Schaffler, Mitchell
name suffix: PhD
first name: Mitchell
last name: Schaffler
full name: Mitchell B Schaffler, PhD
has faculty rank: Professor
has network: research areas
has network: similar to
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Person ID: 2398238
person in primary position: Professor
similar to: Wang, Xiaodu
similar to: Zhang, John
similar to: Tarbell, John
similar to: Perry, George
similar to: Zvolensky, Michael
type: Agent
type: Person
selected publications: Authorship 84413
selected publications: Authorship 84797
selected publications: Authorship 89875
selected publications: Authorship 84011
selected publications: Authorship 89199
selected publications: Authorship 84007
selected publications: Authorship 82369
selected publications: Authorship 89046
selected publications: Authorship 88111
selected publications: Authorship 82495
selected publications: Authorship 82784
selected publications: Authorship 82114
selected publications: Authorship 87855
selected publications: Authorship 89826
selected publications: Authorship 86560
selected publications: Authorship 84285
selected publications: Authorship 87625
selected publications: Authorship 85162
selected publications: Authorship 85580
selected publications: Authorship 82048
selected publications: Authorship 85661
selected publications: Authorship 82546
selected publications: Authorship 84586
selected publications: Authorship 89081
selected publications: Authorship 89784
selected publications: Authorship 85170
selected publications: Authorship 82115
selected publications: Authorship 82611
selected publications: Authorship 86144
selected publications: Authorship 83633
selected publications: Authorship 89423
selected publications: Authorship 86039
selected publications: Authorship 83981
selected publications: Authorship 84541
selected publications: Authorship 86487
selected publications: Authorship 85483
selected publications: Authorship 88680
selected publications: Authorship 86257
selected publications: Authorship 88037
selected publications: Authorship 89690
selected publications: Authorship 82811
selected publications: Authorship 85432
selected publications: Authorship 83070
selected publications: Authorship 82527
selected publications: Authorship 87621
selected publications: Authorship 86253
selected publications: Authorship 82657
selected publications: Authorship 88225
selected publications: Authorship 84261
selected publications: Authorship 81741
selected publications: Authorship 83612
selected publications: Authorship 86159
selected publications: Authorship 83272
selected publications: Authorship 83823
selected publications: Authorship 81822
selected publications: Authorship 86360
selected publications: Authorship 88665
selected publications: Authorship 87173
selected publications: Authorship 88678
selected publications: Authorship 88379
selected publications: Authorship 84230
selected publications: Authorship 89171

Zvolensky, Michael
first name: Michael
last name: Zvolensky
full name: Michael J. Zvolensky, PhD
has faculty rank: Professor
Person ID: 2397388
person in primary position: Hugh Roy and Lillie Cranz Cullen Distinguished University Professor of Clinical Psychology
type: Agent
type: Person
preferred title: Hugh Roy and Lillie Cranz Cullen Distinguished University Professor of Clinical Psychology

Professor
sort order: 91
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http://connect.rtrn.net/profiles/profile/21595496
type: Address
address line 1: 160 Convent Ave
city: New York
postal code: 10031
state or province: NY

Dr.
is primary position: true
position in department: College of Sciences
sort order: 1
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HR job title: Dr.
position in organization: University of Texas at San Antonio

Professor
is primary position: true
position in department: Health & Kinesiology
sort order: 1
type: Position
HR job title: Professor
position in organization: University of Texas at San Antonio

Professor
is primary position: true
position in department: Mechanical Engineering
sort order: 1
type: Position
HR job title: Professor
position in organization: University of Texas at San Antonio

Hugh Roy and Lillie Cranz Cullen Distinguished University Professor of Clinical Psychology
is primary position: true
position in department: Psychology
sort order: 1
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HR job title: Hugh Roy and Lillie Cranz Cullen Distinguished University Professor of Clinical Psychology
position in organization: University of Houston

Distinguished Professor
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position in department: Biomedical Engineering
position in division: Grove School of Engineering
sort order: 1
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HR job title: Distinguished Professor
position in organization: City College, CUNY

Professor
is primary position: true
position in department: Biomedical Engineering
position in division: Grove School of Engineering
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position in organization: City College, CUNY

Grove School of Engineering
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selected publications
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Structural, Molecular, and Functional Specialization in Osteocyte Mechanosensing
end date: 2016-08-31
grant awarded by: NIH
principal investigator name: WEINBAUM, SHELDON
start date: 2010-09-06
type: Agreement
type: Grant
sponsor award id: R01AR057139

Structural, Molecular and Functional Specialization in Osteocyte Mechanosensing
end date: 2024-04-30
grant awarded by: NIH
principal investigator name: SCHAFFLER, MITCHELL B ;SPRAY, DAVID C
start date: 2018-07-11
type: Agreement
type: Grant
sponsor award id: R01AR070547

MICRODAMAGE AND BONE REMODELING IN STRESS FRACTURE
end date: 1997-08-31
grant awarded by: NIH
principal investigator name: SCHAFFLER, MITCHELL B
start date: 1992-09-15
type: Agreement
type: Grant
sponsor award id: R29AR041210

Diverse effects of somatopause and aging on the skeleton
end date: 2024-04-30
grant awarded by: NIH
principal investigator name: SCHAFFLER, MITCHELL B;YAKAR, SHOSHANA
start date: 2018-09-15
type: Agreement
type: Grant
sponsor award id: R01AG056397

Diffuse microdamage in bone: Direct repair without remodeling
end date: 2013-12-31
grant awarded by: NIH
principal investigator name: SCHAFFLER, MITCHELL B
start date: 2011-01-01
type: Agreement
type: Grant
sponsor award id: R21AR060445

Ostecocyte Intergrity and Bone Remodeling
end date: 2021-02-28
grant awarded by: NIH
principal investigator name: SCHAFFLER, MITCHELL B
start date: 1992-09-15
type: Agreement
type: Grant
sponsor award id: R01AR041210

Renewed bone remodeling after pausing long-term bisphosphonate use: Does it replace regions of impaired bone quality and restore mechanical integrity?
end date: 2029-03-31
grant awarded by: NIH
principal investigator name: SCHAFFLER, MITCHELL B
start date: 2023-09-05
type: Agreement
type: Grant
sponsor award id: R01AR081381

Co-Principal Investigator
type: Researcher Role
type: Role
researcher role of: Schaffler, Mitchell
contributes to: Structural, Molecular, and Functional Specialization in Osteocyte Mechanosensing

Principal Investigator
type: Researcher Role
type: Role
researcher role of: Schaffler, Mitchell
contributes to: Structural, Molecular and Functional Specialization in Osteocyte Mechanosensing

Principal Investigator
type: Researcher Role
type: Role
researcher role of: Schaffler, Mitchell
contributes to: Diffuse microdamage in bone: Direct repair without remodeling

Principal Investigator
type: Researcher Role
type: Role
researcher role of: Schaffler, Mitchell
contributes to: MICRODAMAGE AND BONE REMODELING IN STRESS FRACTURE

Principal Investigator
type: Researcher Role
type: Role
researcher role of: Schaffler, Mitchell
contributes to: Ostecocyte Intergrity and Bone Remodeling

Principal Investigator
type: Researcher Role
type: Role
researcher role of: Schaffler, Mitchell
contributes to: Diverse effects of somatopause and aging on the skeleton

Principal Investigator
type: Researcher Role
type: Role
researcher role of: Schaffler, Mitchell
contributes to: Renewed bone remodeling after pausing long-term bisphosphonate use: Does it replace regions of impaired bone quality and restore mechanical integrity?

