PROFILES - Connect with RTRN Researchers

SAKINA E ELTOM
Title PROFESSOR
Faculty Rank
Degree D.V.M., M.S., PH.D.
Institution Meharry Medical College
Department Biochemistry & Cancer Biology
Clusters Cancer
Genes and Environmental Health/Toxicology
Women's Health and Reproductive Biology
Address
Dr. D.B. Todd BLVD.,
WEST BASIC SCIENCES Bldg., Room 2130
City NASHVILLE
State TN
Postal Code 37208
Telephone 615 327 5713
Fax
Email
QR Barcode

Narrative icon

  Dr. Sakina Elzebair Eltom is an Associate Professor in the Department of Biochemistry and Cancer Biology at Meharry Medical College in Nashville, TN. Her education includes a professional degree in Veterinary Medicine where she was trained in large animal medicine and surgery in University of Khartoum in Sudan, with further training in University of Liverpool, England and Veterinary School of Hannover, Germany. Dr. Eltom went on to earn a Masters of Science and a Ph.D. in Pharmacology from Cornell University in Ithaca NY.
Her postdoctoral research experience includes training in chemical carcinogenesis at the McArdle Laboratory for Cancer Research, and training in environmental and molecular toxicology at the Center for Environmental Toxicology at University of Wisconsin-Madison. She held numerous academic positions at Cornell University and University of Wisconsin-Madison. She also ventured in the biotechnology world, where she held a Senior Scientist position in Paracelsian Inc., an IPO Biotech Company in Upstate NY. Before joining the faculty at Meharry, she was an Assistant Scientist in the Department of Pharmacology at the University of Wisconsin Medical School in Madison.
Dr. Eltom’s research is investigating the molecular mechanisms of carcinogenesis induced by exposure to environmental Organochlorines and polyaromatic hydrocarbons. The major emphasis is on characterizing the role of the aryl hydrocarbon receptor in the development and progression of breast carcinoma. Another research area in her laboratory is investigating the role of environmental endocrine disruptors in breast cancer of pre-menopausal women and how the gene-environment interaction contributes as a risk factor to the high incidence of breast cancer in pre-menopausal African American women.
In addition to research, Dr. Eltom has a vast interest in graduate education, contributing as a trainer for Ph.D. students in biomedical sciences. She served as the inaugural director of graduate studies in pharmacology, and she set the foundation on the curriculum for the training program in pharmacology and toxicology at Meharry Medical College.
Dr. Eltom has served on several review panels at the NIH, DOD and Philip Morris External Research Program and she is currently a chartered member of the Cancer Etiology Study section until 2018. Dr. Eltom is author of several peer-reviewed Publications. She served as a member of ASPET Committee on Diversity (2006-2010), and on the Advisory Committee for organizing the National Meetings of the Directors of Graduate Studies in Pharmacology (2005- ).

Online Resources icon

NIH Awarded Grants icon

  Research projects funded by the National Institutes of Health (NIH), the Centers for Disease Control (CDC), the Food and Drug Administration (FDA), and the Department of Veterans Affairs (VA)

Loading
Please wait
1.
2014The Aryl Hydrocarbon Receptor and Breast Cancer5SC1CA153326-05
2.
2013The Aryl Hydrocarbon Receptor and Breast Cancer5SC1CA153326-04
3.
2012The Aryl Hydrocarbon Receptor and Breast Cancer5SC1CA153326-03
4.
2011The Aryl Hydrocarbon Receptor and Breast Cancer5SC1CA153326-02
5.
2010ROLE OF THE ARYL HYDROCARBON RECEPTOR IN BREAST CANCER2G12RR003032-26
6.
2010The Aryl Hydrocarbon Receptor and Breast Cancer1SC1CA153326-01A1
7.
2009ROLE OF THE ARYL HYDROCARBON RECEPTOR IN BREAST CANCER5G12RR003032-25
8.
2008ROLE OF THE ARYL HYDROCARBON RECEPTOR IN BREAST CANCER5G12RR003032-24
9.
2007ROLE OF THE ARYL HYDROCARBON RECEPTOR IN BREAST CANCER5G12RR003032-23
10.
2006HUMAN MAMMARY STROMA AS A TARGET FOR ORGANOCHLORINES5G12RR003032-22

