Renato J. Aguilera to Apoptosis
This is a "connection" page, showing publications Renato J. Aguilera has written about Apoptosis.
Connection Strength
4.184
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Borrego EA, Guerena CD, Schiaffino Bustamante AY, Gutierrez DA, Valenzuela CA, Betancourt AP, Varela-Ramirez A, Aguilera RJ. A Novel Pyrazole Exhibits Potent Anticancer Cytotoxicity via Apoptosis, Cell Cycle Arrest, and the Inhibition of Tubulin Polymerization in Triple-Negative Breast Cancer Cells. Cells. 2024 07 20; 13(14).
Score: 0.497
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Contreras L, Medina S, Schiaffino Bustamante AY, Borrego EA, Valenzuela CA, Das U, Karki SS, Dimmock JR, Aguilera RJ. Three novel piperidones exhibit tumor-selective cytotoxicity on leukemia cells via protein degradation and stress-mediated mechanisms. Pharmacol Rep. 2022 Feb; 74(1):159-174.
Score: 0.406
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Villanueva PJ, Martinez A, Baca ST, DeJesus RE, Larragoity M, Contreras L, Gutierrez DA, Varela-Ramirez A, Aguilera RJ. Pyronaridine exerts potent cytotoxicity on human breast and hematological cancer cells through induction of apoptosis. PLoS One. 2018; 13(11):e0206467.
Score: 0.334
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Contreras L, Calderon RI, Varela-Ramirez A, Zhang HY, Quan Y, Das U, Dimmock JR, Skouta R, Aguilera RJ. Induction of apoptosis via proteasome inhibition in leukemia/lymphoma cells by two potent piperidones. Cell Oncol (Dordr). 2018 Dec; 41(6):623-636.
Score: 0.329
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Robles-Escajeda E, Das U, Ortega NM, Parra K, Francia G, Dimmock JR, Varela-Ramirez A, Aguilera RJ. A novel curcumin-like dienone induces apoptosis in triple-negative breast cancer cells. Cell Oncol (Dordr). 2016 Jun; 39(3):265-77.
Score: 0.277
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Varela-Ramirez A, Costanzo M, Carrasco YP, Pannell KH, Aguilera RJ. Cytotoxic effects of two organotin compounds and their mode of inflicting cell death on four mammalian cancer cells. Cell Biol Toxicol. 2011 Jun; 27(3):159-68.
Score: 0.192
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Mart?nez A, Rajapakse CS, S?nchez-Delgado RA, Varela-Ramirez A, Lema C, Aguilera RJ. Arene-Ru(II)-chloroquine complexes interact with DNA, induce apoptosis on human lymphoid cell lines and display low toxicity to normal mammalian cells. J Inorg Biochem. 2010 Sep; 104(9):967-77.
Score: 0.186
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Gutierrez DA, Robles-Escajeda E, Lopez-Saenz JA, Kirken RA, Borrego EA, Betancourt AP, Nair S, Roy S, Varela-Ramirez A, Aguilera RJ. Discovery of Two Novel Pyrazole Derivatives as Anticancer Agents Targeting Tubulin Polymerization and MAPK Signaling Pathways. Oncol Res. 2026; 34(4):14.
Score: 0.139
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Rasafar N, Sanchez-Michael LA, Torres A, Andujo LA, Gutierrez DA, Varela-Ramirez A, Aguilera RJ, Noveron JC. Novel anticancer alkyl pyridinium derivative exhibits antiproliferative activity via G0/G1 cell cycle arrest and apoptosis activation in triple-negative breast cancer cells. Bioorg Med Chem. 2026 Jun; 137:118638.
Score: 0.139
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Sanchez-Michael LA, Sudarshan V, Elias A, Gutierrez DA, Lopez-Saenz JA, Pena-Zacarias J, Torres GC, Varela-Ramirez A, Kumar S, Karki SS, Aguilera RJ. Functional Characterization of VS-186B, a Novel HDAC Inhibitor with Anticancer Activity. Int J Mol Sci. 2025 Nov 24; 26(23).