Authorship 81822
type: Authorship
author rank in publication: 7
linked author: Schaffler, Mitchell
linked information resource: Matrix metalloproteinase-3 in articular cartilage is upregulated by joint immobilization and suppressed by passive joint motion.

Authorship 82657
type: Authorship
author rank in publication: 5
linked author: Schaffler, Mitchell
linked information resource: Tibial compression is anabolic in the adult mouse skeleton despite reduced responsiveness with aging.

Authorship 83981
type: Authorship
author rank in publication: 3
linked author: Schaffler, Mitchell
linked information resource: Primary cilia exist in a small fraction of cells in trabecular bone and marrow.

Authorship 84011
type: Authorship
author rank in publication: 11
linked author: Schaffler, Mitchell
linked information resource: Lifelong Excess in GH Elicits Sexually Dimorphic Effects on Skeletal Morphology and Bone Mechanical Properties.

Authorship 84059
type: Authorship
author rank in publication: 3
linked author: Schaffler, Mitchell
linked information resource: A model for the role of integrins in flow induced mechanotransduction in osteocytes.

Authorship 84576
type: Authorship
author rank in publication: 5
linked author: Schaffler, Mitchell
linked information resource: Type 2 diabetic mice demonstrate slender long bones with increased fragility secondary to increased osteoclastogenesis.

Authorship 84586
type: Authorship
author rank in publication: 4
linked author: Schaffler, Mitchell
linked information resource: Regional differences in oxidative metabolism and mitochondrial activity among cortical bone osteocytes.

Authorship 85162
type: Authorship
author rank in publication: 3
linked author: Schaffler, Mitchell
linked information resource: A multiscale fluidic device for the study of dendrite-mediated cell to cell communication.

Authorship 85483
type: Authorship
author rank in publication: 5
linked author: Schaffler, Mitchell
linked information resource: Osteocyte apoptosis is required for production of osteoclastogenic signals following bone fatigue in vivo.

Authorship 85580
type: Authorship
author rank in publication: 10
linked author: Schaffler, Mitchell
linked information resource: Ablation of Hepatic Production of the Acid-Labile Subunit in Bovine-GH Transgenic Mice: Effects on Organ and Skeletal Growth.

Authorship 85905
type: Authorship
author rank in publication: 4
linked author: Schaffler, Mitchell
linked information resource: Spatial distribution of Bax and Bcl-2 in osteocytes after bone fatigue: complementary roles in bone remodeling regulation?

Authorship 86039
type: Authorship
author rank in publication: 5
linked author: Schaffler, Mitchell
linked information resource: Structural and mechanical repair of diffuse damage in cortical bone in vivo.

Authorship 86050
type: Authorship
author rank in publication: 2
linked author: Schaffler, Mitchell
linked information resource: Novel procedure for high-fidelity tendon histology.

Authorship 86144
type: Authorship
author rank in publication: 3
linked author: Schaffler, Mitchell
linked information resource: Bone microdamage, remodeling and bone fragility: how much damage is too much damage?

Authorship 86159
type: Authorship
author rank in publication: 10
linked author: Schaffler, Mitchell
linked information resource: Physiological loading of joints prevents cartilage degradation through CITED2.

Authorship 86257
type: Authorship
author rank in publication: 12
linked author: Schaffler, Mitchell
linked information resource: Reductions in serum IGF-1 during aging impair health span.

Authorship 86360
type: Authorship
author rank in publication: 11
linked author: Schaffler, Mitchell
linked information resource: Growth hormone protects against ovariectomy-induced bone loss in states of low circulating insulin-like growth factor (IGF-1).

Authorship 86407
type: Authorship
author rank in publication: 3
linked author: Schaffler, Mitchell
linked information resource: Relationship between bone morphology and bone quality in male tibias: implications for stress fracture risk.

Authorship 86560
type: Authorship
author rank in publication: 7
linked author: Schaffler, Mitchell
linked information resource: Potential role for a specialized ?3 integrin-based structure on osteocyte processes in bone mechanosensation.

Authorship 86970
type: Authorship
author rank in publication: 8
linked author: Schaffler, Mitchell
linked information resource: Long-term disuse osteoporosis seems less sensitive to bisphosphonate treatment than other osteoporosis.

Authorship 87173
type: Authorship
author rank in publication: 6
linked author: Schaffler, Mitchell
linked information resource: Sustained release of multiple growth factors from injectable polymeric system as a novel therapeutic approach towards angiogenesis.

Authorship 87366
type: Authorship
author rank in publication: 17
linked author: Schaffler, Mitchell
linked information resource: Loss of MMP-2 disrupts skeletal and craniofacial development and results in decreased bone mineralization, joint erosion and defects in osteoblast and osteoclast growth.

Authorship 88033
type: Authorship
author rank in publication: 17
linked author: Schaffler, Mitchell
linked information resource: FSH directly regulates bone mass.

Authorship 88037
type: Authorship
author rank in publication: 3
linked author: Schaffler, Mitchell
linked information resource: Mechanosensory responses of osteocytes to physiological forces occur along processes and not cell body and require aV?3 integrin.

Authorship 88111
type: Authorship
author rank in publication: 7
linked author: Schaffler, Mitchell
linked information resource: A Bisphosphonate With a Low Hydroxyapatite Binding Affinity Prevents Bone Loss in Mice After Ovariectomy and Reverses Rapidly With Treatment Cessation.

Authorship 88225
type: Authorship
author rank in publication: 4
linked author: Schaffler, Mitchell
linked information resource: Material and mechanical properties of bones deficient for fibrillin-1 or fibrillin-2 microfibrils.

Authorship 88379
type: Authorship
author rank in publication: 3
linked author: Schaffler, Mitchell
linked information resource: The dependency of solute diffusion on molecular weight and shape in intact bone.

Authorship 88680
type: Authorship
author rank in publication: 8
linked author: Schaffler, Mitchell
linked information resource: Skeletal response of male mice to anabolic hormone therapy in the absence of the Igfals gene.

Authorship 88918
type: Authorship
author rank in publication: 2
linked author: Schaffler, Mitchell
linked information resource: Genetic background influences cortical bone response to ovariectomy.

Authorship 89046
type: Authorship
author rank in publication: 11
linked author: Schaffler, Mitchell
linked information resource: Skeletal Response to Insulin in the Naturally Occurring Type 1 Diabetes Mellitus Mouse Model.

