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Frida Kleiman

TitleAssociate Professor of Chemistry
InstitutionHunter College, CUNY
Departmentchemistry
AddressRoom 1307 HN, Hunter College, CUNY
695 Park Avenue
New York NY 10065
Phone(212) 772-5355
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    Collapse Research 
    Collapse research activities and funding
    F05TW005379     (KLEIMAN, FRIDA E)Sep 15, 1997
    NIH
    PROTEIN/PROTEIN INTERACTIONS IN THE POLYADENYLATION COMP
    Role: Principal Investigator
    SC1GM083806     (KLEIMAN, FRIDA E)May 1, 2008 - Apr 30, 2012
    NIH
    Mechanisms of Response to DNA Damage Nuclear Factors
    Role: Principal Investigator
    R21CA175794     (KLEIMAN, FRIDA E)Apr 1, 2013 - Mar 31, 2016
    NIH
    Role of nucleolin in regulating mRNA stability during DNA damage response (DDR)
    Role: Principal Investigator
    R21CA204610     (KLEIMAN, FRIDA E)Mar 8, 2017 - Feb 29, 2020
    NIH
    Role of the mRNA 3? processing factor CstF-50 in regulating the BRCA1/BARD1 E3 ubiquitin ligase activity during the DNA damage response
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Murphy MR, Ramadei A, Doymaz A, Varriano S, Natelson DM, Yu A, Aktas S, Mazzeo M, Mazzeo M, Zakusilo G, Kleiman FE. Long non-coding RNA generated from CDKN1A gene by alternative polyadenylation regulates p21 expression during DNA damage response. Nucleic Acids Res. 2023 Nov 27; 51(21):11911-11926. PMID: 37870464.
      Citations:    Fields:    Translation:HumansCells
    2. Alonso ADC, El Idrissi A, Candia R, Morozova V, Kleiman FE. Tau: More than a microtubule-binding protein in neurons. Cytoskeleton (Hoboken). 2024 Jan; 81(1):71-77. PMID: 37819542.
      Citations:    Fields:    Translation:HumansCells
    3. Murphy MR, Ramadei A, Doymaz A, Varriano S, Natelson D, Yu A, Aktas S, Mazzeo M, Mazzeo M, Zakusilo G, Kleiman FE. Long Non-Coding RNA Generated from CDKN1A Gene by Alternative Polyadenylation Regulates p21 Expression during DNA Damage Response. bioRxiv. 2023 Jan 10. PMID: 36711808.
      Citations:    
    4. Ghosh J, Schultz BM, Chan J, Wultsch C, Singh R, Shureiqi I, Chow S, Doymaz A, Varriano S, Driscoll M, Muse J, Kleiman FE, Krampis K, Issa JJ, Sapienza C. Epigenome-Wide Study Identifies Epigenetic Outliers in Normal Mucosa of Patients with Colorectal Cancer. Cancer Prev Res (Phila). 2022 11 01; 15(11):755-766. PMID: 36219239.
      Citations:    Fields:    Translation:HumansCells
    5. Murphy MR, Doymaz A, Kleiman FE. Poly(A) tail dynamics: Measuring polyadenylation, deadenylation and poly(A) tail length. Methods Enzymol. 2021; 655:265-290. PMID: 34183126.
      Citations: 2     Fields:    Translation:Cells
    6. Murphy MR, Kleiman FE. Connections between 3' end processing and DNA damage response: Ten years later. Wiley Interdiscip Rev RNA. 2020 03; 11(2):e1571. PMID: 31657151.
      Citations: 5     Fields:    Translation:Humans
    7. Baquero J, Varriano S, Ordonez M, Kuczaj P, Murphy MR, Aruggoda G, Lundine D, Morozova V, Makki AE, Alonso ADC, Kleiman FE. Nuclear Tau, p53 and Pin1 Regulate PARN-Mediated Deadenylation and Gene Expression. Front Mol Neurosci. 2019; 12:242. PMID: 31749682.
      Citations:    
    8. Alonso AD, Cohen LS, Corbo C, Morozova V, ElIdrissi A, Phillips G, Kleiman FE. Hyperphosphorylation of Tau Associates With Changes in Its Function Beyond Microtubule Stability. Front Cell Neurosci. 2018; 12:338. PMID: 30356756.
