| Item Type | Name |
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Academic Article
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Identification of 3-phenylaminoquinolinium and 3-phenylaminopyridinium salts as new agents against opportunistic fungal pathogens.
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Academic Article
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Multi-receptor drug design: Haloperidol as a scaffold for the design and synthesis of atypical antipsychotic agents.
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Academic Article
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Benzothiazoles as probes for the 5HT1A receptor and the serotonin transporter (SERT): a search for new dual-acting agents as potential antidepressants.
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Academic Article
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Identification of a new selective dopamine D4 receptor ligand.
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Academic Article
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Synthesis and evaluation of the structural elements in alkylated tetrahydroisoquinolines for binding to CNS receptors.
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Academic Article
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The Mechanistic Targets of Antifungal Agents: An Overview.
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Academic Article
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Design and synthesis of dual 5-HT1A and 5-HT7 receptor ligands.
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Academic Article
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Evaluation of SYA16263 as a new potential antipsychotic agent without catalepsy.
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Academic Article
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Enantioseparation of 5-chloro-2-{2-[3,4-dihydroisoquinoline-2(1H)-yl]ethyl}-2-methyl-2,3-dihydro-1H-inden-1-one (SYA 40247), a high-affinity 5-HT7 receptor ligand, by HPLC-PDA using amylose tris-(3, 5- dimethylphenylcarbamate) as a chiral stationary phase.
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Academic Article
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Design, synthesis, and evaluation of metabolism-based analogues of haloperidol incapable of forming MPP+-like species.
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Academic Article
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Identification of bis-quindolines as new antiinfective agents.
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Academic Article
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1H-NMR and 13C-NMR Assignments of Cryptolepine, A 3:4-Benz-delta-carboline Derivative Isolated from Cryptolepis sanguinolenta.
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Academic Article
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Haloperidol: towards further understanding of the structural contributions of its pharmacophoric elements at D2-like receptors.
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Academic Article
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Indolo[3,2-b]quinolines: synthesis, biological evaluation and structure activity-relationships.
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Academic Article
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Identification of a butyrophenone analog as a potential atypical antipsychotic agent: 4-[4-(4-chlorophenyl)-1,4-diazepan-1-yl]-1-(4-fluorophenyl)butan-1-one.
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Concept
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Acetyl-CoA Carboxylase
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Concept
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Adrenergic alpha-Antagonists
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Concept
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Animals
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Concept
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Anti-Infective Agents
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Concept
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Anti-Bacterial Agents
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Concept
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Antidepressive Agents
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Concept
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Antifungal Agents
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Concept
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Antimalarials
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Concept
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Antineoplastic Agents
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Concept
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Antioxidants
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Concept
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Antiparasitic Agents
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Concept
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Antiprotozoal Agents
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Concept
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Apomorphine
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Concept
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Binding Sites
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Concept
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Binding, Competitive
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Concept
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Bromocriptine
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Concept
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Butanones
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Concept
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Butyrophenones
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Concept
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Calcium
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Concept
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Catalepsy
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Concept
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Clinical Trials as Topic
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Concept
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Cricetulus
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Concept
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Disease Models, Animal
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Concept
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Droperidol
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Concept
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Drug Screening Assays, Antitumor
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Concept
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Guinea Pigs
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Concept
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Haloperidol
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Concept
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Cricetinae
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Concept
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Humans
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Concept
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Hypoglycemic Agents
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Concept
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Indenes
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Concept
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Isomerism
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Concept
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Lethal Dose 50
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Concept
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Methylation
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Concept
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Microbial Sensitivity Tests
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Concept
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Models, Biological
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Concept
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Models, Chemical
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Concept
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Models, Molecular
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Concept
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Motor Activity
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Concept
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Magnetic Resonance Spectroscopy
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Concept
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Opportunistic Infections
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Concept
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Pancreatic Neoplasms
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Concept
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Plasmodium falciparum
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Concept
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Platelet Aggregation
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Concept
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Platelet Aggregation Inhibitors
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Concept
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Protein Conformation
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Concept
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Protein Methyltransferases
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Concept
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Psychomotor Performance
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Concept
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Rabbits
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Concept
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Rana pipiens
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Concept
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Receptors, Dopamine
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Concept
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Receptors, Serotonin
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Concept
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Serotonin Antagonists
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Concept
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Stereoisomerism
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Concept
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Swine
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Concept
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Temperature
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Concept
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Antipsychotic Agents
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Concept
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Vasodilator Agents
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Concept
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1-Methyl-3-isobutylxanthine
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Concept
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Drug Design
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Concept
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Reproducibility of Results
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Concept
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Dopamine Agents
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Concept
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Molecular Probes
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Concept
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Molecular Structure
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Concept
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1-Methyl-4-phenylpyridinium
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Concept
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Cryopreservation
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Concept
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Least-Squares Analysis
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Concept
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AIDS-Related Opportunistic Infections
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Concept
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Rats, Sprague-Dawley
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Concept
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Rats, Wistar
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Concept
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Protein Prenylation
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Concept
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Receptors, Dopamine D2
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Concept
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Receptors, sigma
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Concept
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Dopamine Agonists
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Concept
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Dopamine Antagonists
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Concept
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Hand Strength
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Concept
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Inhibitory Concentration 50
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Concept
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Quantitative Structure-Activity Relationship
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Concept
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Carcinoma, Pancreatic Ductal
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Concept
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Tetrahydroisoquinolines
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Concept
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Receptor, Serotonin, 5-HT1A
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Concept
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Receptor, Serotonin, 5-HT2B
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Concept
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Phenylcarbamates
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Concept
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Serotonin Plasma Membrane Transport Proteins
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Concept
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Receptors, Dopamine D4
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Concept
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Mice
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Concept
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Rats
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Academic Article
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A Mechanistic Investigation on the Anticancer Properties of SYA013, a Homopiperazine Analogue of Haloperidol with Activity against Triple Negative Breast Cancer Cells.
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Academic Article
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New dual 5-HT1A and 5-HT7 receptor ligands derived from SYA16263.
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Academic Article
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Design and discovery of a high affinity, selective and ?-arrestin biased 5-HT7 Receptor Agonist.
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Academic Article
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Enantiomeric Separation, Absolute Configuration by X-ray Crystallographic Analysis, and Functional Evaluation of Enantiomers of the Dual Ligand, SYA0340 at 5-HT1A and 5-HT7A Receptors.
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Grant
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Development of Novel Agents for CNS-related Diseases
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Grant
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Discovery of a High Affinity, Selective and ?-arrestin Biased 5-HT7R Agonist
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Grant
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A New Approach for the Development of Novel Antipsychotic Drugs
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