Authorship 89171
type: Authorship
author rank in publication: 7
linked author: Schaffler, Mitchell
linked information resource: Subrupture tendon fatigue damage.

Authorship 89199
type: Authorship
author rank in publication: 7
linked author: Schaffler, Mitchell
linked information resource: Induction of somatopause in adult mice compromises bone morphology and exacerbates bone loss during aging.

Authorship 89423
type: Authorship
author rank in publication: 7
linked author: Schaffler, Mitchell
linked information resource: Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse post-traumatic osteoarthritis model.

Authorship 89690
type: Authorship
author rank in publication: 1
linked author: Schaffler, Mitchell
linked information resource: Osteocytes: master orchestrators of bone.

Authorship 89826
type: Authorship
author rank in publication: 4
linked author: Schaffler, Mitchell
linked information resource: Role of pannexin 1 channels in load-induced skeletal response.

Authorship 82114
type: Authorship
author rank in publication: 7
linked author: Schaffler, Mitchell
linked information resource: Correction to: Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse posttraumatic osteoarthritis model.

Authorship 82115
type: Authorship
author rank in publication: 6
linked author: Schaffler, Mitchell
linked information resource: DMP-1-mediated Ghr gene recombination compromises skeletal development and impairs skeletal response to intermittent PTH.

Authorship 82369
type: Authorship
author rank in publication: 7
linked author: Schaffler, Mitchell
linked information resource: Reply to: A Bisphosphonate With a Low Hydroxyapatite Binding Affinity Prevents Bone Loss in Mice After Ovariectomy and Reverses Rapidly With Treatment Cessation.

Authorship 82495
type: Authorship
author rank in publication: 4
linked author: Schaffler, Mitchell
linked information resource: Apoptotic Osteocytes Induce RANKL Production in Bystanders via Purinergic Signaling and Activation of Pannexin Channels.

Authorship 82546
type: Authorship
author rank in publication: 4
linked author: Schaffler, Mitchell
linked information resource: Thermally induced osteocyte damage initiates pro-osteoclastogenic gene expression in vivo.

Authorship 82592
type: Authorship
author rank in publication: 4
linked author: Schaffler, Mitchell
linked information resource: Aging of microstructural compartments in human compact bone.

Authorship 83070
type: Authorship
author rank in publication: 2
linked author: Schaffler, Mitchell
linked information resource: The roles of osteocyte signaling in bone.

Authorship 84230
type: Authorship
author rank in publication: 6
linked author: Schaffler, Mitchell
linked information resource: Osteocyte apoptosis controls activation of intracortical resorption in response to bone fatigue.

Authorship 84285
type: Authorship
author rank in publication: 5
linked author: Schaffler, Mitchell
linked information resource: Reduced Serum IGF-1 Associated With Hepatic Osteodystrophy Is a Main Determinant of Low Cortical but Not Trabecular Bone Mass.

Authorship 84413
type: Authorship
author rank in publication: 10
linked author: Schaffler, Mitchell
linked information resource: The impact of inactivation of the GH/IGF axis during aging on healthspan.

Authorship 84541
type: Authorship
author rank in publication: 4
linked author: Schaffler, Mitchell
linked information resource: Authors response to letter from Plotkin and Bellido.

Authorship 84797
type: Authorship
author rank in publication: 11
linked author: Schaffler, Mitchell
linked information resource: Targeting mitochondrial dysfunction using methylene blue or mitoquinone to improve skeletal aging.

Authorship 84873
type: Authorship
author rank in publication: 3
linked author: Schaffler, Mitchell
linked information resource: Age-related changes in physicochemical properties of mineral crystals are related to impaired mechanical function of cortical bone.

Authorship 85119
type: Authorship
author rank in publication: 7
linked author: Schaffler, Mitchell
linked information resource: Mice lacking cathepsin K maintain bone remodeling but develop bone fragility despite high bone mass.

Authorship 85661
type: Authorship
author rank in publication: 6
linked author: Schaffler, Mitchell
linked information resource: Microdamage induced by in vivo Reference Point Indentation in mice is repaired by osteocyte-apoptosis mediated remodeling.

Authorship 85729
type: Authorship
author rank in publication: 5
linked author: Schaffler, Mitchell
linked information resource: High-dose risedronate treatment partially preserves cancellous bone mass and microarchitecture during long-term disuse.

Authorship 85786
type: Authorship
author rank in publication: 2
linked author: Schaffler, Mitchell
linked information resource: Prestress due to dimensional changes caused by demineralization: a potential mechanism for microcracking in bone.

Authorship 86487
type: Authorship
author rank in publication: 4
linked author: Schaffler, Mitchell
linked information resource: Temporal effect of in vivo tendon fatigue loading on the apoptotic response explained in the context of number of fatigue loading cycles and initial damage parameters.

Authorship 86761
type: Authorship
author rank in publication: 7
linked author: Schaffler, Mitchell
linked information resource: In situ measurement of solute transport in the bone lacunar-canalicular system.

Authorship 87618
type: Authorship
author rank in publication: 5
linked author: Schaffler, Mitchell
linked information resource: Comparative assessment of bone mass and structure using texture-based and histomorphometric analyses.

Authorship 87621
type: Authorship
author rank in publication: 1
linked author: Schaffler, Mitchell
linked information resource: Osteocyte signaling in bone.

Authorship 87625
type: Authorship
author rank in publication: 10
linked author: Schaffler, Mitchell
linked information resource: Osteocyte calcium signals encode strain magnitude and loading frequency in vivo.

Authorship 87855
type: Authorship
author rank in publication: 3
linked author: Schaffler, Mitchell
linked information resource: Mitochondrial Function Is Compromised in Cortical Bone Osteocytes of Long-Lived Growth Hormone Receptor Null Mice.

Authorship 88762
type: Authorship
author rank in publication: 1
linked author: Schaffler, Mitchell
linked information resource: Role of bone turnover in microdamage.

Authorship 89081
type: Authorship
author rank in publication: 3
linked author: Schaffler, Mitchell
linked information resource: P2X7R-Panx1 Complex Impairs Bone Mechanosignaling under High Glucose Levels Associated with Type-1 Diabetes.

Authorship 89875
type: Authorship
author rank in publication: 6
linked author: Schaffler, Mitchell
linked information resource: A Fluorescent Intravital Imaging Approach to Study Load-Induced Calcium Signaling Dynamics in Mouse Osteocytes.

Authorship 82527
type: Authorship
author rank in publication: 6
linked author: Schaffler, Mitchell
linked information resource: Low levels of plasma IGF-1 inhibit intracortical bone remodeling during aging.

Authorship 82611
type: Authorship
author rank in publication: 7
linked author: Schaffler, Mitchell
linked information resource: Fibrillin-1 Regulates Skeletal Stem Cell Differentiation by Modulating TGF? Activity Within the Marrow Niche.

Authorship 82784
type: Authorship
author rank in publication: 6
linked author: Schaffler, Mitchell
linked information resource: CITED2 mediates the cross-talk between mechanical loading and IL-4 to promote chondroprotection.

