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Quirk, Gregory J.

One or more keywords matched the following properties of Quirk, Gregory J.

Property	Value
keywords	fear
overview	My research focuses on the neural circuits of fear regulation, using rodent and human models of fear conditioning, extinction, and active avoidance. My lab uses a variety of experimental techniques including multichannel unit recording, optogenetics, immunocytochemistry, electrical stimulation, and computational modeling. We focus on how the prefrontal cortex influences fear-related activity in the amygdala, thalamus and striatum. This work is applicable to PTSD and OCD, and is funded by the National Institute of Mental Health. My lab has been in Puerto Rico for 18 years and consists of approximately 14 students, post-docs, and technicians, from the U.S., Puerto Rico, and other parts of Latin America. My long-term goal is to promote neuroscience research and training in Latin America.

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Value

keywords

fear

overview

My research focuses on the neural circuits of fear regulation, using rodent and human models of fear conditioning, extinction, and active avoidance. My lab uses a variety of experimental techniques including multichannel unit recording, optogenetics, immunocytochemistry, electrical stimulation, and computational modeling. We focus on how the prefrontal cortex influences fear-related activity in the amygdala, thalamus and striatum. This work is applicable to PTSD and OCD, and is funded by the National Institute of Mental Health. My lab has been in Puerto Rico for 18 years and consists of approximately 14 students, post-docs, and technicians, from the U.S., Puerto Rico, and other parts of Latin America. My long-term goal is to promote neuroscience research and training in Latin America.

One or more keywords matched the following items that are connected to Quirk, Gregory J.

