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Robert F. Hunter
Title Director
Faculty Rank Professor
Degree M.D.
Institution Universidad Central Del Caribe
Department Retrovirus Research Center
Clusters Cancer
HIV/AIDS
Address
Universidad Central del Caribe
Call Box 60-237
City Bayamon
State PR
Postal Code 00960
Telephone (787) 787-8710
Fax (787) 787-8722
Email
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1977 Alpha Omega Alpha

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  As a formally trained Medical Oncologist with many years of experience in the evaluation and therapy of patients with HIV, HCV and malignant disorders, I have a commitment to accelerate the delivery of research advances to improve patient care in these catastrophic diseases. I believe that fostering and initiating translational research, participation in physician education and research mentoring is likely the best way I can do this. During my professional career I have been active in the education and mentoring of young students, internal medicine residents and researchers. I am actively involved with basic research on hematological conditions and the various immunodeficiency viruses. I am involved with clinical research in cancer and HIV infection and I have acquired the administrative and people skills necessary to manage research programs from a multidisciplinary point of view. My tenure as Chairman and Program Director of the Internal Medicine of our School of Medicine for 13 years, my role as Principal investigator of the Retrovirus Research Center for 18 years and co-Principal Investigator of the Puerto Rico Comprehensive Center for the Study of HIV Disparities (PR-CCHD), have given me the skills and knowledge to manage the complexities and details of multidisciplinary research programs and help to direct research initiatives. In 2007, I completed a master’s degree in Bioethics and I am one of the few clinicians and researchers in the Island to have formal advanced training in Bioethics. This training has been effectively used to mentor researchers in the area of the ethical conduct of research, as overseer of various DSMB programs and by providing our patients with the highest degree of protection from abuse.

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1. Cruz-Feliciano MA, Miranda-Díaz C, Fernández-Santos DM, Orobitg-Brenes D, Hunter-Mellado RF, Carrión-González IS. Quality of life improvement in Latinas receiving combined substance use disorders and trauma-specific treatment: a cohort evaluation report. Health Qual Life Outcomes. 2017 May 02; 15(1):90.
2. Tossas-Milligan KY, Hunter-Mellado RF, Mayor AM, Fernández-Santos DM, Dworkin MS. Late HIV Testing in a Cohort of HIV-Infected Patients in Puerto Rico. P R Health Sci J. 2016 May 24; 35(2):113-121.
3. Mayor AM, Santiago-Rodriguez EJ, Rios-Olivares E, Tortolero-Luna G, Hunter-Mellado RF. Malignancies Trends in a Hispanic Cohort of HIV Persons in Puerto Rico before and after cART. Int J Cancer Res. 2016; 12(2):92-100.
4. Valderrábano RJ, Blanco A, Santiago-Rodriguez EJ, Miranda C, Rivera-Del Rio Del Rio J, Ruiz J, Hunter R. Risk factors and clinical outcomes of arrhythmias in the medical intensive care unit. J Intensive Care. 2016; 4:9.
5. Fernandez-Santos DM, Miranda-Diaz C, Figueroa-Cosme WI, Ramon RO, Mayor AM, Rios-Olivares E, Hunter-Mellado RF. Impact of ASUMA Intervention on HIV Risk Behaviors among Puerto Rican Adolescents. Int J Environ Res Public Health. 2015 Dec 23; 13(1):ijerph13010060.
6. Santiago-Rodríguez EJ, Mayor AM, Fernández-Santos DM, Hunter-Mellado RF. Profile of HIV-Infected Hispanics with Pancytopenia. Int J Environ Res Public Health. 2015 Dec 22; 13(1):ijerph13010038.
7. Maldonado-Martínez G, Hunter-Mellado RF, Fernández-Santos D, Ríos-Olivares E. Persistent HIV Viremia: Description of a Cohort of HIV Infected Individuals with ART Failure in Puerto Rico. Int J Environ Res Public Health. 2015 Dec 22; 13(1):ijerph13010050.
8. Miranda-Diaz C, Betancourt E, Ruiz-Candelaria Y, Hunter-Mellado RF. Barriers for Compliance to Breast, Colorectal, and Cervical Screening Cancer Tests among Hispanic Patients. Int J Environ Res Public Health. 2015 Dec 22; 13(1):ijerph13010021.
