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Jaydutt V Vadgama, PhD
Title Professor
Faculty Rank Professor
Degree PhD
Institution Charles R. Drew University of Medicine and Science
Department Internal Medicine
Clusters College of Medicine
Address
1731 E. 120th Street, Hawkins Building
1731 E. 120th Street, Hawkins Building
City Los Angeles
State CA
Postal Code 90059
Telephone (323) 563-9397
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Community Faculty Status Non-Community Faculty

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1. Chung S, Dwabe S, Elshimali Y, Sukhija H, Aroh C, Vadgama JV. Identification of Novel Biomarkers for Metastatic Colorectal Cancer Using Angiogenesis-Antibody Array and Intracellular Signaling Array. PLoS One. 2015; 10(8):e0134948.
2. Bazargan M, Lucas-Wright A, Jones L, Vargas R, Vadgama JV, Evers-Manly S, Maxwell AE. Understanding Perceived Benefit of Early Cancer Detection: Community-Partnered Research with African American Women in South Los Angeles. J Womens Health (Larchmt). 2015 Sep; 24(9):755-61.
3. Wu Y, Sarkissyan M, Mcghee E, Lee S, Vadgama JV. Combined inhibition of glycolysis and AMPK induces synergistic breast cancer cell killing. Breast Cancer Res Treat. 2015 Jun; 151(3):529-39.
4. Li Y, Wu Y, Abbatiello TC, Wu WL, Kim JR, Sarkissyan M, Sarkissyan S, Chung SS, Elshimali Y, Vadgama JV. Slug contributes to cancer progression by direct regulation of ERa signaling pathway. Int J Oncol. 2015 Apr; 46(4):1461-72.
5. Wang P, Henning SM, Heber D, Vadgama JV. Sensitization to docetaxel in prostate cancer cells by green tea and quercetin. J Nutr Biochem. 2015 Apr; 26(4):408-15.
6. Wu Y, Sarkissyan M, Vadgama JV. Epigenetics in breast and prostate cancer. Methods Mol Biol. 2015; 1238:425-66.
7. Chung SS, Vadgama JV. Curcumin and epigallocatechin gallate inhibit the cancer stem cell phenotype via down-regulation of STAT3-NF?B signaling. Anticancer Res. 2015 Jan; 35(1):39-46.
8. Wang P, Phan T, Gordon D, Chung S, Henning SM, Vadgama JV. Arctigenin in combination with quercetin synergistically enhances the anti-proliferative effect in prostate cancer cells. Mol Nutr Food Res. 2014 Nov 7.
9. Wang P, Wang B, Chung S, Wu Y, Henning SM, Vadgama JV. Increased chemopreventive effect by combining arctigenin, green tea polyphenol and curcumin in prostate and breast cancer cells. RSC Adv. 2014 Aug 5; 4(66):35242-35250.
10. Sarkissyan S, Sarkissyan M, Wu Y, Cardenas J, Koeffler HP, Vadgama JV. IGF-1 Regulates Cyr61 Induced Breast Cancer Cell Proliferation and Invasion. PLoS One. 2014; 9(7):e103534.
11. Wu Y, Kim J, Elshimali Y, Sarkissyan M, Vadgama JV. Activation of Akt1 accelerates carcinogen-induced tumorigenesis in mammary gland of virgin and post-lactating transgenic mice. BMC Cancer. 2014; 14(1):266.
12. Sarkissyan M, Wu Y, Chen Z, Mishra DK, Sarkissyan S, Giannikopoulos I, Vadgama JV. Vitamin D receptor FokI gene polymorphisms may be associated with colorectal cancer among African American and Hispanic participants. Cancer. 2014 May 1; 120(9):1387-93.
13. Lucas-Wright A, Bazargan M, Jones L, Vadgama JV, Vargas R, Sarkissyan M, Smith J, Yazdanshenas H, Maxwell AE. Correlates of perceived risk of developing cancer among african-americans in South los angeles. J Community Health. 2014 Feb; 39(1):173-80.
14. Chung SS, Aroh C, Vadgama JV. Constitutive Activation of STAT3 Signaling Regulates hTERT and Promotes Stem Cell-Like Traits in Human Breast Cancer Cells. PLoS One. 2013; 8(12):e83971.
15. Chung SS, Giehl N, Wu Y, Vadgama JV. STAT3 activation in HER2-overexpressing breast cancer promotes epithelial-mesenchymal transition and cancer stem cell traits. Int J Oncol. 2014 Feb; 44(2):403-11.