Publications icon

  Check NIH Public Access Policy Compliance

Loading
Please wait
1. Ochieng J, Nangami GN, Ogunkua O, Miousse IR, Koturbash I, Odero-Marah V, McCawley LJ, Nangia-Makker P, Ahmed N, Luqmani Y, Chen Z, Papagerakis S, Wolf GT, Dong C, Zhou BP, Brown DG, Colacci AM, Hamid RA, Mondello C, Raju J, Ryan EP, Woodrick J, Scovassi AI, Singh N, Vaccari M, Roy R, Forte S, Memeo L, Salem HK, Amedei A, Al-Temaimi R, Al-Mulla F, Bisson WH, Eltom SE. The impact of low-dose carcinogens and environmental disruptors on tissue invasion and metastasis. Carcinogenesis. 2015 Jun; 36 Suppl 1:S128-59.
2. Goodson WH, Lowe L, Carpenter DO, Gilbertson M, Manaf Ali A, Lopez de Cerain Salsamendi A, Lasfar A, Carnero A, Azqueta A, Amedei A, Charles AK, Collins AR, Ward A, Salzberg AC, Colacci A, Olsen AK, Berg A, Barclay BJ, Zhou BP, Blanco-Aparicio C, Baglole CJ, Dong C, Mondello C, Hsu CW, Naus CC, Yedjou C, Curran CS, Laird DW, Koch DC, Carlin DJ, Felsher DW, Roy D, Brown DG, Ratovitski E, Ryan EP, Corsini E, Rojas E, Moon EY, Laconi E, Marongiu F, Al-Mulla F, Chiaradonna F, Darroudi F, Martin FL, Van Schooten FJ, Goldberg GS, Wagemaker G, Nangami GN, Calaf GM, Williams G, Wolf GT, Koppen G, Brunborg G, Lyerly HK, Krishnan H, Ab Hamid H, Yasaei H, Sone H, Kondoh H, Salem HK, Hsu HY, Park HH, Koturbash I, Miousse IR, Scovassi AI, Klaunig JE, Vondrácek J, Raju J, Roman J, Wise JP, Whitfield JR, Woodrick J, Christopher JA, Ochieng J, Martinez-Leal JF, Weisz J, Kravchenko J, Sun J, Prudhomme KR, Narayanan KB, Cohen-Solal KA, Moorwood K, Gonzalez L, Soucek L, Jian L, D'Abronzo LS, Lin LT, Li L, Gulliver L, McCawley LJ, Memeo L, Vermeulen L, Leyns L, Zhang L, Valverde M, Khatami M, Romano MF, Chapellier M, Williams MA, Wade M, Manjili MH, Lleonart ME, Xia M, Gonzalez MJ, Karamouzis MV, Kirsch-Volders M, Vaccari M, Kuemmerle NB, Singh N, Cruickshanks N, Kleinstreuer N, van Larebeke N, Ahmed N, Ogunkua O, Krishnakumar PK, Vadgama P, Marignani PA, Ghosh PM, Ostrosky-Wegman P, Thompson PA, Dent P, Heneberg P, Darbre P, Sing Leung P, Nangia-Makker P, Cheng QS, Robey RB, Al-Temaimi R, Roy R, Andrade-Vieira R, Sinha RK, Mehta R, Vento R, Di Fiore R, Ponce-Cusi R, Dornetshuber-Fleiss R, Nahta R, Castellino RC, Palorini R, Abd Hamid R, Langie SA, Eltom SE, Brooks SA, Ryeom S, Wise SS, Bay SN, Harris SA, Papagerakis S, Romano S, Pavanello S, Eriksson S, Forte S, Casey SC, Luanpitpong S, Lee TJ, Otsuki T, Chen T, Massfelder T, Sanderson T, Guarnieri T, Hultman T, Dormoy V, Odero-Marah V, Sabbisetti V, Maguer-Satta V, Rathmell WK, Engström W, Decker WK, Bisson WH, Rojanasakul Y, Luqmani Y, Chen Z, Hu Z. Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead. Carcinogenesis. 2015 Jun; 36 Suppl 1:S254-96.
3. Humphrey-Johnson A, Abukalam R, Eltom SE. Stability of the aryl hydrocarbon receptor and its regulated genes in the low activity variant of Hepa-1 cell line. Toxicol Lett. 2015 Mar 04; 233(2):59-67.
4. Goode G, Pratap S, Eltom SE. Depletion of the aryl hydrocarbon receptor in MDA-MB-231 human breast cancer cells altered the expression of genes in key regulatory pathways of cancer. PLoS One. 2014; 9(6):e100103.
5. Powell JB, Goode GD, Eltom SE. The Aryl Hydrocarbon Receptor: A Target for Breast Cancer Therapy. J Cancer Ther. 2013 Sep; 4(7):1177-1186.
6. Goode GD, Ballard BR, Manning HC, Freeman ML, Kang Y, Eltom SE. Knockdown of aberrantly upregulated aryl hydrocarbon receptor reduces tumor growth and metastasis of MDA-MB-231 human breast cancer cell line. Int J Cancer. 2013 Dec 15; 133(12):2769-80.