9. Tossas-Milligan KY, Hunter-Mellado RF, Mayor AM, Fernández-Santos DM, Dworkin MS. Late HIV Testing in a Cohort of HIV-Infected Patients in Puerto Rico. P R Health Sci J. 2015 Sep; 34(3):148-54.
10. Esponda OL, Hunter R, Del Río JR, Washington AV. Levels of soluble TREM-like transcript 1 in patients presenting to the emergency department with chest pain. Clin Appl Thromb Hemost. 2015 Jan; 21(1):30-4.
11. Santiago-Rodríguez EJ, Mayor AM, Fernández-Santos DM, Ruiz-Candelaria Y, Hunter-Mellado RF. Anemia in a cohort of HIV-infected Hispanics: prevalence, associated factors and impact on one-year mortality. BMC Res Notes. 2014 Jul 08; 7:439.
12. Ruiz-Candelaria Y, Miranda-Diaz C, Hunter-Mellado RF. K-RAS mutation profile in Puerto Rican patients with colorectal cancer: trends from April 2009 to January 2011. Int J Biol Markers. 2013 Dec 17; 28(4):e393-7.
13. Mayor AM, Fernández DM, Colón H, Thomas JC, Miranda C, Hunter-Mellado RF. Hepatitis-C multimedia prevention program in poor Hispanic HIV-infected injecting drug users: six months after intervention. J Health Care Poor Underserved. 2013 Nov; 24(4 Suppl):29-37.
14. Maldonado-Martínez G, Fernández-Santos DM, Ríos-Olivares E, Mayor AM, Hunter-Mellado RF. HIV/AIDS in the Puerto Rican elderly: immunological changes between gender and body mass index. J Health Care Poor Underserved. 2013 Nov; 24(4 Suppl):94-105.
15. Dworkin MS, Peterson CE, Gao W, Mayor A, Hunter R, Negron E, Fleury A, Besch CL. Efficacy of a food safety comic book on knowledge and self-reported behavior for persons living with AIDS. PLoS One. 2013; 8(10):e72874.
16. Hanna DB, Buchacz K, Gebo KA, Hessol NA, Horberg MA, Jacobson LP, Kirk GD, Kitahata MM, Korthuis PT, Moore RD, Napravnik S, Patel P, Silverberg MJ, Sterling TR, Willig JH, Lau B, Althoff KN, Crane HM, Collier AC, Samji H, Thorne JE, Gill MJ, Klein MB, Martin JN, Rodriguez B, Rourke SB, Gange SJ. Trends and disparities in antiretroviral therapy initiation and virologic suppression among newly treatment-eligible HIV-infected individuals in North America, 2001-2009. Clin Infect Dis. 2013 Apr; 56(8):1174-82.
17. Dworkin MS, Peterson CE, Gao W, Mayor A, Hunter R, Negron E, Fleury A, Besch CL. Food Safety Knowledge, Beliefs and Behavior of Persons with AIDS: A Multicenter Study. Food Prot Trends. 2013 Jan 01; 33(1):32-41.
18. Koenig SP, Rodriguez LA, Bartholomew C, Edwards A, Carmichael TE, Barrow G, Cabié A, Hunter R, Vasquez-Mora G, Quava-Jones A, Adomakoh N, Peter Figueroa J, Liautaud B, Torres M, Pape JW. Long-term antiretroviral treatment outcomes in seven countries in the Caribbean. J Acquir Immune Defic Syndr. 2012 Apr 01; 59(4):e60-71.
19. Mayor AM, Fernández Santos DM, Dworkin MS, Ríos-Olivares E, Hunter-Mellado RF. Toxoplasmic encephalitis in an AIDS cohort at Puerto Rico before and after highly active antiretroviral therapy (HAART). Am J Trop Med Hyg. 2011 May; 84(5):838-41.
20. Pérez-Mercado AE, Maldonado-Martínez G, del Rio JR, Mellado RF. Cardiovascular events during general elections in Bayamon, Puerto Rico. Bol Asoc Med P R. 2010 Jul-Sep; 102(3):28-31.
