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Julio Benabe
Title Key Function Leader, PRCTRC.
Faculty Rank Professor
Degree M.D.
Institution University of Puerto Rico
Department Clinical Sciences
Clusters Cardiovascular and Related Diseases
Address
UPR-Medical Sciences Campus
Puerto Rico Clinical and Translational Research Consort
PO Box 365067
City San Juan
State PR
Postal Code 00936-506
Telephone 787-759-0306
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  Dr. Julio E. Benabe is a graduate of the University of Puerto Rico School of Medicine. He completed his Internal Medicine training at the San Juan VA Medical Center and a fellowship in Renal Diseases and Hypertension at Washington University, Barnes and Wohl Hospital in St. Louis, Mo. Since 1981 he joined the faculty at the UPR-MSC and the San Juan VA Hospital where he served as Staff Physician, Chief of the Renal Division and Acting Chief of Medicine at the VAH. From 1995 to 2010 he was Program Director of the UPR-MSC Clinical Research Center-RCRII and has been ACOS for R&D at the SJVA Caribbean Healthcare System from 11/2004 to 2/2011.

He has been involved in the study of the role of the renin angiotensin system and the renal prostaglandin system in the progression of renal disease and hypertension and has published over 50 peer reviewed papers and textbook chapters in the field. He has been an active member of the American Society of Nephrology, the American Society of Hypertension, the Southern Society of Clinical Investigation and the Latinamerican Society of Nephrology and Hypertension. Dr. Benabe is currently active in clinical trials on hypertension and progression of Chronic Kidney Disease and is Professor of Medicine at the UPR-MSC and leader of the Participants and Clinical Interactions Key Function of the PRCTRC.

