PROFILES - Connect with RTRN Researchers

Ian Pagano
Title Assistant Specialist (Biostatistician)
Faculty Rank Assistant
Degree PhD
Institution University of Hawaii
Department Cancer Center
Clusters Cancer
701 Ilalo St Rm 420
City Honolulu
State HI
Postal Code 96813
Telephone (808) 441-3489
QR Barcode

Narrative icon

Not Available

Publications icon

  Check NIH Public Access Policy Compliance

Please wait
1. Shimizu Y, Furuya H, Tamashiro PM, Iino K, Chan OTM, Goodison S, Pagano I, Hokutan K, Peres R, Loo LWM, Hernandez B, Naing A, Chong CDK, Rosser CJ, Kawamori T. Genetic deletion of sphingosine kinase 1 suppresses mouse breast tumor development in an HER2 transgenic model. Carcinogenesis. 2018 Jan 12; 39(1):47-55.
2. Fagan P, Pokhrel P, Herzog TA, Moolchan ET, Cassel KD, Franke AA, Li X, Pagano I, Trinidad DR, Sakuma KK, Sterling K, Jorgensen D, Lynch T, Kawamoto C, Guy MC, Lagua I, Hanes S, Alexander LA, Clanton MS, Graham-Tutt C, Eissenberg T. Sugar and Aldehyde Content in Flavored Electronic Cigarette Liquids. Nicotine Tob Res. 2017 Nov 22.
3. Pokhrel P, Lam TH, Pagano I, Kawamoto CT, Herzog TA. Young adult e-cigarette use outcome expectancies: Validity of a revised scale and a short scale. Addict Behav. 2018 Mar; 78:193-199.
4. Owen JE, O'Carroll Bantum E, Pagano IS, Stanton A. Randomized Trial of a Social Networking Intervention for Cancer-Related Distress. Ann Behav Med. 2017 Oct; 51(5):661-672.
5. Schweitzer RJ, Wills TA, Tam E, Pagano I, Choi K. E-cigarette use and asthma in a multiethnic sample of adolescents. Prev Med. 2017 Dec; 105:226-231.
6. Chan OTM, Furuya H, Pagano I, Shimizu Y, Hokutan K, Dyrskj√łt L, Jensen JB, Malmstrom PU, Segersten U, Janku F, Rosser CJ. Association of MMP-2, RB and PAI-1 with decreased recurrence-free survival and overall survival in bladder cancer patients. Oncotarget. 2017 Nov 21; 8(59):99707-99721.
7. Szymiczek A, Carbone M, Pastorino S, Napolitano A, Tanji M, Minaai M, Pagano I, Mason JM, Pass HI, Bray MR, Mak TW, Yang H. Inhibition of the spindle assembly checkpoint kinase Mps-1 as a novel therapeutic strategy in malignant mesothelioma. Oncogene. 2017 Nov 16; 36(46):6501-6507.
8. Furuya H, Shimizu Y, Tamashiro PM, Iino K, Bielawski J, Chan OTM, Pagano I, Kawamori T. Sphingosine kinase 1 expression enhances colon tumor growth. J Transl Med. 2017 Jun 06; 15(1):120.
9. Pellegrini L, Xue J, Larson D, Pastorino S, Jube S, Forest KH, Saad-Jube ZS, Napolitano A, Pagano I, Negi VS, Bianchi ME, Morris P, Pass HI, Gaudino G, Carbone M, Yang H. HMGB1 targeting by ethyl pyruvate suppresses malignant phenotype of human mesothelioma. Oncotarget. 2017 Apr 04; 8(14):22649-22661.
10. Yoshikawa Y, Emi M, Hashimoto-Tamaoki T, Ohmuraya M, Sato A, Tsujimura T, Hasegawa S, Nakano T, Nasu M, Pastorino S, Szymiczek A, Bononi A, Tanji M, Pagano I, Gaudino G, Napolitano A, Goparaju C, Pass HI, Yang H, Carbone M. High-density array-CGH with targeted NGS unmask multiple noncontiguous minute deletions on chromosome 3p21 in mesothelioma. Proc Natl Acad Sci U S A. 2016 11 22; 113(47):13432-13437.
