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The Saavedra laboratory at Ponce Health Sciences University studies how alterations in the cell cycle contribute to breast cancer. In particular, Dr. Saavedra’s research involves addressing how centrosome amplification –an abnormal phenotype that contributes to abnormal mitosis, aneuploidy and genomic instability- initiates and sustains mammary tumors.
Another major area of research in the Saavedra laboratory is to address how oncogenes and transcription factors that normally control the cell cycle contribute to chromosome instability and mitotic dysfunction as intermediates to epithelial to mesenchymal transition, invasion, tumor growth and metastasis. To that end, we use three-dimentional cell models, orthotopic, transgenic and knockout models to address the role of oncogenes and transcription factors in tumor growth and metastasis.
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Saavedra, Harold