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Robert R. Alfano
Title Distinguished Professor of Physics
Faculty Rank
Degree Ph.D.
Institution City College, CUNY
City College, CUNY, Marshak Science Building
Covenant Avenue at 138th Street
City New York
State NY
Postal Code 10031
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  Research projects funded by the National Institutes of Health (NIH), the Centers for Disease Control (CDC), the Food and Drug Administration (FDA), and the Department of Veterans Affairs (VA)

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2007NIR Tunable Laser Tissue Welding5R01EB000297-06
2006NIR Tunable Laser Tissue Welding5R01EB000297-05
2005NIR Tunable Laser Tissue Welding2R01EB000297-04A2

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1. Shi L, Lu L, Harvey G, Harvey T, Rodríguez-Contreras A, Alfano RR. Label-Free Fluorescence Spectroscopy for Detecting Key Biomolecules in Brain Tissue from a Mouse Model of Alzheimer's Disease. Sci Rep. 2017 Jun 01; 7(1):2599.
2. Sordillo DC, Sordillo LA, Sordillo PP, Shi L, Alfano RR. Short wavelength infrared optical windows for evaluation of benign and malignant tissues. J Biomed Opt. 2017 04 01; 22(4):45002.
3. Mamani S, Bendau E, Secor J, Ashrafi S, Tu JJ, Alfano RR. Hybrid generation and analysis of vector vortex beams. Appl Opt. 2017 Mar 10; 56(8):2171-2175.
4. Liu CH, Boydston-White S, Weisberg A, Wang W, Sordillo LA, Perotte A, Tomaselli VP, Sordillo PP, Pei Z, Shi L, Alfano RR. Vulnerable atherosclerotic plaque detection by resonance Raman spectroscopy. J Biomed Opt. 2016 12 01; 21(12):127006.
5. Wang WB, Gozali R, Shi L, Lindwasser L, Alfano RR. Deep transmission of Laguerre-Gaussian vortex beams through turbid scattering media. Opt Lett. 2016 May 01; 41(9):2069-72.
6. Milione G, Nguyen TA, Leach J, Nolan DA, Alfano RR. Using the nonseparability of vector beams to encode information for optical communication. Opt Lett. 2015 Nov 01; 40(21):4887-90.
7. Sriramoju V, Alfano RR. In vivo studies of ultrafast near-infrared laser tissue bonding and wound healing. J Biomed Opt. 2015 Oct; 20(10):108001.
8. Milione G, Lavery MP, Huang H, Ren Y, Xie G, Nguyen TA, Karimi E, Marrucci L, Nolan DA, Alfano RR, Willner AE. 4 × 20??Gbit/s mode division multiplexing over free space using vector modes and a q-plate mode (de)multiplexer. Opt Lett. 2015 May 01; 40(9):1980-3.
9. Sordillo LA, Lindwasser L, Budansky Y, Leproux P, Alfano RR. Near-infrared supercontinuum laser beam source in the second and third near-infrared optical windows used to image more deeply through thick tissue as compared with images from a lamp source. J Biomed Opt. 2015 Mar; 20(3):030501.
10. Pu Y, Sordillo LA, Yang Y, Alfano RR. Key native fluorophores analysis of human breast cancer tissues using Gram-Schmidt subspace method. Opt Lett. 2014 Dec 15; 39(24):6787-90.
11. Sordillo LA, Sordillo PP, Budansky Y, Pu Y, Alfano RR. Differences in fluorescence profiles from breast cancer tissues due to changes in relative tryptophan content via energy transfer: tryptophan content correlates with histologic grade and tumor size but not with lymph node metastases. J Biomed Opt. 2014 Dec; 19(12):125002.
12. Shi L, Rodríguez-Contreras A, Alfano RR. Gaussian beam in two-photon fluorescence imaging of rat brain microvessel. J Biomed Opt. 2014 Dec; 19(12):126006.
13. Shi L, Rodríguez-Contreras A, Budansky Y, Pu Y, Nguyen TA, Alfano RR. Deep two-photon microscopic imaging through brain tissue using the second singlet state from fluorescent agent chlorophyll a in spinach leaf. J Biomed Opt. 2014 Jun; 19(6):066009.
14. Sordillo LA, Pu Y, Pratavieira S, Budansky Y, Alfano RR. Deep optical imaging of tissue using the second and third near-infrared spectral windows. J Biomed Opt. 2014 May; 19(5):056004.
15. Zhang L, Pu Y, Xue J, Pratavieira S, Xu B, Achilefu S, Alfano RR. Tryptophan as the fingerprint for distinguishing aggressiveness among breast cancer cell lines using native fluorescence spectroscopy. J Biomed Opt. 2014 Mar; 19(3):37005.
16. Pu Y, Jagtap J, Pradhan A, Alfano RR. Optical quantitative pathology of cervical intraepithelial neoplasia in human tissues using spatial frequency analysis. J Biophotonics. 2015 Mar; 8(3):233-8.
17. Russell S, Nguyen TA, Torres CR, Bhagroo S, Russell MJ, Alfano RR. Spatial frequency analysis of high-density lipoprotein and iron-oxide nanoparticle transmission electron microscope image structure for pattern recognition in heterogeneous fields. J Biomed Opt. 2014 Jan; 19(1):15004.
18. Russell S, Samkoe KS, Gunn JR, Hoopes PJ, Nguyen TA, Russell MJ, Alfano RR, Pogue BW. Spatial frequency analysis of anisotropic drug transport in tumor samples. J Biomed Opt. 2014 Jan; 19(1):15005.
19. Rumala YS, Milione G, Nguyen TA, Pratavieira S, Hossain Z, Nolan D, Slussarenko S, Karimi E, Marrucci L, Alfano RR. Tunable supercontinuum light vector vortex beam generator using a q-plate. Opt Lett. 2013 Dec 01; 38(23):5083-6.
