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Yanagihara, Richard

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overview	Dr. Richard Yanagihara, formerly a tenured intramural NIH investigator, was recruited through an interagency personnel agreement in 1995 to assist in building capacity for a laboratory-based retrovirology research program in the Research Centers in Minority Institutions (RCMI) program at the University of Hawaii at Manoa (UHM). He served as the UHM RCMI Program Director in 2000–2011, has been the principal investigator of the Pacific Center for Emerging Infectious Diseases Research since 2003, and the director of the Research Coordinating Center of the former RCMI Translational Research Network (RTRN) in 2008–2019. Currently, he is one of the multiple principal investigators of the RCMI Coordinating Center. As such, he has played a critical role in coordinating the development of much-needed infrastructure for bioscience research at the university and across the RCMI community. In particular, he has been deeply involved in mentoring junior faculty, as well as developing programs that provide grant support for pilot projects and bridging funds. His extensive knowledge about the biomedical research portfolio and research resources at the RCMI grantee institutions, as well as his long-standing personal relationships with RCMI investigators, makes him eminently qualified to take a leadership role in the RCMI Coordinating Center. Dr. Yanagihara's own research has been conducted largely in the context of exploiting naturally occurring paradigms of high-incidence ‘place diseases’ in populations isolated by virtue of genetics, culture and/or geography. Notable among these scientific explorations, chronicled in more than 300 publications, have been the demonstration of a cohort effect in the high-incidence focus of amyotrophic lateral sclerosis and parkinsonism-dementia among Chamorros on Guam and the discovery and characterization of genetically distinct variants of human T-cell lymphotropic virus type I in remote Melanesian populations in Papua New Guinea and Solomon Islands. In addition, his decades-long research effort on the molecular phylogeny and phylogeography of rodent-borne hantaviruses has led to the realization that shrews and moles (Order Eulipotyphla) and bats (Order Chiroptera) may have served as the original reservoirs of ancestral hantaviruses. New knowledge and insights from this research has required the rewriting of textbook chapters on hantaviruses and changes to their taxonomic classification.

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overview

Dr. Richard Yanagihara, formerly a tenured intramural NIH investigator, was recruited through an interagency personnel agreement in 1995 to assist in building capacity for a laboratory-based retrovirology research program in the Research Centers in Minority Institutions (RCMI) program at the University of Hawaii at Manoa (UHM). He served as the UHM RCMI Program Director in 2000–2011, has been the principal investigator of the Pacific Center for Emerging Infectious Diseases Research since 2003, and the director of the Research Coordinating Center of the former RCMI Translational Research Network (RTRN) in 2008–2019. Currently, he is one of the multiple principal investigators of the RCMI Coordinating Center. As such, he has played a critical role in coordinating the development of much-needed infrastructure for bioscience research at the university and across the RCMI community. In particular, he has been deeply involved in mentoring junior faculty, as well as developing programs that provide grant support for pilot projects and bridging funds. His extensive knowledge about the biomedical research portfolio and research resources at the RCMI grantee institutions, as well as his long-standing personal relationships with RCMI investigators, makes him eminently qualified to take a leadership role in the RCMI Coordinating Center. Dr. Yanagihara's own research has been conducted largely in the context of exploiting naturally occurring paradigms of high-incidence ‘place diseases’ in populations isolated by virtue of genetics, culture and/or geography. Notable among these scientific explorations, chronicled in more than 300 publications, have been the demonstration of a cohort effect in the high-incidence focus of amyotrophic lateral sclerosis and parkinsonism-dementia among Chamorros on Guam and the discovery and characterization of genetically distinct variants of human T-cell lymphotropic virus type I in remote Melanesian populations in Papua New Guinea and Solomon Islands. In addition, his decades-long research effort on the molecular phylogeny and phylogeography of rodent-borne hantaviruses has led to the realization that shrews and moles (Order Eulipotyphla) and bats (Order Chiroptera) may have served as the original reservoirs of ancestral hantaviruses. New knowledge and insights from this research has required the rewriting of textbook chapters on hantaviruses and changes to their taxonomic classification.

One or more keywords matched the following items that are connected to Yanagihara, Richard

Item Type	Name
Academic Article	Complete nef gene sequence of HIV type 1 subtype B' from professional plasma donors in the People's Republic of China.
Academic Article	Genetic diversity and phylogeography of Seewis virus in the Eurasian common shrew in Finland and Hungary.
Academic Article	Gradual loss of IgG antibodies against GB virus C/hepatitis G virus in a patient with AIDS.
Academic Article	Progressive multifocal leukoencephalopathy (PML) and cerebral toxoplasmosis in an adult patient, with no symptoms of underlying immunosuppressing illness.
