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Mariana Gerschenson
Title Associate Professor
Faculty Rank
Degree Ph.D.
Institution University of Hawaii
Department Department of Cell and Molecular Biology
Clusters Cardiovascular and Related Diseases
HIV/AIDS
Address
University of Hawaii HACRP
3675 Kilauea Avenue
Young Building, Bsmt, Room 10
City Honolulu
State HI
Postal Code 96816
Telephone (808) 441-1573
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Email
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  Research projects funded by the National Institutes of Health (NIH), the Centers for Disease Control (CDC), the Food and Drug Administration (FDA), and the Department of Veterans Affairs (VA)

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1.
2017Administrative and Mentoring Core1P20GM113134-01A1
2.
2017COBRE-DIABETES1P20GM113134-01A1
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2016Histopathology Core4P30GM103341-05
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2015Histopathology Core5P30GM103341-04
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2014Histopathology Core5P30GM103341-03
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2014Mitochondrial Determinants of Metabolic Disease in HIV-Infected Children5R01NR012885-05
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2013Mitochondrial Determinants of Metabolic Disease in HIV-Infected Children5R01NR012885-04
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2013Histopathology Core5P30GM103341-02
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2012Mitochondrial Determinants of Metabolic Disease in HIV-Infected Children5R01NR012885-03
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2012Histopathology Core1P30GM103341-01
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2012Global HIV Drug Therapies and Mitochondrial Complications and Mechanisms5R01AI074554-05
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2011Global HIV Drug Therapies and Mitochondrial Complications and Mechanisms5R01AI074554-04
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2011MITOCHODRIAL DYSFUNCTION IN OBESITY AND DIABETES IN BLOOD5P20MD000173-10
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2011Mitochondrial Determinants of Metabolic Disease in HIV-Infected Children5R01NR012885-02
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2010HAWAII AIDS CLINICAL RESEARCH PROGRAM/MEDICINE2P20RR016467-09A1
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2010Global HIV Drug Therapies and Mitochondrial Complications and Mechanisms5R01AI074554-03
17.
2010Mitochondrial Determinants of Metabolic Disease in HIV-Infected Children1R01NR012885-01
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2010MITOCHODRIAL DYSFUNCTION IN OBESITY AND DIABETES IN BLOOD5P20MD000173-09
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2009Global HIV Drug Therapies and Mitochondrial Complications and Mechanisms5R01AI074554-02
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2009MITOCHODRIAL DYSFUNCTION IN OBESITY AND DIABETES IN BLOOD5P20MD000173-08
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2008MITOCHODRIAL DYSFUNCTION IN OBESITY AND DIABETES IN BLOOD5P20MD000173-07
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2008HAWAII AIDS CLINICAL RESEARCH PROGRAM/MEDICINE5P20RR016467-08
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2008Global HIV Drug Therapies and Mitochondrial Complications and Mechanisms1R01AI074554-01A1
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2007MITOCHONDRIAL MECHANISMS IN HIV NEUROPATHY5P20RR016467-07
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2007MITOCHODRIAL DYSFUNCTION IN OBESITY AND DIABETES IN BLOOD2P20MD000173-06
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2006MITOCHONDRIAL MECHANISMS IN HIV NEUROPATHY5P20RR016467-06
27.
2005MITOCHONDRIAL MECHANISMS IN HIV NEUROPATHY5P20RR016467-05

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1. Geffner ME, Patel K, Jacobson DL, Wu J, Miller TL, Hazra R, Gerschenson M, Sharma T, Silio M, Jao J, Takemoto JK, Van Dyke RB, DiMeglio LA. Changes in insulin sensitivity over time and associated factors in HIV-infected adolescents. AIDS. 2018 Mar 13; 32(5):613-622.
2. Berry M, Chen J, Hixon A, Gerschenson M, James N, Jameson D, Lew HL, Lozanoff S, Nichols R, Seifried S, Teshima D, Masaki K, Tam E, Ward B, Ward S. Medical School Hotline: School of Medicine Departments - Year in Review 2017, Part 1. Hawaii J Med Public Health. 2018 Jan; 77(1):14-16.
3. Panee J, Gerschenson M, Chang L. Associations Between Microbiota, Mitochondrial Function, and Cognition in Chronic Marijuana Users. J Neuroimmune Pharmacol. 2018 Mar; 13(1):113-122.