20. Pu Y, Jagtap J, Pradhan A, Alfano RR. Spatial frequency analysis for detecting early stage of cancer in human cervical tissues. Technol Cancer Res Treat. 2014 Oct; 13(5):421-5.
21. Pu Y, Xue J, Wang W, Xu B, Gu Y, Tang R, Ackerstaff E, Koutcher JA, Achilefu S, Alfano RR. Native fluorescence spectroscopy reveals spectral differences among prostate cancer cell lines with different risk levels. J Biomed Opt. 2013 Aug; 18(8):87002.
22. Masilamani V, Das BB, Secor J, AlSalhi M, Devanesan S, Prasad S, Rabah D, Alfano RR. Optical biopsy of benign and malignant tissue by time resolved spectroscopy. Technol Cancer Res Treat. 2013 Dec; 12(6):559-63.
23. Sordillo LA, Pu Y, Sordillo PP, Budansky Y, Alfano RR. Optical spectral fingerprints of tissues from patients with different breast cancer histologies using a novel fluorescence spectroscopic device. Technol Cancer Res Treat. 2013 Oct; 12(5):455-61.
24. Liu CH, Zhou Y, Sun Y, Li JY, Zhou LX, Boydston-White S, Masilamani V, Zhu K, Pu Y, Alfano RR. Resonance Raman and Raman spectroscopy for breast cancer detection. Technol Cancer Res Treat. 2013 Aug; 12(4):371-82.
25. Pu Y, Wang W, Yang Y, Alfano RR. Native fluorescence spectra of human cancerous and normal breast tissues analyzed with non-negative constraint methods. Appl Opt. 2013 Feb 20; 52(6):1293-301.
26. Pu Y, Wang W, Dorshow RB, Das BB, Alfano RR. Mini review of ultrafast fluorescence polarization spectroscopy [invited]. Appl Opt. 2013 Feb 10; 52(5):917-29.
27. Pu Y, Wang W, Alfano RR. Optical detection of meat spoilage using fluorescence spectroscopy with selective excitation wavelength. Appl Spectrosc. 2013 Feb; 67(2):210-3.
28. Masilamani V, Alsalhi MS, Devanesan S, Atif M, Rabah D, Farhat K, Pu Y, Alfano RR. A parallelism between spectral grading and Gleason grading of malignant prostate tissues. Photodiagnosis Photodyn Ther. 2013 May; 10(2):168-72.
29. Pu Y, Wang W, Yang Y, Alfano RR. Stokes shift spectroscopic analysis of multifluorophores for human cancer detection in breast and prostate tissues. J Biomed Opt. 2013 Jan; 18(1):17005.
30. Zhou Y, Liu CH, Sun Y, Pu Y, Boydston-White S, Liu Y, Alfano RR. Human brain cancer studied by resonance Raman spectroscopy. J Biomed Opt. 2012 Nov; 17(11):116021.
31. Sun Y, Pu Y, Yang Y, Alfano RR. Biomarkers spectral subspace for cancer detection. J Biomed Opt. 2012 Oct; 17(10):107005.
32. Pu Y, Wang W, Yang Y, Alfano RR. Stokes shift spectroscopy highlights differences of cancerous and normal human tissues. Opt Lett. 2012 Aug 15; 37(16):3360-2.
33. Pu Y, Wang W, Xu M, Eastham JA, Tang G, Alfano RR. Characterization and three-dimensional localization of cancerous prostate tissue using backscattering scanning polarization imaging and independent component analysis. J Biomed Opt. 2012 Aug; 17(8):081419.
34. Wang Y, Gayen SK, Alrubaiee M, Alfano RR. Near-infrared center-of-intensity time gated imaging for detection of a target in a highly scattering turbid medium. Technol Cancer Res Treat. 2012 Aug; 11(4):309-15.
35. Ebenezar J, Pu Y, Wang WB, Liu CH, Alfano RR. Stokes shift spectroscopy pilot study for cancerous and normal prostate tissues. Appl Opt. 2012 Jun 01; 51(16):3642-9.
36. Milione G, Evans S, Nolan DA, Alfano RR. Higher order Pancharatnam-Berry phase and the angular momentum of light. Phys Rev Lett. 2012 May 11; 108(19):190401.
37. Alfano RR. Advancers in optical imaging in cancer research--part 2. Technol Cancer Res Treat. 2011 Dec; 10(6):505.
38. Pu Y, Wang WB, Xu M, Tang GC, Budansky Y, Sharanov M, Achilefu S, Eastham JA, Alfano RR. Near infrared photonic finger imager for prostate cancer screening. Technol Cancer Res Treat. 2011 Dec; 10(6):507-17.
39. Sriramoju V, Savage H, Katz A, Muthukattil R, Alfano RR. Management of heat in laser tissue welding using NIR cover window material. Lasers Surg Med. 2011 Dec; 43(10):991-7.
40. Sriramoju V, Alfano RR. Laser tissue welding analyzed using fluorescence, Stokes shift spectroscopy, and Huang-Rhys parameter. J Biophotonics. 2012 Feb; 5(2):185-93.
41. Alfano RR. Advances in optical imaging in cancer research--Part 1. Technol Cancer Res Treat. 2011 Oct; 10(5):391-2.
42. Milione G, Sztul HI, Nolan DA, Alfano RR. Higher-order Poincaré sphere, stokes parameters, and the angular momentum of light. Phys Rev Lett. 2011 Jul 29; 107(5):053601.
43. Pu Y, Wang WB, Achilefu S, Alfano RR. Study of rotational dynamics of receptor-targeted contrast agents in cancerous and normal prostate tissues using time-resolved picosecond emission spectroscopy. Appl Opt. 2011 Apr 01; 50(10):1312-22.
