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Hongtao Yu
Title Professor and Chair
Faculty Rank
Degree PhD
Institution Jackson State University
Department Chemistry and Biochemistry
Clusters Genes and Environmental Health/Toxicology
Department of Chemistry
Jackson State University
PO Box 17910
City Jackson
State MS
Postal Code 39217
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MIssissippi State Legislature Higher Education Appreciation Day for Academic Excellence
Mississippi Academy of Sciences Outstanding Contribution to Science
American Chemical Society Stanley C. Israel Award for Advancing Diversity in Chemical Sciences

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  Our research falls into an array of interdisciplinary areas: chemical toxicology, organic chemistry, photochemistry, environmental chemistry, and biochemistry. Our main interest is to study the photochemical fate, DNA interaction and damage, and photo-induced toxicity of environmental chemicals, cosmetics and skin care products, nanomaterials, and industrial waste chemicals. Special focus is on the environmentally carcinogenic polycyclic aromatic hydrocarbons (PAH) and polychlorobyphenyls (PCBs), cosmetic ingredient chemicals, and pharmaceuticals.

· Phototoxicity and photochemical reaction of hair-dye ingredient chemicals, cosmetic chemical, and pharmaceuticals.
· Toxicity study of nano-gold and nano-silver in skin cells and bacteria
· Photochemistry and photodegradation of PAHs, nitroaromatics, PCBs
· Phototoxicity of PAHs, PCBs, electronic waste chemicals
Development of nanopartcle based detection techniques for DNA damages and viruses.

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I have a wealth of research, research administration, teaching, and administration of a department.

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1. Zhang Y, Newton B, Lewis E, Fu PP, Kafoury R, Ray PC, Yu H. Cytotoxicity of organic surface coating agents used for nanoparticles synthesis and stability. Toxicol In Vitro. 2015 Jun; 29(4):762-8.
2. Fan Z, Dai X, Lu Y, Yu E, Brahmbatt N, Carter N, Tchouwou C, Singh AK, Jones Y, Yu H, Ray PC. Enhancing targeted tumor treatment by near IR light-activatable photodynamic-photothermal synergistic therapy. Mol Pharm. 2014 Apr 07; 11(4):1109-16.
3. McShan D, Ray PC, Yu H. Molecular toxicity mechanism of nanosilver. J Food Drug Anal. 2014 Mar; 22(1):116-127.
4. Fan Z, Fu PP, Yu H, Ray PC. Theranostic nanomedicine for cancer detection and treatment. J Food Drug Anal. 2014 Mar; 22(1):3-17.
5. Fu PP, Xia Q, Hwang HM, Ray PC, Yu H. Mechanisms of nanotoxicity: generation of reactive oxygen species. J Food Drug Anal. 2014 Mar; 22(1):64-75.
6. Hughes SI, Dasary SS, Singh AK, Glenn Z, Jamison H, Ray PC, Yu H. Sensitive and selective detection of trivalent chromium using Hyper Rayleigh Scattering with 5,5'-dithio-bis-(2-nitrobenzoic acid)-modified gold nanoparticles. Sens Actuators B Chem. 2013 Mar 01; 178:514-519.
7. Dasary SS, Ray PC, Singh AK, Arbneshi T, Yu H, Senapati D. A surface enhanced Raman scattering probe for highly selective and ultra sensitive detection of iodide in water and salt samples. Analyst. 2013 Feb 21; 138(4):1195-203.
8. Fullove TP, Johnson B, Yu H. Structure-dependent lipid peroxidation by photoirradiation of pyrene and its mono-substituted derivatives. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2013; 48(3):233-41.
9. McShan D, Yu H. DNA damage in human skin keratinocytes caused by multiwalled carbon nanotubes with carboxylate functionalization. Toxicol Ind Health. 2014 Jul; 30(6):489-98.
10. Yedjou CG, Saeed MA, Hossain MA, Dorsey W, Yu H, Tchounwou PB. Basic apoptotic and necrotic cell death in human liver carcinoma (HepG2 ) cells induced by synthetic azamacrocycle. Environ Toxicol. 2014 Jun; 29(6):605-11.
11. Li W, Lu W, Fan Z, Zhu X, Reed A, Newton B, Zhang Y, Courtney S, Tiyyagura PT, Li S, Butler E, Yu H, Ray PC, Gao R. Enhanced Photodynamic Selectivity of Nano-Silica-Attached Porphyrins Against Breast Cancer Cells. J Mater Chem. 2012 Jan 01; 22(25):12701-12708.
