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Shubha Govind
Title Professor of Biology
Faculty Rank Professor
Degree Ph.D.
Institution City College, CUNY
Department Biology Department
Clusters Cancer
Infectious and Immunological Diseases
Address
City College, CUNY, Marshak Science Building
Convent Avenue at 138th Street
City New York
State NY
Postal Code 10031
Telephone 212-650-8571
Fax 212-650-8585
Email
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Title Professor
Institution The City College, CUNY
Department Biology
Division Science
 
Title Professor
Institution The Graduate Center, CUNY
Department PhD Programs in Biology
 
Title Professor
Institution The Graduate Center, CUNY
Department PhD Program in Biochemistry

Awards and Honors icon

1975 NCERT, India National Science Talent Scholar
1988 New Jersey Commission on Cancer Research Postdoctoral Fellowship
1997 American Heart Association American Heart Association New Investigator Development Award
2006 CCNY Excellence in Mentoring Award
2013 CCNY President’s Award for Excellence

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  Research summary

Using the Drosophila model system, we are interested in understanding the mechanisms underlying hematopoietic cancer and inflammation. Our recent interest has focused on sumoylation, a conserved, post-translational protein modification mechanism in eukaryotes. Loss of sumoylation results in aberrant immune signaling, development of hematopoietic microtumors, and chronic inflammation.

We are also actively engaged in identifying virulence factors produced by parasitic wasps that interfere with innate immune signaling and inflammation in Drosophila.

