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One or more keywords matched the following properties of Berry, Marla J.
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overview My scientific background includes three decades of experience in biochemistry and cell and molecular biology utilizing cell culture and animal models of human disease, and over two decades studying the functions of antioxidant selenoenzymes in health and disease. During my postdoctoral studies, I was first author on two publications in Nature. The seminal findings described in these publications led to my first NIH R01 grant, an appointment as Assistant Professor at Harvard Medical School, and issue of a US Patent. I remained on the faculty at Harvard Med for 11 years, where I obtained two additional NIH R01s and was promoted to Associate Professor. In 2002, I was recruited by the University of Hawaii, where I was tenured as a full Professor the following year. I have been continuously funded by the NIH since 1993, serving as PI on two R01s beginning in 1997 and three R01s during the period from 2000 to 2007. I served as a Charter Member of the NIH Nutrition Study Section and the Integrative Nutrition and Metabolic Processes Study Section from 2001 through 2005, as well as ad hoc on numerous study sections since 1993. Research in my laboratory currently includes mouse models with alterations in selenium metabolism, affecting antioxidant enzyme expression and resulting in metabolic syndrome and impaired neurological function. We are also investigating epigenetic changes in preeclampsia and have identified hypermethylation and hypomethylation in genes associated with cardiovascular disease-related processes.
One or more keywords matched the following items that are connected to Berry, Marla J.
Item TypeName
Academic Article Metal transcription factor-1 regulation via MREs in the transcribed regions of selenoprotein H and other metal-responsive genes.
Academic Article The effect of bamboo extract on hepatic biotransforming enzymes--findings from an obese-diabetic mouse model.
Academic Article The neuroprotective functions of selenoprotein M and its role in cytosolic calcium regulation.
Academic Article Dietary selenium modulates activation and differentiation of CD4+ T cells in mice through a mechanism involving cellular free thiols.
Academic Article Supplement of bamboo extract lowers serum monocyte chemoattractant protein-1 concentration in mice fed a diet containing a high level of saturated fat.
Academic Article Disruption of the selenocysteine lyase-mediated selenium recycling pathway leads to metabolic syndrome in mice.
Academic Article Expression and regulation of mouse selenoprotein P transcript variants differing in non-coding RNA.
Academic Article Deletion of selenoprotein M leads to obesity without cognitive deficits.
Academic Article Mice lacking selenoprotein P and selenocysteine lyase exhibit severe neurological dysfunction, neurodegeneration, and audiogenic seizures.
Academic Article Isoform-specific binding of selenoprotein P to the ?-propeller domain of apolipoprotein E receptor 2 mediates selenium supply.
Academic Article Selenoprotein W expression and regulation in mouse brain and neurons.
Academic Article Selenoproteins in nervous system development and function.
Academic Article Diet-induced obesity in the selenocysteine lyase knockout mouse.
Academic Article Competition between the Brain and Testes under Selenium-Compromised Conditions: Insight into Sex Differences in Selenium Metabolism and Risk of Neurodevelopmental Disease.
Academic Article Sexual Dimorphism in the Selenocysteine Lyase Knockout Mouse.
Academic Article Combined Omics Reveals That Disruption of the Selenocysteine Lyase Gene Affects Amino Acid Pathways in Mice.
Academic Article Effects of selenium supplementation on diet-induced obesity in mice with a disruption of the selenocysteine lyase gene.
Academic Article Disruption of Selenium Handling During Puberty Causes Sex-Specific Neurological Impairments in Mice.
Academic Article Agrp-Specific Ablation of Scly Protects against Diet-Induced Obesity and Leptin Resistance.
Academic Article Coupled tRNA(Sec)-dependent assembly of the selenocysteine decoding apparatus.
Academic Article Evidence for direct roles of two additional factors, SECp43 and soluble liver antigen, in the selenoprotein synthesis machinery.
Academic Article Nuclear assembly of UGA decoding complexes on selenoprotein mRNAs: a mechanism for eluding nonsense-mediated decay?
Academic Article Biosynthesis of selenocysteine on its tRNA in eukaryotes.
Academic Article Overexpression of selenoprotein H reduces Ht22 neuronal cell death after UVB irradiation by preventing superoxide formation.
Academic Article The responses of Ht22 cells to oxidative stress induced by buthionine sulfoximine (BSO).
Academic Article The responses of HT22 cells to the blockade of mitochondrial complexes and potential protective effect of selenium supplementation.
Academic Article A role for dietary selenium and selenoproteins in allergic airway inflammation.
Academic Article A novel function of bamboo extract in relieving lipotoxicity.
Academic Article Selenoprotein H is a redox-sensing high mobility group family DNA-binding protein that up-regulates genes involved in glutathione synthesis and phase II detoxification.
Academic Article Glutathione depletion in hippocampal cells increases levels of H and L ferritin and glutathione S-transferase mRNAs.
Academic Article The selenoproteome exhibits widely varying, tissue-specific dependence on selenoprotein P for selenium supply.
Academic Article A new approach for analyzing cellular infiltration during allergic airway inflammation.
Academic Article Podocyte specific knock out of selenoproteins does not enhance nephropathy in streptozotocin diabetic C57BL/6 mice.
Concept Mice, Inbred BALB C
Concept Mice, Inbred C3H
Concept Mice, Inbred C57BL
Concept Mice, Inbred Strains
Concept Mice, Mutant Strains
Concept Mice, Obese
Concept Mice, Transgenic
Concept Mice, Knockout
Concept Mice
Academic Article Structural and functional differences in the dio1 gene in mice with inherited type 1 deiodinase deficiency.
Academic Article Physiological and genetic analyses of inbred mouse strains with a type I iodothyronine 5' deiodinase deficiency.
Academic Article Two distinct SECIS structures capable of directing selenocysteine incorporation in eukaryotes.
Academic Article Decoding apparatus for eukaryotic selenocysteine insertion.
Academic Article Adaptive Thermogenesis in a Mouse Model Lacking Selenoprotein Biosynthesis in Brown Adipocytes.
Academic Article Sex-Specific Metabolic Impairments in a Mouse Model of Disrupted Selenium Utilization.
Academic Article Effect of statin treatment in obese selenium-supplemented mice lacking selenocysteine lyase.
Academic Article Female Mice with Selenocysteine tRNA Deletion in Agrp Neurons Maintain Leptin Sensitivity and Resist Weight Gain While on a High-Fat Diet.
Academic Article Selenium Protects Mouse Hypothalamic Cells from Glucocorticoid-Induced Endoplasmic Reticulum Stress Vulnerability and Insulin Signaling Impairment.
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