Score: 0.136
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Azzman N, Gill MSA, Abdullah N, Gutierrez DA, Varela-Ramirez A, Sanchez-Michael LA, Lopez-Saenz JA, Taib MNAM, Shah SAA, Aguilera RJ, Ahemad N. Novel 4-quinolone derivative inflicted cytotoxicity via intrinsic apoptotic pathway activation on human metastatic triple-negative breast cancer cells. Bioorg Chem. 2025 10; 165:109033.
Score: 0.135
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Aishwarya S, Torres GC, Lopez-Saenz JA, Gutierrez DA, Kumar S, Madarakhandi A, Metikurki B, Teraiya N, Aguilera RJ, Karki SS. Synthesis of novel pyridazine and pyrimidine linked pyrazole derivatives as DNA ligase 1 and IV inhibitors that induce apoptosis. Chem Biol Interact. 2025 Jun 01; 414:111509.
Score: 0.131
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ElMorsy SM, Gutierrez DA, Valdez S, Kumar J, Aguilera RJ, Noufal M, Sarma H, Chinnam S, Narayan M. Graphene acid quantum dots: A highly active multifunctional carbon nano material that intervene in the trajectory towards neurodegeneration. J Colloid Interface Sci. 2024 Sep 15; 670:357-363.
Score: 0.122
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Swain RM, Sanchez A, Gutierrez DA, Varela-Ramirez A, Aguilera RJ. Thiophene derivative inflicts cytotoxicity via an intrinsic apoptotic pathway on human acute lymphoblastic leukemia cells. PLoS One. 2023; 18(12):e0295441.
Score: 0.119
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Swain RM, Contreras L, Varela-Ramirez A, Hossain M, Das U, Valenzuela CA, Penichet ML, Dimmock JR, Aguilera RJ. Two novel piperidones induce apoptosis and antiproliferative effects on human prostate and lymphoma cancer cell lines. Invest New Drugs. 2022 Oct; 40(5):905-921.
Score: 0.108
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Nakamura-Bencomo S, Gutierrez DA, Robles-Escajeda E, Iglesias-Figueroa B, Siqueiros-Cend?n TS, Espinoza-S?nchez EA, Ar?valo-Gallegos S, Aguilera RJ, Rasc?n-Cruz Q, Varela-Ramirez A. Recombinant human lactoferrin carrying humanized glycosylation exhibits antileukemia selective cytotoxicity, microfilament disruption, cell cycle arrest, and apoptosis activities. Invest New Drugs. 2021 04; 39(2):400-415.
Score: 0.096
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Lyon CJ, Evans CJ, Bill BR, Otsuka AJ, Aguilera RJ. The C. elegans apoptotic nuclease NUC-1 is related in sequence and activity to mammalian DNase II. Gene. 2000 Jul 11; 252(1-2):147-54.
Score: 0.094
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Iglesias-Figueroa BF, Siqueiros-Cend?n TS, Gutierrez DA, Aguilera RJ, Espinoza-S?nchez EA, Ar?valo-Gallegos S, Varela-Ramirez A, Rasc?n-Cruz Q. Recombinant human lactoferrin induces apoptosis, disruption of F-actin structure and cell cycle arrest with selective cytotoxicity on human triple negative breast cancer cells. Apoptosis. 2019 08; 24(7-8):562-577.
Score: 0.088
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Montoya A, Varela-Ramirez A, Dickerson E, Pasquier E, Torabi A, Aguilera R, Nahleh Z, Bryan B. The beta adrenergic receptor antagonist propranolol alters mitogenic and apoptotic signaling in late stage breast cancer. Biomed J. 2019 06; 42(3):155-165.