4. Taylor BS, So-Armah K, Tate JP, Marconi VC, Koethe JR, Bedimo RJ, Butt AA, Gibert CL, Goetz MB, Rodriguez-Barradas MC, Womack JA, Gerschenson M, Lo Re V, Rimland D, Yin MT, Leaf D, Tracy RP, Justice AC, Freiberg MS. HIV and Obesity Comorbidity Increase Interleukin 6 but Not Soluble CD14 or D-Dimer. J Acquir Immune Defic Syndr. 2017 08 15; 75(5):500-508.
5. Kocher M, McDermott M, Lindsey R, Shikuma CM, Gerschenson M, Chow DC, Kohorn LB, Hetzler RK, Kimura IF. Short Communication: HIV Patient Systemic Mitochondrial Respiration Improves with Exercise. AIDS Res Hum Retroviruses. 2017 Oct; 33(10):1035-1037.
6. Willcox BJ, Morris BJ, Tranah GJ, Chen R, Masaki KH, He Q, Willcox DC, Allsopp RC, Moisyadi S, Gerschenson M, Davy PMC, Poon LW, Rodriguez B, Newman AB, Harris TB, Cummings SR, Liu Y, Parimi N, Evans DS, Donlon TA. Longevity-Associated FOXO3 Genotype and its Impact on Coronary Artery Disease Mortality in Japanese, Whites, and Blacks: A Prospective Study of Three American Populations. J Gerontol A Biol Sci Med Sci. 2017 May 01; 72(5):724-728.
7. Takemoto JK, Miller TL, Wang J, Jacobson DL, Geffner ME, Van Dyke RB, Gerschenson M. Insulin resistance in HIV-infected youth is associated with decreased mitochondrial respiration. AIDS. 2017 Jan 02; 31(1):15-23.
8. So-Armah KA, Tate JP, Chang CH, Butt AA, Gerschenson M, Gibert CL, Leaf D, Rimland D, Rodriguez-Barradas MC, Budoff MJ, Samet JH, Kuller LH, Deeks SG, Crothers K, Tracy RP, Crane HM, Sajadi MM, Tindle HA, Justice AC, Freiberg MS. Do Biomarkers of Inflammation, Monocyte Activation, and Altered Coagulation Explain Excess Mortality Between HIV Infected and Uninfected People? J Acquir Immune Defic Syndr. 2016 06 01; 72(2):206-213.
9. Willcox BJ, Tranah GJ, Chen R, Morris BJ, Masaki KH, He Q, Willcox DC, Allsopp RC, Moisyadi S, Poon LW, Rodriguez B, Newman AB, Harris TB, Cummings SR, Liu Y, Parimi N, Evans DS, Davy P, Gerschenson M, Donlon TA. The FoxO3 gene and cause-specific mortality. Aging Cell. 2016 08; 15(4):617-24.
10. Kallianpur KJ, Gerschenson M, Mitchell BI, LiButti DE, Umaki TM, Ndhlovu LC, Nakamoto BK, Chow DC, Shikuma CM. Oxidative mitochondrial DNA damage in peripheral blood mononuclear cells is associated with reduced volumes of hippocampus and subcortical gray matter in chronically HIV-infected patients. Mitochondrion. 2016 05; 28:8-15.
11. Lipshultz SE, Anderson LM, Miller TL, Gerschenson M, Stevenson KE, Neuberg DS, Franco VI, LiButti DE, Silverman LB, Vrooman LM, Sallan SE. Impaired mitochondrial function is abrogated by dexrazoxane in doxorubicin-treated childhood acute lymphoblastic leukemia survivors. Cancer. 2016 Mar 15; 122(6):946-53.
12. Shikuma CM, Bennett K, Ananworanich J, Gerschenson M, Teeratakulpisarn N, Jadwattanakul T, DeGruttola V, McArthur JC, Ebenezer G, Chomchey N, Praihirunkit P, Hongchookiat P, Mathajittiphun P, Nakamoto B, Hauer P, Phanuphak P, Phanuphak N. Distal leg epidermal nerve fiber density as a surrogate marker of HIV-associated sensory neuropathy risk: risk factors and change following initial antiretroviral therapy. J Neurovirol. 2015 Oct; 21(5):525-34.