Academic Article	Short report: Genetic diversity of Thottapalayam virus, a Hantavirus harbored by the Asian house shrew (Suncus murinus) in Nepal.
Academic Article	Seewis virus: phylogeography of a shrew-borne hantavirus in Siberia, Russia.
Academic Article	Genetic diversity of Imjin virus in the Ussuri white-toothed shrew (Crocidura lasiura) in the Republic of Korea, 2004-2010.
Academic Article	Identification of a small, naked virus in tumor-like aggregates in cell lines derived from a green turtle, Chelonia mydas, with fibropapillomas.
Academic Article	Molecular evolution of Azagny virus, a newfound hantavirus harbored by the West African pygmy shrew (Crocidura obscurior) in C?te d'Ivoire.
Academic Article	Lack of association between Kawasaki syndrome and infection with parvovirus B19, human herpesvirus 8, TT virus, GB virus C/hepatitis G virus or Chlamydia pneumoniae.
Academic Article	Distinct innate immune responses in human macrophages and endothelial cells infected with shrew-borne hantaviruses.
Academic Article	Verification of HTLV-I infection in the Solomon Islands by virus isolation and gene amplification.
Academic Article	Humoral responses to the immunodominant gag and env epitopes of human T-lymphotropic virus type I among Melanesians.
Academic Article	Boginia virus, a newfound hantavirus harbored by the Eurasian water shrew (Neomys fodiens) in Poland.
Academic Article	Clinical and molecular epidemiological features of hemorrhagic fever with renal syndrome in Korea over a 10-year period.
Academic Article	Induction of endoplasmic reticulum-derived replication-competent membrane structures by West Nile virus non-structural protein 4B.
Academic Article	Whole-genome sequence of muju virus, an arvicolid rodent-borne hantavirus.
Academic Article	Muju virus, harbored by Myodes regulus in Korea, might represent a genetic variant of Puumala virus, the prototype arvicolid rodent-borne hantavirus.
Academic Article	Molecular phylogeny of hantaviruses harbored by insectivorous bats in C?te d'Ivoire and Vietnam.
Academic Article	Hantaviruses induce cell type- and viral species-specific host microRNA expression signatures.
Academic Article	Hantaviruses: rediscovery and new beginnings.
Academic Article	Hantaviruses induce antiviral and pro-inflammatory innate immune responses in astrocytic cells and the brain.
Academic Article	Genetic Diversity of Talpa Europaea and Nova Hanta Virus (NVAV) in France.
Academic Article	Hokkaido genotype of Puumala virus in the grey red-backed vole (Myodes rufocanus) and northern red-backed vole (Myodes rutilus) in Siberia.
Academic Article	Lethal disease in infant and juvenile Syrian hamsters experimentally infected with Imjin virus, a newfound crocidurine shrew-borne hantavirus.
Academic Article	Genetic Diversity of Artybash Virus in the Laxmann's Shrew (Sorex caecutiens).
Academic Article	Characterization of a variant of human T-lymphotropic virus type I isolated from a healthy member of a remote, recently contacted group in Papua New Guinea.
Academic Article	Dahonggou Creek virus, a divergent lineage of hantavirus harbored by the long-tailed mole (Scaptonyx fusicaudus).
Academic Article	A Novel Hantavirus of the European Mole, Bruges Virus, Is Involved in Frequent Nova Virus Coinfections.
Academic Article	Human T-cell lymphotropic virus type I in Iranian-born Mashhadi Jews: genetic and phylogenetic evidence for common source of infection.
Academic Article	Genetic analysis and molecular phylogeny of simian T-cell lymphotropic virus type I: evidence for independent virus evolution in Asia and Africa.
Academic Article	Sequence analysis of human T cell lymphotropic virus type I strains from southern India: gene amplification and direct sequencing from whole blood blotted onto filter paper.
Academic Article	Human retroviruses in Amerindians of Colombia: high prevalence of human T cell lymphotropic virus type II infection among the Tunebo Indians.
Academic Article	Interfamilial and intrafamilial genomic diversity and molecular phylogeny of human T-cell lymphotropic virus type I from Papua New Guinea and the Solomon Islands.
Academic Article	Molecular Phylogeny of Mobatviruses (Hantaviridae) in Myanmar and Vietnam.
Academic Article	Complex History of Codiversification and Host Switching of a Newfound Soricid-Borne Orthohantavirus in North America.
Academic Article	?akr?ng virus, a novel mobatvirus (Hantaviridae) harbored by the Stoliczka's Asian trident bat (Aselliscus stoliczkanus) in Vietnam.