Score: 0.088
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Gutierrez DA, DeJesus RE, Contreras L, Rodriguez-Palomares IA, Villanueva PJ, Balderrama KS, Monterroza L, Larragoity M, Varela-Ramirez A, Aguilera RJ. A new pyridazinone exhibits potent cytotoxicity on human cancer cells via apoptosis and poly-ubiquitinated protein accumulation. Cell Biol Toxicol. 2019 12; 35(6):503-519.
Score: 0.085
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Robles-Escajeda E, Mart?nez A, Varela-Ramirez A, S?nchez-Delgado RA, Aguilera RJ. Analysis of the cytotoxic effects of ruthenium-ketoconazole and ruthenium-clotrimazole complexes on cancer cells. Cell Biol Toxicol. 2013 Dec; 29(6):431-43.
Score: 0.059
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Shaik N, Mart?nez A, Augustin I, Giovinazzo H, Varela-Ram?rez A, Sana? M, Aguilera RJ, Contel M. Synthesis of apoptosis-inducing iminophosphorane organogold(III) complexes and study of their interactions with biomolecular targets. Inorg Chem. 2009 Feb 16; 48(4):1577-87.
Score: 0.043
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Montoya J, Varela-Ramirez A, Estrada A, Martinez LE, Garza K, Aguilera RJ. A fluorescence-based rapid screening assay for cytotoxic compounds. Biochem Biophys Res Commun. 2004 Dec 24; 325(4):1517-23.
Score: 0.032
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Evans CJ, Aguilera RJ. DNase II: genes, enzymes and function. Gene. 2003 Dec 11; 322:1-15.
Score: 0.030
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Jain PM, Gutierrez DA, Kumar S, Aguilera RJ, Karki SS. Synthesis of Novel Pyrazole-Oxindole Conjugates with Cytotoxicity in Human Cancer Cells via Apoptosis. Chem Biodivers. 2023 Sep; 20(9):e202300843.
Score: 0.029
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Chhikara A, Roayapalley PK, Sakagami H, Amano S, Satoh K, Uesawa Y, Das U, Das S, Borrego EA, Guerena CD, Hernandez CR, Aguilera RJ, Dimmock JR. Novel Unsymmetric 3,5-Bis(benzylidene)-4-piperidones That Display Tumor-Selective Toxicity. Molecules. 2022 Oct 09; 27(19).
Score: 0.027
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Roayapalley PK, Dimmock JR, Contreras L, Balderrama KS, Aguilera RJ, Sakagami H, Amano S, Sharma RK, Das U. Design, Synthesis and Tumour-Selective Toxicity of Novel 1-[3-{3,5-Bis(benzylidene)-4-oxo-1-piperidino}-3-oxopropyl]-4-piperidone Oximes and Related Quaternary Ammonium Salts. Molecules. 2021 Nov 25; 26(23).
Score: 0.026
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Tilekar K, Hess JD, Upadhyay N, Bianco AL, Schweipert M, Laghezza A, Loiodice F, Meyer-Almes FJ, Aguilera RJ, Lavecchia A, C S R. Thiazolidinedione "Magic Bullets" Simultaneously Targeting PPAR? and HDACs: Design, Synthesis, and Investigations of their In Vitro and In Vivo Antitumor Effects. J Med Chem. 2021 05 27; 64(10):6949-6971.
Score: 0.025
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Choodamani B, Cano Hernandez KG, Kumar S, Tony AM, Schiaffino Bustamante AY, Aguilera RJ, Schols D, Gopi Mohan C, Karki SS. Synthesis, Molecular Docking and Preliminary Antileukemic Activity of 4-Methoxybenzyl Derivatives Bearing Imidazo[2,1-b][1,3,4]thiadiazole. Chem Biodivers. 2021 Feb; 18(2):e2000800.
Score: 0.024
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Tilekar K, Upadhyay N, Schweipert M, Hess JD, Macias LH, Mrowka P, Meyer-Almes FJ, Aguilera RJ, Iancu CV, Choe JY, Ramaa CS. Permuted 2,4-thiazolidinedione (TZD) analogs as GLUT inhibitors and their in-vitro evaluation in leukemic cells. Eur J Pharm Sci. 2020 Nov 01; 154:105512.
