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Wayne W. Harding

TitleAssistant Professor of Chemistry
InstitutionHunter College, CUNY
Departmentchemistry
AddressRoom 1307 HN, Hunter College, CUNY
695 Park Avenue
New York NY 10065
Phone(212) 772-5359
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Namballa HK, Decker AM, Dorogan M, Gudipally A, Goclon J, Harding WW. Fluoroalkoxylated C-3 and C-9 (S)-12-bromostepholidine analogues with D1R antagonist activity. Bioorg Chem. 2023 12; 141:106862. PMID: 37722267.
      Citations:    Fields:    
    2. Giri R, Namballa HK, Emogaje V, Harding WW. Structure-Activity Relationship Studies on 6-Chloro-1-phenylbenzazepines Leads to the Identification of a New Dopamine D1 Receptor Antagonist. Molecules. 2023 Aug 11; 28(16). PMID: 37630262.
      Citations:    Fields:    
    3. Namballa HK, Dorogan M, Gudipally AR, Okafor S, Gadhiya S, Harding WW. Discovery of Selective Dopamine Receptor Ligands Derived from (-)-Stepholidine via C-3 Alkoxylation and C-3/C-9 Dialkoxylation. J Med Chem. 2023 07 27; 66(14):10060-10079. PMID: 37421373.
      Citations: 1     Fields:    
    4. Cai T, Xie L, Zhang S, Chen M, He D, Badkul A, Liu Y, Namballa HK, Dorogan M, Harding WW, Mura C, Bourne PE, Xie L. End-to-end sequence-structure-function meta-learning predicts genome-wide chemical-protein interactions for dark proteins. PLoS Comput Biol. 2023 01; 19(1):e1010851. PMID: 36652496.
      Citations: 1     Fields:    Translation:HumansCells
    5. Namballa HK, Madapa S, Sigalapalli DK, Harding WW. Semisynthetic Transformations on (+)-Boldine Reveal a 5-HT2A/2CR Antagonist. J Nat Prod. 2022 09 23; 85(9):2149-2158. PMID: 36001775.
      Citations:    Fields:    Translation:HumansCells
    6. Cordone P, Namballa HK, Muniz B, Pal RK, Gallicchio E, Harding WW. New tetrahydroisoquinoline-based D3R ligands with an o-xylenyl linker motif. Bioorg Med Chem Lett. 2021 06 15; 42:128047. PMID: 33882273.
      Citations:    Fields:    Translation:HumansCells
    7. Bennett A, Barrera E, Namballa H, Harding W, Ranaldi R. (-)-Stepholidine blocks expression, but not development, of cocaine conditioned place preference in rats. Neurosci Lett. 2020 08 24; 734:135151. PMID: 32531529.
      Citations: 2     Fields:    Translation:Animals
    8. Karki A, Namballa HK, Alberts I, Harding WW. Structural manipulation of aporphines via C10 nitrogenation leads to the identification of new 5-HT7AR ligands. Bioorg Med Chem. 2020 08 01; 28(15):115578. PMID: 32631561.
      Citations: 1     Fields:    Translation:HumansCells
    9. Giri R, Namballa HK, Sarker A, Alberts I, Harding WW. Synthesis and dopamine receptor pharmacological evaluations on ring C ortho halogenated 1-phenylbenzazepines. Bioorg Med Chem Lett. 2020 08 15; 30(16):127305. PMID: 32631525.
      Citations: 3     Fields:    Translation:Cells
    10. Giri R, Alberts I, Harding WW. Synthesis, pharmacological evaluations, and molecular docking studies on a new 1,3,4,11b-tetrahydro-1H-fluoreno[9,1-cd]azepine framework: Rigidification of D1 receptor selective 1-phenylbenzazepines and discovery of a new 5-HT6 receptor scaffold. Chem Biol Drug Des. 2020 08; 96(2):825-835. PMID: 32279445.
      Citations:    Fields:    Translation:Cells
    11. Cordone P, Namballa HK, Harding WW. First synthesis of thiazepino[3,4-a]isoquinolines, a facile new synthetic route to diazepino[3,4-a]isoquinolines and assessment of their dopamine and s receptor affinities. J Heterocycl Chem. 2020 Oct; 57(10):3709-3713. PMID: 34565832.
      Citations:    
    12. Karki A, Juarez R, Namballa HK, Alberts I, Harding WW. Identification of C10 nitrogen-containing aporphines with dopamine D1 versus D5 receptor selectivity. Bioorg Med Chem Lett. 2020 04 15; 30(8):127053. PMID: 32107165.
