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Kurtz, Donald

One or more keywords matched the following properties of Kurtz, Donald

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overview	A major aspect of our research focuses on the structure, function, and catalytic mechanisms of bacterial and archaeal non-heme iron enzymes that reductively scavenge diatomic oxygen and nitrogen species. These scavenging and sensing reactions require specialized active sites with novel iron coordination environments and novel mechanisms, which we follow by rapid kinetic and spectroscopic techniques as well as protein X-ray crystallography. We are also attempting to develop an oxygen-carrying protein as a blood substitute. A related project focuses on proteins that catalyze storage and release of intracellular iron. An exciting new development is the use of these iron storage proteins as scaffolds to enclose metal and semiconductor nanoparticles for photochemical H2 production and photo-initiated delivery of toxic iron to cancer cells.

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overview

A major aspect of our research focuses on the structure, function, and catalytic mechanisms of bacterial and archaeal non-heme iron enzymes that reductively scavenge diatomic oxygen and nitrogen species. These scavenging and sensing reactions require specialized active sites with novel iron coordination environments and novel mechanisms, which we follow by rapid kinetic and spectroscopic techniques as well as protein X-ray crystallography. We are also attempting to develop an oxygen-carrying protein as a blood substitute. A related project focuses on proteins that catalyze storage and release of intracellular iron. An exciting new development is the use of these iron storage proteins as scaffolds to enclose metal and semiconductor nanoparticles for photochemical H2 production and photo-initiated delivery of toxic iron to cancer cells.

One or more keywords matched the following items that are connected to Kurtz, Donald

