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Jorge Benitez
Title Associate Professor, Dept. of MBI
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Degree Ph.D.
Institution Morehouse School of Medicine
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Telephone 404-752-1580
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1. Ayala JC, Wang H, Benitez JA, Silva AJ. Molecular basis for the differential expression of the global regulator VieA in Vibrio cholerae biotypes directed by H-NS, LeuO and quorum sensing. Mol Microbiol. 2018 Feb; 107(3):330-343.
2. Mewborn L, Benitez JA, Silva AJ. Flagellar motility, extracellular proteases and Vibrio cholerae detachment from abiotic and biotic surfaces. Microb Pathog. 2017 Dec; 113:17-24.
3. Wang H, Silva AJ, Benitez JA. 3-Amino 1,8-naphthalimide, a structural analog of the anti-cholera drug virstatin inhibits chemically-biased swimming and swarming motility in vibrios. Microbes Infect. 2017 06; 19(6):370-375.
4. Ayala JC, Silva AJ, Benitez JA. H-NS: an overarching regulator of the Vibrio cholerae life cycle. Res Microbiol. 2017 Jan; 168(1):16-25.
5. Benitez JA, Silva AJ. Vibrio cholerae hemagglutinin(HA)/protease: An extracellular metalloprotease with multiple pathogenic activities. Toxicon. 2016 Jun 01; 115:55-62.
6. Silva AJ, Benitez JA. Vibrio cholerae Biofilms and Cholera Pathogenesis. PLoS Negl Trop Dis. 2016 Feb; 10(2):e0004330.
7. Ayala JC, Wang H, Benitez JA, Silva AJ. RNA-Seq analysis and whole genome DNA-binding profile of the Vibrio cholerae histone-like nucleoid structuring protein (H-NS). Genom Data. 2015 Sep 01; 5:147-150.
8. Ayala JC, Wang H, Silva AJ, Benitez JA. Repression by H-NS of genes required for the biosynthesis of the Vibrio cholerae biofilm matrix is modulated by the second messenger cyclic diguanylic acid. Mol Microbiol. 2015 Aug; 97(4):630-45.
9. Silva AJ, Parker WB, Allan PW, Ayala JC, Benitez JA. Role of methylthioadenosine/S-adenosylhomocysteine nucleosidase in Vibrio cholerae cellular communication and biofilm development. Biochem Biophys Res Commun. 2015 May 22; 461(1):65-9.
10. Wang H, Ayala JC, Benitez JA, Silva AJ. RNA-seq analysis identifies new genes regulated by the histone-like nucleoid structuring protein (H-NS) affecting Vibrio cholerae virulence, stress response and chemotaxis. PLoS One. 2015; 10(2):e0118295.
11. Wang H, Ayala JC, Benitez JA, Silva AJ. The LuxR-type regulator VpsT negatively controls the transcription of rpoS, encoding the general stress response regulator, in Vibrio cholerae biofilms. J Bacteriol. 2014 Mar; 196(5):1020-30.
12. Wang H, Silva AJ, Rasmussen L, White EL, Benitez JA. A highly specific cell-based high-throughput screening assay for ligands of cyclic adenosine monophosphate receptor protein in gram-negative bacteria. Assay Drug Dev Technol. 2013 Jul; 11(6):382-7.
13. Wang H, Zhang L, Silva AJ, Benitez JA. A quinazoline-2,4-diamino analog suppresses Vibrio cholerae flagellar motility by interacting with motor protein PomB and induces envelope stress. Antimicrob Agents Chemother. 2013 Aug; 57(8):3950-9.
14. Wang H, Ayala JC, Silva AJ, Benitez JA. The histone-like nucleoid structuring protein (H-NS) is a repressor of Vibrio cholerae exopolysaccharide biosynthesis (vps) genes. Appl Environ Microbiol. 2012 Apr; 78(7):2482-8.
15. Wang H, Ayala JC, Benitez JA, Silva AJ. Interaction of the histone-like nucleoid structuring protein and the general stress response regulator RpoS at Vibrio cholerae promoters that regulate motility and hemagglutinin/protease expression. J Bacteriol. 2012 Mar; 194(5):1205-15.
16. Wang H, Wu JH, Ayala JC, Benitez JA, Silva AJ. Interplay among cyclic diguanylate, HapR, and the general stress response regulator (RpoS) in the regulation of Vibrio cholerae hemagglutinin/protease. J Bacteriol. 2011 Dec; 193(23):6529-38.
