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overview Dr. Teale’s research focus is Neurocysticercosis (NCC), a parasitic disease of the central nervous system caused by the helminth Taenia solium. The long term goal of this project has been to characterize the host immune response and the pathology associated with NCC. Apart from analyses of brain specimens from NCC patients, the lab has developed a mouse model of NCC by intra-cranial infection with the related cestode, Mesocestoides corti. Our studies have shown that the parasite releases glycans with distinct sugar specificities that are taken up by host cells in the CNS environment in both human and murine NCC. Immunological events following recognition of these glycan antigens likely play a critical role in the immunopathogenesis of NCC. Parasite glycan induced regulatory responses involving myeloid derived suppressor cells (MDSCs) are thought to be key in host protection; however, the receptors involved in this process are largely uncharacterized. C-type lectin receptors (CLRs) recognize glycan antigens of both pathogen and host origins and function in a wide variety of inflammatory and regulatory immune responses. Little is known regarding the expression of CLRs and their role in CNS infections which is the objective of this project. The lab hypothesizes that parasite released glycans induce differential expression of CLRs which modulate the expression of effector molecules as well as activation and trafficking of leukocytes. They further hypothesize that CLRs differentially modulate functions of MDSCs that likely influence the immunopathology in murine NCC.
One or more keywords matched the following items that are connected to Teale, Judy
Item TypeName
Academic Article Doxycycline treatment decreases morbidity and mortality of murine neurocysticercosis: evidence for reduction of apoptosis and matrix metalloproteinase activity.
Academic Article Aged mice display an altered pulmonary host response to Francisella tularensis live vaccine strain (LVS) infections.
Academic Article TLR-dependent control of Francisella tularensis infection and host inflammatory responses.
Academic Article Mesocestoides corti intracranial infection as a murine model for neurocysticercosis.
Academic Article Analysis of clonal diversity in mouse immunoglobulin heavy chain genes selected for size of the antigen combining site.
Academic Article Development of an animal model for neurocysticercosis: immune response in the central nervous system is characterized by a predominance of gamma delta T cells.
Academic Article Attenuated response of aged mice to respiratory Francisella novicida is characterized by reduced cell death and absence of subsequent hypercytokinemia.
Academic Article Features of sepsis caused by pulmonary infection with Francisella tularensis Type A strain.
Academic Article Skewed B cell VH family repertoire in Bcl-2-Ig transgenic mice.
Academic Article MyD88-deficient mice exhibit decreased parasite-induced immune responses but reduced disease severity in a murine model of neurocysticercosis.
Academic Article Defect in efferocytosis leads to alternative activation of macrophages in Francisella infections.
Academic Article STAT6?/? mice exhibit decreased cells with alternatively activated macrophage phenotypes and enhanced disease severity in murine neurocysticercosis.
Academic Article Increased disease severity of parasite-infected TLR2-/- mice is correlated with decreased central nervous system inflammation and reduced numbers of cells with alternatively activated macrophage phenotypes in a murine model of neurocysticercosis.
Academic Article TLR4-dependent activation of inflammatory cytokine response in macrophages by Francisella elongation factor Tu.
Academic Article Studies on some metacestodes immunohistochemical response in mice as a model for human cysticercosis: II-THI type immune response in experimental Braintaenia crassiceps infected mice.
Academic Article Transcriptome analysis of the ependymal barrier during murine neurocysticercosis.
Academic Article Cloning of B cells positive or negative for surface IgD. II. Triggering and tolerance in the T-dependent splenic focus assay.
Academic Article Changes in gene expression of pial vessels of the blood brain barrier during murine neurocysticercosis.
Academic Article Galectin-3 functions as an alarmin: pathogenic role for sepsis development in murine respiratory tularemia.
Academic Article Increased accumulation of regulatory granulocytic myeloid cells in mannose receptor C type 1-deficient mice correlates with protection in a mouse model of neurocysticercosis.
Academic Article Biochemical and functional analysis of extracellular stress proteins of Mesocestoides corti.
Academic Article Molecular analysis of neonatal IgA expression: implications for class switching, allelic polymorphism and somatic mutation.
Academic Article Effect of fetal exposure to ultrasound on the development of functional, antigen-specific B lymphocytes in fetal and neonatal BALB/c mice.
Academic Article Effect of fetal exposure to ultrasound on B lymphocyte function and antibody class production.
Academic Article Ig VH gene family repertoire of plasma cells derived from lupus-prone MRL/lpr and MRL/++ mice.
Academic Article VH gene family repertoire of resting B cells. Preferential use of D-proximal families early in development may be due to distinct B cell subsets.
Academic Article Comparison of V kappa gene family expression in adult and fetal B cells.
Academic Article The isotype potential of B cells present in BALB/c mice chronically infected with Mesocestoides corti.
Academic Article Surface IgG-bearing cells retain the capacity to secrete IgM.
Academic Article Influence of immunoglobulin-dependent T cells on antibody class switching.
Academic Article B cell immune repertoire diversifies in a predictable temporal order in vitro.
Academic Article In vivo effects of anticytokine antibodies on isotype restriction in Mesocestoides corti-infected BALB/c mice.
Academic Article Immunoglobulin class commitment exhibited by B lymphocytes separated according to surface isotype.
Academic Article A clonal analysis of the IgE response and its implications with regard to isotope commitment.
Academic Article The potential of B lymphocytes for isotype expression.
Academic Article Reduced Leukocyte Infiltration in Absence of Eosinophils Correlates with Decreased Tissue Damage and Disease Susceptibility in ?dblGATA Mice during Murine Neurocysticercosis.
Academic Article Tolerance to azobenzenearsonate: preferential loss of the major normal cross-reactive idiotype.
Academic Article Effect of fetal exposure to ultrasound on B cell development in BALB/c mice.
