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Caroline Appleyard
Title Director, PHSU-NIGMS RISE Training Program; Co-Leader, Training/Career Development Core, U54 PSM-MCC Partnership
Faculty Rank Professor
Degree Ph.D.
Institution Ponce School of Medicine
Department Basic Sciences
Clusters Cancer
Infectious and Immunological Diseases
Women's Health and Reproductive Biology
Address
Ponce School of Medicine
P.O. Box 7004
City Ponce
State PR
Postal Code 00732
Telephone 787-840-2575 x2165
Fax
Email
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Awards and Honors icon

1995 FASEB Young Investigator Award
2000 American Motility Society Travel Award
2002 FASEB FASEB/MARC Travel Award
2007 AACR Minority-serving Institution Faculty Scholar Cancer Research Award
2010 AACR MInority-serving Institution Faculty Scholar Cancer Research Award
2013 FASEB FASEB/MARC Travel Award
2014 Merck Merck Health Innovation Award - Investigation
2016 American Physiological Society Fellow
2017 American Physiological Society A. Clifford Berger Underrepresented Minority Mentorship Award

Narrative icon

  Caroline B. Appleyard, PhD is a Professor in the Department of Basic Sciences (Physiology Division) and Internal Medicine at Ponce Health Sciences University (PHSU) - Ponce Research Institute. She obtained her Bachelor’s degree in Pharmacology from the University of Edinburgh, Scotland before completing her doctoral studies at the University of Southampton, England. She then gained extensive experience in the field of gastrointestinal inflammation, through her post-doctoral studies at the University of Calgary, Canada and at the University of South Dakota. Her current studies center on the interactions between inflammatory mediators, microflora, and behavior, in the pathogenesis and exacerbation of inflammatory conditions of the intestine. She has developed several animal models to study these conditions and help elucidate the neuro-immune mechanisms involved with a view to developing complementary therapies. Dr. Appleyard strongly believes that mentoring and exposure to training, and learning from others experiences will help to ensure that women and minorities stay in science. At PHSU she is heavily involved in scientific training in her capacity as Program Director of the NIGMS RISE graduate training program, and co-leader for the Training/Career Development Core of the U54 PSM-Moffitt Cancer Center partnership, and this extends to her involvement in mentoring programs at the national level. Most recently she was recognized at the national level becoming the Inaugural recipient of the A. Clifford Barger Underrepresented Minority Mentorship Award from the American Physiological Society. She regularly reviews for academic journals and funding agencies and has coordinated several scientific workshops and meetings. She is an active member of several professional societies including the American Physiological Society (currently serving on the Career Opportunities in Physiology Committee; Past-President of the Puerto Rico Physiological Society), the American Gastroenterology Association, the American Association for Cancer Research and the Association for Women In Science.

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NIH Awarded Grants icon

  Research projects funded by the National Institutes of Health (NIH), the Centers for Disease Control (CDC), the Food and Drug Administration (FDA), and the Department of Veterans Affairs (VA)

