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Samuel Adunyah
Title Dr.
Faculty Rank Chair and Professor
Degree Ph.D.
Institution Meharry Medical College
Department Dept. of Biochemistry
Clusters Cancer
Address
1005 Dr. D B Todd Jr. Blvd., 3228 WSB Building,
City Nashville
State TN
Postal Code 37208
Telephone 615.327.6446
Fax 615 327 6440
Email
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Title Co-Director
Institution Meharry Medical College/Vanderbilt-Ingram Cancer Partnership
 
Title Co-Director
Institution Meharry Medical College/Vanderbilt-Ingram Cancer Partnership
 
Title Co-Director
Institution Meharry Medical College/Vanderbilt-Ingram Cancer Partnership
Division MMC/VICC
 
Title Co-Director
Institution Meharry Medical College/Vanderbilt-Ingram Cancer Partnership
Department MMC/VICC
Division MMC/VICC
 
Title Co-Director
Institution MMC/VICC
Department MMC/VICC
Division MMC/VICC

Awards and Honors icon

1987 National Collegiate Natural Sciences USA Achievement Acad. Award
1988 American Society of Hematology Travel Awards
1988 NCI Biomedical Travel Awards Travel Awards
1989 American Society of Hematology Travel Awards
1993 Exemplary Teacher of the Year, Meharry Medical College Dean's Awards for Excellence in Teaching Nominee
1994 NCI Minority School Faculty Development Award
1995 Exemplary Teacher of the Year, Meharry Medical College Dean's Awards for Excellence in Teaching Nominee
1997 Exemplary Teacher of the Year, Meharry Medical College Dean's Awards for Excellence in Teaching Nominee
2000 Nominee, Exemplary Teacher of the Year, Meharry Medical College Nominee, Exemplary Teacher of the Year
2001 Univ. of Louisville Distinguished Alumni Fellow
2004 Meharry Medical College Graduate Mentorship Award of the Year, School. Of Graduate Studies and Research
2005 American Society of Hematology (ASH) Appreciation Award for Active Membership in the Government Affairs Committee
2005 Univ. of Louisville Appreciation Award from the Black Biomedical Graduate Students Association
2005 American Society of Hematology (ASH) Distinction in Advocacy Award
2007 Meharry Medical College Distinguished Chairmanship

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  The goal of this RCTR U54 competing renewal application submitted by Meharry Medical College is to support the enhancement of Meharry’s Clinical Translation Research Center (MeTRC) Program towards promotion of the T2/T3/T4 phases of clinical translational research in health disparities involving diseases that impact on the health of minorities and the underserved population. I have served as the PI/PD as well the Director of the Administrative Core for this center for the last three years. I initially assumed the role as the Interim PI/PD in July 2011 following the departure of Dr. James Hildreth, the original PI/PD from Meharry. As a result of my outstanding leadership, NIMHD confirmed me as the PI/PDI in 2012. Since then, I have continued to provide an outstanding leadership which has significantly enhanced the overall progress of this RCTR. I will continue in this capacity if this current application is funded. As evidenced from my experiences indicated below, I brought rich track record of mentorship, scientific accomplishments and extensive leadership skills to this program. During the first two years of the MeTRC Program, I served as the Chair of the Internal Advisory Committee prior to being appointed as the Interim PI/PD in July of 2011. In that capacity I played an important advisory role in the governance of the program. I have also served as the director and PI for our NHLBI T32 Pre-doctoral Training grant for 16 years. The grant is in its 19th year of funding. As a PhD mentor I have trained and graduated 11 PhD trainees and mentored several postdoctoral trainees, mostly minorities from my laboratory. One of my former PhD trainees is currently an Associate Professor of Biochemistry and a Department Chairman in Loma Linda University, California. Another former PhD trainee is currently an Associate Professor of Microbiology in Northern Illinois University. Three of my former PhD trainees also completed MD degree training after their PhD work and they are now in Heme/Onc Fellowship training programs. I have also served on over 45 previous PhD thesis advisory committees. Currently, I serve as a mentor for two PhD Candidates in my laboratory. I also serve on the Committee of Instruction for 4 PhD students in my institution. I currently serve as a Co-Director in the NCI R25 Imagining Training grant based in Vanderbilt University with Dr. John Gore as the PI and Dr. Yankeelov as the Co-Director. I have served on several study sections including the NCI’s former Cancer Molecular Pathobiology Study Section, F30/F31/F32 NRSA Fellowship Review Panels, Howard Hughes Medical Fellowship Application Review Panels and Special Emphasis Panel for the NCI’s Diversity R21 grants. At the national level I previously served on the AACR’s Science Policy Committee and the Government Affairs Committee of ASH for 2 years. Also, I chaired External Advisory Committees for 2 former NCI MI/CCP Cancer Partnership P20 grants for three years. I have also served on the Program Steering Committee (PSC) for the Charles Drew University/UCLA Cancer Partnership since 2004. I have served on several Internal Advisory Committees including my previous position as the Chair of the IAC for our RCMI (G-12 RCMI) program for eight years. I also served as a board member for the Vanderbilt CTSA during the first cycle. I have served as the PI for the Meharry’s component of the NCI Cancer Partnership U54 grant for the Meharry-Vanderbilt-Ingram-Cancer-Center (MMC-VICC) Partnership now Meharry-Vanderbilt-TSU cancer partnership for 13 years. The goal of this partnership is to reduce cancer health disparities among minorities. In my capacity as the department chair for the last 16 years and as the Co-PI of our cancer partnership U54 grant for 13 years I have effectively and successfully recruited, supervised and mentored many successful junior faculty. For example, my leadership role has led to successful recruitment of 5 new tenure track faculty members to our cancer partnership with tenure track faculty appointments in Meharry Medical College and membership in Vanderbilt-Ingram Cancer Center. An example of such a successful faculty recruit is Dr. Zhenbang Chen who within fifteen months of joining my department at Meharry Medical College received his first R01 grant. In summary, in my capacity as RCTR PI/PD, U54 Cancer Partnership PI, T32 PI/Ph.D mentor and as a Chair of Department, I bring extensive experience and dynamism in leadership, mentorship and other relevant experiences to the MeTRC Program.

