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Shafiq A. Khan
Title Dr.
Faculty Rank Professor of Biological Sciences; GRA Eminent Scholar
Degree Ph.D.
Institution Clark Atlanta University
Department Center for Cancer Research and Therapeutic Development
Clusters Cancer
Address
Clark Atlanta University
Center for Cancer Research and Theraputic Development
223 James P. Brawley Drive, S.W.
City Atlanta
State GA
Postal Code 30314
Telephone (404) 880-6795
Fax 404-880-6756
Email
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  Dr. Khan is the Scientific Director of the Clark Atlanta University Center for Cancer Research and Therapeutic Development (CCRTD), a University Center of Excellence that focuses on research in prostate cancer and is an Eminent Scholar in Cancer Cell Biology, an endowed chair funded by the Georgia Research Alliance. He is also Professor in the Department of Biological Sciences and serves as PI/Program Director of the NIH/NIMHD Center of Excellence for Prostate Cancer Research, Education and Community Services and the NIH/NIMHD/RCMI programs at Clark Atlanta University.

Dr. Khan earned his Master’s degree in Biological Sciences in 1976 from Quaid-i-Azam University in Islamabad, Pakistan, and his Doctorate in Reproductive Endocrinology in 1985 from the Karolinska Institute in Sweden. He was an Associate Professor in the Department of Cell Biology and Biochemistry at Texas Tech University, where he also served as the Director of Basic Research of the Southwest Cancer Center. Prior to this, he was affiliated with the University of Muenster in Germany, the University of Toronto and the University of Kansas Medical Center. Dr. Khan has provided services to the World Health Organization (WHO) through numerous collaborations with researchers from London, Stockholm, and Muenster.

His research focus is on understanding the role of growth factors and cytokines in the regulation of prostate cancer and the regulation of AR function in androgen-independent prostate cancer cells. During his tenure as a scientist and Director of CCRTD, he has mentored 6 junior faculty members, 15 postdoctoral scientists, 21 doctoral graduate students, 29 undergraduate students and 3 medical students. Along with his administrative and research activities, Dr. Khan continues to teach and mentor undergraduate and graduate students in biomedical sciences. Although admired and respected for his research contributions, he particularly enjoys teaching and advising undergraduates and feels that proper mentoring at this level is critical to students’ success as future scientists. His career includes more than 30 years of experience in areas of reproductive endocrinology and cancer research. As a researcher, he has published over 80 journal articles and several book chapters and has 2 patents.



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1. Kimbrough-Allah MN, Millena AC, Khan SA. Differential role of PTEN in transforming growth factor ß (TGF-ß) effects on proliferation and migration in prostate cancer cells. Prostate. 2018 Apr; 78(5):377-389.
2. Barrett CS, Millena AC, Khan SA. TGF-ß Effects on Prostate Cancer Cell Migration and Invasion Require FosB. Prostate. 2017 Jan; 77(1):72-81.
3. Millena AC, Vo BT, Khan SA. JunD Is Required for Proliferation of Prostate Cancer Cells and Plays a Role in Transforming Growth Factor-ß (TGF-ß)-induced Inhibition of Cell Proliferation. J Biol Chem. 2016 08 19; 291(34):17964-76.
4. Vo BT, Morton D, Komaragiri S, Millena AC, Leath C, Khan SA. TGF-ß effects on prostate cancer cell migration and invasion are mediated by PGE2 through activation of PI3K/AKT/mTOR pathway. Endocrinology. 2013 May; 154(5):1768-79.
5. Strong N, Millena AC, Walker L, Chaudhary J, Khan SA. Inhibitor of differentiation 1 (Id1) and Id3 proteins play different roles in TGFß effects on cell proliferation and migration in prostate cancer cells. Prostate. 2013 May; 73(6):624-33.
6. Zhong M, Clarke S, Vo BT, Khan SA. The essential role of Gia2 in prostate cancer cell migration. Mol Cancer Res. 2012 Oct; 10(10):1380-8.
7. Vo BT, Cody B, Cao Y, Khan SA. Differential role of Sloan-Kettering Institute (Ski) protein in Nodal and transforming growth factor-beta (TGF-ß)-induced Smad signaling in prostate cancer cells. Carcinogenesis. 2012 Nov; 33(11):2054-64.
8. Darrington E, Zhong M, Vo BH, Khan SA. Vascular endothelial growth factor A, secreted in response to transforming growth factor-ß1 under hypoxic conditions, induces autocrine effects on migration of prostate cancer cells. Asian J Androl. 2012 Sep; 14(5):745-51.
9. Walker L, Millena AC, Strong N, Khan SA. Expression of TGFß3 and its effects on migratory and invasive behavior of prostate cancer cells: involvement of PI3-kinase/AKT signaling pathway. Clin Exp Metastasis. 2013 Jan; 30(1):13-23.
10. Vo BT, Khan SA. Expression of nodal and nodal receptors in prostate stem cells and prostate cancer cells: autocrine effects on cell proliferation and migration. Prostate. 2011 Jul; 71(10):1084-96.
11. Zhong M, Boseman ML, Millena AC, Khan SA. Oxytocin induces the migration of prostate cancer cells: involvement of the Gi-coupled signaling pathway. Mol Cancer Res. 2010 Aug; 8(8):1164-72.
12. Dillard PR, Lin MF, Khan SA. Androgen-independent prostate cancer cells acquire the complete steroidogenic potential of synthesizing testosterone from cholesterol. Mol Cell Endocrinol. 2008 Nov 25; 295(1-2):115-20.

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