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1.
2018Physical activity as a therapeutic intervention in endometriosis1R15AT009915-01
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2017Research Education Core2U54CA163071-06
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2017Ponce_Health_Sciences_University_RISE_Graduate_Training_Program.2R25GM082406-10
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2016Training and Career Development4U54CA163071-05
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2016RISE Option III: Ponce School of Medicine MBRS-RISE Program4R25GM082406-09
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2015RISE Option III: Ponce School of Medicine MBRS-RISE Program5R25GM082406-08
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2015Training and Career Development5U54CA163071-04
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2014RISE Option III: Ponce School of Medicine MBRS-RISE Program5R25GM082406-07
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2014Training and Career Development5U54CA163071-03
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2013RISE Option III: Ponce School of Medicine MBRS-RISE Program5R25GM082406-06
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2013Training and Career Development5U54CA163071-02
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2013THE ROLE OF BACTERIAL PEPTIDES IN CHRONIC INTESTINAL INFLAMMATION5G12MD007579-28
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2012RISE Option III: Ponce School of Medicine MBRS-RISE Program2R25GM082406-05
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2012THE ROLE OF BACTERIAL PEPTIDES IN CHRONIC INTESTINAL INFLAMMATION8G12MD007579-27
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2012Training and Career Development1U54CA163071-01A1
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2012Stress: Potential Impact on an Animal Model of Endometriosis3R15AT006373-01A1S1
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2011Stress: Potential Impact on an Animal Model of Endometriosis1R15AT006373-01A1
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2011Ponce School of Medicine MBRS-RISE Program5R25GM082406-04
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2011THE ROLE OF BACTERIAL PEPTIDES IN CHRONIC INTESTINAL INFLAMMATION5G12RR003050-26
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2010Ponce School of Medicine MBRS-RISE Program5R25GM082406-03
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2010THE ROLE OF BACTERIAL PEPTIDES IN CHRONIC INTESTINAL INFLAMMATION5G12RR003050-25
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2009Ponce School of Medicine MBRS-RISE Program3R25GM082406-02S1
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2009THE ROLE OF BACTERIAL PEPTIDES IN CHRONIC INTESTINAL INFLAMMATION2G12RR003050-24
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2009Ponce School of Medicine MBRS-RISE Program5R25GM082406-02
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2008THE ROLE OF BACTERIAL PEPTIDES IN CHRONIC INTESTINAL INFLAMMATION3G12RR003050-23S1
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2008Ponce School of Medicine MBRS-RISE Program1R25GM082406-01
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2007THE ROLE OF BACTERIAL PEPTIDES IN CHRONIC INTESTINAL INFLAMMATION5G12RR003050-23
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2006THE ROLE OF BACTERIAL PEPTIDES IN CHRONIC INTESTINAL INFLAMMATION5G12RR003050-22
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2005THE ROLE OF BACTERIAL PEPTIDES IN CHRONIC INTESTINAL INFLAMMATION5G12RR003050-21
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2004THE ROLE OF BACTERIAL PEPTIDES IN CHRONIC INTESTINAL INFLAMMATION5G12RR003050-20
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2002Involvement of TNF-alpha in Intestinal Inflammation in a Model of Colitis5S06GM008239-17
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2002Involvement of TNF-alpha in Intestinal Inflammation in a Model of Colitis3S06GM008239-17S1
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2002Involvement of TNF-alpha in Intestinal Inflammation in a Model of Colitis3S06GM008239-16S2
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2002Involvement of TNF-alpha in Intestinal Inflammation in a Model of Colitis3S06GM008239-17S2
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2002Involvement of TNF-alpha in Intestinal Inflammation in a Model of Colitis3S06GM008239-17S3
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2001Involvement of TNF-alpha in Intestinal Inflammation in a Model of Colitis2S06GM008239-16