13. Berry MJ, Astern J, Bellinger F, Brampton C, Cann R, Gerschenson M, Haymer D, James NG, Jameson DM, LeSaux O, Hoffmann PR, Nichols R, Pitts M, Seale L, Seifried S, Stokes AJ, Todorovic C. Medical school hotline: the research mission of the cell and molecular biology department and program at the john a. Burns school of medicine. Hawaii J Med Public Health. 2015 Apr; 74(4):150-3.
14. Parikh NI, Gerschenson M, Bennett K, Gangcuangco LM, Lopez MS, Mehta NN, Playford MP, Nakamoto BK, Seto TB, Chow DC, Shikuma CM. Lipoprotein concentration, particle number, size and cholesterol efflux capacity are associated with mitochondrial oxidative stress and function in an HIV positive cohort. Atherosclerosis. 2015 Mar; 239(1):50-4.
15. Hulgan T, Levinson RT, Gerschenson M, Phanuphak N, Ananworanich J, Teeratakulpisarm N, Jadwattanakul T, LiButti DE, Fink H, McArthur JC, Ebenezer GJ, Hauer P, Murdock D, Shikuma CM, Samuels DC. Epidermal nerve fiber density, oxidative stress, and mitochondrial haplogroups in HIV-infected Thais initiating therapy. AIDS. 2014 Jul 17; 28(11):1625-33.
16. Shikuma CM, Gangcuangco LM, Killebrew DA, Libutti DE, Chow DC, Nakamoto BK, Liang CY, Milne CI, Ndhlovu LC, Barbour JD, Shiramizu BT, Gerschenson M. The role of HIV and monocytes/macrophages in adipose tissue biology. J Acquir Immune Defic Syndr. 2014 Feb 01; 65(2):151-9.
17. Sharma TS, Jacobson DL, Anderson L, Gerschenson M, Van Dyke RB, McFarland EJ, Miller TL. Short communication: The relationship between mitochondrial dysfunction and insulin resistance in HIV-infected children receiving antiretroviral therapy. AIDS Res Hum Retroviruses. 2013 Sep; 29(9):1211-7.
18. Hulgan T, Stein JH, Cotter BR, Murdock DG, Ritchie MD, Dube MP, Gerschenson M, Haas DW, Torriani FJ. Mitochondrial DNA variation and changes in adiponectin and endothelial function in HIV-infected adults after antiretroviral therapy initiation. AIDS Res Hum Retroviruses. 2013 Oct; 29(10):1293-9.
19. Phanuphak N, Ananworanich J, Teeratakulpisarn N, Jadwattanakul T, Kerr SJ, Chomchey N, Hongchookiat P, Mathajittiphun P, Pinyakorn S, Rungrojrat P, Praihirunyakit P, Gerschenson M, Phanuphak P, Valcour V, Kim JH, Shikuma C. A 72-week randomized study of the safety and efficacy of a stavudine to zidovudine switch at 24 weeks compared to zidovudine or tenofovir disoproxil fumarate when given with lamivudine and nevirapine. Antivir Ther. 2012; 17(8):1521-31.
20. McComsey GA, Daar ES, O'Riordan M, Collier AC, Kosmiski L, Santana JL, Fichtenbaum CJ, Fink H, Sax PE, Libutti DE, Gerschenson M. Changes in fat mitochondrial DNA and function in subjects randomized to abacavir-lamivudine or tenofovir DF-emtricitabine with atazanavir-ritonavir or efavirenz: AIDS Clinical Trials Group study A5224s, substudy of A5202. J Infect Dis. 2013 Feb 15; 207(4):604-11.
21. Shikuma C, Gerschenson M, Ananworanich J, Valcour V, Teeratakulpisarn N, Jadwattanakul T, Degruttola V, Liang CY, McArthur J, Ebenezer G, Chomchey N, Praihirunkit P, Hongchookiath P, Mathajittiphun P, Nakamoto B, Hauer P, Phanuphak P, Phanuphak N. Determinants of epidermal nerve fibre density in antiretroviral-naïve HIV-infected individuals. HIV Med. 2012 Nov; 13(10):602-8.