Item Type	Name
Academic Article	Extending fear extinction beyond anxiety disorders.
Academic Article	The effects of yohimbine and amphetamine on fear expression and extinction in rats.
Academic Article	Systemic propranolol acts centrally to reduce conditioned fear in rats without impairing extinction.
Academic Article	Differential effects of amygdala lesions on early and late plastic components of auditory cortex spike trains during fear conditioning.
Academic Article	Sustained conditioned responses in prelimbic prefrontal neurons are correlated with fear expression and extinction failure.
Academic Article	Induction of fear extinction with hippocampal-infralimbic BDNF.
Academic Article	Memory for fear extinction requires mGluR5-mediated activation of infralimbic neurons.
Academic Article	Erasing fear memories with extinction training.
Academic Article	A time-dependent role of midline thalamic nuclei in the retrieval of fear memory.
Academic Article	Pharmacological facilitation of fear extinction and the search for adjunct treatments for anxiety disorders--the case of yohimbine.
Academic Article	Neuroscience: Editing out fear.
Academic Article	Prefrontal control of fear: more than just extinction.
Academic Article	Infralimbic D2 receptors are necessary for fear extinction and extinction-related tone responses.
Academic Article	Dissociable roles of prelimbic and infralimbic cortices, ventral hippocampus, and basolateral amygdala in the expression and extinction of conditioned fear.
Academic Article	Fear extinction as a model for translational neuroscience: ten years of progress.
Academic Article	Correlations between psychological tests and physiological responses during fear conditioning and renewal.
Academic Article	Gating of fear in prelimbic cortex by hippocampal and amygdala inputs.
Academic Article	Fear signaling in the prelimbic-amygdala circuit: a computational modeling and recording study.
Academic Article	Deep brain stimulation of the ventral striatum increases BDNF in the fear extinction circuit.
Academic Article	Resting amygdala and medial prefrontal metabolism predicts functional activation of the fear extinction circuit.
Academic Article	Deep brain stimulation of the ventral striatum enhances extinction of conditioned fear.
Academic Article	Neural structures mediating expression and extinction of platform-mediated avoidance.
Academic Article	A temporal shift in the circuits mediating retrieval of fear memory.
Academic Article	Enhancement of fear extinction with deep brain stimulation: evidence for medial orbitofrontal involvement.
Academic Article	Hippocampal--prefrontal BDNF and memory for fear extinction.
Academic Article	Ethnic differences in physiological responses to fear conditioned stimuli.
Academic Article	Revisiting the role of infralimbic cortex in fear extinction with optogenetics.
Academic Article	A Cross Species Approach to Understanding DBS Modulation of Fear.
Academic Article	Less fear, more diversity.
Academic Article	The effect of repeated exposure to ethanol on pre-existing fear memories in rats.
Academic Article	Fear conditioning enhances short-latency auditory responses of lateral amygdala neurons: parallel recordings in the freely behaving rat.
Academic Article	Active avoidance requires inhibitory signaling in the rodent prelimbic prefrontal cortex.
Academic Article	Prefrontal circuits signaling active avoidance?retrieval and extinction.
Academic Article	WHEN SCIENTIFIC PARADIGMS LEAD TO TUNNEL VISION: LESSONS FROM THE STUDY OF FEAR.
Academic Article	The study of active avoidance: A platform for discussion.
Academic Article	Fear research: implications for anxiety disorders.
Academic Article	Neurons in medial prefrontal cortex signal memory for fear extinction.
Academic Article	Memory for extinction of conditioned fear is long-lasting and persists following spontaneous recovery.
Academic Article	Inhibition of the amygdala: key to pathological states?
Academic Article	Stimulation of medial prefrontal cortex decreases the responsiveness of central amygdala output neurons.
Academic Article	Learning not to fear, faster.
Academic Article	The role of ventromedial prefrontal cortex in the recovery of extinguished fear.
Academic Article	Consolidation of extinction learning involves transfer from NMDA-independent to NMDA-dependent memory.
Academic Article	Electrical stimulation of medial prefrontal cortex reduces conditioned fear in a temporally specific manner.
Academic Article	New vistas on amygdala networks in conditioned fear.
Academic Article	Consolidation of fear extinction requires protein synthesis in the medial prefrontal cortex.
Academic Article	Lesions of the basal amygdala block expression of conditioned fear but not extinction.
Academic Article	Fear extinction in rats: implications for human brain imaging and anxiety disorders.
Academic Article	Prefrontal mechanisms in extinction of conditioned fear.
Academic Article	Extinction: new excitement for an old phenomenon.
Academic Article	Inactivation of the ventromedial prefrontal cortex reduces expression of conditioned fear and impairs subsequent recall of extinction.
Academic Article	Microstimulation reveals opposing influences of prelimbic and infralimbic cortex on the expression of conditioned fear.
Academic Article	Recall of fear extinction in humans activates the ventromedial prefrontal cortex and hippocampus in concert.
Academic Article	Delayed recall of fear extinction in rats with lesions of ventral medial prefrontal cortex.
Academic Article	Neuronal signalling of fear memory.
Academic Article	Prefrontal involvement in the regulation of emotion: convergence of rat and human studies.
Academic Article	Activity in prelimbic cortex is necessary for the expression of learned, but not innate, fears.
Academic Article	Recalling safety: cooperative functions of the ventromedial prefrontal cortex and the hippocampus in extinction.
Academic Article	Consolidation of fear extinction requires NMDA receptor-dependent bursting in the ventromedial prefrontal cortex.
Academic Article	A role for the human dorsal anterior cingulate cortex in fear expression.
Academic Article	Extinction circuits for fear and addiction overlap in prefrontal cortex.
Academic Article	Fear conditioning enhances different temporal components of tone-evoked spike trains in auditory cortex and lateral amygdala.
Academic Article	Noradrenergic signaling in infralimbic cortex increases cell excitability and strengthens memory for fear extinction.
Academic Article	Translating findings from basic fear research to clinical psychiatry in Puerto Rico.
Academic Article	Fear conditioning and extinction differentially modify the intrinsic excitability of infralimbic neurons.
Academic Article	A biologically realistic network model of acquisition and extinction of conditioned fear associations in lateral amygdala neurons.
Concept	Fear
Grant	Prefrontal amygdala interactions in fear conditioning
Academic Article	Time-Dependent Recruitment of Prelimbic Prefrontal Circuits for Retrieval of Fear Memory.

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Fear