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1. Heavner ME, Ramroop J, Gueguen G, Ramrattan G, Dolios G, Scarpati M, Kwiat J, Bhattacharya S, Wang R, Singh S, Govind S. Novel Organelles with Elements of Bacterial and Eukaryotic Secretion Systems Weaponize Parasites of Drosophila. Curr Biol. 2017 Sep 25; 27(18):2869-2877.e6.
2. Gokhman VE, Bolsheva NL, Govind S, Muravenko OV. A comparative cytogenetic study of Drosophila parasitoids (Hymenoptera, Figitidae) using DNA-binding fluorochromes and FISH with 45S rDNA probe. Genetica. 2016 Jun; 144(3):335-9.
3. Lin CJ, Smibert P, Zhao X, Hu JF, Ramroop J, Kellner SM, Benton MA, Govind S, Dedon PC, Sternglanz R, Lai EC. An extensive allelic series of Drosophila kae1 mutants reveals diverse and tissue-specific requirements for t6A biogenesis. RNA. 2015 Dec; 21(12):2103-18.
4. Leung W, Shaffer CD, Reed LK, Smith ST, Barshop W, Dirkes W, Dothager M, Lee P, Wong J, Xiong D, Yuan H, Bedard JE, Machone JF, Patterson SD, Price AL, Turner BA, Robic S, Luippold EK, McCartha SR, Walji TA, Walker CA, Saville K, Abrams MK, Armstrong AR, Armstrong W, Bailey RJ, Barberi CR, Beck LR, Blaker AL, Blunden CE, Brand JP, Brock EJ, Brooks DW, Brown M, Butzler SC, Clark EM, Clark NB, Collins AA, Cotteleer RJ, Cullimore PR, Dawson SG, Docking CT, Dorsett SL, Dougherty GA, Downey KA, Drake AP, Earl EK, Floyd TG, Forsyth JD, Foust JD, Franchi SL, Geary JF, Hanson CK, Harding TS, Harris CB, Heckman JM, Holderness HL, Howey NA, Jacobs DA, Jewell ES, Kaisler M, Karaska EA, Kehoe JL, Koaches HC, Koehler J, Koenig D, Kujawski AJ, Kus JE, Lammers JA, Leads RR, Leatherman EC, Lippert RN, Messenger GS, Morrow AT, Newcomb V, Plasman HJ, Potocny SJ, Powers MK, Reem RM, Rennhack JP, Reynolds KR, Reynolds LA, Rhee DK, Rivard AB, Ronk AJ, Rooney MB, Rubin LS, Salbert LR, Saluja RK, Schauder T, Schneiter AR, Schulz RW, Smith KE, Spencer S, Swanson BR, Tache MA, Tewilliager AA, Tilot AK, VanEck E, Villerot MM, Vylonis MB, Watson DT, Wurzler JA, Wysocki LM, Yalamanchili M, Zaborowicz MA, Emerson JA, Ortiz C, Deuschle FJ, DiLorenzo LA, Goeller KL, Macchi CR, Muller SE, Pasierb BD, Sable JE, Tucci JM, Tynon M, Dunbar DA, Beken LH, Conturso AC, Danner BL, DeMichele GA, Gonzales JA, Hammond MS, Kelley CV, Kelly EA, Kulich D, Mageeney CM, McCabe NL, Newman AM, Spaeder LA, Tumminello RA, Revie D, Benson JM, Cristostomo MC, DaSilva PA, Harker KS, Jarrell JN, Jimenez LA, Katz BM, Kennedy WR, Kolibas KS, LeBlanc MT, Nguyen TT, Nicolas DS, Patao MD, Patao SM, Rupley BJ, Sessions BJ, Weaver JA, Goodman AL, Alvendia EL, Baldassari SM, Brown AS, Chase IO, Chen M, Chiang S, Cromwell AB, Custer AF, DiTommaso TM, El-Adaimi J, Goscinski NC, Grove RA, Gutierrez N, Harnoto RS, Hedeen H, Hong EL, Hopkins BL, Huerta VF, Khoshabian C, LaForge KM, Lee CT, Lewis BM, Lydon AM, Maniaci BJ, Mitchell RD, Morlock EV, Morris WM, Naik P, Olson NC, Osterloh JM, Perez MA, Presley JD, Randazzo MJ, Regan MK, Rossi FG, Smith MA, Soliterman EA, Sparks CJ, Tran DL, Wan T, Welker AA, Wong JN, Sreenivasan A, Youngblom J, Adams A, Alldredge J, Bryant A, Carranza D, Cifelli A, Coulson K, Debow C, Delacruz N, Emerson C, Farrar C, Foret D, Garibay E, Gooch J, Heslop M, Kaur S, Khan A, Kim V, Lamb T, Lindbeck P, Lucas G, Macias E, Martiniuc D, Mayorga L, Medina J, Membreno N, Messiah S, Neufeld L, Nguyen SF, Nichols Z, Odisho G, Peterson D, Rodela L, Rodriguez P, Rodriguez V, Ruiz J, Sherrill W, Silva V, Sparks J, Statton G, Townsend A, Valdez I, Waters M, Westphal K, Winkler S, Zumkehr J, DeJong RJ, Hoogewerf AJ, Ackerman CM, Armistead IO, Baatenburg L, Borr MJ, Brouwer LK, Burkhart BJ, Bushhouse KT, Cesko L, Choi TY, Cohen H, Damsteegt AM, Darusz JM, Dauphin CM, Davis YP, Diekema EJ, Drewry M, Eisen ME, Faber HM, Faber KJ, Feenstra E, Felzer-Kim IT, Hammond BL, Hendriksma J, Herrold MR, Hilbrands JA, Howell