12. Zhu X, Lu W, Zhang Y, Reed A, Newton B, Fan Z, Yu H, Ray PC, Gao R. Imidazole-modified porphyrin as a pH-responsive sensitizer for cancer photodynamic therapy. Chem Commun (Camb). 2011 Oct 07; 47(37):10311-3.
13. Wang Y, Aker WG, Hwang HM, Yedjou CG, Yu H, Tchounwou PB. A study of the mechanism of in vitro cytotoxicity of metal oxide nanoparticles using catfish primary hepatocytes and human HepG2 cells. Sci Total Environ. 2011 Oct 15; 409(22):4753-62.
14. Senapati D, Dasary SS, Singh AK, Senapati T, Yu H, Ray PC. A label-free gold-nanoparticle-based SERS assay for direct cyanide detection at the parts-per-trillion level. Chemistry. 2011 Jul 18; 17(30):8445-51.
15. Pramanik A, Thompson B, Hayes T, Tucker K, Powell DR, Bonnesen PV, Ellis ED, Lee KS, Yu H, Hossain MA. Seven-coordinate anion complex with a tren-based urea: binding discrepancy of hydrogen sulfate in solid and solution states. Org Biomol Chem. 2011 Jun 21; 9(12):4444-7.
16. Wang S, Lawson R, Ray PC, Yu H. Toxic effects of gold nanoparticles on Salmonella typhimurium bacteria. Toxicol Ind Health. 2011 Jul; 27(6):547-54.
17. Ray PC, Yu H, Fu PP. Nanogold-based sensing of environmental toxins: excitement and challenges. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2011; 29(1):52-89.
18. Lu W, Singh AK, Khan SA, Senapati D, Yu H, Ray PC. Gold nano-popcorn-based targeted diagnosis, nanotherapy treatment, and in situ monitoring of photothermal therapy response of prostate cancer cells using surface-enhanced Raman spectroscopy. J Am Chem Soc. 2010 Dec 29; 132(51):18103-14.
19. Stewart G, Smith K, Chornes A, Harris T, Honeysucker T, Dasary SR, Yu H. PHOTOCHEMICAL REACTION OF NITRO-POLYCYCLIC AROMATIC HYDROCARBONS: EFFECT BY SOLVENT AND STRUCTURE. Environ Chem Lett. 2010 Dec 01; 8(4):301-306.
20. Dasary SS, Senapati D, Singh AK, Anjaneyulu Y, Yu H, Ray PC. Highly sensitive and selective dynamic light-scattering assay for TNT detection using p-ATP attached gold nanoparticle. ACS Appl Mater Interfaces. 2010 Dec; 2(12):3455-60.
21. Dasary SS, Saloni J, Fletcher A, Anjaneyulu Y, Yu H. Photodegradation of selected PCBs in the presence of Nano-TiO2 as catalyst and H2O2 as an oxidant. Int J Environ Res Public Health. 2010 11; 7(11):3987-4001.
22. Wang S, Singh AK, Senapati D, Neely A, Yu H, Ray PC. Rapid colorimetric identification and targeted photothermal lysis of Salmonella bacteria by using bioconjugated oval-shaped gold nanoparticles. Chemistry. 2010 May 17; 16(19):5600-6.
23. Lu W, Arumugam SR, Senapati D, Singh AK, Arbneshi T, Khan SA, Yu H, Ray PC. Multifunctional oval-shaped gold-nanoparticle-based selective detection of breast cancer cells using simple colorimetric and highly sensitive two-photon scattering assay. ACS Nano. 2010 Mar 23; 4(3):1739-49.
24. Lu W, Senapati D, Wang S, Tovmachenko O, Singh AK, Yu H, Ray PC. Effect of Surface Coating on the Toxicity of Silver Nanomaterials on Human Skin Keratinocytes. Chem Phys Lett. 2010 Feb 25; 487(1-3).
25. Dasary SS, Singh AK, Senapati D, Yu H, Ray PC. Gold nanoparticle based label-free SERS probe for ultrasensitive and selective detection of trinitrotoluene. J Am Chem Soc. 2009 Sep 30; 131(38):13806-12.