44. Alfano RR. Advances in optical biopsy for cancer diagnosis. Technol Cancer Res Treat. 2011 Apr; 10(2):101.
45. Pu Y, Tang GC, Wang WB, Savage HE, Schantz SP, Alfano RR. Native fluorescence spectroscopic evaluation of chemotherapeutic effects on malignant cells using nonnegative matrix factorization analysis. Technol Cancer Res Treat. 2011 Apr; 10(2):113-20.
46. Ebenezar J, Pu Y, Liu CH, Wang WB, Alfano RR. Diagnostic potential of Stokes Shift spectroscopy of breast and prostate tissues-- a preliminary pilot study. Technol Cancer Res Treat. 2011 Apr; 10(2):153-61.
47. Shumyatsky P, Alfano RR. Terahertz sources. J Biomed Opt. 2011 Mar; 16(3):033001.
48. Pu Y, Wang W, Wang WB, Tang G, Tang GC, Alfano RR. Changes of collagen and nicotinamide adenine dinucleotide in human cancerous and normal prostate tissues studied using native fluorescence spectroscopy with selective excitation wavelength. J Biomed Opt. 2010 Jul-Aug; 15(4):047008.
49. Myint T, Alfano RR. Spatial phase modulation from permanent memory in doped glass. Opt Lett. 2010 Apr 15; 35(8):1275-7.
50. Alimova A, Chakraverty R, Muthukattil R, Elder S, Katz A, Sriramoju V, Lipper S, Alfano RR. In vivo molecular evaluation of guinea pig skin incisions healing after surgical suture and laser tissue welding using Raman spectroscopy. J Photochem Photobiol B. 2009 Sep 04; 96(3):178-83.
51. Zeylikovich I, Shumyatsky P, Gayen TK, Alfano RR. Ultraviolet-to-visible image conversion microscopy using photoluminescence from self-assembled CdSe/ZnCdMgSe quantum dots and quantum wells. Appl Opt. 2009 May 20; 48(15):2942-5.
52. Sharonov MY, Bykov AB, Petricevic V, Alfano RR. Spectroscopic study of optical centers formed in Bi-, Pb-, Sb-, Sn-, Te-, and In-doped germanate glasses. Opt Lett. 2008 Sep 15; 33(18):2131-3.
53. Sztul HI, Alfano RR. The Poynting vector and angular momentum of Airy beams. Opt Express. 2008 Jun 23; 16(13):9411-6.
54. Pu Y, Wang WB, Das BB, Achilefu S, Alfano RR. Time-resolved fluorescence polarization dynamics and optical imaging of Cytate: a prostate cancer receptor-targeted contrast agent. Appl Opt. 2008 May 01; 47(13):2281-9.
55. Sharonov M, Bykov A, Petricevic V, Alfano R. Continuous tunable laser operation in both the 1.31 and 1.55 microm telecommunication windows in LiIn(Si/Ge)O4 olivines doped with trivalent chromium. Opt Lett. 2007 Dec 15; 32(24):3489-91.
56. Kartazaev V, Alfano RR. Supercontinuum generated in calcite with chirped femtosecond pulses. Opt Lett. 2007 Nov 15; 32(22):3293-5.
57. Zeylikovich I, Sztul HI, Kartazaev V, Le T, Alfano RR. Ultrashort Laguerre-Gaussian pulses with angular and group velocity dispersion compensation. Opt Lett. 2007 Jul 15; 32(14):2025-7.
58. Alimova A, Katz A, Sriramoju V, Budansky Y, Bykov AA, Zeylikovich R, Alfano RR. Hybrid phosphorescence and fluorescence native spectroscopy for breast cancer detection. J Biomed Opt. 2007 Jan-Feb; 12(1):014004.
59. Alfano RR. The ultimate white light. Sci Am. 2006 Dec; 295(6):86-93.
60. Cai W, Ni X, Gayen SK, Alfano RR. Analytical cumulant solution of the vector radiative transfer equation investigates backscattering of circularly polarized light from turbid media. Phys Rev E Stat Nonlin Soft Matter Phys. 2006 Nov; 74(5 Pt 2):056605.
61. Sztul HI, Kartazayev V, Alfano RR. Laguerre-Gaussian supercontinuum. Opt Lett. 2006 Sep 15; 31(18):2725-7.
62. Ni X, Alfano RR. Brillouin precursor propagation in the THz region in Lorentz media. Opt Express. 2006 May 01; 14(9):4188-94.
63. Sztul HI, Alfano RR. Double-slit interference with Laguerre-Gaussian beams. Opt Lett. 2006 Apr 01; 31(7):999-1001.
64. Wang C, Shumyatsky P, Zeng F, Zevallos M, Alfano RR. Computer-controlled optical scanning tile microscope. Appl Opt. 2006 Feb 20; 45(6):1148-52.
65. Alimova A, Katz A, Gottlieb P, Alfano RR. Proteins and dipicolinic acid released during heat shock activation of Bacillus subtilis spores probed by optical spectroscopy. Appl Opt. 2006 Jan 20; 45(3):445-50.
66. Xu M, Alfano RR. Circular polarization memory of light. Phys Rev E Stat Nonlin Soft Matter Phys. 2005 Dec; 72(6 Pt 2):065601.
67. Xu M, Alfano RR. Fractal mechanisms of light scattering in biological tissue and cells. Opt Lett. 2005 Nov 15; 30(22):3051-3.
68. Xu M, Alfano RR. Random walk of polarized light in turbid media. Phys Rev Lett. 2005 Nov 18; 95(21):213901.
69. Alrubaiee M, Gayen SK, Alfano RR, Koutcher JA. Spectral and temporal near-infrared imaging of ex vivo cancerous and normal human breast tissues. Technol Cancer Res Treat. 2005 Oct; 4(5):457-70.