      Citations:    
    9. Fonseca D, Baquero J, Murphy MR, Aruggoda G, Varriano S, Sapienza C, Mashadova O, Rahman S, Kleiman FE. mRNA Processing Factor CstF-50 and Ubiquitin Escort Factor p97 Are BRCA1/BARD1 Cofactors Involved in Chromatin Remodeling during the DNA Damage Response. Mol Cell Biol. 2018 02 15; 38(4). PMID: 29180510.
      Citations: 6     Fields:    Translation:HumansCells
    10. Zhang X, Xiao S, Rameau RD, Devany E, Nadeem Z, Caglar E, Ng K, Kleiman FE, Saxena A. Nucleolin phosphorylation regulates PARN deadenylase activity during cellular stress response. RNA Biol. 2018 02 01; 15(2):251-260. PMID: 29168431.
      Citations: 9     Fields:    Translation:HumansCells
    11. Devany E, Park JY, Murphy MR, Zakusilo G, Baquero J, Zhang X, Hoque M, Tian B, Kleiman FE. Intronic cleavage and polyadenylation regulates gene expression during DNA damage response through U1 snRNA. Cell Discov. 2016; 2:16013. PMID: 27462460.
      Citations:    
    12. Zhang X, Devany E, Murphy MR, Glazman G, Persaud M, Kleiman FE. PARN deadenylase is involved in miRNA-dependent degradation of TP53 mRNA in mammalian cells. Nucleic Acids Res. 2015 Dec 15; 43(22):10925-38. PMID: 26400160.
      Citations: 29     Fields:    Translation:HumansCells
    13. Zhang X, Kleiman FE, Devany E. Deadenylation and its regulation in eukaryotic cells. Methods Mol Biol. 2014; 1125:289-96. PMID: 24590797.
      Citations: 3     Fields:    Translation:HumansCells
    14. Devany E, Zhang X, Park JY, Tian B, Kleiman FE. Positive and negative feedback loops in the p53 and mRNA 3' processing pathways. Proc Natl Acad Sci U S A. 2013 Feb 26; 110(9):3351-6. PMID: 23401530.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    15. Goss DJ, Kleiman FE. Poly(A) binding proteins: are they all created equal? Wiley Interdiscip Rev RNA. 2013 Mar-Apr; 4(2):167-79. PMID: 23424172.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    16. Nazeer FI, Devany E, Mohammed S, Fonseca D, Akukwe B, Taveras C, Kleiman FE. p53 inhibits mRNA 3' processing through its interaction with the CstF/BARD1 complex. Oncogene. 2011 Jul 07; 30(27):3073-83. PMID: 21383700.
      Citations: 24     Fields:    Translation:HumansCells
    17. Zhang X, Virtanen A, Kleiman FE. To polyadenylate or to deadenylate: that is the question. Cell Cycle. 2010 Nov 15; 9(22):4437-49. PMID: 21084869.
      Citations: 44     Fields:    Translation:AnimalsCells
    18. Cevher MA, Kleiman FE. Connections between 3'-end processing and DNA damage response. Wiley Interdiscip Rev RNA. 2010 Jul-Aug; 1(1):193-9. PMID: 21956914.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    19. Cevher MA, Zhang X, Fernandez S, Kim S, Baquero J, Nilsson P, Lee S, Virtanen A, Kleiman FE. Nuclear deadenylation/polyadenylation factors regulate 3' processing in response to DNA damage. EMBO J. 2010 May 19; 29(10):1674-87. PMID: 20379136.
      Citations: 39     Fields:    Translation:HumansCells
    20. Duffy T, Kleiman F, Pietrokovsky S, Issia L, Schijman AG, Wisnivesky-Colli C. Real-time PCR strategy for rapid discrimination among main lymnaeid species from Argentina. Acta Trop. 2009 Jan; 109(1):1-4. PMID: 18983808.
      Citations: 5     Fields:    Translation:Animals
    21. Edwards RA, Lee MS, Tsutakawa SE, Williams RS, Nazeer I, Kleiman FE, Tainer JA, Glover JN. The BARD1 C-terminal domain structure and interactions with polyadenylation factor CstF-50. Biochemistry. 2008 Nov 04; 47(44):11446-56. PMID: 18842000.
