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One or more keywords matched the following properties of Heidner, Hans
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overview Dr. Heidner’s research focuses on the replication of alphaviruses in vertebrate and mosquito cells, as well as the use of alphavirus-based vectors for cell targeting and vaccine applications and development. Alphaviruses are mosquito-borne, zoonotic pathogens that cause outbreaks in humans and animals. Alphaviruses remain a global issue, and each continent has humans at risk from one or more of these arthropod-borne viruses (arboviruses). Humans infected with the alphavirus experience severe encephalitis to polyarthritis. Most infections also cause fever, headaches and muscle pains to severe headache, seizures, and possibly even death. Dr. Heidner’s research also focuses on the design and evaluation of recombinant alphaviruses for the purpose of targeting virus particles to specific cell types such as tumor cells, and to enhance innate and adaptive immune responses to virus-expressed vaccine antigens. He is working on research that could be used to deliver vaccine antigens derived from a broad range of pathogens.
One or more keywords matched the following items that are connected to Heidner, Hans
Item TypeName
Academic Article Recombinant Sindbis virus vectors designed to express protective antigen of Bacillus anthracis protect animals from anthrax and display synergy with ciprofloxacin.
Academic Article An arthropod enzyme, Dfurin1, and a vertebrate furin homolog display distinct cleavage site sequence preferences for a shared viral proprotein substrate.
Academic Article Linkage of an alphavirus host-range restriction to the carbohydrate-processing phenotypes of the host cell.
Academic Article Variation amongst the neutralizing epitopes of bluetongue viruses isolated in the United States in 1979-1981.
Academic Article The pathogenesis of experimental bluetongue virus infection of calves.
Academic Article Bluetongue virus genome remains stable throughout prolonged infection of cattle.
Academic Article Bluetongue virus infection of bovine monocytes.
Academic Article A simplified procedure for oligonucleotide fingerprint analysis of multiple bluetongue virus genome segments utilizing small gels.
Academic Article Neutralization determinants of United States bluetongue virus serotype ten.
Academic Article An influenza A virus vaccine based on an M2e-modified alphavirus.
Academic Article Humoral immune response of calves to bluetongue virus infection.
Academic Article Comparison of virologic and serologic responses of lambs and calves infected with bluetongue virus serotype 10.
Academic Article The furin protease cleavage recognition sequence of Sindbis virus PE2 can mediate virion attachment to cell surface heparan sulfate.
Academic Article Equine arteritis virus derived from an infectious cDNA clone is attenuated and genetically stable in infected stallions.
Academic Article Alphavirus replicon particles expressing the two major envelope proteins of equine arteritis virus induce high level protection against challenge with virulent virus in vaccinated horses.
Academic Article Sindbis virus vectors designed to express a foreign protein as a cleavable component of the viral structural polyprotein.
Academic Article Characterization of the neutralization determinants of equine arteritis virus using recombinant chimeric viruses and site-specific mutagenesis of an infectious cDNA clone.
Academic Article Expression of the two major envelope proteins of equine arteritis virus as a heterodimer is necessary for induction of neutralizing antibodies in mice immunized with recombinant Venezuelan equine encephalitis virus replicon particles.
Academic Article The host range phenotype displayed by a Sindbis virus glycoprotein variant results from virion aggregation and retention on the surface of mosquito cells.
Academic Article Targeting Sindbis virus-based vectors to Fc receptor-positive cell types.
Academic Article Genetic variation and evolutionary relationships amongst bluetongue viruses endemic in the United States.
Academic Article Lethality of PE2 incorporation into Sindbis virus can be suppressed by second-site mutations in E3 and E2.
Academic Article The amino-terminal residue of Sindbis virus glycoprotein E2 influences virus maturation, specific infectivity for BHK cells, and virulence in mice.
Academic Article Identification of four distinct neutralizing epitopes on bluetongue virus serotype 10 using neutralizing monoclonal antibodies and neutralization-escape variants.
Academic Article Deduced consensus sequence of Sindbis virus strain AR339: mutations contained in laboratory strains which affect cell culture and in vivo phenotypes.
Academic Article Differential processing of sindbis virus glycoprotein PE2 in cultured vertebrate and arthropod cells.
Academic Article Development and characterization of an infectious cDNA clone of the virulent Bucyrus strain of Equine arteritis virus.
Academic Article Structural localization of the E3 glycoprotein in attenuated Sindbis virus mutants.
Concept Bluetongue virus
Concept Encephalitis Virus, Venezuelan Equine
Concept Influenza A virus
Concept Receptors, Virus
Concept Sindbis Virus
Concept Virus Replication
Concept Virus Shedding
Concept Virus Assembly
Search Criteria
  • Viruses
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