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1. Lu W, Liu S, Li B, Xie Y, Izban MG, Ballard BR, Sathyanarayana SA, Adunyah SE, Matusik RJ, Chen Z. SKP2 loss destabilizes EZH2 by promoting TRAF6-mediated ubiquitination to suppress prostate cancer. Oncogene. 2017 Mar; 36(10):1364-1373.
2. Ignacio RM, Kabir SM, Lee ES, Adunyah SE, Son DS. NF-?B-Mediated CCL20 Reigns Dominantly in CXCR2-Driven Ovarian Cancer Progression. PLoS One. 2016; 11(10):e0164189.
3. Pulliam SR, Pellom ST, Shanker A, Adunyah SE. Butyrate regulates the expression of inflammatory and chemotactic cytokines in human acute leukemic cells during apoptosis. Cytokine. 2016 08; 84:74-87.
4. Harris KL, Pulliam SR, Okoro E, Guo Z, Washington MK, Adunyah SE, Amos-Landgraf JM, Ramesh A. Western diet enhances benzo(a)pyrene-induced colon tumorigenesis in a polyposis in rat coli (PIRC) rat model of colon cancer. Oncotarget. 2016 May 17; 7(20):28947-60.
5. Pulliam SR, Uzhachenko RV, Adunyah SE, Shanker A. Common gamma chain cytokines in combinatorial immune strategies against cancer. Immunol Lett. 2016 Jan; 169:61-72.
6. Banks LD, Amoah P, Niaz MS, Washington MK, Adunyah SE, Ramesh A. Olive oil prevents benzo(a)pyrene [B(a)P]-induced colon carcinogenesis through altered B(a)P metabolism and decreased oxidative damage in Apc(Min) mouse model. J Nutr Biochem. 2016 Feb; 28:37-50.
7. Booker BE, Clark RS, Pellom ST, Adunyah SE. Interleukin-34 induces monocytic-like differentiation in leukemia cell lines. Int J Biochem Mol Biol. 2015; 6(1):1-16.
8. Son DS, Kabir SM, Dong Y, Lee E, Adunyah SE. Characteristics of chemokine signatures elicited by EGF and TNF in ovarian cancer cells. J Inflamm (Lond). 2013 Jun 25; 10(1):25.
9. Smith JC, Schäffer MW, Ballard BR, Smoot DT, Herline AJ, Adunyah SE, M'Koma AE. Adenocarcinomas After Prophylactic Surgery For Familial Adenomatous Polyposis. J Cancer Ther. 2013; 4(1):260-270.
10. M'Koma AE, Herline AJ, Adunyah SE. Subsequent Adenomas of Ileal Pouch and Anorectal Segment after Prophylactic Surgery for Familial Adenomatous Polyposis. World J Colorectal Surg. 2013; 3(2).
11. Son DS, Kabir SM, Dong YL, Lee E, Adunyah SE. Inhibitory effect of tumor suppressor p53 on proinflammatory chemokine expression in ovarian cancer cells by reducing proteasomal degradation of I?B. PLoS One. 2012; 7(12):e51116.
12. Boadi WY, Harris S, Anderson JB, Adunyah SE. Lipid peroxides and glutathione status in human progenitor mononuclear (U937) cells following exposure to low doses of nickel and copper. Drug Chem Toxicol. 2013 Apr; 36(2):155-62.
13. M'Koma AE, Moses HL, Adunyah SE. Inflammatory bowel disease-associated colorectal cancer: proctocolectomy and mucosectomy do not necessarily eliminate pouch-related cancer incidences. Int J Colorectal Dis. 2011 May; 26(5):533-52.
14. Sampson JJ, Donkor IO, Huang TL, Adunyah SE. Novel piperazine induces apoptosis in U937 cells. Int J Biochem Mol Biol. 2011; 2(1):78-88.