16. Wu Y, Sarkissyan M, Elshimali Y, Vadgama JV. Triple negative breast tumors in African-American and Hispanic/Latina women are high in CD44+, low in CD24+, and have loss of PTEN. PLoS One. 2013; 8(10):e78259.
17. Wang P, Vadgama JV, Said JW, Magyar CE, Doan N, Heber D, Henning SM. Enhanced inhibition of prostate cancer xenograft tumor growth by combining quercetin and green tea. J Nutr Biochem. 2014 Jan; 25(1):73-80.
18. Elshimali YI, Khaddour H, Sarkissyan M, Wu Y, Vadgama JV. The clinical utilization of circulating cell free DNA (CCFDNA) in blood of cancer patients. Int J Mol Sci. 2013; 14(9):18925-58.
19. Mishra DK, Wu Y, Sarkissyan M, Sarkissyan S, Chen Z, Shang X, Ong M, Heber D, Koeffler HP, Vadgama JV. Vitamin D receptor gene polymorphisms and prognosis of breast cancer among African-American and Hispanic women. PLoS One. 2013; 8(3):e57967.
20. Jones L, Bazargan M, Lucas-Wright A, Vadgama JV, Vargas R, Smith J, Otoukesh S, Maxwell AE. Comparing perceived and test-based knowledge of cancer risk and prevention among Hispanic and African Americans: an example of community participatory research. Ethn Dis. 2013; 23(2):210-6.
21. Wu Y, Ginther C, Kim J, Mosher N, Chung S, Slamon D, Vadgama JV. Expression of Wnt3 activates Wnt/ß-catenin pathway and promotes EMT-like phenotype in trastuzumab-resistant HER2-overexpressing breast cancer cells. Mol Cancer Res. 2012 Dec; 10(12):1597-606.
22. Wu Y, Elshimali Y, Sarkissyan M, Mohamed H, Clayton S, Vadgama JV. Expression of FOXO1 is associated with GATA3 and Annexin-1 and predicts disease-free survival in breast cancer. Am J Cancer Res. 2012; 2(1):104-15.
23. Sarkissyan M, Mishra DK, Wu Y, Shang X, Sarkissyan S, Vadgama JV. IGF gene polymorphisms and breast cancer in African-American and Hispanic women. Int J Oncol. 2011 Jun; 38(6):1663-73.
24. Chien W, O'Kelly J, Lu D, Leiter A, Sohn J, Yin D, Karlan B, Vadgama J, Lyons KM, Koeffler HP. Expression of connective tissue growth factor (CTGF/CCN2) in breast cancer cells is associated with increased migration and angiogenesis. Int J Oncol. 2011 Jun; 38(6):1741-7.
25. Sarkissyan M, Wu Y, Vadgama JV. Obesity is associated with breast cancer in African-American women but not Hispanic women in South Los Angeles. Cancer. 2011 Aug 15; 117(16):3814-23.
26. Yin D, Chen W, O'Kelly J, Lu D, Ham M, Doan NB, Xie D, Wang C, Vadgama J, Said JW, Black KL, Koeffler HP. Connective tissue growth factor associated with oncogenic activities and drug resistance in glioblastoma multiforme. Int J Cancer. 2010 Nov 15; 127(10):2257-67.
27. Wu Y, Shang X, Sarkissyan M, Slamon D, Vadgama JV. FOXO1A is a target for HER2-overexpressing breast tumors. Cancer Res. 2010 Jul 1; 70(13):5475-85.
28. Wu Y, Alvarez M, Slamon DJ, Koeffler P, Vadgama JV. Caspase 8 and maspin are downregulated in breast cancer cells due to CpG site promoter methylation. BMC Cancer. 2010; 10:32.
29. Mishra DK, Chen Z, Wu Y, Sarkissyan M, Koeffler HP, Vadgama JV. Global methylation pattern of genes in androgen-sensitive and androgen-independent prostate cancer cells. Mol Cancer Ther. 2010 Jan; 9(1):33-45.
30. Thant AA, Wu Y, Lee J, Mishra DK, Garcia H, Koeffler HP, Vadgama JV. Role of caspases in 5-FU and selenium-induced growth inhibition of colorectal cancer cells. Anticancer Res. 2008 Nov-Dec; 28(6A):3579-92.
31. Wu Y, Mohamed H, Chillar R, Ali I, Clayton S, Slamon D, Vadgama JV. Clinical significance of Akt and HER2/neu overexpression in African-American and Latina women with breast cancer. Breast Cancer Res. 2008; 10(1):R3.