Academic Article Model for the neuromuscular complications of systemic lupus erythematosus.
Academic Article Frequency of B cells expressing germ-line gamma 1 transcripts upon IL-4 induction.
Academic Article Characterization of an unusual cell type (CD4+ CD3-) expanded by helminth infection and related to the parasite stress response.
Academic Article Restricted kappa chain expression in early ontogeny: biased utilization of V kappa exons and preferential V kappa-J kappa recombinations.
Academic Article Release of stress proteins from Mesocestoides corti is a brefeldin A-inhibitable process: evidence for active export of stress proteins.
Academic Article The role of recombination signal sequences in the preferential joining by deletion in DH-JH recombination and in the ordered rearrangement of the IgH locus.
Academic Article Clonotypic analysis of the fetal B cell repertoire: evidence for an early and predominant expression of idiotypes associated with the VH 36-60 family.
Academic Article Isotype restriction during infection of mice with the cestode Mesocestoides corti: role of immune suppression.
Academic Article The contribution of parasite-specific T cells to isotype restriction in Mesocestoides corti-infected mice.
Academic Article Antigen-initiated B lymphocyte differentiation. XVI. Primary and secondary adoptive responses involve two sequential stages, antigen nonspecific then antigen specific, in the generation of specific AFC.
Academic Article Comparative expression of adult and fetal V gene repertoires.
Academic Article Strain-dependent expression of VH gene families.
Academic Article Comparison of the fetal and adult functional B cell repertoires by analysis of VH gene family expression.
Academic Article Effect of growth and differentiation stimuli on the development of antigen-responsive B cells in fetal liver.
Academic Article In vitro model for natural tolerance to self-antigens. Inhibition of the development of surface-immunoglobulin-negative lymphocytes into T-dependent responsive B cells by antigen.
Academic Article Clonal analysis of B-lymphocyte subpopulations separated on the basis of Lyb surface antigens.
Academic Article The use of specific helper T cell clones to study the regulation of isotype expression by antigen-stimulated B cell clones.
Academic Article Leishmania donovani: evolution and architecture of the splenic cellular immune response related to control of infection.
Academic Article Gamma/delta T cell-deficient mice exhibit reduced disease severity and decreased inflammatory response in the brain in murine neurocysticercosis.
Academic Article Membrane and metabolic requirements for tolerance induction of neonatal B cells.
Academic Article CC chemokines mediate leukocyte trafficking into the central nervous system during murine neurocysticercosis: role of gamma delta T cells in amplification of the host immune response.
Academic Article Abnormalities in isotype expression in CBA/N mice due to stimulatory environment rather than a B cell defect.
Academic Article Autoimmune disease and the theory of clonal abortion. Is it still relevant?
Academic Article Breakdown of the blood brain barrier and blood-cerebrospinal fluid barrier is associated with differential leukocyte migration in distinct compartments of the CNS during the course of murine NCC.
Academic Article B lymphocyte subpopulations separated by velocity sedimentation. I. Characterization of immune function in an in vitro splenic focus assay.
Academic Article Comparison of D, JH, and junctional diversity in the fetal, adult, and aged B cell repertoires.
Academic Article Intranasal interleukin-12 treatment promotes antimicrobial clearance and survival in pulmonary Francisella tularensis subsp. novicida infection.
Academic Article Expression and distribution of Toll-like receptors in the brain during murine neurocysticercosis.
Academic Article Evidence for differential changes of junctional complex proteins in murine neurocysticercosis dependent upon CNS vasculature.
Academic Article Contribution of the CD5+ B cell to D-proximal VH family expression early in ontogeny.
Academic Article Lethal pulmonary infection with Francisella novicida causes depletion of alphabeta T cells from lungs.
Academic Article Lethal pulmonary infection with Francisella novicida is associated with severe sepsis.
Academic Article Vaccination with an attenuated strain of Francisella novicida prevents T-cell depletion and protects mice infected with the wild-type strain from severe sepsis.
Academic Article Differential changes in junctional complex proteins suggest the ependymal lining as the main source of leukocyte infiltration into ventricles in murine neurocysticercosis.
Academic Article Ig V kappa family repertoire of plasma cells derived from autoimmune MRL mice.
Academic Article Differential release and phagocytosis of tegument glycoconjugates in neurocysticercosis: implications for immune evasion strategies.
Academic Article Initial delay in the immune response to Francisella tularensis is followed by hypercytokinemia characteristic of severe sepsis and correlating with upregulation and release of damage-associated molecular patterns.
Academic Article Multiple expression of matrix metalloproteinases in murine neurocysticercosis: Implications for leukocyte migration through multiple central nervous system barriers.
Academic Article Rapid dissemination of Francisella tularensis and the effect of route of infection.
Academic Article Expression and distribution of Toll-like receptors 11-13 in the brain during murine neurocysticercosis.
Concept Mice, Inbred A
Concept Mice, Inbred BALB C
Concept Mice, Inbred CBA
Concept Mice, Inbred C3H
Concept Mice, Inbred C57BL
Concept Mice, Inbred Strains
Concept Mice, Mutant Strains
Concept Mice, Transgenic
Concept Mice, Knockout
Concept Mice
Academic Article Tolerance and B cell repertoire establishment.
Academic Article Ontogenic development of B-lymphocyte function and tolerance susceptibility in vivo and in an in vitro organ culture system.
Academic Article Role of IgD in immunological memory.
Academic Article Chrysoidine-dyed bait: a possible carcinogenic hazard to anglers?
Academic Article Tolerance as an active process.
Academic Article Antigen-initiated B-lymphocyte differentiation. XVII. The inhibitory effects of recent antigen prepriming on the subsequent responsiveness of 'pre-progenitor' B cells.
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