22. Armah KA, McGinnis K, Baker J, Gibert C, Butt AA, Bryant KJ, Goetz M, Tracy R, Oursler KK, Rimland D, Crothers K, Rodriguez-Barradas M, Crystal S, Gordon A, Kraemer K, Brown S, Gerschenson M, Leaf DA, Deeks SG, Rinaldo C, Kuller LH, Justice A, Freiberg M. HIV status, burden of comorbid disease, and biomarkers of inflammation, altered coagulation, and monocyte activation. Clin Infect Dis. 2012 Jul; 55(1):126-36.
23. Hulgan T, Gerschenson M. HIV and mitochondria: more than just drug toxicity. J Infect Dis. 2012 Jun 15; 205(12):1769-71.
24. Shikuma CM, Seto T, Liang CY, Bennett K, DeGruttola V, Gerschenson M, Stein JH, Budoff M, Hodis HN, Delaney JA, Ogata-Arakaki D, Pramyothin P, Chow D. Vitamin D levels and markers of arterial dysfunction in HIV. AIDS Res Hum Retroviruses. 2012 Aug; 28(8):793-7.
25. McComsey GA, O'Riordan M, Choi J, Libutti D, Rowe D, Storer N, Harrill D, Gerschenson M. Mitochondrial function, inflammation, fat and bone in HIV lipoatrophy: randomized study of uridine supplementation or switch to tenofovir. Antivir Ther. 2012; 17(2):347-53.
26. Chow DC, Wood R, Choi J, Grandinetti A, Gerschenson M, Sriratanaviriyakul N, Nakamoto B, Shikuma C, Low P. Cardiovagal autonomic function in HIV-infected patients with unsuppressed HIV viremia. HIV Clin Trials. 2011 May-Jun; 12(3):141-50.
27. Côté HC, Gerschenson M, Walker UA, Miro O, Garrabou G, Hammond E, Villarroya J, Giralt M, Villarroya F, Cinque P, Garcia-Arumi E, Andreu AL, Pinti M, Cossarizza A. Quality assessment of human mitochondrial DNA quantification: MITONAUTS, an international multicentre survey. Mitochondrion. 2011 May; 11(3):520-7.
28. Brogly SB, DiMauro S, Van Dyke RB, Williams PL, Naini A, Libutti DE, Choi J, Chung M, Gerschenson M. Short communication: transplacental nucleoside analogue exposure and mitochondrial parameters in HIV-uninfected children. AIDS Res Hum Retroviruses. 2011 Jul; 27(7):777-83.
29. Chow DC, Stein JH, Seto TB, Mitchell C, Sriratanaviriyakul N, Grandinetti A, Gerschenson M, Shiramizu B, Souza S, Shikuma C. Short-term effects of extended-release niacin on endothelial function in HIV-infected patients on stable antiretroviral therapy. AIDS. 2010 Apr 24; 24(7):1019-23.
30. Tungsiripat M, O'Riordan MA, Storer N, Harrill D, Ganz J, Libutti D, Gerschenson M, McComsey GA. Subjective clinical lipoatrophy assessment correlates with DEXA-measured limb fat. HIV Clin Trials. 2009 Sep-Oct; 10(5):314-9.
31. Gerschenson M, Kim C, Berzins B, Taiwo B, Libutti DE, Choi J, Chen D, Weinstein J, Shore J, da Silva B, Belsey E, McComsey GA, Murphy RL. Mitochondrial function, morphology and metabolic parameters improve after switching from stavudine to a tenofovir-containing regimen. J Antimicrob Chemother. 2009 Jun; 63(6):1244-50.
32. Valcour V, Yeh TM, Bartt R, Clifford D, Gerschenson M, Evans SR, Cohen BA, Ebenezer GJ, Hauer P, Millar L, Gould M, Tran P, Shikuma C, Souza S, McArthur JC. Acetyl-l-carnitine and nucleoside reverse transcriptase inhibitor-associated neuropathy in HIV infection. HIV Med. 2009 Feb; 10(2):103-10.
33. Stein JH, Komarow L, Cotter BR, Currier JS, Dubé MP, Fichtenbaum CJ, Gerschenson M, Mitchell CK, Murphy RL, Squires K, Parker RA, Torriani FJ. Lipoprotein Changes in HIV-Infected Antiretroviral-Naïve Individuals after Starting Antiretroviral Therapy: ACTG Study A5152s Stein: Lipoprotein Changes on Antiretroviral Therapy. J Clin Lipidol. 2008 Dec; 2(6):464-471.
