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John R. McCarrey
Title Professor and Kleberg Distinguished Chair in Cellular and Molecular Biolog
Faculty Rank Professor
Degree B.S., M.S., Ph.D.
Institution University of Texas at San Antonio
Department Department of Biology
Clusters Other
Address
One UTSA Circle
City San Antonio
State TX
Postal Code 78249
Telephone (210) 458-4507
Fax
Email
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  Research in Dr. McCarrey’s lab is centered on mammalian germ cells and stem cells. Experimental models include the mouse, the baboon, and the opossum. The lab is interested in the epigenetic regulation of cell functions, including determination of cell fates, maintenance of genetic integrity, regulation of gene expression, genomic imprinting, X-chromosome inactivation and meiotic sex chromosome inactivation, methods of assisted reproduction, the evolution of tissue-specific gene expression in mammalian species, and developing the baboon as a model system for testing stem cell-based therapeutic applications.

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NIH Awarded Grants icon

  Research projects funded by the National Institutes of Health (NIH), the Centers for Disease Control (CDC), the Food and Drug Administration (FDA), and the Department of Veterans Affairs (VA)

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1.
2017Epimutations in Offspring Produced by Assisted Reproductive Technologies (ART)5R01HD078679-04
2.
2016Epimutations in Offspring Produced by Assisted Reproductive Technologies (ART)5R01HD078679-03
3.
2015Epimutations in Offspring Produced by Assisted Reproductive Technologies (ART)5R01HD078679-02
4.
2014Regulation of Spermatogenesis by X-linked miRNAs5R01HD060858-05
5.
2014Epimutations in Offspring Produced by Assisted Reproductive Technologies (ART)1R01HD078679-01A1
6.
20142014 Mammalian Reproduction Gordon Research Conference1R13HD081716-01
7.
2013Regulation of Spermatogenesis by X-linked miRNAs5R01HD060858-04
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2012Regulation of Spermatogenesis by X-linked miRNAs5R01HD060858-03
9.
2011XXIst North American Testis Workshop1R13HD069136-01
10.
2011Regulation of Spermatogenesis by X-linked miRNAs5R01HD060858-02
11.
2010Recruitment of New Stem Cell Biologist5P30GM092334-02
12.
2010Regulation of Spermatogenesis by X-linked miRNAs1R01HD060858-01A2
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2009Recruitment of New Stem Cell Biologist1P30GM092334-01
14.
2009Regulation of a Spermatogenesis-Specific Gene5R01HD046637-05
15.
2008ASSAY FOR MUTATIONS IN STEM CELLS AND THEIR DERIVATIVES1R41RR024772-01
16.
2008Regulation of a Spermatogenesis-Specific Gene5R01HD046637-04
17.
2007Regulation of a Spermatogenesis-Specific Gene5R01HD046637-03
18.
2007Derivation and Characterization of Baboon ES Cells5R21RR022865-02
19.
2007Regulation of a Spermatogenesis-Specific Gene3R01HD046637-03S1
20.
2006APPLICATION OF TRANSGENIC TECHNOLOGIES TO BABOONS5P51RR013986-08
21.
2006Regulation of a Spermatogenesis-Specific Gene5R01HD046637-02
22.
2006Germline-specific reprogramming in cloned mice5R01HD042772-05
23.
2006Derivation and Characterization of Baboon ES Cells1R21RR022865-01
24.
2005Germline-specific reprogramming in cloned mice5R01HD042772-04
25.
2005APPLICATION OF TRANSGENIC TECHNOLOGIES TO BABOONS5P51RR013986-07
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2005Regulation of a Spermatogenesis-Specific Gene1R01HD046637-01A1
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2004APPLICATION OF TRANSGENIC TECHNOLOGIES TO BABOONS2P51RR013986-06
28.
2004Germline-specific reprogramming in cloned mice5R01HD042772-03
29.
2004Gordon Conf: Mammalian Gametogenesis &Embryogenesis1R13HD047487-01
30.
2003GENETIC MANIPULATION OF BABOON SPERMATOGENIC CELLS IN CULTURE5P51RR013986-05
31.
2003APPLICATION OF TRANSGENIC TECHNOLOGIES TO BABOONS5R21RR015389-02
32.
2003APPLICATION OF TRANSGENIC TECHNOLOGIES TO BABOONS5P51RR013986-05
33.
2003Germline-specific reprogramming in cloned mice5R01HD042772-02
34.
2002APPLICATION OF TRANSGENIC TECHNOLOGIES TO BABOONS1R21RR015389-01A1
35.
2002Regulation of Gene Expression by DNA Methylation5R03HD042417-02
36.
2002Germline-specific reprogramming in cloned mice1R01HD042772-01
37.
2001Regulation of Gene Expression by DNA Methylation1R03HD042417-01
38.