11. Sterling K, Fryer C, Pagano I, Jones D, Fagan P. Association between menthol-flavoured cigarette smoking and flavoured little cigar and cigarillo use among African-American, Hispanic, and white young and middle-aged adult smokers. Tob Control. 2016 11; 25(Suppl 2):ii21-ii31.
12. Wills TA, Sargent JD, Gibbons FX, Pagano I, Schweitzer R. E-cigarette use is differentially related to smoking onset among lower risk adolescents. Tob Control. 2016 Sep; 26(5):534-539.
13. Peres R, Furuya H, Pagano I, Shimizu Y, Hokutan K, Rosser CJ. Angiogenin contributes to bladder cancer tumorigenesis by DNMT3b-mediated MMP2 activation. Oncotarget. 2016 Jul 12; 7(28):43109-43123.
14. Sterling KL, Fryer CS, Pagano I, Fagan P. Little Cigars and Cigarillos Use Among Young Adult Cigarette Smokers in the United States: Understanding Risk of Concomitant Use Subtypes. Nicotine Tob Res. 2016 12; 18(12):2234-2242.
15. Wills TA, Knight R, Sargent JD, Gibbons FX, Pagano I, Williams RJ. Longitudinal study of e-cigarette use and onset of cigarette smoking among high school students in Hawaii. Tob Control. 2017 01; 26(1):34-39.
16. Napolitano A, Antoine DJ, Pellegrini L, Baumann F, Pagano I, Pastorino S, Goparaju CM, Prokrym K, Canino C, Pass HI, Carbone M, Yang H. HMGB1 and Its Hyperacetylated Isoform are Sensitive and Specific Serum Biomarkers to Detect Asbestos Exposure and to Identify Mesothelioma Patients. Clin Cancer Res. 2016 Jun 15; 22(12):3087-96.
17. Antonio AM, Fagan P, Hamamura FD, Lagua IJ, Liu J, Park DJ, Pokhrel P, Herzog TA, Pagano I, Cassel K, Sy A, Jorgensen D, Lynch T, Kawamoto C, Boushey CJ, Franke A, Clanton MS, Moolchan ET, Alexander LA. Menthol cigarette smoking and obesity in young adult daily smokers in Hawaii. Prev Med Rep. 2015; 2:946-52.
18. Wills TA, Sargent JD, Knight R, Pagano I, Gibbons FX. E-cigarette use and willingness to smoke: a sample of adolescent non-smokers. Tob Control. 2016 Apr; 25(e1):e52-9.
19. Yang H, Pellegrini L, Napolitano A, Giorgi C, Jube S, Preti A, Jennings CJ, De Marchis F, Flores EG, Larson D, Pagano I, Tanji M, Powers A, Kanodia S, Gaudino G, Pastorino S, Pass HI, Pinton P, Bianchi ME, Carbone M. Aspirin delays mesothelioma growth by inhibiting HMGB1-mediated tumor progression. Cell Death Dis. 2015 Jun 11; 6:e1786.
20. Fagan P, Pokhrel P, Herzog TA, Pagano IS, Franke AA, Clanton MS, Alexander LA, Trinidad DR, Sakuma KL, Johnson CA, Moolchan ET. Nicotine Metabolism in Young Adult Daily Menthol and Nonmenthol Smokers. Nicotine Tob Res. 2016 Apr; 18(4):437-46.
21. Fagan P, Moolchan ET, Pokhrel P, Herzog T, Cassel KD, Pagano I, Franke AA, Kaholokula JK, Sy A, Alexander LA, Trinidad DR, Sakuma KL, Johnson CA, Antonio A, Jorgensen D, Lynch T, Kawamoto C, Clanton MS. Biomarkers of tobacco smoke exposure in racial/ethnic groups at high risk for lung cancer. Am J Public Health. 2015 Jun; 105(6):1237-45.
22. Halm BM, Franke AA, Lai JF, Li X, Custer LJ, Pagano I, Cooney RV, Turner HC, Brenner DJ. Pilot study for the establishment of biomarkers for radiation damage after computed tomography in children. Hawaii J Med Public Health. 2015 Mar; 74(3):112-9.