Academic Article	Highly Divergent Genetic Variants of Soricid-Borne Altai Virus (Hantaviridae) in Eurasia Suggest Ancient Host-Switching Events.
Academic Article	Author Correction: ?akr?ng virus, a novel mobatvirus (Hantaviridae) harbored by the Stoliczka's Asian trident bat (Aselliscus stoliczkanus) in Vietnam.
Academic Article	High prevalence of GB virus C/hepatitis G virus infection among homosexual men infected with human immunodeficiency virus type 1: evidence for sexual transmission.
Academic Article	Lack of association between acquisition of TT virus and risk behavior for HIV and HCV infection in Vietnam.
Academic Article	TT virus: preferential distribution in CD19(+) peripheral blood mononuclear cells and lack of viral integration.
Academic Article	Investigation of TT virus in the etiology of pediatric acute lymphoblastic leukemia.
Academic Article	RT-PCR detection of the expression of the polymerase gene of a novel reptilian herpesvirus in tumor tissues of green turtles with fibropapilloma.
Academic Article	Viral susceptibility of newly established cell lines from the Hawaiian monk seal Monachus schauinslandi.
Academic Article	Characterization of Tula virus from common voles (microtus arvalis) in Poland: evidence for geographic-specific phylogenetic clustering.
Academic Article	West Nile virus surveillance: A simple method for verifying the integrity of RNA in mosquito (Diptera: Culicidae) pools.
Academic Article	Fecal excretion of a novel human circovirus, TT virus, in healthy children.
Academic Article	Reconstructing population history using JC virus: Amerinds, Spanish, and Africans in the ancestry of modern Puerto Ricans.
Academic Article	Predicted amino acid sequences for 100 JCV strains.
Academic Article	Failure to isolate human T cell lymphotropic virus type I and to detect variant-specific genomic sequences by polymerase chain reaction in Melanesians with indeterminate western immunoblot.
Academic Article	JC virus genotypes in the western Pacific suggest Asian mainland relationships and virus association with early population movements.
Academic Article	HIV-1-based defective lentiviral vectors efficiently transduce human monocytes-derived macrophages and suppress replication of wild-type HIV-1.
Academic Article	Soochong virus: an antigenically and genetically distinct hantavirus isolated from Apodemus peninsulae in Korea.
Academic Article	Sequence and phylogenetic analyses of human T cell lymphotropic virus type 1 from a Brazilian woman with adult T cell leukemia: comparison with virus strains from South America and the Caribbean basin.
Academic Article	Development of serological assays for Thottapalayam virus, an insectivore-borne Hantavirus.
Academic Article	Polyomavirus JC infects human brain microvascular endothelial cells independent of serotonin receptor 2A.
Academic Article	Genotyping of human T cell lymphotropic virus type I using Australo-Melanesian topotype-specific oligonucleotide primer-based polymerase chain reaction: insights into viral evolution and dissemination.
Academic Article	Genetic and phylogenetic analyses of human T-cell lymphotropic virus type I variants from Melanesians with and without spastic myelopathy.
Academic Article	JC virus induces altered patterns of cellular gene expression: interferon-inducible genes as major transcriptional targets.
Academic Article	Molecular phylogeny and dissemination of human T-cell lymphotropic virus type I viewed within the context of primate evolution and human migration.
Academic Article	Seewis virus, a genetically distinct hantavirus in the Eurasian common shrew (Sorex araneus).
Academic Article	In vitro effects of selenium deficiency on West Nile virus replication and cytopathogenicity.
Academic Article	Characterization of Imjin virus, a newly isolated hantavirus from the Ussuri white-toothed shrew (Crocidura lasiura).
Academic Article	Muju virus, a novel hantavirus harboured by the arvicolid rodent Myodes regulus in Korea.
Academic Article	Thottapalayam virus, a prototype shrewborne hantavirus.
Academic Article	Inhibition of West Nile Virus replication by retrovirus-delivered small interfering RNA in human neuroblastoma cells.
Academic Article	Effective modifications for improved homologous recombination and high-efficiency generation of recombinant adenovirus-based vectors.