70. Xu M, Alrubaiee M, Gayen SK, Alfano RR. Optical imaging of turbid media using independent component analysis: theory and simulation. J Biomed Opt. 2005 Sep-Oct; 10(5):051705.
71. Pu Y, Wang WB, Tang GC, Zeng F, Achilefu S, Vitenson JH, Sawczuk I, Peters S, Lombardo JM, Alfano RR. Spectral polarization imaging of human prostate cancer tissue using a near-infrared receptor-targeted contrast agent. Technol Cancer Res Treat. 2005 Aug; 4(4):429-36.
72. Alimova A, Katz A, Podder R, Minko G, Wei H, Berriman J, Alfano RR, Gottlieb P. Virus particles and receptor interaction monitored by fluorescence spectroscopy. Photochem Photobiol. 2005 Jul-Aug; 81(4):879-83.
73. Alfano RR, Birman JL, Ni X, Alrubaiee M, Das BB. Comment on "Observation of optical precursors in water". Phys Rev Lett. 2005 Jun 17; 94(23):239401.
74. Wang L, Zhang G, Luo JC, Zeng F, Wang QZ, Alfano SA, Katz A, Zevallos M, Alfano RR. Wireless spectroscopic compact photonic explorer for diagnostic optical imaging. Biomed Microdevices. 2005 Jun; 7(2):111-5.
75. Kartazayeva SA, Ni X, Alfano RR. Backscattering target detection in a turbid medium by use of circularly and linearly polarized light. Opt Lett. 2005 May 15; 30(10):1168-70.
76. Sharonov M, Petricevic V, Bykov A, Alfano RR. Near-infrared laser operation of Cr3+ centers in chromium-doped LiInGeO4 and LiScGeO4 crystals. Opt Lett. 2005 Apr 15; 30(8):851-3.
77. Cai W, Xu M, Alfano RR. Analytical form of the particle distribution based on the cumulant solution of the elastic Boltzmann transport equation. Phys Rev E Stat Nonlin Soft Matter Phys. 2005 Apr; 71(4 Pt 1):041202.
78. Xu M, Alrubaiee M, Gayen SK, Alfano RR. Three-dimensional localization and optical imaging of objects in turbid media with independent component analysis. Appl Opt. 2005 Apr 01; 44(10):1889-97.
79. Katz A, Alimova A, Xu M, Gottlieb P, Rudolph E, Steiner JC, Alfano RR. In situ determination of refractive index and size of Bacillus spores by light transmission. Opt Lett. 2005 Mar 15; 30(6):589-91.
80. Ni X, Alfano RR. Time-resolved backscattering of circularly and linearly polarized light in a turbid medium. Opt Lett. 2004 Dec 01; 29(23):2773-5.
81. Pitman MJ, Rosenthal JM, Savage HE, Yu G, McCormick SA, Katz A, Alfano RR, Schantz SP. The fluorescence of thyroid tissue. Otolaryngol Head Neck Surg. 2004 Nov; 131(5):623-7.
82. Ali JH, Wang WB, Zevallos M, Alfano RR. Near infrared spectroscopy and imaging to probe differences in water content in normal and cancer human prostate tissues. Technol Cancer Res Treat. 2004 Oct; 3(5):491-7.
83. Xu M, Cai W, Alfano RR. Multiple passages of light through an absorption inhomogeneity in optical imaging of turbid media. Opt Lett. 2004 Aug 01; 29(15):1757-9.
84. Alimova A, Katz A, Podder R, Minko G, Wei H, Alfano RR, Gottlieb P. Virus particles monitored by fluorescence spectroscopy: a potential detection assay for macromolecular assembly. Photochem Photobiol. 2004 Jul-Aug; 80:41-6.
85. Yu B, Zeng F, Yang Y, Xing Q, Chechin A, Xin X, Zeylikovich I, Alfano RR. Torsional vibrational modes of tryptophan studied by terahertz time-domain spectroscopy. Biophys J. 2004 Mar; 86(3):1649-54.
86. Savage HE, Halder RK, Kartazayeu U, Rosen RB, Gayen T, McCormick SA, Patel NS, Katz A, Perry HD, Paul M, Alfano RR. NIR laser tissue welding of in vitro porcine cornea and sclera tissue. Lasers Surg Med. 2004; 35(4):293-303.
87. Ni X, Alfano RR. Free-space ballistic laser propagation of a pulse coded data stream through fog. Appl Opt. 2003 Dec 10; 42(35):6980-3.
88. Gayen TK, Katz A, Savage HE, McCormick SA, Al-Rubaiee M, Budansky Y, Lee J, Alfano RR. Aorta and skin tissues welded by near-infrared Cr4+:YAG laser. J Clin Laser Med Surg. 2003 Oct; 21(5):259-69.
89. Alimova A, Katz A, Savage HE, Shah M, Minko G, Will DV, Rosen RB, McCormick SA, Alfano RR. Native fluorescence and excitation spectroscopic changes in Bacillus subtilis and Staphylococcus aureus bacteria subjected to conditions of starvation. Appl Opt. 2003 Jul 01; 42(19):4080-7.
90. Katz A, Kruger EF, Minko G, Liu CH, Rosen RB, Alfano RR. Detection of glutamate in the eye by Raman spectroscopy. J Biomed Opt. 2003 Apr; 8(2):167-72.
91. Ni X, Xing Q, Cai W, Alfano RR. Time-resolved polarization to extract coded information from early ballistic and snake signals through turbid media. Opt Lett. 2003 Mar 01; 28(5):343-5.
92. Xu M, Lax M, Alfano RR. Anomalous diffraction of light with geometrical path statistics of rays and a Gaussian ray approximation. Opt Lett. 2003 Feb 01; 28(3):179-81.