23. Fagan P, Pohkrel P, Herzog T, Pagano I, Vallone D, Trinidad DR, Sakuma KL, Sterling K, Fryer CS, Moolchan E. Comparisons of three nicotine dependence scales in a multiethnic sample of young adult menthol and non-menthol smokers. Drug Alcohol Depend. 2015 Apr 01; 149:203-11.
24. Wills TA, Knight R, Williams RJ, Pagano I, Sargent JD. Risk factors for exclusive e-cigarette use and dual e-cigarette use and tobacco use in adolescents. Pediatrics. 2015 Jan; 135(1):e43-51.
25. Pettersson A, Graff RE, Ursin G, Santos Silva ID, McCormack V, Baglietto L, Vachon C, Bakker MF, Giles GG, Chia KS, Czene K, Eriksson L, Hall P, Hartman M, Warren RM, Hislop G, Chiarelli AM, Hopper JL, Krishnan K, Li J, Li Q, Pagano I, Rosner BA, Wong CS, Scott C, Stone J, Maskarinec G, Boyd NF, van Gils CH, Tamimi RM. Mammographic density phenotypes and risk of breast cancer: a meta-analysis. J Natl Cancer Inst. 2014 May 10; 106(5).
26. Halm BM, Lai JF, Morrison CM, Pagano I, Custer LJ, Cooney RV, Franke AA. In vivo changes in plasma coenzyme Q10, carotenoid, tocopherol, and retinol levels in children after computer tomography. Arch Biochem Biophys. 2014 Apr 01; 547:37-43.
27. Maskarinec G, Suzuki S, Pagano IS, Morimoto Y, Franke AA, Ehya H. Cytology in nipple aspirate fluid during a randomized soy food intervention among premenopausal women. Nutr Cancer. 2013; 65(8):1116-21.
28. Woolcott CG, Conroy SM, Nagata C, Ursin G, Vachon CM, Yaffe MJ, Pagano IS, Byrne C, Maskarinec G. Methods for assessing and representing mammographic density: an analysis of 4 case-control studies. Am J Epidemiol. 2014 Jan 15; 179(2):236-44.
29. Franke AA, Lai JF, Morrison CM, Pagano I, Li X, Halm BM, Soon R, Custer LJ. Coenzyme Q10, carotenoid, tocopherol, and retinol levels in cord plasma from multiethnic subjects in Hawaii. Free Radic Res. 2013 Sep; 47(9):757-68.
30. Maskarinec G, Pagano IS, Little MA, Conroy SM, Park SY, Kolonel LN. Mammographic density as a predictor of breast cancer survival: the Multiethnic Cohort. Breast Cancer Res. 2013 Jan 22; 15(1):R7.
31. Ceria-Ulep CD, Dalusung-Angosta A, Magday-Asselstine RT, Castillo MA, Pagano IS, Li D, Wooton A. Assessing physical activity and function in the Filipino older adults. J Cult Divers. 2013; 20(1):30-9.
32. Halm BM, Lai JF, Pagano I, Cooney W, Soon RA, Franke AA. Vitamin D deficiency in cord plasma from multiethnic subjects living in the tropics. J Am Coll Nutr. 2013; 32(4):215-23.
33. Matsuno RK, Pagano IS, Maskarinec G, Issell BF, Gotay CC. Complementary and alternative medicine use and breast cancer prognosis: a pooled analysis of four population-based studies of breast cancer survivors. J Womens Health (Larchmt). 2012 Dec; 21(12):1252-8.
34. Tutterrow YL, Salanti A, Avril M, Smith JD, Pagano IS, Ako S, Fogako J, Leke RG, Taylor DW. High avidity antibodies to full-length VAR2CSA correlate with absence of placental malaria. PLoS One. 2012; 7(6):e40049.