Authorship 83272
type: Authorship
author rank in publication: 5
linked author: Schaffler, Mitchell
linked information resource: Cancellous bone adaptation to tibial compression is not sex dependent in growing mice.

Authorship 83322
type: Authorship
author rank in publication: 4
linked author: Schaffler, Mitchell
linked information resource: The effect of a short-term delay of puberty on trabecular bone mass and structure in female rats: a texture-based and histomorphometric analysis.

Authorship 81741
type: Authorship
author rank in publication: 8
linked author: Schaffler, Mitchell
linked information resource: Tendon-derived stem/progenitor cell aging: defective self-renewal and altered fate.

Authorship 82048
type: Authorship
author rank in publication: 12
linked author: Schaffler, Mitchell
linked information resource: Lactation-Induced Changes in the Volume of Osteocyte Lacunar-Canalicular Space Alter Mechanical Properties in Cortical Bone Tissue.

Authorship 82064
type: Authorship
author rank in publication: 9
linked author: Schaffler, Mitchell
linked information resource: Selective estrogen receptor modulation influences atherosclerotic plaque composition in a rabbit menopause model.

Authorship 82089
type: Authorship
author rank in publication: 3
linked author: Schaffler, Mitchell
linked information resource: Mechanotransduction and strain amplification in osteocyte cell processes.

Authorship 82150
type: Authorship
author rank in publication: 4
linked author: Schaffler, Mitchell
linked information resource: Ultrastructure of the osteocyte process and its pericellular matrix.

Authorship 82811
type: Authorship
author rank in publication: 10
linked author: Schaffler, Mitchell
linked information resource: Serum IGF-1 is insufficient to restore skeletal size in the total absence of the growth hormone receptor.

Authorship 83612
type: Authorship
author rank in publication: 13
linked author: Schaffler, Mitchell
linked information resource: Cycle-dependent matrix remodeling gene expression response in fatigue-loaded rat patellar tendons.

Authorship 83633
type: Authorship
author rank in publication: 2
linked author: Schaffler, Mitchell
linked information resource: Changes of elastic constants and anisotropy patterns in trabecular bone during disuse-induced bone loss assessed by poroelastic ultrasound.

Authorship 83823
type: Authorship
author rank in publication: 7
linked author: Schaffler, Mitchell
linked information resource: Second harmonic generation imaging and Fourier transform spectral analysis reveal damage in fatigue-loaded tendons.

Authorship 84007
type: Authorship
author rank in publication: 12
linked author: Schaffler, Mitchell
linked information resource: Estrogen depletion on In vivo osteocyte calcium signaling responses to mechanical loading.

Authorship 84261
type: Authorship
author rank in publication: 14
linked author: Schaffler, Mitchell
linked information resource: BMP-12 treatment of adult mesenchymal stem cells in vitro augments tendon-like tissue formation and defect repair in vivo.

Authorship 85120
type: Authorship
author rank in publication: 3
linked author: Schaffler, Mitchell
linked information resource: Osteocyte lacuna size and shape in women with and without osteoporotic fracture.

Authorship 85170
type: Authorship
author rank in publication: 10
linked author: Schaffler, Mitchell
linked information resource: Pannexin-1 and P2X7-Receptor Are Required for Apoptotic Osteocytes in Fatigued Bone to Trigger RANKL Production in Neighboring Bystander Osteocytes.

Authorship 85432
type: Authorship
author rank in publication: 2
linked author: Schaffler, Mitchell
linked information resource: Matrix-dependent adhesion mediates network responses to physiological stimulation of the osteocyte cell process.

Authorship 85581
type: Authorship
author rank in publication: 11
linked author: Schaffler, Mitchell
linked information resource: Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism.

Authorship 85808
type: Authorship
author rank in publication: 7
linked author: Schaffler, Mitchell
linked information resource: Ablation of cathepsin k activity in the young mouse causes hypermineralization of long bone and growth plates.

Authorship 86253
type: Authorship
author rank in publication: 6
linked author: Schaffler, Mitchell
linked information resource: Activation of resorption in fatigue-loaded bone involves both apoptosis and active pro-osteoclastogenic signaling by distinct osteocyte populations.

Authorship 87775
type: Authorship
author rank in publication: 5
linked author: Schaffler, Mitchell
linked information resource: Coordinate regulation of IL-1beta and MMP-13 in rat tendons following subrupture fatigue damage.

Authorship 88665
type: Authorship
author rank in publication: 7
linked author: Schaffler, Mitchell
linked information resource: Development and validation of a motion and loading system for a rat knee joint in vivo.

Authorship 88678
type: Authorship
author rank in publication: 9
linked author: Schaffler, Mitchell
linked information resource: Early response to tendon fatigue damage accumulation in a novel in vivo model.

Authorship 89659
type: Authorship
author rank in publication: 7
linked author: Schaffler, Mitchell
linked information resource: Targeting of androgen receptor in bone reveals a lack of androgen anabolic action and inhibition of osteogenesis: a model for compartment-specific androgen action in the skeleton.

Authorship 89784
type: Authorship
author rank in publication: 7
linked author: Schaffler, Mitchell
linked information resource: Osteocyte Apoptosis Caused by Hindlimb Unloading is Required to Trigger Osteocyte RANKL Production and Subsequent Resorption of Cortical and Trabecular Bone in Mice Femurs.

The impact of inactivation of the GH/IGF axis during aging on healthspan.
PubMed Identifier: 39535693
author list: Poudel SB, Ruff RR, He Z, Dixit M, Yildirim G, Jayarathne H, Manchanayake DH, Basta-Pljakic J, Duran-Ortiz S, Schaffler MB, Kopchick JJ, Sadagurski M, Yakar S
published in: GeroScience
information resource reference: Poudel SB, Ruff RR, He Z, Dixit M, Yildirim G, Jayarathne H, Manchanayake DH, Basta-Pljakic J, Duran-Ortiz S, Schaffler MB, Kopchick JJ, Sadagurski M, Yakar S. The impact of inactivation of the GH/IGF axis during aging on healthspan. Geroscience. 2025 Jun; 47(3):3027-3042.
journal title abbreviation: Geroscience
publication date: 2024-11-13T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