Publications icon

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1. Cuevas M, Cruz ML, Ramirez AE, Flores I, Thompson KJ, Bayona M, Vernon MW, Appleyard CB. Stress During Development of Experimental Endometriosis Influences Nerve Growth and Disease Progression. Reprod Sci. 2018 Mar; 25(3):347-357.
2. Isidro RA, Lopez A, Cruz ML, Gonzalez Torres MI, Chompre G, Isidro AA, Appleyard CB. The Probiotic VSL#3 Modulates Colonic Macrophages, Inflammation, and Microflora in Acute Trinitrobenzene Sulfonic Acid Colitis. J Histochem Cytochem. 2017 08; 65(8):445-461.
3. Hernandez S, Cruz ML, Seguinot II, Torres-Reveron A, Appleyard CB. Impact of Psychological Stress on Pain Perception in an Animal Model of Endometriosis. Reprod Sci. 2017 Oct; 24(10):1371-1381.
4. Torres-Reverón A, Rivera LL, Flores I, Appleyard CB. Environmental Manipulations as an Effective Alternative Treatment to Reduce Endometriosis Progression. Reprod Sci. 2017 Jan 01; 1933719117741374.
5. Isidro RA, Appleyard CB. Colonic macrophage polarization in homeostasis, inflammation, and cancer. Am J Physiol Gastrointest Liver Physiol. 2016 Jul 01; 311(1):G59-73.
6. de Jesus ER, Isidro RA, Cruz ML, Marty H, Appleyard CB. Adoptive Transfer of Dendritic Cells Expressing Fas Ligand Modulates Intestinal Inflammation in a Model of Inflammatory Bowel Disease. J Clin Cell Immunol. 2016 Apr; 7(2).
7. Torres-Reverón A, Palermo K, Hernández-López A, Hernández S, Cruz ML, Thompson KJ, Flores I, Appleyard CB. Endometriosis Is Associated With a Shift in MU Opioid and NMDA Receptor Expression in the Brain Periaqueductal Gray. Reprod Sci. 2016 09; 23(9):1158-67.
8. Abreu-Delgado Y, Isidro RA, Torres EA, González A, Cruz ML, Isidro AA, González-Keelan CI, Medero P, Appleyard CB. Serum vitamin D and colonic vitamin D receptor in inflammatory bowel disease. World J Gastroenterol. 2016 Apr 07; 22(13):3581-91.
9. Hernandez S, Cruz ML, Torres-Reveron A, Appleyard CB. Impact of physical activity on pain perception in an animal model of endometriosis. J Endometr Pelvic Pain Disord. 2015 Jul-Sep; 7(3):89-114.
10. Isidro RA, Isidro AA, Cruz ML, Hernandez S, Appleyard CB. Double immunofluorescent staining of rat macrophages in formalin-fixed paraffin-embedded tissue using two monoclonal mouse antibodies. Histochem Cell Biol. 2015 Dec; 144(6):613-21.
11. Isidro RA, Cruz ML, Isidro AA, Baez A, Arroyo A, González-Marqués WA, González-Keelan C, Torres EA, Appleyard CB. Immunohistochemical expression of SP-NK-1R-EGFR pathway and VDR in colonic inflammation and neoplasia. World J Gastroenterol. 2015 Feb 14; 21(6):1749-58.
12. Pacheco WI, Noel RJ, Porter JT, Appleyard CB. Beyond the GRE: using a composite score to predict ?the success of Puerto Rican students in a biomedical ?PhD program. CBE Life Sci Educ. 2015; 14(2).
13. Appleyard CB, Cruz ML, Hernández S, Thompson KJ, Bayona M, Flores I. Stress management affects outcomes in the pathophysiology of an endometriosis model. Reprod Sci. 2015 Apr; 22(4):431-41.
14. Isidro RA, Bonilla FJ, Pagan H, Cruz ML, Lopez P, Godoy L, Hernandez S, Loucil-Alicea RY, Rivera-Amill V, Yamamura Y, Isidro AA, Appleyard CB. The Probiotic Mixture VSL#3 Alters the Morphology and Secretion Profile of Both Polarized and Unpolarized Human Macrophages in a Polarization-Dependent Manner. J Clin Cell Immunol. 2014 Jun 20; 5(3):1000227.
15. Appleyard CB, Antonia SJ, Sullivan DM, Santiago-Cardona PG, Cáceres W, Velez H, Torres-Ruiz JA, Wright KL. Building a long distance training program to enhance clinical cancer research capacity in Puerto Rico. Rev Recent Clin Trials. 2014; 9(4):254-62.