26. Stewart G, Jiao Y, Valente EJ, Fu PP, Li T, Hu Z, Yu H. Photochemical reaction of 9-nitro-substituted anthracene-like molecules 9-methyl-10-nitroanthracene and 12-methyl-7-nitrobenz[a]anthracene. J Photochem Photobiol A Chem. 2009 Jan 01; 201(1):39-44.
27. Wang L, Wang S, Yin JJ, Fu PP, Yu H. Light-Induced Toxic Effects of Tamoxifen: A Chemotherapeutic and Chemopreventive Agent. J Photochem Photobiol A Chem. 2009 Jan 01; 201(1):50-56.
28. Griffin J, Singh AK, Senapati D, Rhodes P, Mitchell K, Robinson B, Yu E, Ray PC. Size- and distance-dependent nanoparticle surface-energy transfer (NSET) method for selective sensing of hepatitis C virus RNA. Chemistry. 2009; 15(2):342-51.
29. Ray PC, Yu H, Fu PP. Toxicity and environmental risks of nanomaterials: challenges and future needs. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2009 Jan; 27(1):1-35.
30. Mosley-Foreman C, Choi J, Wang S, Yu H. Phototoxicity of phenylenediamine hair dye chemicals in Salmonella typhimurium TA102 and human skin keratinocytes. Food Chem Toxicol. 2008 Dec; 46(12):3780-4.
31. Wang S, Lu W, Tovmachenko O, Rai US, Yu H, Ray PC. Challenge in Understanding Size and Shape Dependent Toxicity of Gold Nanomaterials in Human Skin Keratinocytes. Chem Phys Lett. 2008 Sep 20; 463(1-3):145-149.
32. Dasary SS, Rai US, Yu H, Anjaneyulu Y, Dubey M, Ray PC. Gold Nanoparticle Based Surface Enhanced Fluorescence For Detection of Organophosphorus Agents. Chem Phys Lett. 2008 Jul 20; 460(1-3):187-190.
33. Wang S, Mosley C, Stewart G, Yu H. Photochemical reaction of a dye precursor 4-chloro-1,2-phenylenediamine and its associated mutagenic effects. J Photochem Photobiol A Chem. 2008 Jun 10; 197(1):34-39.
34. Darbha GK, Singh AK, Rai US, Yu E, Yu H, Chandra Ray P. Selective detection of mercury (II) ion using nonlinear optical properties of gold nanoparticles. J Am Chem Soc. 2008 Jun 25; 130(25):8038-43.
35. An R, Li Y, Niu X, Yu H. Responses of antioxidant enzymes in catfish exposed to liquid crystals from E-waste. Int J Environ Res Public Health. 2008 Jun; 5(2):99-103.
36. Wang S, Sheng Y, Feng M, Leszczynski J, Wang L, Tachikawa H, Yu H. Light-induced cytotoxicity of 16 polycyclic aromatic hydrocarbons on the US EPA priority pollutant list in human skin HaCaT keratinocytes: relationship between phototoxicity and excited state properties. Environ Toxicol. 2007 Jun; 22(3):318-27.
37. Mosley CN, Wang L, Gilley S, Wang S, Yu H. Light-induced cytotoxicity and genotoxicity of a sunscreen agent, 2-phenylbenzimidazole in Salmonella typhimurium TA 102 and HaCaT keratinocytes. Int J Environ Res Public Health. 2007 Jun; 4(2):126-31.
38. Yu H, Xia Q, Yan J, Herreno-Saenz D, Wu YS, Tang IW, Fu PP. Photoirradiation of polycyclic aromatic hydrocarbons with UVA light - a pathway leading to the generation of reactive oxygen species, lipid peroxidation, and dna damage. Int J Environ Res Public Health. 2006 Dec; 3(4):348-54.
39. Yu H, Yan J, Jiao Y, Fu PP. Photochemical reaction of 7,12-dimethylbenz[a]anthracene (DMBA) and formation of DNA covalent adducts. Int J Environ Res Public Health. 2005 Apr; 2(1):114-22.
40. Wang S, Yu H. Effect of co-existing biologically relevant molecules and ions on DNA photocleavage caused by pyrene and its derivatives. Int J Environ Res Public Health. 2005 Apr; 2(1):132-7.
41. Yu H, Yan J, Jiao Y. Photochemical Reaction of 7,12-Dimethylbenz[a]anthracene (DMBA) and Formation of DNA Covalent Adducts. Int J Environ Res Public Health. 2005 Apr; 2(1):114-122.