34. Shikuma CM, Gerschenson M, Chow D, Libutti DE, Willis JH, Murray J, Capaldi RA, Marusich M. Mitochondrial oxidative phosphorylation protein levels in peripheral blood mononuclear cells correlate with levels in subcutaneous adipose tissue within samples differing by HIV and lipoatrophy status. AIDS Res Hum Retroviruses. 2008 Oct; 24(10):1255-62.
35. Torriani FJ, Komarow L, Parker RA, Cotter BR, Currier JS, Dubé MP, Fichtenbaum CJ, Gerschenson M, Mitchell CK, Murphy RL, Squires K, Stein JH. Endothelial function in human immunodeficiency virus-infected antiretroviral-naive subjects before and after starting potent antiretroviral therapy: The ACTG (AIDS Clinical Trials Group) Study 5152s. J Am Coll Cardiol. 2008 Aug 12; 52(7):569-76.
36. McComsey GA, Libutti DE, O'Riordan M, Shelton JM, Storer N, Ganz J, Jasper J, Harrill D, Gerschenson M. Mitochondrial RNA and DNA alterations in HIV lipoatrophy are linked to antiretroviral therapy and not to HIV infection. Antivir Ther. 2008; 13(5):715-22.
37. Zhou L, Kitch DW, Evans SR, Hauer P, Raman S, Ebenezer GJ, Gerschenson M, Marra CM, Valcour V, Diaz-Arrastia R, Goodkin K, Millar L, Shriver S, Asmuth DM, Clifford DB, Simpson DM, McArthur JC. Correlates of epidermal nerve fiber densities in HIV-associated distal sensory polyneuropathy. Neurology. 2007 Jun 12; 68(24):2113-9.
38. Simpson DM, Kitch D, Evans SR, McArthur JC, Asmuth DM, Cohen B, Goodkin K, Gerschenson M, So Y, Marra CM, Diaz-Arrastia R, Shriver S, Millar L, Clifford DB. HIV neuropathy natural history cohort study: assessment measures and risk factors. Neurology. 2006 Jun 13; 66(11):1679-87.
39. Shikuma CM, Day LJ, Gerschenson M. Insulin resistance in the HIV-infected population: the potential role of mitochondrial dysfunction. Curr Drug Targets Infect Disord. 2005 Sep; 5(3):255-62.
40. Shikuma CM, Valcour VG, Ratto-Kim S, Williams AE, Souza S, Gerschenson M, Day L, Kim JH, Shiramizu B. HIV-associated wasting in the era of highly active antiretroviral therapy: a syndrome of residual HIV infection in monocytes and macrophages? Clin Infect Dis. 2005 Jun 15; 40(12):1846-8.
41. Gerschenson M, Shiramizu B, LiButti DE, Shikuma CM. Mitochondrial DNA levels of peripheral blood mononuclear cells and subcutaneous adipose tissue from thigh, fat and abdomen of HIV-1 seropositive and negative individuals. Antivir Ther. 2005; 10 Suppl 2:M83-9.
42. Day L, Shikuma C, Gerschenson M. Acetyl-L-carnitine for the treatment of HIV lipoatrophy. Ann N Y Acad Sci. 2004 Nov; 1033:139-46.
43. Gerschenson M, Brinkman K. Mitochondrial dysfunction in AIDS and its treatment. Mitochondrion. 2004 Sep; 4(5-6):763-77.
44. Day L, Shikuma C, Gerschenson M. Mitochondrial injury in the pathogenesis of antiretroviral-induced hepatic steatosis and lactic acidemia. Mitochondrion. 2004 Jul; 4(2-3):95-109.
45. Kamemoto LE, Shiramizu B, Gerschenson M. HIV-associated mitochondrial toxicity in pregnancy. Mitochondrion. 2004 Jul; 4(2-3):153-62.
46. Walsh EJ, Souza S, Gerschenson M, Shikuma C, Chow D. HIV disease progression and limited antiretroviral treatment options for a HIV-1 infected individual with myoclonic epilepsy associated with ragged red fibers. Mitochondrion. 2004 Jul; 4(2-3):169-73.
47. Gerschenson M, Nguyen V, Ewings EL, Ceresa A, Shaw JA, St Claire MC, Nagashima K, Harbaugh SW, Harbaugh JW, Olivero OA, Divi RL, Albert PS, Poirier MC. Mitochondrial toxicity in fetal Erythrocebus patas monkeys exposed transplacentally to zidovudine plus lamivudine. AIDS Res Hum Retroviruses. 2004 Jan; 20(1):91-100.