16. Baez A, Pacheco W, Appleyard CB. The graduate student portfolio: organize and energize your career development. Physiologist. 2012 Oct; 55(5):177-8.
17. Cuevas M, Flores I, Thompson KJ, Ramos-Ortolaza DL, Torres-Reveron A, Appleyard CB. Stress exacerbates endometriosis manifestations and inflammatory parameters in an animal model. Reprod Sci. 2012 Aug; 19(8):851-62.
18. Pagán B, Isidro AA, Cruz ML, Ren Y, Coppola D, Wu J, Appleyard CB. Erlotinib inhibits progression to dysplasia in a colitis-associated colon cancer model. World J Gastroenterol. 2011 Nov 28; 17(44):4858-66.
19. Appleyard CB, Cruz ML, Isidro AA, Arthur JC, Jobin C, De Simone C. Pretreatment with the probiotic VSL#3 delays transition from inflammation to dysplasia in a rat model of colitis-associated cancer. Am J Physiol Gastrointest Liver Physiol. 2011 Dec; 301(6):G1004-13.
20. Uronis JM, Arthur JC, Keku T, Fodor A, Carroll IM, Cruz ML, Appleyard CB, Jobin C. Gut microbial diversity is reduced by the probiotic VSL#3 and correlates with decreased TNBS-induced colitis. Inflamm Bowel Dis. 2011 Jan; 17(1):289-97.
21. Pagán B, Isidro AA, Coppola D, Chen Z, Ren Y, Wu J, Appleyard CB. Effect of a neurokinin-1 receptor antagonist in a rat model of colitis-associated colon cancer. Anticancer Res. 2010 Sep; 30(9):3345-53.
22. Appleyard CB, Cruz ML, Rivera E, Hernández GA, Flores I. Experimental endometriosis in the rat is correlated with colonic motor function alterations but not with bacterial load. Reprod Sci. 2007 Dec; 14(8):815-24.
23. Santiago C, Pagán B, Isidro AA, Appleyard CB. Prolonged chronic inflammation progresses to dysplasia in a novel rat model of colitis-associated colon cancer. Cancer Res. 2007 Nov 15; 67(22):10766-73.
24. Santiago OI, Rivera E, Ferder L, Appleyard CB. An angiotensin II receptor antagonist reduces inflammatory parameters in two models of colitis. Regul Pept. 2008 Feb 07; 146(1-3):250-9.
25. Appleyard CB, Morales M, Santiago C. Chronic inflammation alters the contribution of neurokinin receptor subtypes to epithelial function in rat colon. Dig Dis Sci. 2008 Jan; 53(1):220-8.
26. Flores I, Rivera E, Ruiz LA, Santiago OI, Vernon MW, Appleyard CB. Molecular profiling of experimental endometriosis identified gene expression patterns in common with human disease. Fertil Steril. 2007 May; 87(5):1180-99.
27. Rivera E, Flores I, Rivera E, Appleyard CB. Molecular profiling of a rat model of colitis: validation of known inflammatory genes and identification of novel disease-associated targets. Inflamm Bowel Dis. 2006 Oct; 12(10):950-66.
28. Appleyard CB, Morales M, Percy WH. Regional variations in neurokinin receptor subtype contributions to muscularis mucosae and epithelial function in rat colon. Dig Dis Sci. 2006 Mar; 51(3):506-16.
29. Rojas-Cartagena C, Flores I, Appleyard CB. Role of tumor necrosis factor receptors in an animal model of acute colitis. Cytokine. 2005 Oct 21; 32(2):85-93.
30. Rojas-Cartagena C, Appleyard CB, Santiago OI, Flores I. Experimental intestinal endometriosis is characterized by increased levels of soluble TNFRSF1B and downregulation of Tnfrsf1a and Tnfrsf1b gene expression. Biol Reprod. 2005 Dec; 73(6):1211-8.
31. Hernández GA, Valentín MR, Appleyard CB. Effect of bacterial chemotactic peptides on intestinal inflammation in animal models of acute and chronic "relapsed" colitis. Dig Dis Sci. 2005 Aug; 50(8):1444-53.
32. Appleyard CB, Hernández G, Rios-Bedoya CF. Basic epidemiology of inflammatory bowel disease in Puerto Rico. Inflamm Bowel Dis. 2004 Mar; 10(2):106-11.