1998GENE REGULATION IN SPERMATOGENESIS5R01HD023126-09
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1997NINTH INTERNATIONAL CONGRESS ON GENES, GENE FAMILIES1R13HG001661-01
40.
1997GENE REGULATION IN SPERMATOGENESIS5R01HD023126-08
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1996GENE REGULATION IN SPERMATOGENESIS2R01HD023126-07
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1995GENE REGULATION IN SPERMATOGENESIS5R01HD023126-06
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1994GENE REGULATION IN SPERMATOGENESIS5R01HD023126-05
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1993GENE REGULATION IN SPERMATOGENESIS2R01HD023126-04A1
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1993DOES THE MALE GERM LINE AGE?3P01AG008321-03S1
46.
1992GENE REGULATION IN SPERMATOGENESIS5K04HD000829-05
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1991GENE REGULATION IN SPERMATOGENESIS7K04HD000829-04
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1991DOES THE MALE GERM LINE AGE?5P01AG008321-03
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1990DOES THE MALE GERM LINE AGE?5P01AG008321-02
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1990GENE REGULATION IN SPERMATOGENESIS5K04HD000829-03
51.
1989DOES THE MALE GERM LINE AGE?1P01AG008321-01
52.
1989GENE REGULATION IN SPERMATOGENESIS5K04HD000829-02
53.
1989GENE REGULATION IN SPERMATOGENESIS5R01HD023126-03
54.
1988GENE REGULATION IN SPERMATOGENESIS5R01HD023126-02
55.
1988GENE REGULATION IN SPERMATOGENESIS1K04HD000829-01
56.
1987GENE REGULATION IN SPERMATOGENESIS1R01HD023126-01
57.
1986GENE REGULATION IN SPERMATOGENESIS5R01HD018360-03
58.
1985GENE REGULATION IN SPERMATOGENESIS5R01HD018360-02

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1. Navara CS, Chaudhari S, McCarrey JR. Optimization of culture conditions for the derivation and propagation of baboon (Papio anubis) induced pluripotent stem cells. PLoS One. 2018; 13(3):e0193195.
2. Wichman L, Somasundaram S, Breindel C, Valerio DM, McCarrey JR, Hodges CA, Khalil AM. Dynamic expression of long noncoding RNAs reveals their potential roles in spermatogenesis and fertility. Biol Reprod. 2017 Aug 01; 97(2):313-323.
3. Cooper DJ, Chen IC, Hernandez C, Wang Y, Walter CA, McCarrey JR. Pluripotent cells display enhanced resistance to mutagenesis. Stem Cell Res. 2017 03; 19:113-117.
4. McCarrey JR, Lehle JD, Raju SS, Wang Y, Nilsson EE, Skinner MK. Tertiary Epimutations - A Novel Aspect of Epigenetic Transgenerational Inheritance Promoting Genome Instability. PLoS One. 2016; 11(12):e0168038.
5. Mutoji K, Singh A, Nguyen T, Gildersleeve H, Kaucher AV, Oatley MJ, Oatley JM, Velte EK, Geyer CB, Cheng K, McCarrey JR, Hermann BP. TSPAN8 Expression Distinguishes Spermatogonial Stem Cells in the Prepubertal Mouse Testis. Biol Reprod. 2016 12; 95(6):117.
6. Chen IC, Hernandez C, Xu X, Cooney A, Wang Y, McCarrey JR. Dynamic Variations in Genetic Integrity Accompany Changes in Cell Fate. Stem Cells Dev. 2016 11 15; 25(22):1698-1708.
7. Lesch BJ, Silber SJ, McCarrey JR, Page DC. Corrigendum: Parallel evolution of male germline epigenetic poising and somatic development in animals. Nat Genet. 2016 09 28; 48(10):1296.
8. Grow DA, McCarrey JR, Navara CS. Advantages of nonhuman primates as preclinical models for evaluating stem cell-based therapies for Parkinson's disease. Stem Cell Res. 2016 09; 17(2):352-366.
9. Grow DA, Simmons DV, Gomez JA, Wanat MJ, McCarrey JR, Paladini CA, Navara CS. Differentiation and Characterization of Dopaminergic Neurons From Baboon Induced Pluripotent Stem Cells. Stem Cells Transl Med. 2016 09; 5(9):1133-44.
10. Lesch BJ, Silber SJ, McCarrey JR, Page DC. Parallel evolution of male germline epigenetic poising and somatic development in animals. Nat Genet. 2016 08; 48(8):888-94.
11. Shum EY, Jones SH, Shao A, Dumdie J, Krause MD, Chan WK, Lou CH, Espinoza JL, Song HW, Phan MH, Ramaiah M, Huang L, McCarrey JR, Peterson KJ, De Rooij DG, Cook-Andersen H, Wilkinson MF. The Antagonistic Gene Paralogs Upf3a and Upf3b Govern Nonsense-Mediated RNA Decay. Cell. 2016 Apr 07; 165(2):382-95.