Concept	Borna disease virus
Concept	Defective Viruses
Concept	DNA Virus Infections
Concept	DNA Viruses
Concept	Hepatitis Viruses
Concept	JC Virus
Concept	Moloney murine leukemia virus
Concept	Influenza A virus
Concept	Parainfluenza Virus 1, Human
Concept	Parainfluenza Virus 2, Human
Concept	RNA Viruses
Concept	Tumor Virus Infections
Concept	Viruses, Unclassified
Concept	Vesicular stomatitis Indiana virus
Concept	Virus Cultivation
Concept	Virus Replication
Concept	Viruses
Concept	West Nile virus
Concept	Simian T-lymphotropic virus 1
Concept	Human T-lymphotropic virus 1
Concept	Virus Integration
Concept	Reassortant Viruses
Concept	Hantaan virus
Concept	Virus Assembly
Concept	Torque teno virus
Concept	Puumala virus
Concept	Seoul virus
Concept	Influenza A Virus, H1N1 Subtype
Concept	env Gene Products, Human Immunodeficiency Virus
Concept	nef Gene Products, Human Immunodeficiency Virus
Grant	Intraspecies Transmission and Infectivity of Insectivore-Borne Hantaviruses
Academic Article	New hemorrhagic fever with renal syndrome-related virus in rodents in the United States.
Academic Article	Other serotypes of hemorrhagic fever with renal syndrome viruses in Europe.
Academic Article	Sensitivity and specificity of a recombinant transmembrane glycoprotein (rgp21)-spiked western immunoblot for serological confirmation of human T-cell lymphotropic virus type I and type II infections.
Academic Article	LTR sequence and phylogenetic analyses of a newly discovered variant of HTLV-I isolated from the Hagahai of Papua New Guinea.
Academic Article	Human T-lymphotropic virus type I infection in the Solomon Islands.
Academic Article	Experimental infection of human vascular endothelial cells by pathogenic and nonpathogenic hantaviruses.
Academic Article	Human T lymphotropic virus type I infection in Papua New Guinea: high prevalence among the Hagahai confirmed by western analysis.
Academic Article	Reevaluation of the ultrastructural pathology of experimental Creutzfeldt-Jakob disease. Serial studies of the Fujisaki strain of Creutzfeldt-Jakob disease virus in mice.
Academic Article	Simultaneous isolation of simian foamy virus and HTLV-III/LAV from chimpanzee lymphocytes following HTLV-III or LAV inoculation.
Academic Article	Immune spleen cell-mediated protection against fatal Hantaan virus infection in infant mice.
Academic Article	Serological evidence of Hantaan virus infection in the United States.
Academic Article	Experimental infection with Puumala virus, the etiologic agent of nephropathia epidemica, in bank voles (Clethrionomys glareolus).
Academic Article	Differential susceptibility and resistance of immunocompetent and immunodeficient mice to fatal Hantaan virus infection.
Academic Article	Serotypic classification of hantaviruses by indirect immunofluorescent antibody and plaque reduction neutralization tests.
Academic Article	Pathogenesis of experimental Hantaan virus infection in laboratory rats.
Academic Article	Serological survey of Prospect Hill virus infection in indigenous wild rodents in the USA.
Academic Article	Propagation of nephropathia epidemica virus in Mongolian gerbils.
Academic Article	Partial characterization of Prospect Hill virus isolated from meadow voles in the United States.
Academic Article	Isolation and propagation of nephropathia epidemica virus in bank voles.
Academic Article	Cryopreservation of virus-infected cells for use in the fluorescent antibody to membrane antigen test.
Academic Article	Secretory immunological response in infants and children to parainfluenza virus types 1 and 2.
Academic Article	Human T-cell lymphotropic virus type I infection and disease in the Pacific basin.
Academic Article	Coexistence of human T-lymphotropic virus types I and II among the Wayuu Indians from the Guajira Region of Colombia.
Academic Article	Specificity of an oligonucleotide primer pair and of a single-base substitution in the amplification and detection of env gene sequences of HTLV-I variants from Papua New Guinea and the Solomon Islands.
Academic Article	Evolutionary insights on the origin of human T-cell lymphoma/leukemia virus type I (HTLV-I) derived from sequence analysis of a new HTLV-I variant from Papua New Guinea.
Academic Article	Human T-lymphotropic virus type I infection among blood donors in the Solomon Islands.
Academic Article	Experimental Creutzfeldt-Jakob disease: light microscopic, immunohistochemical and ultrastructural studies of the Fujisaki strain of Creutzfeldt-Jakob disease virus in NIH Swiss mice.
Academic Article	Prevalence of human T-cell lymphotropic virus type I infection in Singapore: a preliminary report.
Academic Article	Comparison between strains of human T lymphotropic virus type I isolated from inhabitants of the Solomon Islands and Papua New Guinea.
Academic Article	Highly divergent molecular variants of human T-lymphotropic virus type I from isolated populations in Papua New Guinea and the Solomon Islands.
Academic Article	Spread of Creutzfeldt-Jakob disease virus along visual pathways after intraocular inoculation.
Academic Article	Neuroaxonal dystrophy: an ultrastructural link between subacute spongiform virus encephalopathies and Alzheimer's disease.