21. Miranda C, Fernandez DM, Ramon RO, Velázquez M, Mayor AM, Hunter-Mellado RF. Changes in the socio-demographics, risk behaviors, clinical and immunological profile of a cohort of the Puerto Rican population living with HIV: an update of the Retrovirus Research Center (1992-2008). Bol Asoc Med P R. 2010 Jul-Sep; 102(3):45-51.
22. Gomez LR, Mellado RH. Late presentation of familial mediterranean fever: a case report. Bol Asoc Med P R. 2010 Jul-Sep; 102(3):69-71.
23. Benitez L, Vila S, Mellado RH. Hidden in plain sight: macrophage activation syndrome complicating Adult Onset Still's Disease. Bol Asoc Med P R. 2010 Jul-Sep; 102(3):79-82.
24. Morales J, Villa K, Gattis J, Castro W, Colon K, Lubkowski J, Sanabria P, Hunter R, Washington AV. Soluble TLT-1 modulates platelet-endothelial cell interactions and actin polymerization. Blood Coagul Fibrinolysis. 2010 Apr; 21(3):229-36.
25. Fernández Santos DM, Figueroa-Cosme WI, Gómez Mde L, Maysonet-Cruz J, Miranda-Díaz C, Septúlveda-Santiago M, Ríos-Olivares E, Hunter-Mellado RF. Changes in developmental factors and HIV risk behaviors among early adolescents in Puerto Rico. Ethn Dis. 2010; 20(1 Suppl 1):S1-122-6.
26. Mayor AM, Fernández DM, Colón HM, Thomas JC, Hunter-Mellado RE. The effectiveness evaluation of a multimedia hepatitis C prevention program for Hispanic HIV-infected individuals. Ethn Dis. 2010; 20(1 Suppl 1):S1-158-62.
27. Mayor AM, Dworkin M, Quesada L, Ríos-Olivares E, Hunter-Mellado RF. The morbidity and mortality associated with kidney disease in an HIV-infected cohort in Puerto Rico. Ethn Dis. 2010; 20(1 Suppl 1):S1-163-7.
28. Ramírez-Marrero FA, De Jesús E, Santana-Bagur J, Hunter R, Frontera W, Joyner MJ. Prevalence of cardiometabolic risk factors in Hispanics living with HIV. Ethn Dis. 2010; 20(4):423-8.
29. Washington AV, Gibot S, Acevedo I, Gattis J, Quigley L, Feltz R, De La Mota A, Schubert RL, Gomez-Rodriguez J, Cheng J, Dutra A, Pak E, Chertov O, Rivera L, Morales J, Lubkowski J, Hunter R, Schwartzberg PL, McVicar DW. TREM-like transcript-1 protects against inflammation-associated hemorrhage by facilitating platelet aggregation in mice and humans. J Clin Invest. 2009 Jun; 119(6):1489-501.
30. Hunter R, Cameron R, Norrie J. Using patient-reported outcomes in schizophrenia: the Scottish Schizophrenia Outcomes Study. Psychiatr Serv. 2009 Feb; 60(2):240-5.
31. Báez Feliciano DV, Gómez MA, Fernández-Santos DM, Quintana R, Rios-Olivares E, Hunter-Mellado RF. Profile of Puerto Rican HIV/AIDS patients with early and non-early initiation of injection drug use. Ethn Dis. 2008; 18(2 Suppl 2):S2-99-104.
32. Cruz-Amy M, Serrano J, Labrador I, Hernandez D, Fernandez DM, Quintana R, Hunter-Mellado RF. Changes in profile and colorectal cancer stage over 15 years in Puerto Rico. Ethn Dis. 2008; 18(2 Suppl 2):S2-128-31.
33. Fernández DM, Figueroa WI, Gómez Mde L, Maysonet J, Olivares ER, Hunter RF. Changes in HIV/AIDS knowledge among early adolescents in Puerto Rico. Ethn Dis. 2008; 18(2 Suppl 2):S2-146-50.
34. Mayor AM, Gómez MA, Ríos-Olivares E, Hunter-Mellado RF. AIDS-defining neoplasm prevalence in a cohort of HIV-infected patients, before and after highly active antiretroviral therapy. Ethn Dis. 2008; 18(2 Suppl 2):S2-189-94.