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1. Fleming ES, Perkins J, Easa D, Conde JG, Baker RS, Southerland WM, Dottin R, Benabe JE, Ofili EO, Bond VC, McClure SA, Sayre MH, Beanan MJ, Norris KC. The role of translational research in addressing health disparities: a conceptual framework. Ethn Dis. 2008; 18(2 Suppl 2):S2-155-60.
2. Fleming ES, Perkins J, Easa D, Conde JG, Baker RS, Southerland WM, Dottin R, Benabe JE, Ofili EO, Bond VC, McClure SA, Sayre MH, Beanan MJ, Norris KC. Addressing health disparities through multi-institutional, multidisciplinary collaboratories. Ethn Dis. 2008; 18(2 Suppl 2):S2-161-7.
3. Benabe JE, Rios EV. Kidney disease in the Hispanic population: facing the growing challenge. J Natl Med Assoc. 2004 Jun; 96(6):789-98.
4. Benabe JE, Martinez-Maldonado M. The impact of malnutrition on kidney function. Miner Electrolyte Metab. 1998; 24(1):20-6.
5. Benabe JE, Wang S, Wilcox JN, Martinez-Maldonado M. Modulation of ANG II receptor and its mRNA in normal rat by low-protein feeding. Am J Physiol. 1993 Nov; 265(5 Pt 2):F660-9.
6. Benabe JE, Martinez-Maldonado M. Dietary modification of the renin angiotensin system. Semin Nephrol. 1993 Nov; 13(6):567-72.
7. Benabe JE, Pedraza-Chaverri J, Martínez-Maldonado M. Mechanisms of ozolinone-induced renin release and diuresis. Am J Hypertens. 1993 Aug; 6(8):701-7.
8. Benabe JE, Fernández-Repollet E, Tapia E, Luo C, Martinez-Maldonado M. Angiotensin II and catecholamines interaction in short-term low protein feeding. Kidney Int. 1993 Aug; 44(2):285-93.
9. Martinez-Maldonado M, Benabe JE, Wilcox JN, Wang S, Luo C. Renal renin, angiotensinogen, and ANG I-converting-enzyme gene expression: influence of dietary protein. Am J Physiol. 1993 Jun; 264(6 Pt 2):F981-8.
10. Martinez-Maldonado M, Delafontaine P, Anwar A, Fath KA, Pimentel JL, Bernstein KE, Luo C, Wang S, Benabe JE. Aortic and renal regulation of the renin-angiotensin system in interrenal aortic coarctation. Trans Assoc Am Physicians. 1993; 106:120-7.
11. Benabe JE, Cordova HR. Effect of high-protein diet on renal concentration capacity in rabbits. Am J Physiol. 1992 Dec; 263(6 Pt 2):F1051-6.
12. Benabe JE, Martinez-Maldonado M. Renal effects of dietary protein excess and deprivation. Semin Nephrol. 1991 Mar; 11(2):76-85.
13. Martínez-Maldonado M, Gely R, Tapia E, Benabe JE. Role of macula densa in diuretics-induced renin release. Hypertension. 1990 Sep; 16(3):261-8.
14. Fried T, Aronoff GR, Benabe JE, Brunner HR, DiBona GF, Fleischhauer T, Lam M, Lawton WJ, Luft FC, Martinez-Maldonado M, et al. Renal and hemodynamic effects of atrial natriuretic peptide in patients with cirrhosis. Am J Med Sci. 1990 Jan; 299(1):2-9.
15. Martínez-Maldonado M, López-Novoa JM, Fernández-Repollet E, Baldizón C, Opava-Stitzer S, Benabe JE. Functional studies in experimental renal cortical necrosis in the rat. Am J Physiol. 1989 Dec; 257(6 Pt 2):F925-36.
16. Martinez-Maldonado M, Benabe JE. Electrolyte abnormalities in cancer. Adv Exp Med Biol. 1989; 252:135-45.
17. Benabe JE, Martínez-Maldonado M. Tubulo-interstitial nephritis associated with systemic disease and electrolyte abnormalities. Semin Nephrol. 1988 Mar; 8(1):29-40.
18. Benabe JE, Echegoyen LA, Pastrana B, Martínez-Maldonado M. Mechanism of inhibition of glycolysis by vanadate. J Biol Chem. 1987 Jul 15; 262(20):9555-60.
19. Nieves J, Kim L, Puett D, Echegoyen L, Benabe J, Martinez-Maldonado M. Electron spin resonance of calmodulin-vanadyl complexes. Biochemistry. 1987 Jul 14; 26(14):4523-7.
20. Martinez-Maldonado M, Benabe JE. Hypertension in renovascular disease. Contrib Nephrol. 1987; 54:124-33.
21. Benabe JE, Echegoyen LA, Martínez-Maldonado M. Mechanism of inhibition of glycolysis by vanadate. Adv Exp Med Biol. 1986; 208:517-28.
22. Cruz-Soto M, Benabe JE, López-Novoa JM, Martínez-Maldonado M. Na+-K+-ATPase inhibitors and renin release: relationship to calcium. Am J Physiol. 1984 Oct; 247(4 Pt 2):F650-5.
23. Benabe JE, Cruz-Soto MA, Martínez-Maldonado M. Critical role of extracellular calcium in vanadate-induced renal vasoconstriction. Am J Physiol. 1984 Mar; 246(3 Pt 2):F317-22.
24. Benabe JE, Martínez-Maldonado M. Importance of calcium in the renal hemodynamic changes induced by vanadate. Adv Exp Med Biol. 1984; 178:329-36.
25. Cruz-Soto MA, Benabe JE, López-Novoa JM, Martínez-Maldonado M. Renal Na+-K+-ATPase in renin release. Am J Physiol. 1982 Dec; 243(6):F598-603.
26. López Novoa JM, García JC, Cruz-Soto MA, Benabe JE, Martínez-Maldonado M. Effect of sodium orthovanadate on renal renin secretion in vivo. J Pharmacol Exp Ther. 1982 Aug; 222(2):447-51.
27. Benabe JE, Spry LA, Morrison AR. Effects of angiotensin II on phosphatidylinositol and polyphosphoinositide turnover in rat kidney. Mechanism of prostaglandin release. J Biol Chem. 1982 Jul 10; 257(13):7430-4.
28. Morrison AR, Benabe JE. Prostaglandins in vascular tone in experimental obstructive nephropathy. Kidney Int. 1981 Jun; 19(6):786-90.
29. Benabe JE, Klahr S, Hoffman MK, Morrison AR. Production of thromboxane A2 by the kidney in glycerol-induced acute renal failure in the rabbit. Prostaglandins. 1980 Mar; 19(3):333-47.
30. Morrison AR, Benabe JE, Hoffman MK. Identification of thromboxane A2 in glycerol-induced acute renal failure in the rabbit. Adv Prostaglandin Thromboxane Res. 1980; 7:1131-3.
31. Benabe J, Martinez-Maldonado M. Some characteristics of recurrent calcium stone formers in Puerto Rico. Urology. 1979 Jul; 14(1):13-7.
32. Benabe JE, Martinez-Maldonado M. Hypercalcemic nephropathy. Arch Intern Med. 1978 May; 138(5):777-9.

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