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Felicite Noubissi
Title Dr
Faculty Rank Assistant Professor
Degree Ph.D.
Institution Jackson State University
Department Biology
Clusters Cancer
1400 J. R. Lynch St.
John A. People's Building, Room 429
City Jackson
State MS
Postal Code 39217
Telephone 6082397040
Fax 601 979 5853
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  My research program is focused on the investigation of the cellular and molecular mechanisms underlying tumor development with the goal of identifying new therapeutic targets for cancer treatment.

-My previous research uncovered an RNA-binding protein, CRD-BP (coding region determinant-binding protein) which is a Wnt/Bcatenin target. It seems to play a critical role in cancer development and metastasis. CRD-BP also mediates a cross talk between Wnt and Hh signaling pathways in colorectal cancer development. The role of CRD-BP in the cross talk between Wnt and Hh appears critical for basal cell carcinoma development as suggested the basal cell carcinoma cell line UW-BCC1 that we generated. Using this cell line, my lab continues to study the role of Wnt and CRD-BP in basal cell carcinoma developement.

-My research has expanded on investigating mechanisms of cancer metastasis and drug resistance. Identifying mechanisms of cancer heterogeneity leading to drug resistance and metastasis are some aspects of my current research program. We previously demonstrated that breast tumor cells fuse with mesenchymal stem/stromal cells (MSCs) spontaneously and fusion products showed increased metastatic potential. We also observed that fusion between non metastatic breast cancer cells and MSCs was enhanced with hypoxia by a mechanism involving apoptosis. My lab is investigating cellular and molecular aspects of cancer cell fusion-driven heterogeneity and metastasis.

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1. McArdle TJ, Ogle BM, Noubissi FK. Moving Upwards: A Simple and Flexible In Vitro Three-dimensional Invasion Assay Protocol. J Vis Exp. 2018 Mar 12; (133).
2. McArdle TJ, Ogle BM, Noubissi FK. An In Vitro Inverted Vertical Invasion Assay to Avoid Manipulation of Rare or Sensitive Cell Types. J Cancer. 2016; 7(15):2333-2340.
3. Noubissi FK, Ogle BM. Cancer Cell Fusion: Mechanisms Slowly Unravel. Int J Mol Sci. 2016 Sep 21; 17(9).
4. Hamilton KE, Chatterji P, Lundsmith ET, Andres SF, Giroux V, Hicks PD, Noubissi FK, Spiegelman VS, Rustgi AK. Loss of Stromal IMP1 Promotes a Tumorigenic Microenvironment in the Colon. Mol Cancer Res. 2015 Nov; 13(11):1478-86.
5. Noubissi FK, Harkness T, Alexander CM, Ogle BM. Apoptosis-induced cancer cell fusion: a mechanism of breast cancer metastasis. FASEB J. 2015 Sep; 29(9):4036-45.
6. Chamcheu JC, Pal HC, Siddiqui IA, Adhami VM, Ayehunie S, Boylan BT, Noubissi FK, Khan N, Syed DN, Elmets CA, Wood GS, Afaq F, Mukhtar H. Prodifferentiation, anti-inflammatory and antiproliferative effects of delphinidin, a dietary anthocyanidin, in a full-thickness three-dimensional reconstituted human skin model of psoriasis. Skin Pharmacol Physiol. 2015; 28(4):177-88.
7. Noubissi FK, Kim T, Kawahara TN, Aughenbaugh WD, Berg E, Longley BJ, Athar M, Spiegelman VS. Role of CRD-BP in the growth of human basal cell carcinoma cells. J Invest Dermatol. 2014 Jun; 134(6):1718-1724.
8. Hamilton KE, Noubissi FK, Katti PS, Hahn CM, Davey SR, Lundsmith ET, Klein-Szanto AJ, Rhim AD, Spiegelman VS, Rustgi AK. IMP1 promotes tumor growth, dissemination and a tumor-initiating cell phenotype in colorectal cancer cell xenografts. Carcinogenesis. 2013 Nov; 34(11):2647-54.
9. Mongroo PS, Noubissi FK, Cuatrecasas M, Kalabis J, King CE, Johnstone CN, Bowser MJ, Castells A, Spiegelman VS, Rustgi AK. IMP-1 displays cross-talk with K-Ras and modulates colon cancer cell survival through the novel proapoptotic protein CYFIP2. Cancer Res. 2011 Mar 15; 71(6):2172-82.
10. Noubissi FK, Nikiforov MA, Colburn N, Spiegelman VS. Transcriptional Regulation of CRD-BP by c-myc: Implications for c-myc Functions. Genes Cancer. 2010 Oct; 1(10):1074-82.
11. Noubissi FK, Goswami S, Sanek NA, Kawakami K, Minamoto T, Moser A, Grinblat Y, Spiegelman VS. Wnt signaling stimulates transcriptional outcome of the Hedgehog pathway by stabilizing GLI1 mRNA. Cancer Res. 2009 Nov 15; 69(22):8572-8.
12. Elcheva I, Goswami S, Noubissi FK, Spiegelman VS. CRD-BP protects the coding region of betaTrCP1 mRNA from miR-183-mediated degradation. Mol Cell. 2009 Jul 31; 35(2):240-6.
13. Noubissi FK, Elcheva I, Bhatia N, Shakoori A, Ougolkov A, Liu J, Minamoto T, Ross J, Fuchs SY, Spiegelman VS. CRD-BP mediates stabilization of betaTrCP1 and c-myc mRNA in response to beta-catenin signalling. Nature. 2006 Jun 15; 441(7095):898-901.
14. Bhat A, Noubissi FK, Vyas M, Kasbekar DP. Genetic analysis of wild-isolated Neurospora crassa strains identified as dominant suppressors of repeat-induced point mutation. Genetics. 2003 Jul; 164(3):947-61.
15. Noubissi FK, Aparna K, McCluskey K, Kasbekar DP. Evidence for dominant suppression of repeat-induced point mutation (RIP) in crosses with the wild-isolated Neurospora crassa strains Sugartown and Adiopodoume-7. J Genet. 2001 Aug; 80(2):55-61.
16. Noubissi FK, McCluskey K, Kasbekar DP. Repeat-induced point mutation (RIP) in crosses with wild-isolated strains of Neurospora crassa: evidence for dominant reduction of RIP. Fungal Genet Biol. 2000 Nov; 31(2):91-7.

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