12. McCarrey JR. EPIGENETICS. The epigenome--a family affair. Science. 2015 Nov 06; 350(6261):634-5.
13. Sosa E, Flores L, Yan W, McCarrey JR. Escape of X-linked miRNA genes from meiotic sex chromosome inactivation. Development. 2015 Nov 01; 142(21):3791-800.
14. Hermann BP, Mutoji KN, Velte EK, Ko D, Oatley JM, Geyer CB, McCarrey JR. Transcriptional and translational heterogeneity among neonatal mouse spermatogonia. Biol Reprod. 2015 Feb; 92(2):54.
15. Ortogero N, Schuster AS, Oliver DK, Riordan CR, Hong AS, Hennig GW, Luong D, Bao J, Bhetwal BP, Ro S, McCarrey JR, Yan W. A novel class of somatic small RNAs similar to germ cell pachytene PIWI-interacting small RNAs. J Biol Chem. 2014 Nov 21; 289(47):32824-34.
16. Cooper DJ, Walter CA, McCarrey JR. Co-regulation of pluripotency and genetic integrity at the genomic level. Stem Cell Res. 2014 Nov; 13(3 Pt A):508-19.
17. McCarrey JR. Distinctions between transgenerational and non-transgenerational epimutations. Mol Cell Endocrinol. 2014 Dec; 398(1-2):13-23.
18. Navara CS, Hornecker J, Grow D, Chaudhari S, Hornsby PJ, Ichida JK, Eggan K, McCarrey JR. Derivation of induced pluripotent stem cells from the baboon: a nonhuman primate model for preclinical testing of stem cell therapies. Cell Reprogram. 2013 Dec; 15(6):495-502.
19. Yang Z, Yoshioka H, McCarrey JR. Sequence-specific promoter elements regulate temporal-specific changes in chromatin required for testis-specific activation of the Pgk2 gene. Reproduction. 2013; 146(5):501-16.
20. Lesch BJ, Dokshin GA, Young RA, McCarrey JR, Page DC. A set of genes critical to development is epigenetically poised in mouse germ cells from fetal stages through completion of meiosis. Proc Natl Acad Sci U S A. 2013 Oct 01; 110(40):16061-6.
21. McCarrey JR. Toward a more precise and informative nomenclature describing fetal and neonatal male germ cells in rodents. Biol Reprod. 2013 Aug; 89(2):47.
22. Skinner MK, Guerrero-Bosagna C, Haque M, Nilsson E, Bhandari R, McCarrey JR. Environmentally induced transgenerational epigenetic reprogramming of primordial germ cells and the subsequent germ line. PLoS One. 2013; 8(7):e66318.
23. Zhou J, McCarrey JR, Wang PJ. A 1.1-Mb segmental deletion on the X chromosome causes meiotic failure in male mice. Biol Reprod. 2013 Jun; 88(6):159.
24. Arango NA, Li L, Dabir D, Nicolau F, Pieretti-Vanmarcke R, Koehler C, McCarrey JR, Lu N, Donahoe PK. Meiosis I arrest abnormalities lead to severe oligozoospermia in meiosis 1 arresting protein (M1ap)-deficient mice. Biol Reprod. 2013 Mar; 88(3):76.
25. Ortogero N, Hennig GW, Langille C, Ro S, McCarrey JR, Yan W. Computer-assisted annotation of murine Sertoli cell small RNA transcriptome. Biol Reprod. 2013 Jan; 88(1):3.
26. Murphey P, McLean DJ, McMahan CA, Walter CA, McCarrey JR. Enhanced genetic integrity in mouse germ cells. Biol Reprod. 2013 Jan; 88(1):6.
27. de Waal E, Yamazaki Y, Ingale P, Bartolomei MS, Yanagimachi R, McCarrey JR. Gonadotropin stimulation contributes to an increased incidence of epimutations in ICSI-derived mice. Hum Mol Genet. 2012 Oct 15; 21(20):4460-72.
28. Grant J, Mahadevaiah SK, Khil P, Sangrithi MN, Royo H, Duckworth J, McCarrey JR, VandeBerg JL, Renfree MB, Taylor W, Elgar G, Camerini-Otero RD, Gilchrist MJ, Turner JM. Rsx is a metatherian RNA with Xist-like properties in X-chromosome inactivation. Nature. 2012 Jul 12; 487(7406):254-8.
29. Song HW, Dann CT, McCarrey JR, Meistrich ML, Cornwall GA, Wilkinson MF. Dynamic expression pattern and subcellular localization of the Rhox10 homeobox transcription factor during early germ cell development. Reproduction. 2012 May; 143(5):611-24.
30.