A Fluorescent Intravital Imaging Approach to Study Load-Induced Calcium Signaling Dynamics in Mouse Osteocytes.
PubMed Identifier: 36912542
author list: Lewis KJ, Boorman-Padgett JF, Castaneda M, Spray DC, Thi MM, Schaffler MB
published in: Journal of visualized experiments : JoVE
information resource reference: Lewis KJ, Boorman-Padgett JF, Castaneda M, Spray DC, Thi MM, Schaffler MB. A Fluorescent Intravital Imaging Approach to Study Load-Induced Calcium Signaling Dynamics in Mouse Osteocytes. J Vis Exp. 2023 02 24; (192).
journal title abbreviation: J Vis Exp
publication date: 2023-02-24T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Estrogen depletion on In vivo osteocyte calcium signaling responses to mechanical loading.
PubMed Identifier: 34171514
author list: Lewis KJ, Cabahug-Zuckerman P, Boorman-Padgett JF, Basta-Pljakic J, Louie J, Stephen S, Spray DC, Thi MM, Seref-Ferlengez Z, Majeska RJ, Weinbaum S, Schaffler MB
published in: Bone
information resource reference: Lewis KJ, Cabahug-Zuckerman P, Boorman-Padgett JF, Basta-Pljakic J, Louie J, Stephen S, Spray DC, Thi MM, Seref-Ferlengez Z, Majeska RJ, Weinbaum S, Schaffler MB. Estrogen depletion on In vivo osteocyte calcium signaling responses to mechanical loading. Bone. 2021 11; 152:116072.
journal title abbreviation: Bone
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Prestress due to dimensional changes caused by demineralization: a potential mechanism for microcracking in bone.
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published in: Annals of biomedical engineering
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Coordinate regulation of IL-1beta and MMP-13 in rat tendons following subrupture fatigue damage.
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published in: Clinical orthopaedics and related research
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Subrupture tendon fatigue damage.
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published in: Journal of orthopaedic research : official publication of the Orthopaedic Research Society
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Ablation of cathepsin k activity in the young mouse causes hypermineralization of long bone and growth plates.
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The dependency of solute diffusion on molecular weight and shape in intact bone.
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Early response to tendon fatigue damage accumulation in a novel in vivo model.
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published in: Journal of biomechanics
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Sustained release of multiple growth factors from injectable polymeric system as a novel therapeutic approach towards angiogenesis.
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Development and validation of a motion and loading system for a rat knee joint in vivo.
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Second harmonic generation imaging and Fourier transform spectral analysis reveal damage in fatigue-loaded tendons.
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author list: Fung DT, Sereysky JB, Basta-Pljakic J, Laudier DM, Huq R, Jepsen KJ, Schaffler MB, Flatow EL
published in: Annals of biomedical engineering
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Growth hormone protects against ovariectomy-induced bone loss in states of low circulating insulin-like growth factor (IGF-1).
PubMed Identifier: 19619004
author list: Fritton JC, Emerton KB, Sun H, Kawashima Y, Mejia W, Wu Y, Rosen CJ, Panus D, Bouxsein M, Majeska RJ, Schaffler MB, Yakar S
published in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
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Tendon-derived stem/progenitor cell aging: defective self-renewal and altered fate.
PubMed Identifier: 20569237
author list: Zhou Z, Akinbiyi T, Xu L, Ramcharan M, Leong DJ, Ros SJ, Colvin AC, Schaffler MB, Majeska RJ, Flatow EL, Sun HB
published in: Aging cell
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Cancellous bone adaptation to tibial compression is not sex dependent in growing mice.
PubMed Identifier: 20576844
author list: Lynch ME, Main RP, Xu Q, Walsh DJ, Schaffler MB, Wright TM, van der Meulen MC
published in: Journal of applied physiology (Bethesda, Md. : 1985)
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journal title abbreviation: J Appl Physiol (1985)
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Cycle-dependent matrix remodeling gene expression response in fatigue-loaded rat patellar tendons.
PubMed Identifier: 20839322
author list: Sun HB, Andarawis-Puri N, Li Y, Fung DT, Lee JY, Wang VM, Basta-Pljakic J, Leong DJ, Sereysky JB, Ros SJ, Klug RA, Braman J, Schaffler MB, Jepsen KJ, Flatow EL
published in: Journal of orthopaedic research : official publication of the Orthopaedic Research Society
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BMP-12 treatment of adult mesenchymal stem cells in vitro augments tendon-like tissue formation and defect repair in vivo.
PubMed Identifier: 21412429
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published in: PloS one
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Aging of microstructural compartments in human compact bone.
PubMed Identifier: 12817753
author list: Akkus O, Polyakova-Akkus A, Adar F, Schaffler MB
published in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
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Role of bone turnover in microdamage.
PubMed Identifier: 14504710
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published in: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
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Spatial distribution of Bax and Bcl-2 in osteocytes after bone fatigue: complementary roles in bone remodeling regulation?
PubMed Identifier: 12009022
author list: Verborgt O, Tatton NA, Majeska RJ, Schaffler MB
published in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
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Age-related changes in physicochemical properties of mineral crystals are related to impaired mechanical function of cortical bone.
PubMed Identifier: 15003792
author list: Akkus O, Adar F, Schaffler MB
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Ultrastructure of the osteocyte process and its pericellular matrix.
PubMed Identifier: 15164337
author list: You LD, Weinbaum S, Cowin SC, Schaffler MB
published in: The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology
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Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse post-traumatic osteoarthritis model.
PubMed Identifier: 25516005
author list: Leong DJ, Choudhury M, Hanstein R, Hirsh DM, Kim SJ, Majeska RJ, Schaffler MB, Hardin JA, Spray DC, Goldring MB, Cobelli NJ, Sun HB
published in: Arthritis research & therapy
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Osteocyte lacuna size and shape in women with and without osteoporotic fracture.
PubMed Identifier: 14996569
author list: McCreadie BR, Hollister SJ, Schaffler MB, Goldstein SA
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Long-term disuse osteoporosis seems less sensitive to bisphosphonate treatment than other osteoporosis.
PubMed Identifier: 15619677
author list: Li CY, Price C, Delisser K, Nasser P, Laudier D, Clement M, Jepsen KJ, Schaffler MB
published in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
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Temporal effect of in vivo tendon fatigue loading on the apoptotic response explained in the context of number of fatigue loading cycles and initial damage parameters.
PubMed Identifier: 24838769
author list: Andarawis-Puri N, Philip A, Laudier D, Schaffler MB, Flatow EL
published in: Journal of orthopaedic research : official publication of the Orthopaedic Research Society
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High-dose risedronate treatment partially preserves cancellous bone mass and microarchitecture during long-term disuse.
PubMed Identifier: 16006205
author list: Yang Li C, Majeska RJ, Laudier DM, Mann R, Schaffler MB
published in: Bone
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Relationship between bone morphology and bone quality in male tibias: implications for stress fracture risk.
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author list: Tommasini SM, Nasser P, Schaffler MB, Jepsen KJ
published in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
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Mice lacking cathepsin K maintain bone remodeling but develop bone fragility despite high bone mass.
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published in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
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In situ measurement of solute transport in the bone lacunar-canalicular system.
PubMed Identifier: 16087872
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published in: Proceedings of the National Academy of Sciences of the United States of America
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Comparative assessment of bone mass and structure using texture-based and histomorphometric analyses.
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Type 2 diabetic mice demonstrate slender long bones with increased fragility secondary to increased osteoclastogenesis.
PubMed Identifier: 19150422
author list: Kawashima Y, Fritton JC, Yakar S, Epstein S, Schaffler MB, Jepsen KJ, LeRoith D
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Targeting of androgen receptor in bone reveals a lack of androgen anabolic action and inhibition of osteogenesis: a model for compartment-specific androgen action in the skeleton.
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author list: Wiren KM, Semirale AA, Zhang XW, Woo A, Tommasini SM, Price C, Schaffler MB, Jepsen KJ
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DMP-1-mediated Ghr gene recombination compromises skeletal development and impairs skeletal response to intermittent PTH.
PubMed Identifier: 26481310
author list: Liu Z, Kennedy OD, Cardoso L, Basta-Pljakic J, Partridge NC, Schaffler MB, Rosen CJ, Yakar S
published in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology
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Pannexin-1 and P2X7-Receptor Are Required for Apoptotic Osteocytes in Fatigued Bone to Trigger RANKL Production in Neighboring Bystander Osteocytes.
PubMed Identifier: 26553756
author list: Cheung WY, Fritton JC, Morgan SA, Seref-Ferlengez Z, Basta-Pljakic J, Thi MM, Suadicani SO, Spray DC, Majeska RJ, Schaffler MB
published in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
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Matrix metalloproteinase-3 in articular cartilage is upregulated by joint immobilization and suppressed by passive joint motion.
PubMed Identifier: 20153826
author list: Leong DJ, Gu XI, Li Y, Lee JY, Laudier DM, Majeska RJ, Schaffler MB, Cardoso L, Sun HB
published in: Matrix biology : journal of the International Society for Matrix Biology
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Physiological loading of joints prevents cartilage degradation through CITED2.
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published in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology
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Material and mechanical properties of bones deficient for fibrillin-1 or fibrillin-2 microfibrils.
PubMed Identifier: 21440062
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Tibial compression is anabolic in the adult mouse skeleton despite reduced responsiveness with aging.
PubMed Identifier: 21642027
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Activation of resorption in fatigue-loaded bone involves both apoptosis and active pro-osteoclastogenic signaling by distinct osteocyte populations.
PubMed Identifier: 22342796
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Osteocyte signaling in bone.
PubMed Identifier: 22552701
author list: Schaffler MB, Kennedy OD
published in: Current osteoporosis reports
information resource reference: Schaffler MB, Kennedy OD. Osteocyte signaling in bone. Curr Osteoporos Rep. 2012 Jun; 10(2):118-25.
journal title abbreviation: Curr Osteoporos Rep
publication date: 2012-06-01T00:00:00
year: 2012
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The roles of osteocyte signaling in bone.
PubMed Identifier: 23027697
author list: Kennedy OD, Schaffler MB
published in: The Journal of the American Academy of Orthopaedic Surgeons
information resource reference: Kennedy OD, Schaffler MB. The roles of osteocyte signaling in bone. J Am Acad Orthop Surg. 2012 Oct; 20(10):670-1.
journal title abbreviation: J Am Acad Orthop Surg
publication date: 2012-10-01T00:00:00
year: 2012
type: Academic Article
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type: Document
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Mechanotransduction and strain amplification in osteocyte cell processes.
PubMed Identifier: 15539460
author list: Han Y, Cowin SC, Schaffler MB, Weinbaum S
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Han Y, Cowin SC, Schaffler MB, Weinbaum S. Mechanotransduction and strain amplification in osteocyte cell processes. Proc Natl Acad Sci U S A. 2004 Nov 23; 101(47):16689-94.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2004-11-11T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
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Genetic background influences cortical bone response to ovariectomy.
PubMed Identifier: 16294268
author list: Li CY, Schaffler MB, Wolde-Semait HT, Hernandez CJ, Jepsen KJ
published in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
information resource reference: Li CY, Schaffler MB, Wolde-Semait HT, Hernandez CJ, Jepsen KJ. Genetic background influences cortical bone response to ovariectomy. J Bone Miner Res. 2005 Dec; 20(12):2150-8.
journal title abbreviation: J Bone Miner Res
publication date: 2005-08-22T00:00:00
year: 2005
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FSH directly regulates bone mass.
PubMed Identifier: 16630814
author list: Sun L, Peng Y, Sharrow AC, Iqbal J, Zhang Z, Papachristou DJ, Zaidi S, Zhu LL, Yaroslavskiy BB, Zhou H, Zallone A, Sairam MR, Kumar TR, Bo W, Braun J, Cardoso-Landa L, Schaffler MB, Moonga BS, Blair HC, Zaidi M
published in: Cell
information resource reference: Sun L, Peng Y, Sharrow AC, Iqbal J, Zhang Z, Papachristou DJ, Zaidi S, Zhu LL, Yaroslavskiy BB, Zhou H, Zallone A, Sairam MR, Kumar TR, Bo W, Braun J, Cardoso-Landa L, Schaffler MB, Moonga BS, Blair HC, Zaidi M. FSH directly regulates bone mass. Cell. 2006 Apr 21; 125(2):247-60.
journal title abbreviation: Cell
publication date: 2006-04-21T00:00:00
year: 2006
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Matrix-dependent adhesion mediates network responses to physiological stimulation of the osteocyte cell process.
PubMed Identifier: 23818616
author list: Wu D, Schaffler MB, Weinbaum S, Spray DC
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Wu D, Schaffler MB, Weinbaum S, Spray DC. Matrix-dependent adhesion mediates network responses to physiological stimulation of the osteocyte cell process. Proc Natl Acad Sci U S A. 2013 Jul 16; 110(29):12096-101.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2013-07-01T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
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Novel procedure for high-fidelity tendon histology.
PubMed Identifier: 17149746
author list: Laudier D, Schaffler MB, Flatow EL, Wang VM
published in: Journal of orthopaedic research : official publication of the Orthopaedic Research Society
information resource reference: Laudier D, Schaffler MB, Flatow EL, Wang VM. Novel procedure for high-fidelity tendon histology. J Orthop Res. 2007 Mar; 25(3):390-5.
journal title abbreviation: J Orthop Res
publication date: 2007-03-01T00:00:00
year: 2007
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Loss of MMP-2 disrupts skeletal and craniofacial development and results in decreased bone mineralization, joint erosion and defects in osteoblast and osteoclast growth.
PubMed Identifier: 17400654
author list: Mosig RA, Dowling O, DiFeo A, Ramirez MC, Parker IC, Abe E, Diouri J, Aqeel AA, Wylie JD, Oblander SA, Madri J, Bianco P, Apte SS, Zaidi M, Doty SB, Majeska RJ, Schaffler MB, Martignetti JA
published in: Human molecular genetics
information resource reference: Mosig RA, Dowling O, DiFeo A, Ramirez MC, Parker IC, Abe E, Diouri J, Aqeel AA, Wylie JD, Oblander SA, Madri J, Bianco P, Apte SS, Zaidi M, Doty SB, Majeska RJ, Schaffler MB, Martignetti JA. Loss of MMP-2 disrupts skeletal and craniofacial development and results in decreased bone mineralization, joint erosion and defects in osteoblast and osteoclast growth. Hum Mol Genet. 2007 May 01; 16(9):1113-23.
journal title abbreviation: Hum Mol Genet
publication date: 2007-03-30T00:00:00
year: 2007
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A model for the role of integrins in flow induced mechanotransduction in osteocytes.
PubMed Identifier: 17895377
author list: Wang Y, McNamara LM, Schaffler MB, Weinbaum S
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Wang Y, McNamara LM, Schaffler MB, Weinbaum S. A model for the role of integrins in flow induced mechanotransduction in osteocytes. Proc Natl Acad Sci U S A. 2007 Oct 02; 104(40):15941-6.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2007-09-25T00:00:00
year: 2007
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The effect of a short-term delay of puberty on trabecular bone mass and structure in female rats: a texture-based and histomorphometric analysis.
PubMed Identifier: 16979963
author list: Yingling VR, Xiang Y, Raphan T, Schaffler MB, Koser K, Malique R
published in: Bone
information resource reference: Yingling VR, Xiang Y, Raphan T, Schaffler MB, Koser K, Malique R. The effect of a short-term delay of puberty on trabecular bone mass and structure in female rats: a texture-based and histomorphometric analysis. Bone. 2007 Feb; 40(2):419-24.
journal title abbreviation: Bone
publication date: 2006-09-18T00:00:00
year: 2006
type: Academic Article
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Osteocytes: master orchestrators of bone.
PubMed Identifier: 24042263
author list: Schaffler MB, Cheung WY, Majeska R, Kennedy O
published in: Calcified tissue international
information resource reference: Schaffler MB, Cheung WY, Majeska R, Kennedy O. Osteocytes: master orchestrators of bone. Calcif Tissue Int. 2014 Jan; 94(1):5-24.
journal title abbreviation: Calcif Tissue Int
publication date: 2013-09-17T00:00:00
year: 2013
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Skeletal response of male mice to anabolic hormone therapy in the absence of the Igfals gene.
PubMed Identifier: 24424061
author list: Kennedy OD, Sun H, Wu Y, Courtland HW, Williams GA, Cardoso L, Basta-Pljakic J, Schaffler MB, Yakar S
published in: Endocrinology
information resource reference: Kennedy OD, Sun H, Wu Y, Courtland HW, Williams GA, Cardoso L, Basta-Pljakic J, Schaffler MB, Yakar S. Skeletal response of male mice to anabolic hormone therapy in the absence of the Igfals gene. Endocrinology. 2014 Mar; 155(3):987-99.
journal title abbreviation: Endocrinology
publication date: 2014-01-01T00:00:00
year: 2014
type: Academic Article
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type: Document
type: Information Resource