35. Jube S, Rivera ZS, Bianchi ME, Powers A, Wang E, Pagano I, Pass HI, Gaudino G, Carbone M, Yang H. Cancer cell secretion of the DAMP protein HMGB1 supports progression in malignant mesothelioma. Cancer Res. 2012 Jul 01; 72(13):3290-301.
36. Morimoto Y, Conroy SM, Pagano IS, Isaki M, Franke AA, Nordt FJ, Maskarinec G. Urinary estrogen metabolites during a randomized soy trial. Nutr Cancer. 2012; 64(2):307-14.
37. Woolcott CG, Koga K, Conroy SM, Byrne C, Nagata C, Ursin G, Vachon CM, Yaffe MJ, Pagano I, Maskarinec G. Mammographic density, parity and age at first birth, and risk of breast cancer: an analysis of four case-control studies. Breast Cancer Res Treat. 2012 Apr; 132(3):1163-71.
38. Carbone M, Ly BH, Dodson RF, Pagano I, Morris PT, Dogan UA, Gazdar AF, Pass HI, Yang H. Malignant mesothelioma: facts, myths, and hypotheses. J Cell Physiol. 2012 Jan; 227(1):44-58.
39. Morimoto Y, Conroy SM, Pagano IS, Franke AA, Stanczyk FZ, Maskarinec G. Influence of diet on nipple aspirate fluid production and estrogen levels. Food Funct. 2011 Nov; 2(11):665-70.
40. Ciotta L, Pagano I, Stracquadanio M, Formuso C. [Polycystic ovarian syndrome incidence in young women with non-alcoholic fatty liver disease]. Minerva Ginecol. 2011 Oct; 63(5):429-37.
41. Conroy SM, Woolcott CG, Koga KR, Byrne C, Nagata C, Ursin G, Vachon CM, Yaffe MJ, Pagano I, Maskarinec G. Mammographic density and risk of breast cancer by adiposity: an analysis of four case-control studies. Int J Cancer. 2012 Apr 15; 130(8):1915-24.
42. Franke AA, Lai JF, Pagano I, Morimoto Y, Maskarinec G. Equol production changes over time in pre-menopausal women. Br J Nutr. 2012 Apr; 107(8):1201-6.
43. Franke AA, Lai JF, Halm BM, Pagano I, Kono N, Mack WJ, Hodis HN. Equol production changes over time in postmenopausal women. J Nutr Biochem. 2012 Jun; 23(6):573-9.
44. Maskarinec G, Ollberding NJ, Conroy SM, Morimoto Y, Pagano IS, Franke AA, Gentzschein E, Stanczyk FZ. Estrogen levels in nipple aspirate fluid and serum during a randomized soy trial. Cancer Epidemiol Biomarkers Prev. 2011 Sep; 20(9):1815-21.
45. Maskarinec G, Morimoto Y, Conroy SM, Pagano IS, Franke AA. The volume of nipple aspirate fluid is not affected by 6 months of treatment with soy foods in premenopausal women. J Nutr. 2011 Apr 01; 141(4):626-30.
46. Maskarinec G, Pagano I, Lurie G, Bantum E, Gotay CC, Issell BF. Factors affecting survival among women with breast cancer in Hawaii. J Womens Health (Larchmt). 2011 Feb; 20(2):231-7.
47. Conroy SM, Pagano I, Kolonel LN, Maskarinec G. Mammographic density and hormone receptor expression in breast cancer: the Multiethnic Cohort Study. Cancer Epidemiol. 2011 Oct; 35(5):448-52.
48. Morimoto Y, Schembre SM, Steinbrecher A, Erber E, Pagano I, Grandinetti A, Kolonel LN, Maskarinec G. Ethnic differences in weight gain and diabetes risk: the Multiethnic Cohort Study. Diabetes Metab. 2011 Jun; 37(3):230-6.