Item Type	Name
Academic Article	Insights into the nitric oxide reductase mechanism of flavodiiron proteins from a flavin-free enzyme.
Academic Article	Iron-nucleated folding of a metalloprotein in high urea: resolution of metal binding and protein folding events.
Academic Article	Vibrational analysis of mononitrosyl complexes in hemerythrin and flavodiiron proteins: relevance to detoxifying NO reductase.
Academic Article	Treponema denticola superoxide reductase: in vivo role, in vitro reactivities, and a novel [Fe(Cys)(4)] site.
Academic Article	Histidine ligand variants of a flavo-diiron protein: effects on structure and activities.
Academic Article	The high potential iron-sulfur cluster of aconitase is a binuclear iron-sulfur cluster.
Academic Article	Cloning and sequencing of the gene for rubrerythrin from Desulfovibrio vulgaris (Hildenborough).
Academic Article	Metal substitutions at the diiron sites of hemerythrin and myohemerythrin: contributions of divalent metals to stability of a four-helix bundle protein.
Academic Article	Conversion of non-functional to functional iron following reconstitution of hemerythrin.
Academic Article	An HD-GYP cyclic di-guanosine monophosphate phosphodiesterase with a non-heme diiron-carboxylate active site.
Academic Article	The nitric oxide reductase mechanism of a flavo-diiron protein: identification of active-site intermediates and products.
Academic Article	A diferrous-dinitrosyl intermediate in the N2O-generating pathway of a deflavinated flavo-diiron protein.
Academic Article	Intrapeptide sequence homology in rubrerythrin from Desulfovibrio vulgaris: identification of potential ligands to the diiron site.
Academic Article	H2O2-dependent substrate oxidation by an engineered diiron site in a bacterial hemerythrin.
Academic Article	Oxidative protection of hemoglobin and hemerythrin by cross-linking with a nonheme iron peroxidase: potentially improved oxygen carriers for use in blood substitutes.
Academic Article	Nitric oxide adducts of the binuclear iron site of hemerythrin: spectroscopy and reactivity.
Academic Article	Reconstitution of the diiron sites in hemerythrin and myohemerythrin.
Academic Article	High-resolution crystal structures of Desulfovibrio vulgaris (Hildenborough) nigerythrin: facile, redox-dependent iron movement, domain interface variability, and peroxidase activity in the rubrerythrins.
Academic Article	CD/MCD/VTVH-MCD Studies of Escherichia coli Bacterioferritin Support a Binuclear Iron Cofactor Site.
Academic Article	Active Site Metal Occupancy and Cyclic Di-GMP Phosphodiesterase Activity of Thermotoga maritima HD-GYP.
Academic Article	Trojan Horse for Light-Triggered Bifurcated Production of Singlet Oxygen and Fenton-Reactive Iron within Cancer Cells.
Academic Article	Resonance Raman spectroscopic evidence for the FeS4 and Fe-O-Fe sites in rubrerythrin from Desulfovibrio vulgaris.
Academic Article	Spectroscopy and DFT Calculations of a Flavo-diiron Enzyme Implicate New Diiron Site Structures.
Academic Article	Spectroscopic characterization of 57Fe-reconstituted rubrerythrin, a non-heme iron protein with structural analogies to ribonucleotide reductase.
Academic Article	Structural, Photophysical, and Photochemical Characterization of Zinc Protoporphyrin IX in a Dimeric Variant of an Iron Storage Protein: Insights into the Mechanism of Photosensitized H2 Generation.
Academic Article	Targeted cancer cell delivery of arsenate as a reductively activated prodrug.
Academic Article	Structure of a Zinc Porphyrin-Substituted Bacterioferritin and Photophysical Properties of Iron Reduction.
Academic Article	Analysis of metal incorporation during overexpression of Clostridium pasteurianum rubredoxin by electrospray FTICR mass spectrometry.
Academic Article	EPR and ENDOR evidence for a 1-His, hydroxo-bridged mixed-valent diiron site in Desulfovibrio vulgaris rubrerythrin.
Academic Article	Spectroscopic characterization of the [Fe(His)(4)(Cys)] site in 2Fe-superoxide reductase from Desulfovibrio vulgaris.
Academic Article	Histidine ligand protonation and redox potential in the rieske dioxygenases: role of a conserved aspartate in anthranilate 1,2-dioxygenase.
Academic Article	X-ray crystal structure of Desulfovibrio vulgaris rubrerythrin with zinc substituted into the [Fe(SCys)4] site and alternative diiron site structures.
Academic Article	Rubrerythrin and rubredoxin oxidoreductase in Desulfovibrio vulgaris: a novel oxidative stress protection system.
Academic Article	Characterization and evolution of anthranilate 1,2-dioxygenase from Acinetobacter sp. strain ADP1.
Academic Article	A role for rubredoxin in oxidative stress protection in Desulfovibrio vulgaris: catalytic electron transfer to rubrerythrin and two-iron superoxide reductase.
Academic Article	Kinetics and mechanism of superoxide reduction by two-iron superoxide reductase from Desulfovibrio vulgaris.
Academic Article	Thermal stability of the [Fe(SCys)(4)] site in Clostridium pasteurianum rubredoxin: contributions of the local environment and Cys ligand protonation.
Academic Article	X-ray crystal structures of reduced rubrerythrin and its azide adduct: a structure-based mechanism for a non-heme diiron peroxidase.
Academic Article	A flavodiiron protein and high molecular weight rubredoxin from Moorella thermoacetica with nitric oxide reductase activity.
Academic Article	An engineered two-iron superoxide reductase lacking the [Fe(SCys)4] site retains its catalytic properties in vitro and in vivo.
Academic Article	Computational study of the non-heme iron active site in superoxide reductase and its reaction with superoxide.
Academic Article	Sulfide-bridged derivatives of the binuclear iron site of hemerythrin at both met and semi-met oxidation levels.
Academic Article	Contribution of the [FeII(SCys)4] site to the thermostability of rubredoxins.
Academic Article	Displacement of iron by zinc at the diiron site of Desulfovibrio vulgaris rubrerythrin: X-ray crystal structure and anomalous scattering analysis.
Academic Article	Microbial detoxification of superoxide: the non-heme iron reductive paradigm for combating oxidative stress.
Academic Article	X-ray crystal structures of Moorella thermoacetica FprA. Novel diiron site structure and mechanistic insights into a scavenging nitric oxide reductase.
Academic Article	High-resolution crystal structures of Desulfovibrio vulgaris (Hildenborough) nigerythrin: facile, redox-dependent iron movement, domain interface variability, and peroxidase activity in the rubrerythrins.
Academic Article	Geometries and electronic structures of cyanide adducts of the non-heme iron active site of superoxide reductases: vibrational and ENDOR studies.
Academic Article	Recombinant Desulfovibrio vulgaris rubrerythrin. Isolation and characterization of the diiron domain.
Academic Article	A flavo-diiron protein from Desulfovibrio vulgaris with oxidase and nitric oxide reductase activities. Evidence for an in vivo nitric oxide scavenging function.
Academic Article	Avoiding high-valent iron intermediates: superoxide reductase and rubrerythrin.
Academic Article	A [2Fe-2S] protein encoded by an open reading frame upstream of the Escherichia coli bacterioferritin gene.
Academic Article	The structure of Desulfovibrio vulgaris rubrerythrin reveals a unique combination of rubredoxin-like FeS4 and ferritin-like diiron domains.
Academic Article	Reaction of Desulfovibrio vulgaris two-iron superoxide reductase with superoxide: insights from stopped-flow spectrophotometry.
Academic Article	"Iron priming" guides folding of denatured aporubredoxins.
Concept	Iron
Concept	Iron Isotopes
Concept	Iron-Sulfur Proteins
Concept	Nonheme Iron Proteins
Concept	Iron-Binding Proteins
Academic Article	Structure of hexakis(N-methylimidazole-N')iron(II) tetraphenylborate dichloromethane solvate.
Academic Article	Chromatographic separation of extruded iron-sulfur cores from the apoproteins of Clostridium pasteurianum and spinach ferredoxins in aqueous Triton X-100/urea.
Academic Article	A new method for extrusion of iron-sulfur cores from active centers of proteins.
Academic Article	Electrospray mass spectrometry studies of non-heme iron-containing proteins.
Academic Article	Characterization of the iron-sulfur centers in succinate dehydrogenase.
Academic Article	Identification of iron-sulfur centers in the iron-molybdenum proteins of nitrogenase.
Academic Article	Rubredoxin refolding on nanostructured hydrophobic surfaces: evidence for a new type of biomimetic chaperones.
Concept	Iron Compounds
Academic Article	Particle Swarm Fitting of Spin Hamiltonians: Magnetic Circular Dichroism of Reduced and NO-Bound Flavodiiron Protein.
Academic Article	Preparation of platinum nanoparticles using iron(ii) as reductant and photosensitized H2 generation on an iron storage protein scaffold.

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Iron