
9. Zenón F, Segarra AC, Gonzalez M, Meléndez LM. Cocaine potentiates cathepsin B secretion and neuronal apoptosis from HIV-infected macrophages. J Neuroimmune Pharmacol. 2014 Dec; 9(5):703-15.
10. Agsalda-Garcia M, Shiramizu B, Melendez L, Plaud M, Liang CY, Wojna V. Different levels of HIV DNA copy numbers in cerebrospinal fluid cellular subsets. J Health Care Poor Underserved. 2013 Nov; 24(4 Suppl):8-16.
11. Cantres-Rosario Y, Plaud-Valentín M, Gerena Y, Skolasky RL, Wojna V, Meléndez LM. Cathepsin B and cystatin B in HIV-seropositive women are associated with infection and HIV-1-associated neurocognitive disorders. AIDS. 2013 Jan 28; 27(3):347-56.
12. Rodriguez-Franco EJ, Cantres-Rosario YM, Plaud-Valentin M, Romeu R, Rodríguez Y, Skolasky R, Meléndez V, Cadilla CL, Melendez LM. Dysregulation of macrophage-secreted cathepsin B contributes to HIV-1-linked neuronal apoptosis. PLoS One. 2012; 7(5):e36571.
13. Rivera-Rivera L, Perez-Laspiur J, Colón K, Meléndez LM. Inhibition of interferon response by cystatin B: implication in HIV replication of macrophage reservoirs. J Neurovirol. 2012 Feb; 18(1):20-9.
14. Meléndez LM, Colon K, Rivera L, Rodriguez-Franco E, Toro-Nieves D. Proteomic analysis of HIV-infected macrophages. J Neuroimmune Pharmacol. 2011 Mar; 6(1):89-106.
15. Kraft-Terry S, Gerena Y, Wojna V, Plaud-Valentin M, Rodriguez Y, Ciborowski P, Mayo R, Skolasky R, Gendelman HE, Meléndez LM. Proteomic analyses of monocytes obtained from Hispanic women with HIV-associated dementia show depressed antioxidants. Proteomics Clin Appl. 2010 Sep; 4(8-9):706-14.
16. García-Crespo K, Cadilla C, Skolasky R, Meléndez LM. Restricted HIV-1 replication in placental macrophages is caused by inefficient viral transcription. J Leukoc Biol. 2010 Apr; 87(4):633-6.
17. Luciano-Montalvo C, Meléndez LM. Cystatin B associates with signal transducer and activator of transcription 1 in monocyte-derived and placental macrophages. Placenta. 2009 May; 30(5):464-7.
18. Toro-Nieves DM, Rodriguez Y, Plaud M, Ciborowski P, Duan F, Pérez Laspiur J, Wojna V, Meléndez LM. Proteomic analyses of monocyte-derived macrophages infected with human immunodeficiency virus type 1 primary isolates from Hispanic women with and without cognitive impairment. J Neurovirol. 2009 Jan; 15(1):36-50.
19. Velázquez I, Plaud M, Wojna V, Skolasky R, Laspiur JP, Meléndez LM. Antioxidant enzyme dysfunction in monocytes and CSF of Hispanic women with HIV-associated cognitive impairment. J Neuroimmunol. 2009 Jan 03; 206(1-2):106-11.
20. García K, García V, Pérez Laspiur J, Duan F, Meléndez LM. Characterization of the placental macrophage secretome: implications for antiviral activity. Placenta. 2009 Feb; 30(2):149-55.
21. Luciano-Montalvo C, Ciborowski P, Duan F, Gendelman HE, Meléndez LM. Proteomic analyses associate cystatin B with restricted HIV-1 replication in placental macrophages. Placenta. 2008 Dec; 29(12):1016-23.
22. Wojna V, Robles L, Skolasky RL, Mayo R, Selnes O, de la Torre T, Maldonado E, Nath A, Meléndez LM, Lasalde-Dominicci J. Associations of cigarette smoking with viral immune and cognitive function in human immunodeficiency virus-seropositive women. J Neurovirol. 2007 Dec; 13(6):561-8.
23. Laspiur JP, Anderson ER, Ciborowski P, Wojna V, Rozek W, Duan F, Mayo R, Rodríguez E, Plaud-Valentín M, Rodríguez-Orengo J, Gendelman HE, Meléndez LM. CSF proteomic fingerprints for HIV-associated cognitive impairment. J Neuroimmunol. 2007 Dec; 192(1-2):157-70.
24. Rozek W, Ricardo-Dukelow M, Holloway S, Gendelman HE, Wojna V, Melendez LM, Ciborowski P. Cerebrospinal fluid proteomic profiling of HIV-1-infected patients with cognitive impairment. J Proteome Res. 2007 Nov; 6(11):4189-99.
25. Nieves DM, Plaud M, Wojna V, Skolasky R, Meléndez LM. Characterization of peripheral blood human immunodeficiency virus isolates from Hispanic women with cognitive impairment. J Neurovirol. 2007 Aug; 13(4):315-27.
26. Wojna V, Skolasky RL, Hechavarría R, Mayo R, Selnes O, McArthur JC, Meléndez LM, Maldonado E, Zorrilla CD, García H, Kraiselburd E, Nath A. Prevalence of human immunodeficiency virus-associated cognitive impairment in a group of Hispanic women at risk for neurological impairment. J Neurovirol. 2006 Oct; 12(5):356-64.
27. Wojna V, Carlson KA, Luo X, Mayo R, Meléndez LM, Kraiselburd E, Gendelman HE. Proteomic fingerprinting of human immunodeficiency virus type 1-associated dementia from patient monocyte-derived macrophages: A case study. J Neurovirol. 2004; 10 Suppl 1:74-81.
28. Luo X, Carlson KA, Wojna V, Mayo R, Biskup TM, Stoner J, Anderson J, Gendelman HE, Meléndez LM. Macrophage proteomic fingerprinting predicts HIV-1-associated cognitive impairment. Neurology. 2003 Jun 24; 60(12):1931-7.