      Citations: 19     Fields:    Translation:HumansCells
    22. Mirkin N, Fonseca D, Mohammed S, Cevher MA, Manley JL, Kleiman FE. The 3' processing factor CstF functions in the DNA repair response. Nucleic Acids Res. 2008 Apr; 36(6):1792-804. PMID: 18252771.
      Citations: 29     Fields:    Translation:HumansCells
    23. Kim HS, Li H, Cevher M, Parmelee A, Fonseca D, Kleiman FE, Lee SB. DNA damage-induced BARD1 phosphorylation is critical for the inhibition of messenger RNA processing by BRCA1/BARD1 complex. Cancer Res. 2006 May 01; 66(9):4561-5. PMID: 16651405.
      Citations: 24     Fields:    Translation:HumansCells
    24. Shin C, Kleiman FE, Manley JL. Multiple properties of the splicing repressor SRp38 distinguish it from typical SR proteins. Mol Cell Biol. 2005 Sep; 25(18):8334-43. PMID: 16135820.
      Citations: 14     Fields:    Translation:HumansCells
    25. Kleiman FE, Wu-Baer F, Fonseca D, Kaneko S, Baer R, Manley JL. BRCA1/BARD1 inhibition of mRNA 3' processing involves targeted degradation of RNA polymerase II. Genes Dev. 2005 May 15; 19(10):1227-37. PMID: 15905410.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    26. Chen A, Kleiman FE, Manley JL, Ouchi T, Pan ZQ. Autoubiquitination of the BRCA1*BARD1 RING ubiquitin ligase. J Biol Chem. 2002 Jun 14; 277(24):22085-92. PMID: 11927591.
      Citations: 74     Fields:    Translation:HumansCells
    27. Kleiman FE, Manley JL. The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression. Cell. 2001 Mar 09; 104(5):743-53. PMID: 11257228.
      Citations: 98     Fields:    Translation:HumansCells
    28. Kleiman FE, Manley JL. Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50. Science. 1999 Sep 03; 285(5433):1576-9. PMID: 10477523.
      Citations: 64     Fields:    Translation:HumansCells
    29. Kleiman FE, Ram?rez AO, Dodelson de Kremer R, Gravel RA, Argara?a CE. A frequent TG deletion near the polyadenylation signal of the human HEXB gene: occurrence of an irregular DNA structure and conserved nucleotide sequence motif in the 3' untranslated region. Hum Mutat. 1998; 12(5):320-9. PMID: 9792408.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    30. Kleiman FE, de Kremer RD, de Ramirez AO, Gravel RA, Argara?a CE. Sandhoff disease in Argentina: high frequency of a splice site mutation in the HEXB gene and correlation between enzyme and DNA-based tests for heterozygote detection. Hum Genet. 1994 Sep; 94(3):279-82. PMID: 8076944.
      Citations: 9     Fields:    Translation:HumansCells
    31. Speiser AM, Kleiman MA, Saczawa AF, Kleiman F. Toothpaste discoloration of composite resin in vitro. Quintessence Int Dent Dig. 1983 Jul; 14(7):761-7. PMID: 6577501.
      Citations:    Fields:    
    32. Izzo JL, Roncone AM, Kleiman F. Subcellular distribution of 125I-insulin by rat liver: specificity and regulatory factors. Am J Physiol. 1983 Mar; 244(3):E272-81. PMID: 6338739.
      Citations:    Fields:    Translation:AnimalsCells
    33. KLEIMAN F. [Effects of anesthesia on the newborn infant]. Prensa Med Argent. 1961 Dec 01; 48:3250-61. PMID: 14456726.
      Citations:    
    34. KLEIMAN F. [Levomepromazine in anesthesiological practice]. Dia Med. 1961 Jul 17; 33:1369-72. PMID: 13756627.
      Citations:    
    35. KLEIMAN F. Obstetric anesthesia; trichlorethylene. Sem Med. 1949 Feb 17; 56(7):207-14. PMID: 18114235.
      Citations:    
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