42. Wang L, Yan J, Hardy W, Mosley C, Wang S, Yu H. Light-induced mutagenicity in Salmonella TA102 and genotoxicity/cytotoxicity in human T-cells by 3,3'-dichlorobenzidine: a chemical used in the manufacture of dyes and pigments and in tattoo inks. Toxicology. 2005 Feb 28; 207(3):411-8.
43. Graham-Evans B, Cohly HH, Yu H, Tchounwou PB. Arsenic-induced genotoxic and cytotoxic effects in human keratinocytes, melanocytes and dendritic cells. Int J Environ Res Public Health. 2004 Sep; 1(2):83-9.
44. Wang L, Yan J, Wang S, Cohly H, Fu PP, Hwang HM, Yu H. Phototoxicity and DNA damage induced by the cosmetic ingredient chemical azulene in human Jurkat T-cells. Mutat Res. 2004 Aug 08; 562(1-2):143-50.
45. Wang L, Cohly H, Yan J, Graham-Evans B, Hwang HM, Yu H. UVA light-induced toxic effects of 1-hydroxypyrene on human jurkat T-cells. Bull Environ Contam Toxicol. 2004 Jun; 72(6):1240-6.
46. Zeng K, Hwang HM, Dong S, Shi X, Wilson K, Green J, Jiao Y, Yu H. Photochemical transformation and phototoxicity of 1-aminopyrene. Environ Toxicol Chem. 2004 Jun; 23(6):1400-7.
47. Hwang HM, Balarezo AL, Jones VN, Yu H. Effect of river humic acid on 1-aminopyrene ecotoxicity in a dynamic solar photolysis process. Bull Environ Contam Toxicol. 2004 May; 72(5):1059-66.
48. Yan J, Wang L, Fu PP, Yu H. Photomutagenicity of 16 polycyclic aromatic hydrocarbons from the US EPA priority pollutant list. Mutat Res. 2004 Jan 10; 557(1):99-108.
49. Zheng B, Hwang HM, Yu H, Ekunwe S. DNA damage produced in HaCaT cells by combined fluoranthene exposure and ultraviolet A irradiation. Environ Mol Mutagen. 2004; 44(2):151-5.
50. Zeng K, Hwang HM, Zhang Y, Yu H. Identification of 6-aminochrysene photoproducts and study of the effect of a humic acid and riboflavin on its photolysis. J Photochem Photobiol B. 2003 Dec 05; 72(1-3):95-100.
51. Wang L, Yan J, Fu PP, Parekh KA, Yu H. Photomutagenicity of cosmetic ingredient chemicals azulene and guaiazulene. Mutat Res. 2003 Sep 29; 530(1-2):19-26.
52. Yu H. Environmental carcinogenic polycyclic aromatic hydrocarbons: photochemistry and phototoxicity. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2002 Nov; 20(2):149-83.
53. Cui H, Hwang HM, Zeng K, Glover H, Yu H, Liu Y. Riboflavin-photosensitized degradation of atrazine in a freshwater environment. Chemosphere. 2002 Jun; 47(9):991-9.
54. Jiao Y, Stringfellow S, Yu H. Distinguishing "looped-out" and "stacked-in" DNA bulge conformation using fluorescent 2-aminopurine replacing a purine base. J Biomol Struct Dyn. 2002 Apr; 19(5):929-34.
55. Dong S, Fu PP, Shirsat RN, Hwang HM, Leszczynski J, Yu H. UVA light-induced DNA cleavage by isomeric methylbenz[a]anthracenes. Chem Res Toxicol. 2002 Mar; 15(3):400-7.
56. Hwang HM, Shi X, Ero I, Jayasinghe A, Dong S, Yu H. Microbial ecotoxicity and mutagenicity of 1-hydroxypyrene and its photoproducts. Chemosphere. 2001 Nov; 45(4-5):445-51.
57. Dong S, Hwang HM, Shi X, Holloway L, Yu H. UVA-Induced DNA single-strand cleavage by 1-hydroxypyrene and formation of covalent adducts between DNA and 1-hydroxypyrene. Chem Res Toxicol. 2000 Jul; 13(7):585-93.
58. Dong S, Hwang HM, Harrison C, Holloway L, Shi X, Yu H. UVA light-induced DNA cleavage by selected polycyclic aromatic hydrocarbons. Bull Environ Contam Toxicol. 2000 Apr; 64(4):467-74.

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