Original Articles icon

 

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1. Rivera LE, Kraiselburd E, Meléndez LM. J Neurovirol. Cystatin B and HIV regulate the STAT-1 signaling circuit in HIV-infected and INF-β-treated human macrophages. 2016; 22(5):666-673.
2. Delgado-Vélez M, Báez-Pagán CA, Gerena Y, Quesada O, Santiago-Pérez LI, Capó-Vélez CM, Wojna V, Meléndez L, León-Rivera R, Silva W, Lasalde-Dominicci JA. Clin Transl Immunology. The α7-nicotinic receptor is upregulated in immune cells from HIV-seropositive women: consequences to the cholinergic anti-inflammatory response. 2015; 4(12):e53.
3. Zenón F, Jorge I, Cruz A, Suárez E, Segarra AC, Vázquez J, Meléndez LM, Serrano H. . Proteomics Clin Appl. 18O proteomics reveal increased human apolipoprotein CIII in Hispanic HIV-1+ women with HAART that use cocaine. 2015; 10(2):144-55.
4. Colon K, Perez-Laspiur J, Quiles R, Rodriguez Y, Wojna V, Shaffer SA, Leszyk J, Skolasky RL Jr, Melendez LM. . Proteomics Clin Appl. Macrophage secretome from women with HIV-associated neurocognitive disorders. 2015; 10(2):136-43.
5. Cantres-Rosario YM, Hernandez N, Negron K, Perez-Laspiur J, Leszyk J, Shaffer SA, Meléndez LM. . J Virol Antivir Res. Interacting partners of macrophage-secreted cathepsin B contribute to HIV-induced neuronal apoptosis. 2015; 29(16):2081-92.
6. Colón K, Vázquez-Santiago F, Rivera-Amill V, Delgado G, Massey SE, Wojna V, Noel RJ Jr, Meléndez LM. J Virol Antivir Res. HIV gp120 sequence variability associated with HAND in Hispanic Women. 2015; 4(3):143.
7. Vázquez-Santiago F, García Y, Rivera-Román I, Noel RJ Jr, Wojna V, Meléndez LM, Rivera-Amill V. . J Virol Antivir Res. Longitudinal Analysis of Cerebrospinal Fluid and Plasma HIV-1 Envelope Sequences Isolated From a Single Donor with HIV Asymptomatic Neurocognitive Impairment. 2015; 4(1).
8. Zenón F, Cantres-Rosario Y, Adiga R, Gonzalez M, Rodriguez-Franco E, Langford D, Melendez LM. . J Neurovirol. HIV-infected microglia mediate cathepsin B-induced neurotoxicity. 2015; 21(5):544-58.
9. Zenon F, Segarra A, Gonzalez M, and Meléndez LM*, 2014. J Neuroimmune Pharmacology. P. J Neuroimmune Pharmacology. Cocaine Potentiates Cathepsin B Secretion and Neuronal Apoptosis from in HIV-infected Macrophages. 2014; 9(5):703-15.

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1. Rivera LE, Colon K, Cantres-Rosario YM, Zenon FM, Melendez LM. Curr HIV Res. Macrophage derived cystatin B/cathepsin B in HIV replication and neuropathogenesis. 2014; 12(2):111-20.

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HIV Infections
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