      Citations: 2     Fields:    Translation:HumansCells
    13. Gadhiya S, Cordone P, Pal RK, Gallicchio E, Wickstrom L, Kurtzman T, Ramsey S, Harding WW. New Dopamine D3-Selective Receptor Ligands Containing a 6-Methoxy-1,2,3,4-tetrahydroisoquinolin-7-ol Motif. ACS Med Chem Lett. 2018 Oct 11; 9(10):990-995. PMID: 30344905.
      Citations:    
    14. Manuszak M, Harding W, Gadhiya S, Ranaldi R. (-)-Stepholidine reduces cue-induced reinstatement of cocaine seeking and cocaine self-administration in rats. Drug Alcohol Depend. 2018 08 01; 189:49-54. PMID: 29879681.
      Citations: 7     Fields:    Translation:Animals
    15. Madapa S, Gadhiya S, Kurtzman T, Alberts IL, Ramsey S, Reith M, Harding WW. Synthesis and evaluation of C9 alkoxy analogues of (-)-stepholidine as dopamine receptor ligands. Eur J Med Chem. 2017 Jan 05; 125:255-268. PMID: 27688181.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    16. Galaj E, Harding W, Ranaldi R. Dopamine D1 and D3 receptor interactions in cocaine reward and seeking in rats. Psychopharmacology (Berl). 2016 Dec; 233(23-24):3881-3890. PMID: 27582181.
      Citations: 8     Fields:    Translation:Animals
    17. Kapadia N, Ahmed S, Harding WW. New halogenated tris-(phenylalkyl)amines as h5-HT2B receptor ligands. Bioorg Med Chem Lett. 2016 07 15; 26(14):3216-3219. PMID: 27261181.
      Citations: 2     Fields:    Translation:HumansCells
    18. Gadhiya S, Madapa S, Kurtzman T, Alberts IL, Ramsey S, Pillarsetty NK, Kalidindi T, Harding WW. Tetrahydroprotoberberine alkaloids with dopamine and s receptor affinity. Bioorg Med Chem. 2016 May 01; 24(9):2060-71. PMID: 27032890.
      Citations: 4     Fields:    
    19. Ponnala S, Kapadia N, Madapa S, Alberts IL, Harding WW. Synthesis and evaluation of aporphine analogs containing C1 allyl isosteres at the h5-HT(2A) receptor. Bioorg Med Chem Lett. 2015 Nov 15; 25(22):5102-6. PMID: 26475518.
      Citations: 3     Fields:    Translation:Humans
    20. Kapadia N, Harding WW. C4 phenyl aporphines with selective h5-HT(2B) receptor affinity. Bioorg Med Chem Lett. 2015 Sep 01; 25(17):3451-4. PMID: 26227772.
      Citations: 2     Fields:    Translation:Cells
    21. Gadhiya S, Ponnala S, Harding WW. A divergent route to 9, 10-oxygenated tetrahydroprotoberberine and 8-oxoprotoberberine alkaloids: synthesis of (?)-isocorypalmine and oxypalmatine. Tetrahedron. 2015 Feb 25; 71(8):1227-1231. PMID: 25691805.
      Citations: 8     Fields:    
    22. Madapa S, Harding WW. Semisynthetic Studies on and Biological Evaluation of N-Methyllaurotetanine Analogues as Ligands for 5-HT Receptors. J Nat Prod. 2015 Apr 24; 78(4):722-9. PMID: 25695425.
      Citations: 2     Fields:    Translation:Cells
    23. Ponnala S, Kapadia N, Navarro HA, Harding WW. Aporphinoid antagonists of 5-HT2A receptors: further evaluation of ring A substituents and the size of ring C. Chem Biol Drug Des. 2014 Nov; 84(5):558-66. PMID: 24766771.
      Citations: 3     Fields:    
    24. Ponnala S, Gonzales J, Kapadia N, Navarro HA, Harding WW. Evaluation of structural effects on 5-HT(2A) receptor antagonism by aporphines: identification of a new aporphine with 5-HT(2A) antagonist activity. Bioorg Med Chem Lett. 2014 Apr 01; 24(7):1664-7. PMID: 24630561.
      Citations: 6     Fields:    Translation:HumansCells
    25. Kapadia N, Harding W. Facile synthesis of 4,5,6a,7-tetrahydrodibenzo[de,g]chromene heterocycles and their transformation to phenanthrene alkaloids. Tetrahedron. 2013 Oct 21; 69(42). PMID: 24187388.
      Citations: 1     Fields:    
    26. Ponnala S, Harding WW. A New Route to Azafluoranthene Natural Products via Direct Arylation. European J Org Chem. 2013 Feb 01; 3013(6):1107-1115. PMID: 23503080.
