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Jarrett, Harry

One or more keywords matched the following properties of Jarrett, Harry

Property	Value
overview	Signal transduction, and more specifically the role of Ca2+ and its receptor protein, calmodulin, in cellular regulation We have shown that dystrophin, the protein product of the Duchenne muscular dystrophy gene locus, is a specific calmodulin-binding protein and discovered a signal transduction pathway, which links laminin-a-dystroglycan-ß-dystroglycan-dystrophin-syntrophin-Grb2-Sos1-Rac1-PAK1-MKK4/7-JNK, causing c-jun phosphorylation and activation. This work is supported by National Institutes of Health grant 1R01AR051440. Transcription factor purification and characterization We first coupled DNA to HPLC silica and have made a significant contribution to the purification and characterization of transcription factors. Most recently we developed systematic oligonucleotide trapping, a method for purifying transcription factors to near homogeneity in a single step. Current experiments involve promoter trapping, a method which interfaces DNA-HPLC with proteomic techniques (MALDI-TOF and ESE-ion trap) to characterize the transcription complex of the c-jun promoter. This work is supported by National Institutes of Health grant 1R01GM43609.

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overview

Signal transduction, and more specifically the role of Ca2+ and its receptor protein, calmodulin, in cellular regulation We have shown that dystrophin, the protein product of the Duchenne muscular dystrophy gene locus, is a specific calmodulin-binding protein and discovered a signal transduction pathway, which links laminin-a-dystroglycan-ß-dystroglycan-dystrophin-syntrophin-Grb2-Sos1-Rac1-PAK1-MKK4/7-JNK, causing c-jun phosphorylation and activation. This work is supported by National Institutes of Health grant 1R01AR051440. Transcription factor purification and characterization We first coupled DNA to HPLC silica and have made a significant contribution to the purification and characterization of transcription factors. Most recently we developed systematic oligonucleotide trapping, a method for purifying transcription factors to near homogeneity in a single step. Current experiments involve promoter trapping, a method which interfaces DNA-HPLC with proteomic techniques (MALDI-TOF and ESE-ion trap) to characterize the transcription complex of the c-jun promoter. This work is supported by National Institutes of Health grant 1R01GM43609.

One or more keywords matched the following items that are connected to Jarrett, Harry

Item Type	Name
Academic Article	LG4-5 domains of laminin-211 binds alpha-dystroglycan to allow myotube attachment and prevent anoikis.
Academic Article	Laminin-a1 LG4-5 domain binding to dystroglycan mediates muscle cell survival, growth, and the AP-1 and NF-?B transcription factors but also has adverse effects.
Academic Article	Dystrophin-glycoprotein complex and Ras and Rho GTPase signaling are altered in muscle atrophy.
Academic Article	Skeletal muscle signaling pathway through the dystrophin glycoprotein complex and Rac1.
Academic Article	Binding of laminin alpha1-chain LG4-5 domain to alpha-dystroglycan causes tyrosine phosphorylation of syntrophin to initiate Rac1 signaling.
Academic Article	Laminin-alpha1 globular domains 3 and 4 induce heterotrimeric G protein binding to alpha-syntrophin's PDZ domain and alter intracellular Ca2+ in muscle.
Academic Article	Laminin-induced activation of Rac1 and JNKp46 is initiated by Src family kinases and mimics the effects of skeletal muscle contraction.
Academic Article	Dystrophin glycoprotein complex-associated Gbetagamma subunits activate phosphatidylinositol-3-kinase/Akt signaling in skeletal muscle in a laminin-dependent manner.
Concept	Laminin

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Laminin