Score: 0.024
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Tilekar K, Upadhyay N, Hess JD, Macias LH, Mrowka P, Aguilera RJ, Meyer-Almes FJ, Iancu CV, Choe JY, Ramaa CS. Structure guided design and synthesis of furyl thiazolidinedione derivatives as inhibitors of GLUT 1 and GLUT 4, and evaluation of their anti-leukemic potential. Eur J Med Chem. 2020 Sep 15; 202:112603.
Score: 0.023
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Donoso-Bustamante V, Borrego EA, Schiaffino-Bustamante Y, Guti?rrez DA, Millas-Vargas JP, Fuentes-Retamal S, Correa P, Carrillo I, Aguilera RJ, Miranda D, Ch?vez-B?ez I, Pulgar R, Urra FA, Varela-Ram?rez A, Araya-Maturana R. An acylhydroquinone derivative produces OXPHOS uncoupling and sensitization to BH3 mimetic ABT-199 (Venetoclax) in human promyelocytic leukemia cells. Bioorg Chem. 2020 07; 100:103935.
Score: 0.023
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Upadhyay N, Tilekar K, J?nsch N, Schweipert M, Hess JD, Henze Macias L, Mrowka P, Aguilera RJ, Choe JY, Meyer-Almes FJ, Ramaa CS. Discovery of novel N-substituted thiazolidinediones (TZDs) as HDAC8 inhibitors: in-silico studies, synthesis, and biological evaluation. Bioorg Chem. 2020 07; 100:103934.
Score: 0.023
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Solis LH, Ayala Y, Portillo S, Varela-Ramirez A, Aguilera R, Boland T. Thermal inkjet bioprinting triggers the activation of the VEGF pathway in human microvascular endothelial cells in vitro. Biofabrication. 2019 07 09; 11(4):045005.
Score: 0.022
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Santiago-Vazquez Y, Das S, Das U, Robles-Escajeda E, Ortega NM, Lema C, Varela-Ram?rez A, Aguilera RJ, Balzarini J, De Clercq E, Dimmock SG, Gorecki DK, Dimmock JR. Novel 3,5-bis(arylidene)-4-oxo-1-piperidinyl dimers: structure-activity relationships and potent antileukemic and antilymphoma cytotoxicity. Eur J Med Chem. 2014 Apr 22; 77:315-22.
Score: 0.015
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Pedroza DA, De Leon F, Varela-Ramirez A, Lema C, Aguilera RJ, Mito S. The cytotoxic effect of 2-acylated-1,4-naphthohydroquinones on leukemia/lymphoma cells. Bioorg Med Chem. 2014 Jan 15; 22(2):842-7.
Score: 0.015
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Robles-Escajeda E, Lerma D, Nyakeriga AM, Ross JA, Kirken RA, Aguilera RJ, Varela-Ramirez A. Searching in mother nature for anti-cancer activity: anti-proliferative and pro-apoptotic effect elicited by green barley on leukemia/lymphoma cells. PLoS One. 2013; 8(9):e73508.
Score: 0.015
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Oldham ED, Seelam S, Lema C, Aguilera RJ, Fiegel J, Rankin SE, Knutson BL, Lehmler HJ. Synthesis, surface properties, and biocompatibility of 1,2,3-triazole-containing alkyl ?-D-xylopyranoside surfactants. Carbohydr Res. 2013 Sep 20; 379:68-77.
Score: 0.014
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Xu W, Osei-Prempeh G, Lema C, Davis Oldham E, Aguilera RJ, Parkin S, Rankin SE, Knutson BL, Lehmler HJ. Synthesis, thermal properties, and cytotoxicity evaluation of hydrocarbon and fluorocarbon alkyl ?-D-xylopyranoside surfactants. Carbohydr Res. 2012 Feb 15; 349:12-23.
Score: 0.013