EJ, Jelgerhuis SA, Jelsema TR, Johnson BK, Jones KK, Kim A, Kooienga RD, Menyes EE, Nollet EA, Plescher BE, Rios L, Rose JL, Schepers AJ, Scott G, Smith JR, Sterling AM, Tenney JC, Uitvlugt C, VanDyken RE, VanderVennen M, Vue S, Kokan NP, Agbley K, Boham SK, Broomfield D, Chapman K, Dobbe A, Dobbe I, Harrington W, Ibrahem M, Kennedy A, Koplinsky CA, Kubricky C, Ladzekpo D, Pattison C, Ramirez RE, Wande L, Woehlke S, Wawersik M, Kiernan E, Thompson JS, Banker R, Bartling JR, Bhatiya CI, Boudoures AL, Christiansen L, Fosselman DS, French KM, Gill IS, Havill JT, Johnson JL, Keny LJ, Kerber JM, Klett BM, Kufel CN, May FJ, Mecoli JP, Merry CR, Meyer LR, Miller EG, Mullen GJ, Palozola KC, Pfeil JJ, Thomas JG, Verbofsky EM, Spana EP, Agarwalla A, Chapman J, Chlebina B, Chong I, Falk IN, Fitzgibbons JD, Friedman H, Ighile O, Kim AJ, Knouse KA, Kung F, Mammo D, Ng CL, Nikam VS, Norton D, Pham P, Polk JW, Prasad S, Rankin H, Ratliff CD, Scala V, Schwartz NU, Shuen JA, Xu A, et al. Drosophila muller f elements maintain a distinct set of genomic properties over 40 million years of evolution. G3 (Bethesda). 2015 Mar 04; 5(5):719-40.
5. Heavner ME, Hudgins AD, Rajwani R, Morales J, Govind S. Harnessing the natural Drosophila-parasitoid model for integrating insect immunity with functional venomics. Curr Opin Insect Sci. 2014 Dec 01; 6:61-67.
6. Shaffer CD, Alvarez CJ, Bednarski AE, Dunbar D, Goodman AL, Reinke C, Rosenwald AG, Wolyniak MJ, Bailey C, Barnard D, Bazinet C, Beach DL, Bedard JE, Bhalla S, Braverman J, Burg M, Chandrasekaran V, Chung HM, Clase K, Dejong RJ, Diangelo JR, Du C, Eckdahl TT, Eisler H, Emerson JA, Frary A, Frohlich D, Gosser Y, Govind S, Haberman A, Hark AT, Hauser C, Hoogewerf A, Hoopes LL, Howell CE, Johnson D, Jones CJ, Kadlec L, Kaehler M, Silver Key SC, Kleinschmit A, Kokan NP, Kopp O, Kuleck G, Leatherman J, Lopilato J, Mackinnon C, Martinez-Cruzado JC, McNeil G, Mel S, Mistry H, Nagengast A, Overvoorde P, Paetkau DW, Parrish S, Peterson CN, Preuss M, Reed LK, Revie D, Robic S, Roecklein-Canfield J, Rubin MR, Saville K, Schroeder S, Sharif K, Shaw M, Skuse G, Smith CD, Smith MA, Smith ST, Spana E, Spratt M, Sreenivasan A, Stamm J, Szauter P, Thompson JS, Wawersik M, Youngblom J, Zhou L, Mardis ER, Buhler J, Leung W, Lopatto D, Elgin SC. A course-based research experience: how benefits change with increased investment in instructional time. CBE Life Sci Educ. 2014; 13(1):111-30.
7. Lopatto D, Hauser C, Jones CJ, Paetkau D, Chandrasekaran V, Dunbar D, MacKinnon C, Stamm J, Alvarez C, Barnard D, Bedard JE, Bednarski AE, Bhalla S, Braverman JM, Burg M, Chung HM, DeJong RJ, DiAngelo JR, Du C, Eckdahl TT, Emerson J, Frary A, Frohlich D, Goodman AL, Gosser Y, Govind S, Haberman A, Hark AT, Hoogewerf A, Johnson D, Kadlec L, Kaehler M, Key SC, Kokan NP, Kopp OR, Kuleck GA, Lopilato J, Martinez-Cruzado JC, McNeil G, Mel S, Nagengast A, Overvoorde PJ, Parrish S, Preuss ML, Reed LD, Regisford EG, Revie D, Robic S, Roecklien-Canfield JA, Rosenwald AG, Rubin MR, Saville K, Schroeder S, Sharif KA, Shaw M, Skuse G, Smith CD, Smith M, Smith ST, Spana EP, Spratt M, Sreenivasan A, Thompson JS, Wawersik M, Wolyniak MJ, Youngblom J, Zhou L, Buhler J, Mardis E, Leung W, Shaffer CD, Threlfall J, Elgin SC. A central support system can facilitate implementation and sustainability of a Classroom-based Undergraduate Research Experience (CURE) in Genomics. CBE Life Sci Educ. 2014; 13(4):711-23.
8. Small C, Ramroop J, Otazo M, Huang LH, Saleque S, Govind S. An unexpected link between notch signaling and ROS in restricting the differentiation of hematopoietic progenitors in Drosophila. Genetics. 2014 Jun; 197(2):471-83.
9. Gueguen G, Kalamarz ME, Ramroop J, Uribe J, Govind S. Polydnaviral ankyrin proteins aid parasitic wasp survival by coordinate and selective inhibition of hematopoietic and immune NF-kappa B signaling in insect hosts. PLoS Pathog. 2013; 9(8):e1003580.