Selective estrogen receptor modulation influences atherosclerotic plaque composition in a rabbit menopause model.
PubMed Identifier: 18367192
author list: Choi BG, Vilahur G, Zafar MU, Cardoso L, Yadegar D, Ibanez B, Tunstead J, Viles-Gonzalez JF, Schaffler MB, Fuster V, Badimon JJ
published in: Atherosclerosis
information resource reference: Choi BG, Vilahur G, Zafar MU, Cardoso L, Yadegar D, Ibanez B, Tunstead J, Viles-Gonzalez JF, Schaffler MB, Fuster V, Badimon JJ. Selective estrogen receptor modulation influences atherosclerotic plaque composition in a rabbit menopause model. Atherosclerosis. 2008 Nov; 201(1):76-84.
journal title abbreviation: Atherosclerosis
publication date: 2008-02-21T00:00:00
year: 2008
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Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism.
PubMed Identifier: 18952711
author list: Yakar S, Rosen CJ, Bouxsein ML, Sun H, Mejia W, Kawashima Y, Wu Y, Emerton K, Williams V, Jepsen K, Schaffler MB, Majeska RJ, Gavrilova O, Gutierrez M, Hwang D, Pennisi P, Frystyk J, Boisclair Y, Pintar J, Jasper H, Domene H, Cohen P, Clemmons D, LeRoith D
published in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology
information resource reference: Yakar S, Rosen CJ, Bouxsein ML, Sun H, Mejia W, Kawashima Y, Wu Y, Emerton K, Williams V, Jepsen K, Schaffler MB, Majeska RJ, Gavrilova O, Gutierrez M, Hwang D, Pennisi P, Frystyk J, Boisclair Y, Pintar J, Jasper H, Domene H, Cohen P, Clemmons D, LeRoith D. Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism. FASEB J. 2009 Mar; 23(3):709-19.
journal title abbreviation: FASEB J
publication date: 2008-10-24T00:00:00
year: 2008
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Osteocyte apoptosis controls activation of intracortical resorption in response to bone fatigue.
PubMed Identifier: 19049324
author list: Cardoso L, Herman BC, Verborgt O, Laudier D, Majeska RJ, Schaffler MB
published in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
information resource reference: Cardoso L, Herman BC, Verborgt O, Laudier D, Majeska RJ, Schaffler MB. Osteocyte apoptosis controls activation of intracortical resorption in response to bone fatigue. J Bone Miner Res. 2009 Apr; 24(4):597-605.
journal title abbreviation: J Bone Miner Res
publication date: 2009-04-01T00:00:00
year: 2009
type: Academic Article
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Low levels of plasma IGF-1 inhibit intracortical bone remodeling during aging.
PubMed Identifier: 22976122
author list: Courtland HW, Kennedy OD, Wu Y, Gao Y, Sun H, Schaffler MB, Yakar S
published in: Age (Dordrecht, Netherlands)
information resource reference: Courtland HW, Kennedy OD, Wu Y, Gao Y, Sun H, Schaffler MB, Yakar S. Low levels of plasma IGF-1 inhibit intracortical bone remodeling during aging. Age (Dordr). 2013 Oct; 35(5):1691-703.
journal title abbreviation: Age (Dordr)
publication date: 2012-09-14T00:00:00
year: 2012
type: Academic Article
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type: Document
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Serum IGF-1 is insufficient to restore skeletal size in the total absence of the growth hormone receptor.
PubMed Identifier: 23456957
author list: Wu Y, Sun H, Basta-Pljakic J, Cardoso L, Kennedy OD, Jasper H, Domen? H, Karabatas L, Guida C, Schaffler MB, Rosen CJ, Yakar S
published in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
information resource reference: Wu Y, Sun H, Basta-Pljakic J, Cardoso L, Kennedy OD, Jasper H, Domen? H, Karabatas L, Guida C, Schaffler MB, Rosen CJ, Yakar S. Serum IGF-1 is insufficient to restore skeletal size in the total absence of the growth hormone receptor. J Bone Miner Res. 2013 Jul; 28(7):1575-86.
journal title abbreviation: J Bone Miner Res
publication date: 2013-07-01T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Structural and mechanical repair of diffuse damage in cortical bone in vivo.
PubMed Identifier: 25042459
author list: Seref-Ferlengez Z, Basta-Pljakic J, Kennedy OD, Philemon CJ, Schaffler MB
published in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
information resource reference: Seref-Ferlengez Z, Basta-Pljakic J, Kennedy OD, Philemon CJ, Schaffler MB. Structural and mechanical repair of diffuse damage in cortical bone in vivo. J Bone Miner Res. 2014 Dec; 29(12):2537-44.
journal title abbreviation: J Bone Miner Res
publication date: 2014-12-01T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Osteocyte apoptosis is required for production of osteoclastogenic signals following bone fatigue in vivo.
PubMed Identifier: 24709687
author list: Kennedy OD, Laudier DM, Majeska RJ, Sun HB, Schaffler MB
published in: Bone
information resource reference: Kennedy OD, Laudier DM, Majeska RJ, Sun HB, Schaffler MB. Osteocyte apoptosis is required for production of osteoclastogenic signals following bone fatigue in vivo. Bone. 2014 Jul; 64:132-7.
journal title abbreviation: Bone
publication date: 2014-04-04T00:00:00
year: 2014
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type: Document
type: Information Resource