7. Brooks J, Eltom SE. Malignant transformation of mammary epithelial cells by ectopic overexpression of the aryl hydrocarbon receptor. Curr Cancer Drug Targets. 2011 Jun; 11(5):654-69.
8. Dale Y, Eltom SE. The induction of CYP1A1 by oltipraz is mediated through calcium-dependent-calpain. Toxicol Lett. 2006 Oct 10; 166(2):150-9.
9. Dale YR, Eltom SE. Calpain mediates the dioxin-induced activation and down-regulation of the aryl hydrocarbon receptor. Mol Pharmacol. 2006 Nov; 70(5):1481-7.
10. Brown KA, Aakre ME, Gorska AE, Price JO, Eltom SE, Pietenpol JA, Moses HL. Induction by transforming growth factor-beta1 of epithelial to mesenchymal transition is a rare event in vitro. Breast Cancer Res. 2004; 6(3):R215-31.
11. Eltom SE, Schwark WS. CYP1A1 and CYP1B1, two hydrocarbon-inducible cytochromes P450, are constitutively expressed in neonate and adult goat liver, lung and kidney. Pharmacol Toxicol. 1999 Aug; 85(2):65-73.
12. Eltom SE, Zhang L, Jefcoate CR. Regulation of cytochrome P-450 (CYP) 1B1 in mouse Hepa-1 variant cell lines: A possible role for aryl hydrocarbon receptor nuclear translocator (ARNT) as a suppressor of CYP1B1 gene expression. Mol Pharmacol. 1999 Mar; 55(3):594-604.
13. Eltom SE, Larsen MC, Jefcoate CR. Expression of CYP1B1 but not CYP1A1 by primary cultured human mammary stromal fibroblasts constitutively and in response to dioxin exposure: role of the Ah receptor. Carcinogenesis. 1998 Aug; 19(8):1437-44.
14. Larsen MC, Angus WG, Brake PB, Eltom SE, Sukow KA, Jefcoate CR. Characterization of CYP1B1 and CYP1A1 expression in human mammary epithelial cells: role of the aryl hydrocarbon receptor in polycyclic aromatic hydrocarbon metabolism. Cancer Res. 1998 Jun 01; 58(11):2366-74.
15. Alexander DL, Eltom SE, Jefcoate CR. Ah receptor regulation of CYP1B1 expression in primary mouse embryo-derived cells. Cancer Res. 1997 Oct 15; 57(20):4498-506.
16. Bhattacharyya KK, Brake PB, Eltom SE, Otto SA, Jefcoate CR. Identification of a rat adrenal cytochrome P450 active in polycyclic hydrocarbon metabolism as rat CYP1B1. Demonstration of a unique tissue-specific pattern of hormonal and aryl hydrocarbon receptor-linked regulation. J Biol Chem. 1995 May 12; 270(19):11595-602.
17. Eltom SE, Park SS, Schwark WS. Studies on the ontogeny of goat hepatic cytochrome P-450-associated O-dealkylase activities using monoclonal antibodies: comparison to adult lung activity. Dev Pharmacol Ther. 1993; 20(1-2):93-9.
18. Eltom SE, Babish JG, Ferguson DC. The interaction of L-triiodothyronine and 2,3,7,8-tetrachlorodibenzo-p-dioxin on Ah-receptor-mediated hepatic Phase I and Phase II enzymes and iodothyronine 5'-deiodinase in thyroidectomized rats. Toxicol Lett. 1992 Jul; 61(2-3):125-39.

Research Resources icon

Funding Opportunities icon

Browse active NIH & NSF funding opportunities, requests for applications (RFAs), and program announcements (PAs)

Publications Timeline

Top MeSH Keywords

Tree Map of Keyword Semantic Groups (Categories)

Left-click a node to move down the tree, right-click the graph to move back up the tree

Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile:
 
Keyword
Last Name
Institution
 
See all (4) people See all (60) people Search for (3) people
Feedback

RTRN Collaboration and Professional Networking Feedback