Academic Article	Leakey virus: a new hantavirus isolated from Mus musculus in the United States.
Academic Article	Intra-blood-brain barrier synthesis of human immunodeficiency virus antigen and antibody in humans and chimpanzees.
Academic Article	Morphology and morphogenesis of viruses of hemorrhagic fever with renal syndrome. II. Inclusion bodies--ultrastructural markers of hantavirus-infected cells.
Academic Article	Propagation of nephropathia epidemica virus in cell culture.
Academic Article	Prospect Hill virus: serologic evidence for infection in mammalogists.
Academic Article	Cross-neutralizing antibodies against cosmopolitan and Melanesian strains of human T cell leukemia/lymphotropic virus type I in sera from inhabitants of Africa and the Solomon Islands.
Academic Article	Geographic-specific genotypes or topotypes of human T-cell lymphotropic virus type I as markers for early and recent migrations of human populations.
Academic Article	Prophylaxis against a Melanesian variant of human T-lymphotropic virus type I (HTLV-I) in rabbits using HTLV-I immune globulin from asymptomatically infected Japanese carriers.
Academic Article	Sequence analysis of an immunogenic and neutralizing domain of the human T-cell lymphoma/leukemia virus type I gp46 surface membrane protein among various primate T-cell lymphoma/leukemia virus isolates including those from a patient with both HTLV-I-associated myelopathy and adult T-cell leukemia.
Academic Article	Attempts to establish cell cultures infected with the viruses of subacute spongiform encephalopathies.
Academic Article	Antigenic differences between European and East Asian strains of HFRS virus.
Academic Article	Molecular linkage of hantavirus pulmonary syndrome to the white-footed mouse, Peromyscus leucopus: genetic characterization of the M genome of New York virus.
Academic Article	Functional conservation of the neutralizing domains on the external envelope glycoprotein of cosmopolitan and melanesian strains of human T cell leukemia/lymphoma virus type I.
Academic Article	Immune recognition of genetically diverse simian T-cell lymphotropic virus type I isolates.
Academic Article	Ultrastructural pathology of human T-cell lymphotropic virus type I encephalomyelopathy in a white patient with adult T-cell leukemia/lymphoma.
Academic Article	Belgrade virus, a cause of hemorrhagic fever with renal syndrome in the Balkans, is closely related to Dobrava virus of field mice.
Academic Article	Complete nucleotide sequence of a highly divergent human T-cell leukemia (lymphotropic) virus type I (HTLV-I) variant from melanesia: genetic and phylogenetic relationship to HTLV-I strains from other geographical regions.
Academic Article	Genetic and phylogenetic analyses of hantaviral sequences amplified from archival tissues of deer mice (Peromyscus maniculatus nubiterrae) captured in the eastern United States.
Academic Article	Sequence analysis of the complete S genomic segment of a newly identified hantavirus isolated from the white-footed mouse (Peromyscus leucopus): phylogenetic relationship with other sigmodontine rodent-borne hantaviruses.
Academic Article	Failure to demonstrate Borna disease virus genome in peripheral blood mononuclear cells from psychiatric patients in Korea.
Academic Article	Human polyomavirus JC variants in Papua New Guinea and Guam reflect ancient population settlement and viral evolution.
Academic Article	Asian genotypes of JC virus in Native Americans and in a Pacific Island population: markers of viral evolution and human migration.
Academic Article	Exacerbation of influenzavirus pneumonia by intranasal administration of surfactant in a mouse model.
Academic Article	Genetic diversity of Apodemus agrarius-borne hantaan virus in Korea.
Academic Article	New JC virus (JCV) genotypes from papua new guinea and micronesia (type 8 and type 2E) and evolutionary analysis of 32 complete JCV genomes.
Academic Article	Neuropathogenesis of Zika Virus Infection : Potential Roles of Antibody-Mediated Pathology.
Academic Article	Reassortment Between Divergent Strains of Camp Ripley Virus (Hantaviridae) in the Northern Short-Tailed Shrew (Blarina brevicauda).
Academic Article	Geographic Distribution and Phylogeny of Soricine Shrew-Borne Seewis Virus and Altai Virus in Russia.
Academic Article	Rodent-Borne Orthohantaviruses in Vietnam, Madagascar and Japan.
Academic Article	Academ Virus, a Novel Hantavirus in the Siberian Mole (Talpa altaica) from Russia.
Academic Article	Phylogeny of Shrew- and Mole-Borne Hantaviruses in Poland and Ukraine.
Academic Article	Multiple Lineages of Hantaviruses Harbored by the Iberian Mole (Talpa occidentalis) in Spain.

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