17. Rasmussen L, White EL, Pathak A, Ayala JC, Wang H, Wu JH, Benitez JA, Silva AJ. A high-throughput screening assay for inhibitors of bacterial motility identifies a novel inhibitor of the Na+-driven flagellar motor and virulence gene expression in Vibrio cholerae. Antimicrob Agents Chemother. 2011 Sep; 55(9):4134-43.
18. Silva AJ, Benitez JA, Wu JH. Attenuation of bacterial virulence by quorum sensing-regulated lysis. J Biotechnol. 2010 Oct 01; 150(1):22-30.
19. Sultan SZ, Silva AJ, Benitez JA. The PhoB regulatory system modulates biofilm formation and stress response in El Tor biotype Vibrio cholerae. FEMS Microbiol Lett. 2010 Jan; 302(1):22-31.
20. Ali SA, Benitez JA. Differential response of Vibrio cholerae planktonic and biofilm cells to autoinducer 2 deficiency. Microbiol Immunol. 2009 Oct; 53(10):582-6.
21. Liang W, Sultan SZ, Silva AJ, Benitez JA. Cyclic AMP post-transcriptionally regulates the biosynthesis of a major bacterial autoinducer to modulate the cell density required to activate quorum sensing. FEBS Lett. 2008 Nov 12; 582(27):3744-50.
22. Silva AJ, Sultan SZ, Liang W, Benitez JA. Role of the histone-like nucleoid structuring protein in the regulation of rpoS and RpoS-dependent genes in Vibrio cholerae. J Bacteriol. 2008 Nov; 190(22):7335-45.
23. Silva AJ, Eko FO, Benitez JA. Exploiting cholera vaccines as a versatile antigen delivery platform. Biotechnol Lett. 2008 Apr; 30(4):571-9.
24. Liang W, Silva AJ, Benitez JA. The cyclic AMP receptor protein modulates colonial morphology in Vibrio cholerae. Appl Environ Microbiol. 2007 Nov; 73(22):7482-7.
25. Liang W, Pascual-Montano A, Silva AJ, Benitez JA. The cyclic AMP receptor protein modulates quorum sensing, motility and multiple genes that affect intestinal colonization in Vibrio cholerae. Microbiology. 2007 Sep; 153(Pt 9):2964-75.
26. Hazra A, Silva AJ, Benitez JA. Expression of foreign proteins in a Vibrio cholerae vaccine strain using the stationary phase hemagglutinin/protease promoter. Biotechnol Lett. 2007 Jul; 29(7):1093-7.
27. Jahid IK, Silva AJ, Benitez JA. Polyphosphate stores enhance the ability of Vibrio cholerae to overcome environmental stresses in a low-phosphate environment. Appl Environ Microbiol. 2006 Nov; 72(11):7043-9.
28. Silva AJ, Leitch GJ, Camilli A, Benitez JA. Contribution of hemagglutinin/protease and motility to the pathogenesis of El Tor biotype cholera. Infect Immun. 2006 Apr; 74(4):2072-9.
29. Silva AJ, Benitez JA. A Vibrio cholerae relaxed (relA) mutant expresses major virulence factors, exhibits biofilm formation and motility, and colonizes the suckling mouse intestine. J Bacteriol. 2006 Jan; 188(2):794-800.
30. Silva AJ, Benitez JA. Th1-type immune response to a Coccidioides immitis antigen delivered by an attenuated strain of the non-invasive enteropathogen Vibrio cholerae. FEMS Immunol Med Microbiol. 2005 Mar 01; 43(3):393-8.
31. Silva AJ, Benitez JA. Transcriptional regulation of Vibrio cholerae hemagglutinin/protease by the cyclic AMP receptor protein and RpoS. J Bacteriol. 2004 Oct; 186(19):6374-82.
32. Zhou X, Gao DQ, Michalski J, Benitez JA, Kaper JB. Induction of interleukin-8 in T84 cells by Vibrio cholerae. Infect Immun. 2004 Jan; 72(1):389-97.
33. Silva AJ, Mohan A, Benitez JA. Cholera vaccine candidate 638: intranasal immunogenicity and expression of a foreign antigen from the pulmonary pathogen Coccidioides immitis. Vaccine. 2003 Dec 01; 21(32):4715-21.
34. Silva AJ, Pham K, Benitez JA. Haemagglutinin/protease expression and mucin gel penetration in El Tor biotype Vibrio cholerae. Microbiology. 2003 Jul; 149(Pt 7):1883-91.

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