32. Padda M, Vadgama J, Sandhu P, Dev A, Giannikopoulos I. Clinical significance of incidental colorectal wall thickening on computed tomography scan in African-American and Hispanic patients. Dig Dis Sci. 2007 Nov; 52(11):3159-64.
33. Wu Y, Shen D, Chen Z, Clayton S, Vadgama JV. Taxol induced apoptosis regulates amino acid transport in breast cancer cells. Apoptosis. 2007 Mar; 12(3):593-612.
34. Vadgama JV, Scuric Z, Chakrabarti R, Marzo E, Shen D, Wu Y. Insulin-like growth factor I differentially regulates the expression of HIRF1/hCAF1 and BTG1 genes in human MCF-7 breast cancer cells. Int J Mol Med. 2006 Jul; 18(1):129-39.
35. O'Kelly J, Uskokovic M, Lemp N, Vadgama J, Koeffler HP. Novel Gemini-vitamin D3 analog inhibits tumor cell growth and modulates the Akt/mTOR signaling pathway. J Steroid Biochem Mol Biol. 2006 Aug; 100(4-5):107-16.
36. Gery S, Tanosaki S, Bose S, Bose N, Vadgama J, Koeffler HP. Down-regulation and growth inhibitory role of C/EBPalpha in breast cancer. Clin Cancer Res. 2005 May 1; 11(9):3184-90.
37. Bhat HK, Calaf G, Hei TK, Loya T, Vadgama JV. Critical role of oxidative stress in estrogen-induced carcinogenesis. Proc Natl Acad Sci U S A. 2003 Apr 1; 100(7):3913-8.
38. Wu Y, Saldana L, Chillar R, Vadgama JV. Plasma vascular endothelial growth factor is useful in assessing progression of breast cancer post surgery and during adjuvant treatment. Int J Oncol. 2002 Mar; 20(3):509-16.
39. Bhat HK, Vadgama JV. Role of estrogen receptor in the regulation of estrogen induced amino acid transport of System A in breast cancer and other receptor positive tumor cells. Int J Mol Med. 2002 Mar; 9(3):271-9.
40. Pellegrin K, Peterson VM, Vadgama J, Wu Y, Fleming AW. TNF-alpha in trauma patients: a touch is just enough. Curr Surg. 2000 Nov; 57(6):638.
41. Vadgama JV, Wu Y, Shen D, Hsia S, Block J. Effect of selenium in combination with Adriamycin or Taxol on several different cancer cells. Anticancer Res. 2000 May-Jun; 20(3A):1391-414.
42. Liu W, Vadgama JV. Identification and characterization of amino acid starvation-induced CD24 gene in MCF-7 human breast cancer cells. Int J Oncol. 2000 May; 16(5):1049-54.
43. Shen D, Wu Y, Chillar R, Vadgama JV. Missense alterations of BRCA1 gene detected in diverse cancer patients. Anticancer Res. 2000 Mar-Apr; 20(2B):1129-32.
44. Bhat HK, Vadgama JV. Hamster estrogen receptor cDNA: cloning and mRNA expression. J Steroid Biochem Mol Biol. 2000 Jan-Feb; 72(1-2):47-53.
45. Shen D, Wu Y, Subbarao M, Bhat H, Chillar R, Vadgama JV. Mutation analysis of BRCA1 gene in African-American patients with breast cancer. J Natl Med Assoc. 2000 Jan; 92(1):29-35.
46. Vadgama JV, Wu Y, Datta G, Khan H, Chillar R. Plasma insulin-like growth factor-I and serum IGF-binding protein 3 can be associated with the progression of breast cancer, and predict the risk of recurrence and the probability of survival in African-American and Hispanic women. Oncology. 1999 Nov; 57(4):330-40.
47. Wu Y, Khan H, Chillar R, Vadgama JV. Prognostic value of plasma HER-2/neu in African American and Hispanic women with breast cancer. Int J Oncol. 1999 Jun; 14(6):1021-37.
48. Shen D, Vadgama JV. BRCA1 and BRCA2 gene mutation analysis: visit to the Breast Cancer Information Core (BIC). Oncol Res. 1999; 11(2):63-9.
49. Qing DP, Ding H, Vadgama J, Wu YY, Kopple JD. Elevated myocardial cytosolic calcium impairs insulin-like growth factor-1-stimulated protein synthesis in chronic renal failure. J Am Soc Nephrol. 1999 Jan; 10(1):84-92.
50. Bhat HK, Vadgama JV, Liehr JG. Accumulation of albumin in renal cytosol of hamsters treated with estradiol and in estrogen-induced hamster kidney tumors. Int J Oncol. 1998 Nov; 13(5):1087-91.