93. Xu M, Cai W, Lax M, Alfano RR. Photon migration in turbid media using a cumulant approximation to radiative transfer. Phys Rev E Stat Nonlin Soft Matter Phys. 2002 Jun; 65(6 Pt 2):066609.
94. Yang Y, Celmer EJ, Koutcher JA, Alfano RR. DNA and protein changes caused by disease in human breast tissues probed by the Kubelka-Munk spectral functional. Photochem Photobiol. 2002 Jun; 75(6):627-32.
95. Cai W, Xu M, Lax M, Alfano RR. Diffusion coefficient depends on time, not on absorption. Opt Lett. 2002 May 01; 27(9):731-3.
96. Katz A, Savage HE, Schantz SP, McCormick SA, Alfano RR. Noninvasive native fluorescence imaging of head and neck tumors. Technol Cancer Res Treat. 2002 Feb; 1(1):9-15.
97. Xu M, Cai W, Lax M, Alfano RR. Photon-transport forward model for imaging in turbid media. Opt Lett. 2001 Jul 15; 26(14):1066-8.
98. Xu M, Lax M, Alfano RR. Time-resolved Fourier optical diffuse tomography. J Opt Soc Am A Opt Image Sci Vis. 2001 Jul; 18(7):1535-42.
99. Yang Y, Celmer EJ, Koutcher JA, Alfano RR. UV reflectance spectroscopy probes DNA and protein changes in human breast tissues. J Clin Laser Med Surg. 2001 Feb; 19(1):35-9.
100. Tang J, Zhang G, Zeng F, Ho PP, Alfano RR. Near-infrared photo-excited emission from tissues treated at different temperature levels. Lasers Surg Med. 2001; 29(1):18-22.
101. Cai W, Lax M, Alfano RR. Analytical solution of the polarized photon transport equation in an infinite uniform medium using cumulant expansion. Phys Rev E Stat Nonlin Soft Matter Phys. 2001 Jan; 63(1 Pt 2):016606.
102. Zhang G, Katz A, Alfano RR, Kofinas AD, Kofinas DA, Stubblefield PG, Rosenfeld W, Beyer D, Maulik D, Stankovic MR. Brain perfusion monitoring with frequency-domain and continuous-wave near-infrared spectroscopy: a cross-correlation study in newborn piglets. Phys Med Biol. 2000 Nov; 45(11):3143-58.
103. Xu B, Evans JM, Petri Evi V, Guo SP, Maksimov O, Tamargo MC, Alfano RR. Continuous-Wave and Passively Mode-Locked Operation of a Cunyite (Cr(4+):Ca(2)GeO(4)) Laser. Appl Opt. 2000 Sep 20; 39(27):4975-8.
104. Ali JH, Wang WB, Ho PP, Alfano RR. Detection of corrosion beneath a paint layer by use of spectral polarization optical imaging. Opt Lett. 2000 Sep 01; 25(17):1303-5.
105. Ying J, Liu F, Ho PP, Alfano RR. Nondestructive evaluation of incipient corrosion in a metal beneath paint by second-harmonic tomography. Opt Lett. 2000 Aug 15; 25(16):1189-91.
106. Spielman AJ, Zhang G, Yang CM, D'Ambrosio P, Serizawa S, Nagata M, von Gizycki H, Alfano RR. Intracerebral hemodynamics probed by near infrared spectroscopy in the transition between wakefulness and sleep. Brain Res. 2000 Jun 02; 866(1-2):313-25.
107. Tang J, Zeng F, Evans JM, Xu B, Savage H, Ho PP, Alfano RR. A comparison of Cunyite and Fosterite NIR tunable laser tissue welding using native collagen fluorescence imaging. J Clin Laser Med Surg. 2000 Jun; 18(3):117-23.
108. Tang J, Zeng F, Savage H, Ho PP, Alfano RR. Fluorescence spectroscopic imaging to detect changes in collagen and elastin following laser tissue welding. J Clin Laser Med Surg. 2000 Feb; 18(1):3-8.
109. Ying J, Liu F, Alfano RR. Effect of scattering on nonlinear optical scanning microscopy imaging of highly scattering media. Appl Opt. 2000 Feb 01; 39(4):509-14.
110. Tang J, Zeng F, Savage H, Ho PP, Alfano RR. Laser irradiative tissue probed in situ by collagen 380-nm fluorescence imaging. Lasers Surg Med. 2000; 27(2):158-64.
111. Guo Y, Savage HE, Liu F, Schantz SP, Ho PP, Alfano RR. Subsurface tumor progression investigated by noninvasive optical second harmonic tomography. Proc Natl Acad Sci U S A. 1999 Sep 14; 96(19):10854-6.
112. Papadopoulos AJ, Zhadin NN, Steinberg ML, Alfano RR. Fluorescence spectroscopy of normal, SV40-transformed human keratinocytes, and carcinoma cells. Cancer Biochem Biophys. 1999 Jul; 17(1-2):13-23.
113. Cai W, Gayen SK, Xu M, Zevallos M, Alrubaiee M, Lax M, Alfano RR. Optical tomographic image reconstruction from ultrafast time-sliced transmission measurements. Appl Opt. 1999 Jul 01; 38(19):4237-46.
114. Ying J, Liu F, Alfano RR. Spatial distribution of two-photon-excited fluorescence in scattering media. Appl Opt. 1999 Jan 01; 38(1):224-9.
115. Zeylikovich I, Gilerson A, Alfano RR. Nonmechanical grating-generated scanning coherence microscopy. Opt Lett. 1998 Dec 01; 23(23):1797-9.
116. Evans JM, Petri Evi V, Alfano RR, Fu Q. Kilohertz Cr:forsterite regenerative amplifier. Opt Lett. 1998 Nov 01; 23(21):1692-4.
