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Odero-Marah, Valerie
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overview Our research interests focus on epithelial-mesenchymal transition (EMT), a process that occurs during normal embryonic development and epithelial tumor progression. Several factors such as Snail transcription factor, are associated with EMT, and contribute to motility, invasion, and tumor progression. Understanding the factors that contribute to EMT and prostate cancer metastasis is crucial for development of cancer therapies. My laboratory focuses on the role of Snail transcription factor in prostate cancer progression and metastasis and antagonizing signaling with natural products.
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Grant The Role of Snail Signaling in Prostate Cancer Metastasis
Academic Article Reciprocal regulation of ZEB1 and AR in triple negative breast cancer cells.
Academic Article Snail transcription factor regulates neuroendocrine differentiation in LNCaP prostate cancer cells.
Academic Article Snail-mediated regulation of reactive oxygen species in ARCaP human prostate cancer cells.
Academic Article Snail negatively regulates cell adhesion to extracellular matrix and integrin expression via the MAPK pathway in prostate cancer cells.
Academic Article The phytoalexin camalexin mediates cytotoxicity towards aggressive prostate cancer cells via reactive oxygen species.
Academic Article Snail transcription factor negatively regulates maspin tumor suppressor in human prostate cancer cells.
Academic Article The role of Snail in prostate cancer.
Academic Article Snail promotes epithelial mesenchymal transition in breast cancer cells in part via activation of nuclear ERK2.
Academic Article Muscadine grape skin extract can antagonize Snail-cathepsin L-mediated invasion, migration and osteoclastogenesis in prostate and breast cancer cells.
Academic Article Muscadine grape skin extract reverts snail-mediated epithelial mesenchymal transition via superoxide species in human prostate cancer cells.
Academic Article Snail promotes cell migration through PI3K/AKT-dependent Rac1 activation as well as PI3K/AKT-independent pathways during prostate cancer progression.
Academic Article Targeting the Nuclear Cathepsin L CCAAT Displacement Protein/Cut Homeobox Transcription Factor-Epithelial Mesenchymal Transition Pathway in Prostate and Breast Cancer Cells with the Z-FY-CHO Inhibitor.
Academic Article Snail transcription factor NLS and importin ?1 regulate the subcellular localization of Cathepsin L and Cux1.
Academic Article Association of Epithelial Mesenchymal Transition with prostate and breast health disparities.
Academic Article Epithelial-Mesenchymal Transition (EMT) and Prostate Cancer.
Academic Article CCAAT-displacement protein/cut homeobox transcription factor (CUX1) represses estrogen receptor-alpha (ER-a) in triple-negative breast cancer cells and can be antagonized by muscadine grape skin extract (MSKE).
Academic Article Cancer-bone microenvironmental interactions promotes STAT3 signaling.
Academic Article Insulin-like growth factor-I-dependent up-regulation of ZEB1 drives epithelial-to-mesenchymal transition in human prostate cancer cells.
Academic Article Receptor activator of NF-kappaB Ligand (RANKL) expression is associated with epithelial to mesenchymal transition in human prostate cancer cells.
Concept Transcription Factors
Concept STAT3 Transcription Factor
Academic Article SNAIL Transctiption factor in prostate cancer cells promotes neurite outgrowth.
Academic Article Correction for Burton et al., "Targeting the Nuclear Cathepsin L CCAAT Displacement Protein/Cut Homeobox Transcription Factor-Epithelial Mesenchymal Transition Pathway in Prostate and Breast Cancer Cells with the Z-FY-CHO Inhibitor".
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  • Transcription Factors
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