15. Adunyah SE, Beech BM, Moses HL. Meharry Medical College-Vanderbilt-Ingram Cancer Center partnership: its history and role in cancer health disparities research. J Health Care Poor Underserved. 2010 Feb; 21(1 Suppl):1-4.
16. Fuqua CF, Akomeah R, Price JO, Adunyah SE. Involvement of ERK-1/2 in IL-21-induced cytokine production in leukemia cells and human monocytes. Cytokine. 2008 Oct; 44(1):101-7.
17. Boadi WY, Iyere PA, Adunyah SE. In vitro exposure to quercetin and genistein alters lipid peroxides and prevents the loss of glutathione in human progenitor mononuclear (U937) cells. J Appl Toxicol. 2005 Jan-Feb; 25(1):82-8.
18. Boadi WY, Iyere PA, Adunyah SE. Effect of quercetin and genistein on copper- and iron-induced lipid peroxidation in methyl linolenate. J Appl Toxicol. 2003 Sep-Oct; 23(5):363-9.
19. Iyamu EW, Adunyah SE, Fasold H, Horiuchi K, Baliga S, Ohene-Frempong K, Turner EA, Asakura T. Combined use of nonmyelosuppressive nitrosourea analogues with hydroxyurea in the induction of F-cell production in a human erythroleukemic cell line. Exp Hematol. 2003 Jul; 31(7):592-600.
20. Iyamu WE, Adunyah SE, Fasold H, Horiuchi K, Elford HL, Asakura T, Turner EA. Enhancement of hemoglobin and F-cell production by targeting growth inhibition and differentiation of K562 cells with ribonucleotide reductase inhibitors (didox and trimidox) in combination with streptozotocin. Am J Hematol. 2000 Apr; 63(4):176-83.
21. Subramaniam SV, Cooper RS, Adunyah SE. Evidence for the involvement of JAK/STAT pathway in the signaling mechanism of interleukin-17. Biochem Biophys Res Commun. 1999 Aug 19; 262(1):14-9.
22. Subramaniam SV, Pearson LL, Adunyah SE. Interleukin-17 induces rapid tyrosine phosphorylation and activation of raf-1 kinase in human monocytic progenitor cell line U937. Biochem Biophys Res Commun. 1999 May 27; 259(1):172-7.
23. Rivero JA, Adunyah SE. Sodium butyrate stimulates PKC activation and induces differential expression of certain PKC isoforms during erythroid differentiation. Biochem Biophys Res Commun. 1998 Jul 30; 248(3):664-8.
24. Iyamu EW, Adunyah SE, Elford HL, Fasold H, Turner EA. Trimidox-mediated morphological changes during erythroid differentiation is associated with the stimulation of hemoglobin and F-cell production in human K562 cells. Biochem Biophys Res Commun. 1998 Jun 29; 247(3):759-64.
25. Adunyah SE, Wheeler BJ, Cooper RS. Evidence for the involvement of LCK and MAP kinase (ERK-1) in the signal transduction mechanism of interleukin-15. Biochem Biophys Res Commun. 1997 Mar 27; 232(3):754-8.
26. Spencer GC, Adunyah SE. Interleukin-11 induces rapid PKC activation and cytosolic to particulate translocation of alpha and beta PKC isoforms in human erythroleukemia K562 cells. Biochem Biophys Res Commun. 1997 Mar 06; 232(1):61-4.