48. Gerschenson M. Mitochondria and lipodystrophy: where are we now? Antivir Ther. 2003 Aug; 8(4):261-3.
49. Shiramizu B, Shikuma KM, Kamemoto L, Gerschenson M, Erdem G, Pinti M, Cossarizza A, Shikuma C. Placenta and cord blood mitochondrial DNA toxicity in HIV-infected women receiving nucleoside reverse transcriptase inhibitors during pregnancy. J Acquir Immune Defic Syndr. 2003 Apr 01; 32(4):370-4.
50. Dagan T, Sable C, Bray J, Gerschenson M. Mitochondrial dysfunction and antiretroviral nucleoside analog toxicities: what is the evidence? Mitochondrion. 2002 May; 1(5):397-412.
51. Low RL, Gerschenson M. Endonuclease G isolation and assays. Methods Mol Biol. 2002; 197:331-49.
52. Gerschenson M, Nguyen VT, St Claire MC, Harbaugh SW, Harbaugh JW, Proia LA, Poirier MC. Chronic stavudine exposure induces hepatic mitochondrial toxicity in adult Erythrocebus patas monkeys. J Hum Virol. 2001 Nov-Dec; 4(6):335-42.
53. Gerschenson M, Paik CY, Gaukler EL, Diwan BA, Poirier MC. Cisplatin exposure induces mitochondrial toxicity in pregnant rats and their fetuses. Reprod Toxicol. 2001 Sep-Oct; 15(5):525-31.
54. DasGupta SF, Rapoport SI, Gerschenson M, Murphy E, Fiskum G, Russell SJ, Chandrasekaran K. ATP synthesis is coupled to rat liver mitochondrial RNA synthesis. Mol Cell Biochem. 2001 May; 221(1-2):3-10.
55. Gerschenson M, Poirier MC. Fetal patas monkeys sustain mitochondrial toxicity as a result of in utero zidovudine exposure. Ann N Y Acad Sci. 2000 Nov; 918:269-81.
56. Ewings EL, Gerschenson M, St Claire MC, Nagashima K, Skopets B, Harbaugh SW, Harbaugh JW, Poirier MC. Genotoxic and functional consequences of transplacental zidovudine exposure in fetal monkey brain mitochondria. J Acquir Immune Defic Syndr. 2000 Jun 01; 24(2):100-5.
57. Bialkowska A, Bialkowski K, Gerschenson M, Diwan BA, Jones AB, Olivero OA, Poirier MC, Anderson LM, Kasprzak KS, Sipowicz MA. Oxidative DNA damage in fetal tissues after transplacental exposure to 3'-azido-3'-deoxythymidine (AZT). Carcinogenesis. 2000 May; 21(5):1059-62.
58. Gerschenson M, Erhart SW, Paik CY, St Claire MC, Nagashima K, Skopets B, Harbaugh SW, Harbaugh JW, Quan W, Poirier MC. Fetal mitochondrial heart and skeletal muscle damage in Erythrocebus patas monkeys exposed in utero to 3'-azido-3'-deoxythymidine. AIDS Res Hum Retroviruses. 2000 May 01; 16(7):635-44.
59. Gerschenson M, Houmiel KL, Low RL. Endonuclease G from mammalian nuclei is identical to the major endonuclease of mitochondria. Nucleic Acids Res. 1995 Jan 11; 23(1):88-97.
60. Gerschenson M, Low RL, Loehr J. Levels of the mitochondrial endonuclease during rat cardiac development implicate a role for the enzyme in repair of oxidative damage in mitochondrial DNA. J Mol Cell Cardiol. 1994 Jan; 26(1):31-40.
61. Houmiel KL, Gerschenson M, Low RL. Mitochondrial endonuclease activity in the rat varies markedly among tissues in relation to the rate of tissue metabolism. Biochim Biophys Acta. 1991 Aug 30; 1079(2):197-202.
62. Gerschenson M, Graves K, Carson SD, Wells RS, Pierce GB. Regulation of melanoma by the embryonic skin. Proc Natl Acad Sci U S A. 1986 Oct; 83(19):7307-10.

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