49. Chai W, Nigg CR, Pagano IS, Motl RW, Horwath C, Dishman RK. Associations of quality of life with physical activity, fruit and vegetable consumption, and physical inactivity in a free living, multiethnic population in Hawaii: a longitudinal study. Int J Behav Nutr Phys Act. 2010 Nov 22; 7:83.
50. Franke AA, Hebshi SM, Pagano I, Kono N, Mack WJ, Hodis HN. Urine accurately reflects circulating isoflavonoids and ascertains compliance during soy intervention. Cancer Epidemiol Biomarkers Prev. 2010 Jul; 19(7):1775-83.
51. Chai W, Conroy SM, Maskarinec G, Franke AA, Pagano IS, Cooney RV. Associations between obesity and serum lipid-soluble micronutrients among premenopausal women. Nutr Res. 2010 Apr; 30(4):227-32.
52. Woolcott CG, Maskarinec G, Haiman CA, Verheus M, Pagano IS, Le Marchand L, Henderson BE, Kolonel LN. Association between breast cancer susceptibility loci and mammographic density: the Multiethnic Cohort. Breast Cancer Res. 2009; 11(1):R10.
53. Issell BF, Gotay CC, Pagano I, Franke AA. Using quality of life measures in a Phase I clinical trial of noni in patients with advanced cancer to select a Phase II dose. J Diet Suppl. 2009; 6(4):347-59.
54. Pagano I. Complementary and alternative medicine. Hawaii Med J. 2008 May; 67(5):136-7.
55. Gotay CC, Ransom S, Pagano IS. Quality of life in survivors of multiple primary cancers compared with cancer survivor controls. Cancer. 2007 Nov 01; 110(9):2101-9.
56. Maskarinec G, Takata Y, Chen Z, Gram IT, Nagata C, Pagano I, Hayashi K, Arendell L, Skeie G, Rinaldi S, Kaaks R. IGF-I and mammographic density in four geographic locations: a pooled analysis. Int J Cancer. 2007 Oct 15; 121(8):1786-92.
57. Dodgson JE, Codier E, Kaiwi P, Oneha MF, Pagano I. Breastfeeding patterns in a community of Native Hawaiian mothers participating in WIC. Fam Community Health. 2007 Apr-Jun; 30(2 Suppl):S46-58.
58. Gotay CC, Pagano IS. Assessment of Survivor Concerns (ASC): a newly proposed brief questionnaire. Health Qual Life Outcomes. 2007 Mar 13; 5:15.
59. Maskarinec G, Carlin L, Pagano I, Yamamoto J, Shumay D, Wilkens LR, Kolonel LN. Lifestyle risk factors for chronic disease in a multiethnic population: an analysis of two prospective studies over a 20-year period. Ethn Dis. 2007; 17(4):597-603.
60. Maskarinec G, Pagano I, Chen Z, Nagata C, Gram IT. Ethnic and geographic differences in mammographic density and their association with breast cancer incidence. Breast Cancer Res Treat. 2007 Jul; 104(1):47-56.
61. Gill JK, Maskarinec G, Pagano I, Kolonel LN. The association of mammographic density with ductal carcinoma in situ of the breast: the Multiethnic Cohort. Breast Cancer Res. 2006; 8(3):R30.
62. Maskarinec G, Zhang Y, Takata Y, Pagano I, Shumay DM, Goodman MT, Le Marchand L, Nomura AM, Wilkens LR, Kolonel LN. Trends of breast cancer incidence and risk factor prevalence over 25 years. Breast Cancer Res Treat. 2006 Jul; 98(1):45-55.
63. Maskarinec G, Takata Y, Pagano I, Lurie G, Wilkens LR, Kolonel LN. Alcohol consumption and mammographic density in a multiethnic population. Int J Cancer. 2006 May 15; 118(10):2579-83.