117. Ganesan S, Sacks PG, Yang Y, Katz A, Al-Rawi M, Savage HE, Schantz SP, Alfano RR. Native fluorescence spectroscopy of normal and malignant epithelial cells. Cancer Biochem Biophys. 1998 Nov; 16(4):365-73.
118. Gayen SK, Zevallos ME, Alrubaiee M, Evans JM, Alfano RR. Two-dimensional near-infrared transillumination imaging of biomedical media with a chromium-doped forsterite laser. Appl Opt. 1998 Aug 01; 37(22):5327-36.
119. Cai W, Luo B, Lax M, Alfano RR. Time-resolved optical backscattering model in highly scattering media. Opt Lett. 1998 Jul 01; 23(13):983-5.
120. Schantz SP, Kolli V, Savage HE, Yu G, Shah JP, Harris DE, Katz A, Alfano RR, Huvos AG. In vivo native cellular fluorescence and histological characteristics of head and neck cancer. Clin Cancer Res. 1998 May; 4(5):1177-82.
121. Zhadin NN, Alfano RR. Correction of the internal absorption effect in fluorescence emission and excitation spectra from absorbing and highly scattering media: theory and experiment. J Biomed Opt. 1998 Apr; 3(2):171-86.
122. Alfano RR, Demos SG, Galland P, Gayen SK, Guo Y, Ho PP, Liang X, Liu F, Wang L, Wang QZ, Wang WB. Time-resolved and nonlinear optical imaging for medical applications. Ann N Y Acad Sci. 1998 Feb 09; 838:14-28.
123. Demos SG, Wang WB, Alfano RR. Imaging objects hidden in scattering media with fluorescence polarization preservation of contrast agents. Appl Opt. 1998 Feb 01; 37(4):792-7.
124. Guo Y, Ho PP, Savage H, Harris D, Sacks P, Schantz S, Liu F, Zhadin N, Alfano RR. Second-harmonic tomography of tissues: errata. Opt Lett. 1998; 23(9):733.
125. Tang GC, Chen JT, Katz A, Celmer EJ, Krumm RW, Alfano RR. Ultraviolet-visible acousto-optic tunable spectroscopic imager for medical diagnosis. J Biomed Opt. 1998 Jan; 3(1):80-4.
126. Demos SG, Papadopoulos AJ, Savage H, Heerdt AS, Schantz S, Alfano RR. Polarization filter for biomedical tissue optical imaging. Photochem Photobiol. 1997 Dec; 66(6):821-5.
127. Yang Y, Katz A, Celmer EJ, Zurawska-Szczepaniak M, Alfano RR. Fundamental differences of excitation spectrum between malignant and benign breast tissues. Photochem Photobiol. 1997 Oct; 66(4):518-22.
128. Zeng F, Zhang G, Liu F, Alfano RR. Diffuse optical tomography based on a WKB approximation. J Biomed Opt. 1997 Oct; 2(4):426-36.
129. Guo Y, Ho PP, Savage H, Harris D, Sacks P, Schantz S, Liu F, Zhadin N, Alfano RR. Second-harmonic tomography of tissues. Opt Lett. 1997 Sep 01; 22(17):1323-5.
130. Zeylikovich I, Alfano RR. Heterodyne grating-generated scan correlation interferometry for reflectometry and signal-processing applications. Opt Lett. 1997 Aug 15; 22(16):1259-61.
131. Evans JM, Petri Evi V, Bykov AB, Delgado A, Alfano RR. Direct diode-pumped continuous-wave near-inf rared tunable laser operation of Cr(4+):forsterite and Cr(4+):Ca(2)GeO(4). Opt Lett. 1997 Aug 01; 22(15):1171-3.
132. Schantz SP, Savage HE, Sacks P, Alfano RR. Native cellular fluorescence and its application to cancer prevention. Environ Health Perspect. 1997 Jun; 105 Suppl 4:941-4.
133. Alfano RR, Demos SG, Gayen SK. Advances in optical imaging of biomedical media. Ann N Y Acad Sci. 1997 May 30; 820:248-70; discussion 271.
134. Ho PP, Wang QZ, Chen J, Liu QD, Alfano RR. Ultrafast optical pulse digitization with unary spectrally encoded cross-phase modulation. Appl Opt. 1997 May 20; 36(15):3425-9.
135. Fu Q, Seier F, Gayen SK, Alfano RR. High-average-power kilohertz-repetition-rate sub-100-fs Ti:sapphire amplifier system. Opt Lett. 1997 May 15; 22(10):712-4.
136. Liang X, Wang L, Ho PP, Alfano RR. Time-resolved polarization shadowgrams in turbid media. Appl Opt. 1997 May 01; 36(13):2984-9.
137. Polishchuk AY, Dolne J, Liu F, Alfano RR. Average and most-probable photon paths in random media. Opt Lett. 1997 Apr 01; 22(7):430-2.
138. Xiang Y, Raphan T, Liang X, Wang L, Ho PP, Alfano RR. Image-quality enhancement of objects in turbid media by use of a combined computational-photonics approach. Appl Opt. 1997 Feb 10; 36(5):1045-53.
139. Guo Y, Wang QZ, Zhadin N, Liu F, Demos S, Calistru D, Tirksliunas A, Katz A, Budansky Y, Ho PP, Alfano RR. Two-photon excitation of fluorescence from chicken tissue. Appl Opt. 1997 Feb 01; 36(4):968-70.
140. Demos SG, Alfano RR. Optical polarization imaging. Appl Opt. 1997 Jan 01; 36(1):150-5.
141. Zhang JC, Savage HE, Sacks PG, Delohery T, Alfano RR, Katz A, Schantz SP. Innate cellular fluorescence reflects alterations in cellular proliferation. Lasers Surg Med. 1997; 20(3):319-31.
142. Yang Y, Mitchell LD, Alfano RR. Fluorescence spectroscopy of dermal wounds in rats. J Biomed Opt. 1997 Jan; 2(1):53-7.