      Citations:    
    27. He F, Lindqvist C, Harding WW. Leonurenones A-C: Labdane diterpenes from Leonotis leonurus. Phytochemistry. 2012 Nov; 83:168-72. PMID: 22892215.
      Citations: 2     Fields:    Translation:AnimalsCells
    28. Chaudhary S, Ponnala S, Legendre O, Gonzales JA, Navarro HA, Harding WW. New aporphinoid 5-HT2A and a1A antagonists via structural manipulations of nantenine. Bioorg Med Chem. 2011 Oct 01; 19(19):5861-8. PMID: 21900013.
      Citations: 7     Fields:    
    29. Ponnala S, Chaudhary S, Gonz?lez-Sarrias A, Seeram NP, Harding WW. Cytotoxicity of aporphines in human colon cancer cell lines HCT-116 and Caco-2: an SAR study. Bioorg Med Chem Lett. 2011 Aug 01; 21(15):4462-4. PMID: 21724394.
      Citations: 7     Fields:    Translation:HumansCells
    30. Chaudhary S, Harding WW. Synthesis of C-Homoaporphines via Microwave-Assisted Direct Arylation. Tetrahedron. 2011 Jan 21; 67(3):569-575. PMID: 21399710.
      Citations: 5     Fields:    
    31. Pecic S, McAnuff MA, Harding WW. Nantenine as an acetylcholinesterase inhibitor: SAR, enzyme kinetics and molecular modeling investigations. J Enzyme Inhib Med Chem. 2011 Feb; 26(1):46-55. PMID: 20583856.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    32. Pecic S, Makkar P, Chaudhary S, Reddy BV, Navarro HA, Harding WW. Affinity of aporphines for the human 5-HT2A receptor: insights from homology modeling and molecular docking studies. Bioorg Med Chem. 2010 Aug 01; 18(15):5562-75. PMID: 20621490.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    33. Legendre O, Pecic S, Chaudhary S, Zimmerman SM, Fantegrossi WE, Harding WW. Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine. Bioorg Med Chem Lett. 2010 Jan 15; 20(2):628-31. PMID: 19963380.
      Citations: 9     Fields:    Translation:AnimalsCells
    34. Chaudhary S, Pecic S, Legendre O, Harding WW. Microwave-Assisted Direct Biaryl Coupling: First Application to the Synthesis of Aporphines. Tetrahedron Lett. 2009 May 20; 50(20):2437-2439. PMID: 20161231.
      Citations: 14     Fields:    
    35. Chaudhary S, Pecic S, Legendre O, Navarro HA, Harding WW. (+/-)-Nantenine analogs as antagonists at human 5-HT(2A) receptors: C1 and flexible congeners. Bioorg Med Chem Lett. 2009 May 01; 19(9):2530-2. PMID: 19328689.
      Citations: 15     Fields:    Translation:HumansCells
    36. Chaudhary S, Thomas V, Todaro L, Legendre O, Pecic S, Harding WW. New Drimane Sesquiterpenoids from Tidestromia oblongifolia. Nat Prod Commun. 2008; 3(11):1747-1750. PMID: 21552503.
      Citations:    Fields:    
    37. Simpson DS, Katavic PL, Lozama A, Harding WW, Parrish D, Deschamps JR, Dersch CM, Partilla JS, Rothman RB, Navarro H, Prisinzano TE. Synthetic studies of neoclerodane diterpenes from Salvia divinorum: preparation and opioid receptor activity of salvinicin analogues. J Med Chem. 2007 Jul 26; 50(15):3596-603. PMID: 17580847.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    38. Harding WW, Schmidt M, Tidgewell K, Kannan P, Holden KG, Dersch CM, Rothman RB, Prisinzano TE. Synthetic studies of neoclerodane diterpenes from Salvia divinorum: selective modification of the furan ring. Bioorg Med Chem Lett. 2006 Jun 15; 16(12):3170-4. PMID: 16621556.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    39. Harding WW, Schmidt M, Tidgewell K, Kannan P, Holden KG, Gilmour B, Navarro H, Rothman RB, Prisinzano TE. Synthetic studies of neoclerodane diterpenes from Salvia divinorum: semisynthesis of salvinicins A and B and other chemical transformations of salvinorin A. J Nat Prod. 2006 Jan; 69(1):107-12. PMID: 16441078.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    40. Tidgewell K, Harding WW, Schmidt M, Holden KG, Murry DJ, Prisinzano TE. A facile method for the preparation of deuterium labeled salvinorin A: synthesis of [2,2,2-2H3]-salvinorin A. Bioorg Med Chem Lett. 2004 Oct 18; 14(20):5099-102. PMID: 15380207.
      Citations: 31     Fields:    Translation:HumansPHPublic Health
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