35. Mayor AM, Fernández DM, Colón HM, Thomas JC, Hunter-Mellado RF. The feasibility and acceptability of a multimedia hepatitis C prevention program for Hispanic HIV-infected persons. Ethn Dis. 2008; 18(2 Suppl 2):S2-195-9.
36. Quintana-Ortiz RA, Gomez MA, Báez Feliciano DV, Hunter-Mellado RF. Suicide attempts among Puerto Rican men and women with HIV/AIDS: a study of prevalence and risk factors. Ethn Dis. 2008; 18(2 Suppl 2):S2-219-24.
37. Rodríguez JW, Pagan NO, Ocasio MC, Ríos Z, Cubano LA, Boukli NM, Otero M, Hunter R, Nair MP, Rios-Olivares E. Induction of a Soluble Anti-HIV-1 factor (s) with IFN-?, IL-10, and ß-Chemokine Modulating Activity by an Influenza-Bacterial Polyantigenic Mixture. Am J Infect Dis. 2007; 3(4).
38. Báez-Feliciano DV, Quintana R, Gómez MA, Fernández DM, Velázquez M, Olivares E, León Valiente C, Mayor AM, Hunter-Mellado RF. Trends in the HIV and AIDS epidemic in a Puerto Rican cohort of patients: 1992-2005. Bol Asoc Med P R. 2006 Jul-Sep; 98(3):174-83.
39. Giron J, Perez Blair E, Hunter Mellado R. A clinico-pathologic presentation of a 23-year old-female with lymphangioleiomyomatosis and Wilm's tumor. Bol Asoc Med P R. 2006 Jul-Sep; 98(3):196-202.
40. Cruz-Amy M, Hunter-Mellado R. Factor V Leiden thrombophilia: presentation of three patients and a literature review. Bol Asoc Med P R. 2006 Jul-Sep; 98(3):213-21.
41. Mayor AM, Gomez MA, Fernandez DM, Rios-Olivares E, Thomas JC, Hunter RF. Morbidity and mortality profile of human immunodeficiency virus-infected patients with and without hepatitis C co-infection. Am J Trop Med Hyg. 2006 Feb; 74(2):239-45.
42. Báez-Feliciano DV, Thomas JC, Gómez MA, Miranda S, Fernández DM, Velázquez M, Ríos-Olivares E, Hunter-Mellado RF. Changes in the AIDS epidemiologic situation in Puerto Rico following health care reform and the introduction of HAART. Rev Panam Salud Publica. 2005 Feb; 17(2):92-101.
43. Mayor AM, Gómez MA, Ríos-Oliveras E, Hunter-Mellado RF. Mortality trends of HIV-infected patients after the introduction of highly active antiretroviral therapy: analysis of a cohort of 3,322 HIV-infected persons. Ethn Dis. 2005; 15(4 Suppl 5):S5-57-62.
44. Fernández DM, Gómez Mde L, Figueroa W, Velázquez M, Báez DV, Ríos-Olivares E, Hunter RF. A comparison of the sociodemographic, risk-behavior, and substance-abuse profile of young vs older HIV-infected Puerto Rican patients. Ethn Dis. 2005; 15(4 Suppl 5):S5-25-9.
45. Amill A, Gómez Mde L, Fernández DM, Bangdiwala SI, Ríos E, Hunter RF. Changing profiles of injecting drug users with AIDS in a Hispanic population. Addiction. 2004 Sep; 99(9):1147-56.
46. Mayor AM, Gomez MA, Rios E, Hunter RF. Recurrent pneumonia mortality risk in a HIV/AIDS Puerto Rican cohort. Cell Mol Biol (Noisy-le-grand). 2003 Dec; 49(8):1199-204.
47. Mayor AM, Gomez MA, Rios E, Hunter RF. Differences between patients with non-Hodgkin's lymphomas in a cohort of HIV/AIDS patients in Puerto Rico. Cell Mol Biol (Noisy-le-grand). 2003 Nov; 49(7):1145-9.
48. Roman M, Rodriguez JW, Pagán NO, Rios-Olivares E, Amill A, Hunter R. Distribution of naïve (CD45RA+) and memory (CD45RO+) T-cells in HIV-infected Puerto Rican population. P R Health Sci J. 2002 Sep; 21(3):195-201.