10. Heavner ME, Gueguen G, Rajwani R, Pagan PE, Small C, Govind S. Partial venom gland transcriptome of a Drosophila parasitoid wasp, Leptopilina heterotoma, reveals novel and shared bioactive profiles with stinging Hymenoptera. Gene. 2013 Sep 10; 526(2):195-204.
11. Gueguen G, Onemola B, Govind S. Association of a new Wolbachia strain with, and its effects on, Leptopilina victoriae, a virulent wasp parasitic to Drosophila spp. Appl Environ Microbiol. 2012 Aug; 78(16):5962-6.
12. Small C, Paddibhatla I, Rajwani R, Govind S. An introduction to parasitic wasps of Drosophila and the antiparasite immune response. J Vis Exp. 2012 May 07; (63):e3347.
13. Kalamarz ME, Paddibhatla I, Nadar C, Govind S. Sumoylation is tumor-suppressive and confers proliferative quiescence to hematopoietic progenitors in Drosophila melanogaster larvae. Biol Open. 2012 Mar 15; 1(3):161-72.
14. Gokhman VE, Johnston JS, Small C, Rajwani R, Hanrahan SJ, Govind S. Genomic and karyotypic variation in Drosophila parasitoids (Hymenoptera, Cynipoidea, Figitidae). Comp Cytogenet. 2011; 5(3):211-21.
15. Gueguen G, Rajwani R, Paddibhatla I, Morales J, Govind S. VLPs of Leptopilina boulardi share biogenesis and overall stellate morphology with VLPs of the heterotoma clade. Virus Res. 2011 Sep; 160(1-2):159-65.
16. Lee MJ, Mondal A, Small C, Paddibhatla I, Kawaguchi A, Govind S. A database for the analysis of immunity genes in Drosophila: PADMA database. Fly (Austin). 2011 Apr-Jun; 5(2):155-61.
17. Paddibhatla I, Lee MJ, Kalamarz ME, Ferrarese R, Govind S. Role for sumoylation in systemic inflammation and immune homeostasis in Drosophila larvae. PLoS Pathog. 2010 Dec 23; 6(12):e1001234.
18. Tokusumi T, Sorrentino RP, Russell M, Ferrarese R, Govind S, Schulz RA. Characterization of a lamellocyte transcriptional enhancer located within the misshapen gene of Drosophila melanogaster. PLoS One. 2009 Jul 29; 4(7):e6429.
19. Ferrarese R, Morales J, Fimiarz D, Webb BA, Govind S. A supracellular system of actin-lined canals controls biogenesis and release of virulence factors in parasitoid venom glands. J Exp Biol. 2009 Jul; 212(Pt 14):2261-8.
20. Lee MJ, Kalamarz ME, Paddibhatla I, Small C, Rajwani R, Govind S. Virulence factors and strategies of Leptopilina spp.: selective responses in Drosophila hosts. Adv Parasitol. 2009; 70:123-45.
21. Govind S. Innate immunity in Drosophila: Pathogens and pathways. Insect Sci. 2008 Feb; 15(1):29-43.
22. Schlenke TA, Morales J, Govind S, Clark AG. Contrasting infection strategies in generalist and specialist wasp parasitoids of Drosophila melanogaster. PLoS Pathog. 2007 Oct 26; 3(10):1486-501.
23. Chiu H, Morales J, Govind S. Identification and immuno-electron microscopy localization of p40, a protein component of immunosuppressive virus-like particles from Leptopilina heterotoma, a virulent parasitoid wasp of Drosophila. J Gen Virol. 2006 Feb; 87(Pt 2):461-70.
24. Chiu H, Ring BC, Sorrentino RP, Kalamarz M, Garza D, Govind S. dUbc9 negatively regulates the Toll-NF-kappa B pathways in larval hematopoiesis and drosomycin activation in Drosophila. Dev Biol. 2005 Dec 01; 288(1):60-72.
25. Morales J, Chiu H, Oo T, Plaza R, Hoskins S, Govind S. Biogenesis, structure, and immune-suppressive effects of virus-like particles of a Drosophila parasitoid, Leptopilina victoriae. J Insect Physiol. 2005 Feb; 51(2):181-95.
26. Govind S, Nehm RH. Innate immunity in fruit flies: a textbook example of genomic recycling. PLoS Biol. 2004 Aug; 2(8):E276.
27. Sorrentino RP, Melk JP, Govind S. Genetic analysis of contributions of dorsal group and JAK-Stat92E pathway genes to larval hemocyte concentration and the egg encapsulation response in Drosophila. Genetics. 2004 Mar; 166(3):1343-56.