Reductions in serum IGF-1 during aging impair health span.
PubMed Identifier: 24341939
author list: Gong Z, Kennedy O, Sun H, Wu Y, Williams GA, Klein L, Cardoso L, Matheny RW, Hubbard GB, Ikeno Y, Farrar RP, Schaffler MB, Adamo ML, Muzumdar RH, Yakar S
published in: Aging cell
information resource reference: Gong Z, Kennedy O, Sun H, Wu Y, Williams GA, Klein L, Cardoso L, Matheny RW, Hubbard GB, Ikeno Y, Farrar RP, Schaffler MB, Adamo ML, Muzumdar RH, Yakar S. Reductions in serum IGF-1 during aging impair health span. Aging Cell. 2014 Jun; 13(3):408-18.
journal title abbreviation: Aging Cell
publication date: 2013-12-30T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Fibrillin-1 Regulates Skeletal Stem Cell Differentiation by Modulating TGF? Activity Within the Marrow Niche.
PubMed Identifier: 26189658
author list: Smaldone S, Clayton NP, del Solar M, Pascual G, Cheng SH, Wentworth BM, Schaffler MB, Ramirez F
published in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
information resource reference: Smaldone S, Clayton NP, del Solar M, Pascual G, Cheng SH, Wentworth BM, Schaffler MB, Ramirez F. Fibrillin-1 Regulates Skeletal Stem Cell Differentiation by Modulating TGF? Activity Within the Marrow Niche. J Bone Miner Res. 2016 Jan; 31(1):86-97.
journal title abbreviation: J Bone Miner Res
publication date: 2015-08-17T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Thermally induced osteocyte damage initiates pro-osteoclastogenic gene expression in vivo.
PubMed Identifier: 27335224
author list: Dolan EB, Tallon D, Cheung WY, Schaffler MB, Kennedy OD, McNamara LM
published in: Journal of the Royal Society, Interface
information resource reference: Dolan EB, Tallon D, Cheung WY, Schaffler MB, Kennedy OD, McNamara LM. Thermally induced osteocyte damage initiates pro-osteoclastogenic gene expression in vivo. J R Soc Interface. 2016 06; 13(119).
journal title abbreviation: J R Soc Interface
publication date: 2016-06-01T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
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Regional differences in oxidative metabolism and mitochondrial activity among cortical bone osteocytes.
PubMed Identifier: 27260646
author list: Frikha-Benayed D, Basta-Pljakic J, Majeska RJ, Schaffler MB
published in: Bone
information resource reference: Frikha-Benayed D, Basta-Pljakic J, Majeska RJ, Schaffler MB. Regional differences in oxidative metabolism and mitochondrial activity among cortical bone osteocytes. Bone. 2016 09; 90:15-22.
journal title abbreviation: Bone
publication date: 2016-05-31T00:00:00
year: 2016
type: Academic Article
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type: Document
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Microdamage induced by in vivo Reference Point Indentation in mice is repaired by osteocyte-apoptosis mediated remodeling.
PubMed Identifier: 27919734
author list: Kennedy OD, Lendhey M, Mauer P, Philip A, Basta-Pljakic J, Schaffler MB
published in: Bone
information resource reference: Kennedy OD, Lendhey M, Mauer P, Philip A, Basta-Pljakic J, Schaffler MB. Microdamage induced by in vivo Reference Point Indentation in mice is repaired by osteocyte-apoptosis mediated remodeling. Bone. 2017 02; 95:192-198.
journal title abbreviation: Bone
publication date: 2016-12-02T00:00:00
year: 2016
type: Academic Article
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type: Document
type: Information Resource