51. Fong RL, Vadgama JV, Laguer MR, Ward HJ. Low density lipoprotein receptors mediate intracellular calcium signals in microalbuminuric hypertensives. Am J Hypertens. 1998 Jan; 11(1 Pt 1):113-6.
52. Liu JY, Diaz TG, Vadgama JV, Henry JP. Tail sectioning: a rapid and simple method for repeated blood sampling of the rat for corticosterone determination. Lab Anim Sci. 1996 Apr; 46(2):243-5.
53. Ding H, Gao XL, Hirschberg R, Vadgama JV, Kopple JD. Impaired actions of insulin-like growth factor 1 on protein Synthesis and degradation in skeletal muscle of rats with chronic renal failure. Evidence for a postreceptor defect. J Clin Invest. 1996 Feb 15; 97(4):1064-75.
54. Kuhlmann MK, Shahmir E, Maasarani E, Akhtar S, Thevanayagam V, Vadgama JV, Kopple JD. New experimental model of acute renal failure and sepsis in rats. JPEN J Parenter Enteral Nutr. 1994 Nov-Dec; 18(6):477-85.
55. Chou HF, Vadgama J, Jonas AJ. Lysosomal transport of small molecules. Biochem Med Metab Biol. 1992 Dec; 48(3):179-93.
56. Vadgama JV, Evered DF. Characteristics of L-citrulline transport across rat small intestine in vitro. Pediatr Res. 1992 Oct; 32(4):472-8.
57. Vadgama JV, Evered DF. Absorption of amino acids from the human mouth. Amino Acids. 1992 Oct; 3(3):271-86.
58. Kuhlmann MK, Vadgama JV. Characterization of threonine transport into a kidney epithelial cell line (BSC-1). Evidence for the presence of Na(+)-independent system asc [corrected]. J Biol Chem. 1991 Aug 15; 266(23):15042-7.
59. Vadgama JV, Chang K, Kopple JD, Idriss JM, Jonas AJ. Characteristics of taurine transport in rat liver lysosomes. J Cell Physiol. 1991 Jun; 147(3):447-54.
60. Vadgama JV, Chan MN, Wu JM. Differential expression of amino acid transport systems A and ASC during erythroleukemia cell differentiation. Am J Physiol. 1991 Mar; 260(3 Pt 1):C392-9.
61. Vadgama JV. Design of simple devices to measure solute fluxes and binding in monolayer cell cultures. Methods Enzymol. 1989; 171:133-44.
62. Vadgama JV, Castro M, Christensen HN. Characterization of amino acid transport during erythroid cell differentiation. J Biol Chem. 1987 Sep 25; 262(27):13273-84.
63. Vadgama JV, Christensen HN. Discrimination of Na+-independent transport systems L, T, and asc in erythrocytes. Na+ independence of the latter a consequence of cell maturation? J Biol Chem. 1985 Mar 10; 260(5):2912-21.
64. Vadgama JV, Christensen HN. A new Na+-independent transport system for dipolar amino acids apparently corresponding to systems persisting after erythrocyte maturation in some mammalian genotypes. Ann N Y Acad Sci. 1985; 456:454-6.
65. Bannai S, Christensen HN, Vadgama JV, Ellory JC, Englesberg E, Guidotti GG, Gazzola GC, Kilberg MS, Lajtha A, Sacktor B, et al. Amino acid transport systems. Nature. 1984 Sep 27-Oct 3; 311(5984):308.
66. Vadgama JV, Christensen HN. Wide distribution of pH-dependent service of transport system ASC for both anionic and zwitterionic amino acids. J Biol Chem. 1984 Mar 25; 259(6):3648-52.
67. Christensen HN, Handlogten ME, Vadgama JV, de la Cuesta E, Ballesteros P, Trigo GG, Avendaño C. Synthesis and transport applications of 3-aminobicyclo[3.2.1] octane-3-carboxylic acids. J Med Chem. 1983 Oct; 26(10):1374-8.
68. Vadgama JV, Christensen HN. Comparison of system N in fetal hepatocytes and in related cell lines. J Biol Chem. 1983 May 25; 258(10):6422-9.
69. Evered DF, Vadgama JV. Absorption of homocitrulline from the gastrointestinal tract. Br J Nutr. 1983 Jan; 49(1):35-42.
70. Evered DF, Vadgama JV. Absorption of amino acids from the human buccal cavity. Biochem Soc Trans. 1981 Feb; 9(1):132-3.

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