28. Bodian DL, Leung S, Chiu H, Govind S. Cytokines in Drosophila hematopoiesis and cellular immunity. Prog Mol Subcell Biol. 2004; 34:27-46.
29. Chiu H, Govind S. Natural infection of D. melanogaster by virulent parasitic wasps induces apoptotic depletion of hematopoietic precursors. Cell Death Differ. 2002 Dec; 9(12):1379-81.
30. Sorrentino RP, Small CN, Govind S. Quantitative analysis of phenol oxidase activity in insect hemolymph. Biotechniques. 2002 Apr; 32(4):815-6, 818, 820, 822-3.
31. Sorrentino RP, Carton Y, Govind S. Cellular immune response to parasite infection in the Drosophila lymph gland is developmentally regulated. Dev Biol. 2002 Mar 01; 243(1):65-80.
32. Chiu H, Sorrentino RP, Govind S. Suppression of the Drosophila cellular immune response by Ganaspis xanthopoda. Adv Exp Med Biol. 2001; 484:161-7.
33. Govind S, Melk JP, Morales J. Developmental arrest and physical entrapment eliminates supernumerary Ganaspis xanthopoda parasitoids in Drosophila melanogaster. J Parasitol. 2000 Jun; 86(3):463-70.
34. Drier EA, Govind S, Steward R. Cactus-independent regulation of Dorsal nuclear import by the ventral signal. Curr Biol. 2000 Jan 13; 10(1):23-6.
35. Govind S. Control of development and immunity by rel transcription factors in Drosophila. Oncogene. 1999 Nov 22; 18(49):6875-87.
36. Melk JP, Govind S. Developmental analysis of Ganaspis xanthopoda, a larval parasitoid of Drosophila melanogaster. J Exp Biol. 1999 Jul; 202(Pt 14):1885-96.
37. Ahmed S, Prigmore E, Govind S, Veryard C, Kozma R, Wientjes FB, Segal AW, Lim L. Cryptic Rac-binding and p21(Cdc42Hs/Rac)-activated kinase phosphorylation sites of NADPH oxidase component p67(phox). J Biol Chem. 1998 Jun 19; 273(25):15693-701.
38. Qiu P, Pan PC, Govind S. A role for the Drosophila Toll/Cactus pathway in larval hematopoiesis. Development. 1998 May; 125(10):1909-20.
39. Govind S, Drier E, Huang LH, Steward R. Regulated nuclear import of the Drosophila rel protein dorsal: structure-function analysis. Mol Cell Biol. 1996 Mar; 16(3):1103-14.
40. Govind S. Rel signalling pathway and the melanotic tumour phenotype of Drosophila. Biochem Soc Trans. 1996 Feb; 24(1):39-44.
41. Cooper K, Taylor L, Govind S. Human papillomavirus DNA in oesophageal carcinomas in South Africa. J Pathol. 1995 Mar; 175(3):273-7.
42. Lemaitre B, Meister M, Govind S, Georgel P, Steward R, Reichhart JM, Hoffmann JA. Functional analysis and regulation of nuclear import of dorsal during the immune response in Drosophila. EMBO J. 1995 Feb 01; 14(3):536-45.
43. Steward R, Govind S. Dorsal-ventral polarity in the Drosophila embryo. Curr Opin Genet Dev. 1993 Aug; 3(4):556-61.
44. Govind S, Steward R. Gene regulation: coming to grips with cactus. Curr Biol. 1993 Jun 01; 3(6):351-4.
45. Govind S, Brennan L, Steward R. Homeostatic balance between dorsal and cactus proteins in the Drosophila embryo. Development. 1993 Jan; 117(1):135-48.
46. Govind S, Whalen AM, Steward R. In vivo self-association of the Drosophila rel-protein dorsal. Proc Natl Acad Sci U S A. 1992 Sep 01; 89(17):7861-5.
47. Govind S, Steward R. Dorsoventral pattern formation in Drosophila: signal transduction and nuclear targeting. Trends Genet. 1991 Apr; 7(4):119-25.
48. Zhao J, Chan G, Govind S, Bell P, Kemper B. Structure of 5' regions and expression of phenobarbital-inducible rabbit cytochrome P450IIC genes. DNA Cell Biol. 1990 Jan-Feb; 9(1):37-48.
49. Govind S, Bell PA, Kemper B. Structure of genes in the cytochrome P-450PBc subfamily: conservation of intron locations in the phenobarbital-inducible family. DNA. 1986 Oct; 5(5):371-82.

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1. Meister M, Govind S. Hematopoietic Stem Cells. Hematopoiesis in Drosophila melanogaster. A parallel with vertebrates. 2003; 1-18.

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Drosophila Proteins
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