143. Guo Y, Ho PP, Tirksliunas A, Liu F, Alfano RR. Optical harmonic generation from animal tissues by the use of picosecond and femtosecond laser pulses. Appl Opt. 1996 Dec 01; 35(34):6810-3.
144. Cai W, Das BB, Liu F, Zevallos M, Lax M, Alfano RR. Time-resolved optical diffusion tomographic image reconstruction in highly scattering turbid media. Proc Natl Acad Sci U S A. 1996 Nov 26; 93(24):13561-4.
145. Petricevic V, Bykov AB, Evans JM, Alfano RR. Room-temperature near-infrared tunable laser operation of Cr(4+):Ca(2)GeO(4). Opt Lett. 1996 Nov 01; 21(21):1750-2.
146. Zeylikovich I, Alfano RR. Ultrafast dark-field interferometric microscopic reflectometry. Opt Lett. 1996 Oct 15; 21(20):1682-4.
147. Siddique M, Wang QZ, Alfano RR. Laser action in condensed disordered media of active dye-stained animal tissues and sandy colloidal scattering walls. J Biomed Opt. 1996 Oct; 1(4):442-7.
148. Sha WL, Liu CH, Liu F, Alfano RR. Competition between two lasing modes of Sulforhodamine 640 in highly scattering media. Opt Lett. 1996 Aug 15; 21(16):1277-9.
149. Sacks PG, Savage HE, Levine J, Kolli VR, Alfano RR, Schantz SP. Native cellular fluorescence identifies terminal squamous differentiation of normal oral epithelial cells in culture: a potential chemoprevention biomarker. Cancer Lett. 1996 Jul 12; 104(2):171-81.
150. Polishchuk AY, Alfano RR. Photon diffusion on the velocity sphere. Opt Lett. 1996 Jul 01; 21(13):916-8.
151. Siddique M, Alfano RR, Berger GA, Kempe M, Genack AZ. Time-resolved studies of stimulated emission from colloidal dye solutions. Opt Lett. 1996 Apr 01; 21(7):450-2.
152. Demos SG, Alfano RR. Temporal gating in highly scattering media by the degree of optical polarization. Opt Lett. 1996 Jan 15; 21(2):161-3.
153. Polishchuk AY, Alfano RR. Fermat photons in turbid media: an exact analytic solution for most favorable paths-a step toward optical tomography. Opt Lett. 1995 Oct 01; 20(19):1937-9.
154. Cordeiro PG, Kirschner RE, Hu QY, Chiao JJ, Savage H, Alfano RR, Hoffman LA, Hidalgo DA. Ultraviolet excitation fluorescence spectroscopy: a noninvasive method for the measurement of redox changes in ischemic myocutaneous flaps. Plast Reconstr Surg. 1995 Sep; 96(3):673-80.
155. Zeylikovich I, Bai G, Alfano RR. Observation of light diffraction by time-resolved femtosecond correlation interferometry. Opt Lett. 1995 Jul 15; 20(14):1580-2.
156. Wang QZ, Liang X, Wang L, Ho PP, Alfano RR. Fourier spatial filter acts as a temporal gate for light propagating through a turbid medium. Opt Lett. 1995 Jul 01; 20(13):1498-500.
157. Liang X, Wang L, Ho PP, Alfano RR. Two-dimensional Kerr-Fourier imaging of translucent phantoms in thick turbid media. Appl Opt. 1995 Jun 20; 34(18):3463-7.
158. Wang L, Liang X, Galland P, Ho PP, Alfano RR. True scattering coefficients of turbid matter measured by early-time gating. Opt Lett. 1995 Apr 15; 20(8):913-5.
159. Zeylikovich I, Bai G, Gorokhovsky A, Alfano RR. Terabit speed retrieval of femtosecond accumulated photon echoes. Opt Lett. 1995 Apr 01; 20(7):749-51.
160. Liu QD, Chen JT, Wang QZ, Ho PP, Alfano RR. Single-pulse degenerate-cross-phase modulation in a single-mode optical fiber. Opt Lett. 1995 Mar 15; 20(6):542-4.
161. Sha WL, Liu CH, Alfano RR. Spectral and temporal measurements of laser action of Rhodamine 640 dye in strongly scattering media. Opt Lett. 1994 Dec 01; 19(23):1922-4.
162. Wang QZ, Liu QD, Ho PP, Walge EK, Alfano RR. High-resolution spectra of cross-phase modulation in optical fibers. Opt Lett. 1994 Oct 15; 19(20):1636-8.
163. Anderson GE, Liu F, Alfano RR. Microscope imaging through highly scattering media. Opt Lett. 1994 Jul 01; 19(13):981-3.
164. Alfano RR, Liang X, Wang L, Ho PP. Time-resolved imaging of translucent droplets in highly scattering turbid media. Science. 1994 Jun 24; 264(5167):1913-5.
165. Liu F, Yoo KM, Alfano RR. Transmitted photon intensity through biological tissues within various time windows. Opt Lett. 1994 May 15; 19(10):740-2.
166. Ahmed SA, Zang ZW, Yoo KM, Ali MA, Alfano RR. Effect of multiple light scattering and self-absorption on the fluorescence and excitation spectra of dyes in random media. Appl Opt. 1994 May 01; 33(13):2746-50.
167. Silberberg MB, Savage HE, Tang GC, Sacks PG, Alfano RR, Schantz SP. Detecting retinoic acid-induced biochemical alterations in squamous cell carcinoma using intrinsic fluorescence spectroscopy. Laryngoscope. 1994 Mar; 104(3 Pt 1):278-82.