27. Rivero JA, Adunyah SE. Sodium butyrate induces tyrosine phosphorylation and activation of MAP kinase (ERK-1) in human K562 cells. Biochem Biophys Res Commun. 1996 Jul 25; 224(3):796-801.
28. Adunyah SE, Ceesay KJ, Rivero JA. Regulation of jun expression and activation of AP-1 activity by erythropoietin. Biochem Biophys Res Commun. 1996 Apr 16; 221(2):213-8.
29. Adunyah SE, Spencer GC, Cooper RS, Rivero JA, Ceesay K. Interleukin-11 induces tyrosine phosphorylation, and c-jun and c-fos mRNA expression in human K562 and U937 cells. Ann N Y Acad Sci. 1995 Sep 07; 766:296-9.
30. Adunyah SE, Chander R, Barner VK, Cooper RS, Copper RS. Regulation of c-jun mRNA expression by hydroxyurea in human K562 cells during erythroid differentiation. Biochim Biophys Acta. 1995 Aug 22; 1263(2):123-32.
31. Adunyah SE, Pegram ML, Cooper RS. Interleukin-13 induces rapid tyrosine phosphorylation and activation of Raf-1 kinase in human monocytic progenitor cell line U937. Biochem Biophys Res Commun. 1995 Jan 05; 206(1):103-11.
32. Adunyah SE. Granulocyte-macrophage colony stimulating factor stimulates rapid phosphorylation of proteins on tyrosines in human U937 and HL-60 leukemic cells. Biochem Biophys Res Commun. 1993 Jun 30; 193(3):890-6.
33. Adunyah SE, Unlap TM, Franklin CC, Kraft AS. Induction of differentiation and c-jun expression in human leukemic cells by okadaic acid, an inhibitor of protein phosphatases. J Cell Physiol. 1992 May; 151(2):415-26.
34. Adunyah SE, Unlap TM, Wagner F, Kraft AS. Regulation of c-jun expression and AP-1 enhancer activity by granulocyte-macrophage colony-stimulating factor. J Biol Chem. 1991 Mar 25; 266(9):5670-5.
35. Adunyah SE, Jones LR, Dean WL. Structural and functional comparison of a 22 kDa protein from internal human platelet membranes with cardiac phospholamban. Biochim Biophys Acta. 1988 Jun 07; 941(1):63-70.
36. Adunyah SE, Dean WL. Regulation of human platelet membrane Ca2+ transport by cAMP- and calmodulin-dependent phosphorylation. Biochim Biophys Acta. 1987 Oct 01; 930(3):401-9.
37. Adunyah SE, Dean WL. Effects of sulfhydryl reagents and other inhibitors on Ca2+ transport and inositol trisphosphate-induced Ca2+ release from human platelet membranes. J Biol Chem. 1986 Oct 05; 261(28):13071-5.
38. Adunyah SE, Dean WL. Effect of phorbol esters and diacylglycerols on calcium transport by human platelet membranes. Cell Calcium. 1986 Jun; 7(3):193-202.
39. Adunyah SE, Dean WL. Ca2+ transport in human platelet membranes. Kinetics of active transport and passive release. J Biol Chem. 1986 Mar 05; 261(7):3122-7.
40. Dean WL, Adunyah SE, Cohn DV. Calcium uptake and inositol trisphosphate-induced calcium release from parathyroid gland membranes. Bone Miner. 1986 Feb; 1(1):59-67.
41. Adunyah SE, Dean WL. Inositol triphosphate-induced Ca2+ release from human platelet membranes. Biochem Biophys Res Commun. 1985 May 16; 128(3):1274-80.

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