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Wojna, Valerie

One or more keywords matched the following properties of Wojna, Valerie

Property	Value
keywords	HIV HAND
overview	I have been fortunate to work with my patients as a neurologist and as a clinical researcher. My clinical experience and personal commitment to help ameliorate health disparities, has led to me to the study of HIV-associated neurocognitive disorders (HAND). I have been the PI of the Hispanic/Latino Longitudinal NeuroAIDS women cohort for the evaluation of HAND as part of the NeuroAIDS Specialized Neuroscience Research Program (SNRP). My areas of research experience address the impact of sex hormones, insulin resistance, oxidative stress, chronic inflammation, and biomarkers on cognitive performance among HIV positive cisgender women. Recent scientific literature has evidenced that the chronic infection and increase survival of HIV-seropositive patients is associated with increase co-morbidities such as stroke, metabolic syndrome, and cancer. Since 2011 we have been studying the effect of insulin resistance and neurocognitive performance in patients with HIV infection. Since than we have obtained a R21 (R21MH095524) and a R01 (R01NS099036) to study further the mechanisms involved in the secretion of the insulin receptor and its effect on cellular insulin resistance and neurocognitive impairment. Our preliminary data shows that HIV tat alters the cellular splicing factors facilitating the release of the insulin receptor extracellularly. Since this receptor is functional (binds to insulin) it facilitates de development of cellular insulin resistance as determined by altered IRS-1 phosphorylation. We believe that the secretion of the soluble insulin receptor and its effects precipitates a continuous cellular (and neuronal) insulin resistance that eventually will synergize with other HIV pathological mechanisms such as chronic inflammation, oxidative stress, and neurotoxic effects of virotoxins with residual neuronal injury and cognitive impairment. At present I am enrolled in the NINDS R25 Clinical Trials Methodology Course where will like to develop a clinical trial with approved medications that affects splicing factors (i.e. resveratrol) and improves insulin resistance (i.e. intranasal insulin). Other areas of interest include neurodegenerative disorders, multiple sclerosis, and HIV-associated sleep disorders.

Property

Value

keywords

HIV HAND

overview

I have been fortunate to work with my patients as a neurologist and as a clinical researcher. My clinical experience and personal commitment to help ameliorate health disparities, has led to me to the study of HIV-associated neurocognitive disorders (HAND). I have been the PI of the Hispanic/Latino Longitudinal NeuroAIDS women cohort for the evaluation of HAND as part of the NeuroAIDS Specialized Neuroscience Research Program (SNRP). My areas of research experience address the impact of sex hormones, insulin resistance, oxidative stress, chronic inflammation, and biomarkers on cognitive performance among HIV positive cisgender women. Recent scientific literature has evidenced that the chronic infection and increase survival of HIV-seropositive patients is associated with increase co-morbidities such as stroke, metabolic syndrome, and cancer. Since 2011 we have been studying the effect of insulin resistance and neurocognitive performance in patients with HIV infection. Since than we have obtained a R21 (R21MH095524) and a R01 (R01NS099036) to study further the mechanisms involved in the secretion of the insulin receptor and its effect on cellular insulin resistance and neurocognitive impairment. Our preliminary data shows that HIV tat alters the cellular splicing factors facilitating the release of the insulin receptor extracellularly. Since this receptor is functional (binds to insulin) it facilitates de development of cellular insulin resistance as determined by altered IRS-1 phosphorylation. We believe that the secretion of the soluble insulin receptor and its effects precipitates a continuous cellular (and neuronal) insulin resistance that eventually will synergize with other HIV pathological mechanisms such as chronic inflammation, oxidative stress, and neurotoxic effects of virotoxins with residual neuronal injury and cognitive impairment. At present I am enrolled in the NINDS R25 Clinical Trials Methodology Course where will like to develop a clinical trial with approved medications that affects splicing factors (i.e. resveratrol) and improves insulin resistance (i.e. intranasal insulin). Other areas of interest include neurodegenerative disorders, multiple sclerosis, and HIV-associated sleep disorders.

