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Hermann, Brian
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overview Dr. Hermann’s laboratory studies the basic biology of spermatogonial stem cells (SSCs), which are adult-tissue stem cells responsible for sperm production in the mammalian testis and which are essential for male fertility. Ongoing studies in the lab are focused on 1) determining how these cells are regulated and behave like stem cells, 2) how SSC loss due to sterilizing treatments can be prevented, 3) how SSCs participate in the etiology of male infertility, and 4) how the male germline ages. The lab’s work has potential implications for basic stem cell biology, reproduction, as well as translational significance for treatment and prevention of male infertility. The approaches used in the lab are multidisciplinary, including animal models (rodents, primates), human tissues, an in vitro SSC culture system, an in vivo transplantation assay for stem cells, various wide-field microscopy techniques, as well as conventional and high-throughput molecular biology and genomic approaches.
One or more keywords matched the following items that are connected to Hermann, Brian
Item TypeName
Academic Article Spermatogonial stem cells in higher primates: are there differences from those in rodents?
Academic Article The elusive spermatogonial stem cell marker?
Academic Article Direct differentiation of human pluripotent stem cells into haploid spermatogenic cells.
Academic Article Eliminating malignant contamination from therapeutic human spermatogonial stem cells.
Academic Article Separating spermatogonia from cancer cells in contaminated prepubertal primate testis cell suspensions.
Academic Article Spermatogonial stem cell transplantation into rhesus testes regenerates spermatogenesis producing functional sperm.
Academic Article Transcriptional and translational heterogeneity among neonatal mouse spermatogonia.
Academic Article Granulocyte colony-stimulating factor prevents loss of spermatogenesis after sterilizing busulfan chemotherapy.
Academic Article TSPAN8 Expression Distinguishes Spermatogonial Stem Cells in the Prepubertal Mouse Testis.
Academic Article Granulocyte colony-stimulating factor (G-CSF) promotes spermatogenic regeneration from surviving spermatogonia after high-dose alkylating chemotherapy.
Academic Article The regulatory repertoire of PLZF and SALL4 in undifferentiated spermatogonia.
Academic Article Mechanisms Regulating Spermatogonial Differentiation.
Academic Article The Mammalian Spermatogenesis Single-Cell Transcriptome, from Spermatogonial Stem Cells to Spermatids.
Academic Article Dynamic cytoplasmic projections connect mammalian spermatogonia in vivo.
Academic Article Acyl-CoA synthetase 6 enriches seminiferous tubules with the ?-3 fatty acid docosahexaenoic acid and is required for male fertility in the mouse.
Academic Article Differential RA responsiveness directs formation of functionally distinct spermatogonial populations at the initiation of spermatogenesis in the mouse.
Academic Article What has single-cell RNA-seq taught us about mammalian spermatogenesis?
Academic Article Silencing of Fshr occurs through a conserved, hypersensitive site in the first intron.
Academic Article In vivo regulation of follicle-stimulating hormone receptor by the transcription factors upstream stimulatory factor 1 and upstream stimulatory factor 2 is cell specific.
Academic Article Molecular dissection of the male germ cell lineage identifies putative spermatogonial stem cells in rhesus macaques.
Academic Article Characterization, cryopreservation, and ablation of spermatogonial stem cells in adult rhesus macaques.
Concept Infertility, Male
Concept Male
Academic Article Reconstitution of prospermatogonial specification in vitro from human induced pluripotent stem cells.
Academic Article An mTORC1-dependent switch orchestrates the transition between mouse spermatogonial stem cells and clones of progenitor spermatogonia.
Academic Article Differential RA responsiveness among subsets of mouse late progenitor spermatogonia.
Academic Article Modeling mammalian spermatogonial differentiation and meiotic initiation in vitro.
Academic Article The germ cell-specific RNA binding protein RBM46 is essential for spermatogonial differentiation in mice.
Academic Article Granulocyte-colony stimulating factor does not prevent in vitro cisplatin-induced germ cell reduction in immature human and mouse testis.
Academic Article Conserved Transcriptome Features Define Prepubertal Primate Spermatogonial Stem Cells as Adark Spermatogonia and Identify Unique Regulators.
Academic Article Retinoic acid is dispensable for meiotic initiation but required for spermiogenesis in the mammalian testis.
Academic Article Single-Molecule Fluorescence In Situ Hybridization for Spatial Detection of mRNAs in Sections of Mammalian Testes.
Academic Article Bulk and Single-Cell RNA-Seq Analyses for Studies of Spermatogonia.
Academic Article Introduction: The Why's and How's for Studying Spermatogenesis and Spermatogonial Stem Cells.
Academic Article Isolation of Undifferentiated Spermatogonia from Adult and Developing Mouse Testes.
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