64. Maskarinec G, Pagano I, Lurie G, Kolonel LN. A longitudinal investigation of mammographic density: the multiethnic cohort. Cancer Epidemiol Biomarkers Prev. 2006 Apr; 15(4):732-9.
65. Maskarinec G, Takata Y, Pagano I, Carlin L, Goodman MT, Le Marchand L, Nomura AM, Wilkens LR, Kolonel LN. Trends and dietary determinants of overweight and obesity in a multiethnic population. Obesity (Silver Spring). 2006 Apr; 14(4):717-26.
66. Pagano IS, Gotay CC. Ethnic differential item functioning in the assessment of quality of life in cancer patients. Health Qual Life Outcomes. 2005 Oct 07; 3:60.
67. Maskarinec G, Pagano I, Lurie G, Wilkens LR, Kolonel LN. Mammographic density and breast cancer risk: the multiethnic cohort study. Am J Epidemiol. 2005 Oct 15; 162(8):743-52.
68. Noh JJ, Maskarinec G, Pagano I, Cheung LW, Stanczyk FZ. Mammographic densities and circulating hormones: a cross-sectional study in premenopausal women. Breast. 2006 Feb; 15(1):20-8.
69. Braun KL, Fong M, Gotay C, Pagano IS, Chong C. Ethnicity and breast cancer in Hawaii: increased survival but continued disparity. Ethn Dis. 2005; 15(3):453-60.
70. Issell BF, Maskarinec G, Pagano I, Gotay CC. Breast cancer treatment among women of different ethnicity in Hawaii. Cancer Invest. 2005; 23(6):497-504.
71. Maskarinec G, Dhakal S, Pagano I, Carlin L, Goodman MT, Le Marchand L, Nomura A, Wilkens LR, Kolonel LN. Ethnic differences in trends and determinants of cigarette smoking in Hawaii. Ethn Dis. 2005; 15(2):316-23.
72. Gotay CC, Isaacs P, Pagano I. Quality of life in patients who survive a dire prognosis compared to control cancer survivors. Psychooncology. 2004 Dec; 13(12):882-92.
73. Heiby EM, Pagano IS, Blaine DD, Nelson K, Heath RA. Modeling unipolar depression as a chaotic process. Psychol Assess. 2003 Sep; 15(3):426-34.
74. Maskarinec G, Pagano IS, Yamashiro G, Issell BF. Influences of ethnicity, treatment, and comorbidity on breast cancer survival in Hawaii. J Clin Epidemiol. 2003 Jul; 56(7):678-85.
75. Pagano IS, Morita SY, Dhakal S, Hundahl SA, Maskarinec G. Time dependent ethnic convergence in colorectal cancer survival in Hawaii. BMC Cancer. 2003 Feb 25; 3:5.
76. Gotay CC, Blaine D, Haynes SN, Holup J, Pagano IS. Assessment of quality of life in a multicultural cancer patient population. Psychol Assess. 2002 Dec; 14(4):439-50.
77. Gotay CC, Holup JL, Pagano I. Ethnic differences in quality of life among early breast and prostate cancer survivors. Psychooncology. 2002 Mar-Apr; 11(2):103-13.

Research Resources icon

Funding Opportunities icon

Browse active NIH & NSF funding opportunities, requests for applications (RFAs), and program announcements (PAs)

Publications Timeline

Top MeSH Keywords

Tree Map of Keyword Semantic Groups (Categories)

Left-click a node to move down the tree, right-click the graph to move back up the tree

Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile:
Last Name
Quality of Life
Breast Neoplasms
See all (350) keywords
See all (18) people See all (60) people Search for (8) people

RTRN Collaboration and Professional Networking Feedback