49. Fernández DM, Gómez MA, Mayor AM, Gómez O, Hunter RF. Survival of AIDS according to injecting drug use among Puerto Rican AIDS patients. Cell Mol Biol (Noisy-le-grand). 2001 Nov; 47(7):1121-7.
50. Mayor AM, Gómez MA, Otero JF, Vilá S, Hunter RF. Pulmonary tuberculosis mortality risks in a cohort of HIV/AIDS patients in Puerto Rico. Cell Mol Biol (Noisy-le-grand). 2001 Nov; 47(7):1143-8.
51. Gomez MA, Fernandez DM, Otero JF, Miranda S, Hunter R. The shape of the HIV/AIDS epidemic in Puerto Rico. Rev Panam Salud Publica. 2000 Jun; 7(6):377-83.
52. Fernandez DM, Gómez MA, Velazquez M, Miniño A, Hunter R. Psychological and behavioral issues of a cohort of Puerto Rican HIV/AIDS patients. Cell Mol Biol (Noisy-le-grand). 1997 Nov; 43(7):1115-22.
53. Miniño A, Gómez MA, Velazquez M, Hunter R. Gender-related differences in the spectrum of HIV disease in the Bayamón area, Puerto Rico. Cell Mol Biol (Noisy-le-grand). 1997 Nov; 43(7):1139-43.
54. Gómez MA, Fernandez DM, Hunter R. Psycho social and clinical spectrum of HIV/AIDS injecting drug users in Bayamón, Puerto Rico. Cell Mol Biol (Noisy-le-grand). 1997 Nov; 43(7):1145-52.
55. Rivera Del Rio JR, Flores R, Meléndez J, Gómez MA, Vila S, Hunter R. Profile of HIV patients with and without bacterial endocarditis. Cell Mol Biol (Noisy-le-grand). 1997 Nov; 43(7):1153-60.
56. Hunter Mellado RF, Negron J, Gomez MA. A strategic supportive model for health prevention in the elderly: profile of a Puerto Rican geriatric population in a public health sector. Bol Asoc Med P R. 1997 Jul-Sep; 89(7-9):102-10.
57. Gómez MA, Velázquez M, Hunter RF. Outline of the Human Retrovirus Registry: profile of a Puerto Rican HIV infected population. Bol Asoc Med P R. 1997 Jul-Sep; 89(7-9):111-6.
58. Ríos Z, Ríos EO, Garcia MI, De Leon C, Guzman LM, Rodriguez W, Romero D, Hunter R. Changes in viral expression and cytokine profile induced by a polyantigenic immunomodulator in HIV-infected peripheral blood mononuclear cells. Cell Mol Biol (Noisy-le-grand). 1995; 41 Suppl 1:S93-101.

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1. Mayor AM, Gomez MA, Fernandez DM, Rios-Olivares E, Thomas JC, Hunter RF. Morbidity and mortality profile of human immunodeficiency virus-infected patients with and without hepatitis C co-infection. 2006; 74(2)(Am J Trop ):239-45.

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1. Rodríguez, J.W., Rodríguez, L.A., Font, G., Nieves, K., Cubano, L.A., Boukli, N., Otero, M., Hunter, R., Nair, M.P., and Ríos-Olivares, E. . Co-Expression of Apoptosis-Related Molecules on Activated CD8+CD38+ T-Cells is Associated with HIV-1 Disease Progression. American Journal of Infectious Disease. 2007; 4(3):208-216.
2. Rodríguez, J.W., Figueroa, W.I., Pérez-Casanova, A.E., Machado, M. Pagán, N.O., Ríos, Z., García, O., Cubano, L.A., Alonso, O., Hunter, R., Ríos-Olivares, E. . Immunological Dynomics of CD8+ T-lympocytes During HIV Infection and Its Association with Disease Progression. Immunology. 2004; 215-221.

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1. Mayor, A., Ruiz, Y., Fernández, D., Hunter, R. HIV/AIDS Associated Malignant Disorders: Role of Highly Active Antiretroviral Therapy. Immunosuppression-Role in Health and Diseases. 2012; 433-456.

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