33. Hernández GA, Appleyard CB. Bacterial load in animal models of acute and chronic 'reactivated' colitis. Digestion. 2003; 67(3):161-9.
34. Appleyard CB, Alvarez A, Percy WH. Temporal changes in colonic vascular architecture and inflammatory mediator levels in animal models of colitis. Dig Dis Sci. 2002 Sep; 47(9):2007-14.
35. Asfaha S, MacNaughton WK, Appleyard CB, Chadee K, Wallace JL. Persistent epithelial dysfunction and bacterial translocation after resolution of intestinal inflammation. Am J Physiol Gastrointest Liver Physiol. 2001 Sep; 281(3):G635-44.
36. Hathaway CA, Appleyard CB, Percy WH, Williams JL. Experimental colitis increases blood-brain barrier permeability in rabbits. Am J Physiol. 1999 May; 276(5 Pt 1):G1174-80.
37. Appleyard CB, Williams JL, Hathaway CA, Percy WH. Temporal patterns of colonic blood flow and tissue damage in an animal model of colitis. Dig Dis Sci. 1999 Feb; 44(2):431-8.
38. Swain MG, Appleyard C, Wallace J, Wong H, Le T. Endogenous glucocorticoids released during acute toxic liver injury enhance hepatic IL-10 synthesis and release. Am J Physiol. 1999 Jan; 276(1 Pt 1):G199-205.
39. Ferraz JG, Tigley AW, Appleyard CB, Wallace JL. TNF-alpha contributes to the pathogenesis of ethanol-induced gastric damage in cirrhotic rats. Am J Physiol. 1997 Apr; 272(4 Pt 1):G809-14.
40. Davies NM, Røseth AG, Appleyard CB, McKnight W, Del Soldato P, Calignano A, Cirino G, Wallace JL. NO-naproxen vs. naproxen: ulcerogenic, analgesic and anti-inflammatory effects. Aliment Pharmacol Ther. 1997 Feb; 11(1):69-79.
41. Swain MG, Appleyard CB, Wallace JL, Maric M. TNF-alpha facilitates inflammation-induced glucocorticoid secretion in rats with biliary obstruction. J Hepatol. 1997 Feb; 26(2):361-8.
42. Appleyard CB, McCafferty DM, Tigley AW, Swain MG, Wallace JL. Tumor necrosis factor mediation of NSAID-induced gastric damage: role of leukocyte adherence. Am J Physiol. 1996 Jan; 270(1 Pt 1):G42-8.
43. Wallace JL, Le T, Carter L, Appleyard CB, Beck PL. Hapten-induced chronic colitis in the rat: alternatives to trinitrobenzene sulfonic acid. J Pharmacol Toxicol Methods. 1995 Aug; 33(4):237-9.
44. Appleyard CB, Wallace JL. Reactivation of hapten-induced colitis and its prevention by anti-inflammatory drugs. Am J Physiol. 1995 Jul; 269(1 Pt 1):G119-25.
45. Appleyard CB, Hillier K. Biosynthesis of platelet-activating factor in normal and inflamed human colon mucosa: evidence for the involvement of the pathway of platelet-activating factor synthesis de novo in inflammatory bowel disease. Clin Sci (Lond). 1995 Jun; 88(6):713-7.
46. Appleyard CB, Hillier K. Catabolism of platelet-activating factor by human colonic mucosa. Calcium dependence of the catabolizing enzymes. Biochem Pharmacol. 1992 Jun 23; 43(12):2503-9.

Original Articles icon

 

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1. Santana C, Santiago C, Appleyard CB . Ethnicity and Disease. Aberrant crypt foci (ACF) in DMH reactivated rat model of colitis. 2005; 2(15):85-93.
2. Swain M G, Appleyard C B, Wallace J L and Maric M. Journal of Hepatology. TNF facilitates inflammation-induced glucocorticoid secretion in rats with biliary obstruction. 1997; 2(26):361-368.
3. Bessos H, Appleyard C, Micklem L R and Pepper D S. Preparative Chromatography. Monoclonal antibody leakage from gels: Effect of support, activation and eluent composition. 1991; 3(1):207-220.

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Keywords
Colitis
Colon
Inflammatory Bowel Diseases
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Endometriosis
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