One or more keywords matched the following items that are connected to Wojna, Valerie

Item Type	Name
Academic Article	Proteomic analyses of monocytes obtained from Hispanic women with HIV-associated dementia show depressed antioxidants.
Academic Article	Soluble and cell-associated insulin receptor dysfunction correlates with severity of HAND in HIV-infected women.
Academic Article	Translational spatial task and its relationship to HIV-associated neurocognitive disorders and apolipoprotein E in HIV-seropositive women.
Academic Article	YWHAE/14-3-3e: a potential novel genetic risk factor and CSF biomarker for HIV neurocognitive impairment.
Academic Article	A lipid storage-like disorder contributes to cognitive decline in HIV-infected subjects.
Academic Article	Cathepsin B and cystatin B in HIV-seropositive women are associated with infection and HIV-1-associated neurocognitive disorders.
Academic Article	Different levels of HIV DNA copy numbers in cerebrospinal fluid cellular subsets.
Academic Article	Soluble insulin receptor as a source of insulin resistance and cognitive impairment in HIV-seropositive women.
Academic Article	Longitudinal Analysis of Cerebrospinal Fluid and Plasma HIV-1 Envelope Sequences Isolated From a Single Donor with HIV Asymptomatic Neurocognitive Impairment.
Academic Article	Highlights of the Global HIV-1 CSF Escape Consortium Meeting, 9 June 2016, Bethesda, MD, USA.
Academic Article	Macrophage secretome from women with HIV-associated neurocognitive disorders.
Academic Article	The a7-nicotinic receptor is upregulated in immune cells from HIV-seropositive women: consequences to the cholinergic anti-inflammatory response.
Academic Article	HIV gp120 sequence variability associated with HAND in Hispanic Women.
Academic Article	Assessing health-related resiliency in HIV+ Latin women: Preliminary psychometric findings.
Academic Article	Microwave & magnetic proteomics of macrophages from patients with HIV-associated cognitive impairment.
Academic Article	In Vitro Blood-Brain Barrier Modeling adapted for Peripheral Blood Mononuclear Cell Transmigration from HIV-Positive Patients for Clinical Research on Therapeutic Drug Intervention.
Academic Article	Release of Soluble Insulin Receptor From Neurons by Cerebrospinal Fluid From Patients With Neurocognitive Dysfunction and HIV Infection.
Academic Article	Brief Report: Effects of Low-Volume High-Intensity Interval Training in Hispanic HIV+ Women: A Nonrandomized Study.
Academic Article	A recombinant gp145 Env glycoprotein from HIV-1 expressed in two different cell lines: Effects on glycosylation and antigenicity.
Academic Article	Macrophage proteomic fingerprinting predicts HIV-1-associated cognitive impairment.
Academic Article	Proteomic fingerprinting of human immunodeficiency virus type 1-associated dementia from patient monocyte-derived macrophages: A case study.
Academic Article	Neuroprotective therapy for HIV dementia.
Academic Article	Molecular basis for interactions of HIV and drugs of abuse.
Academic Article	Challenges to the diagnosis and management of HIV dementia.
Academic Article	Prevalence of human immunodeficiency virus-associated cognitive impairment in a group of Hispanic women at risk for neurological impairment.
Academic Article	Characterization of peripheral blood human immunodeficiency virus isolates from Hispanic women with cognitive impairment.
Academic Article	Updated research nosology for HIV-associated neurocognitive disorders.
Academic Article	Cerebrospinal fluid proteomic profiling of HIV-1-infected patients with cognitive impairment.
Academic Article	CSF proteomic fingerprints for HIV-associated cognitive impairment.
Academic Article	Associations of cigarette smoking with viral immune and cognitive function in human immunodeficiency virus-seropositive women.
Academic Article	Antioxidant enzyme dysfunction in monocytes and CSF of Hispanic women with HIV-associated cognitive impairment.
Concept	HIV
Concept	HIV Seropositivity
Concept	HIV Antibodies
Concept	HIV-1
Concept	HIV Infections
Concept	HIV Envelope Protein gp120
Concept	HIV Seronegativity
Concept	Anti-HIV Agents
Concept	env Gene Products, Human Immunodeficiency Virus
Concept	tat Gene Products, Human Immunodeficiency Virus
Academic Article	Spanish validation of the HIV dementia scale in women.
Academic Article	Assessment, diagnosis, and treatment of HIV-associated neurocognitive disorder: a consensus report of the mind exchange program.
Award or Honor Receipt	Pathophysiology of HIV Dementia
Award or Honor Receipt	Soluble Insulin Receptor Dysfunction Correlates with HAND in HIV+ Women on CART
Grant	Soluble Insulin Receptor Dysfunction Correlates with HAND in HIV+ women on CART
Grant	Exosome-mediated soluble insulin receptor secretion correlates with HAND
Grant	Pathophysiology of HIV Dementia in Women
Academic Article	Soluble Insulin Receptor Levels in Plasma, Exosomes, and Urine and Its Association With HIV-Associated Neurocognitive Disorders.
Academic Article	Neuroinflammation and HIV-Associated Cognitive Impairment: Can They Be Eradicated?
Academic Article	Impact of antiretroviral therapy intensification with C-C motif chemokine receptor 5 antagonist maraviroc on HIV-associated neurocognitive impairment.

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