168. Xing Q, Yoo KM, Alfano RR. Self-bending of light: reply to comment. Opt Lett. 1994 Jan 01; 19(1):72.
169. Kalpaxis LL, Wang LM, Galland P, Liang X, Ho PP, Alfano RR. Three-dimensional temporal image reconstruction of an object hidden in highly scattering media by time-gated optical tomography. Opt Lett. 1993 Oct 15; 18(20):1691-3.
170. Wang L, Ho PP, Alfano RR. Time-resolved Fourier spectrum and imaging in highly scattering media. Appl Opt. 1993 Sep 10; 32(26):5043-8.
171. Mikhailov VP, Wang QZ, Chu M, Buchert JM, Alfano RR. Ultrahigh repetition rate picosecond pulses from a passively mode-locked neodymium glass laser by solid-state saturable dye films. Appl Opt. 1993 Jul 20; 32(21):3944-7.
172. Das BB, Yoo KM, Alfano RR. Ultrafast time-gated imaging in thick tissues: a step toward optical mammography. Opt Lett. 1993 Jul 01; 18(13):1092.
173. Seas A, Petricevic V, Alfano RR. Self-mode-locked chromium-doped forsterite laser generates 50-fs pulses. Opt Lett. 1993 Jun 01; 18(11):891.
174. Xing Q, Yoo KM, Alfano RR. Conical emission by four-photon parametric generation by using femtosecond laser pulses. Appl Opt. 1993 Apr 20; 32(12):2087-9.
175. Xing Q, Yoo KM, Alfano RR. Self-bending of light. Opt Lett. 1993 Apr 01; 18(7):479-81.
176. Demos SG, Takiguchi Y, Alfano RR. Upconverted hot-luminescence spectroscopy investigation of nonradiative relaxation in forsterite. Opt Lett. 1993 Apr 01; 18(7):522-4.
177. Liu F, Yoo KM, Alfano RR. Should the photon flux or the photon density be used to describe the temporal profiles of scattered ultrashort laser pulses in random media? Opt Lett. 1993 Mar 15; 18(6):432-4.
178. Wang L, Ho PP, Liang X, Dai H, Alfano RR. Kerr - Fourier imaging of hidden objects in thick turbid media. Opt Lett. 1993 Feb 01; 18(3):241.
179. Tang GC, Oka N, Nagamatsu GR, Alfano RR. Laser fluorescence spectroscopy from human spermatozoa. Appl Opt. 1993 Feb 01; 32(4):464-7.
180. Wang LM, Ho PP, Alfano RR. Double-stage picosecond Kerr gate for ballistic time-gated optical imaging in turbid media. Appl Opt. 1993 Feb 01; 32(4):535-40.
181. Das BB, Yoo KM, Liu F, Cleary J, Prudente R, Celmer E, Alfano RR. Spectral optical-density measurements of small particles and breast tissues. Appl Opt. 1993 Feb 01; 32(4):549-53.
182. Liu F, Yoo KM, Alfano RR. Ultrafast laser-pulse transmission and imaging through biological tissues. Appl Opt. 1993 Feb 01; 32(4):554-8.
183. Seas A, Petricevic V, Alfano RR. Generation of sub-100-fs pulses from a cw mode-locked chromium-doped forsterite laser. Opt Lett. 1992 Jul 01; 17(13):937-9.
184. Yoo KM, Das BB, Alfano RR. Imaging of a translucent object hidden in a highly scattering medium from the early portion of the diffuse component of a transmitted ultrafast laser pulse. Opt Lett. 1992 Jul 01; 17(13):958-60.
185. Yang L, Dorsinville R, Wang QZ, Ye PX, Alfano RR, Zamboni R, Taliani C. Excited-state nonlinearity in polythiophene thin films investigated by the Z-scan technique. Opt Lett. 1992 Mar 01; 17(5):323-5.
186. Yoo KM, Alfano RR. Nonlinear photon localization for high-intensity laser protection systems for photodetectors and eyes. Opt Lett. 1991 Dec 01; 16(23):1823-5.
187. Seas A, Petricevic V, Alfano RR. Continuous-wave mode-locked operation of a chromium-doped forsterite laser. Opt Lett. 1991 Nov 01; 16(21):1668-70.
188. Yan M, Manor D, Weng G, Chao H, Rothberg L, Jedju TM, Alfano RR, Callender RH. Ultrafast spectroscopy of the visual pigment rhodopsin. Proc Natl Acad Sci U S A. 1991 Nov 01; 88(21):9809-12.
189. Wang L, Ho PP, Liu C, Zhang G, Alfano RR. Ballistic 2-d imaging through scattering walls using an ultrafast optical kerr gate. Science. 1991 Aug 16; 253(5021):769-71.
190. Yoo KM, Zang ZW, Ahmed SA, Alfano RR. Imaging objects hidden in scattering media using a fluorescence-absorption technique. Opt Lett. 1991 Aug 15; 16(16):1252-4.
191. Wang QZ, Ho PP, Alfano RR. Effect of degenerate four-wave mixing on pulse amplification and compression in the degenerate cross-phase-modulation process: erratum. Opt Lett. 1991 Aug 15; 16(16):1286.
192. Yoo KM, Liu F, Alfano RR. Imaging through a scattering wall using absorption. Opt Lett. 1991 Jul 15; 16(14):1068-70.
193. Yoo KM, Xing Q, Alfano RR. Imaging objects hidden in highly scattering media using femtosecond second-harmonic-generation cross-correlation time gating. Opt Lett. 1991 Jul 01; 16(13):1019-21.
194. Ho PP, Wang QZ, Alfano RR. Second-harmonic generation of femtosecond pulses: observation of phase-mismatch effects: comment. Opt Lett. 1991 Jun 15; 16(12):970.
195. Petricevic V, Seas A, Alfano RR. Slope efficiency measurements of a chromium-doped forsterite laser. Opt Lett. 1991 Jun 01; 16(11):811-3.