Osteocyte Apoptosis Caused by Hindlimb Unloading is Required to Trigger Osteocyte RANKL Production and Subsequent Resorption of Cortical and Trabecular Bone in Mice Femurs.
PubMed Identifier: 26852281
author list: Cabahug-Zuckerman P, Frikha-Benayed D, Majeska RJ, Tuthill A, Yakar S, Judex S, Schaffler MB
published in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
information resource reference: Cabahug-Zuckerman P, Frikha-Benayed D, Majeska RJ, Tuthill A, Yakar S, Judex S, Schaffler MB. Osteocyte Apoptosis Caused by Hindlimb Unloading is Required to Trigger Osteocyte RANKL Production and Subsequent Resorption of Cortical and Trabecular Bone in Mice Femurs. J Bone Miner Res. 2016 07; 31(7):1356-65.
journal title abbreviation: J Bone Miner Res
publication date: 2016-03-22T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

P2X7R-Panx1 Complex Impairs Bone Mechanosignaling under High Glucose Levels Associated with Type-1 Diabetes.
PubMed Identifier: 27159053
author list: Seref-Ferlengez Z, Maung S, Schaffler MB, Spray DC, Suadicani SO, Thi MM
published in: PloS one
information resource reference: Seref-Ferlengez Z, Maung S, Schaffler MB, Spray DC, Suadicani SO, Thi MM. P2X7R-Panx1 Complex Impairs Bone Mechanosignaling under High Glucose Levels Associated with Type-1 Diabetes. PLoS One. 2016; 11(5):e0155107.
journal title abbreviation: PLoS One
publication date: 2016-05-09T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Lifelong Excess in GH Elicits Sexually Dimorphic Effects on Skeletal Morphology and Bone Mechanical Properties.
PubMed Identifier: 36069368
author list: Dixit M, Louis LD, Basta-Pljakic J, Yildirim G, Poudel SB, Kumararaja F, List EO, Duran SO, Kopchick JJ, Ruff RR, Schaffler MB, Yakar S
published in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
information resource reference: Dixit M, Louis LD, Basta-Pljakic J, Yildirim G, Poudel SB, Kumararaja F, List EO, Duran SO, Kopchick JJ, Ruff RR, Schaffler MB, Yakar S. Lifelong Excess in GH Elicits Sexually Dimorphic Effects on Skeletal Morphology and Bone Mechanical Properties. J Bone Miner Res. 2022 11; 37(11):2201-2214.
journal title abbreviation: J Bone Miner Res
publication date: 2022-09-16T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Reduced Serum IGF-1 Associated With Hepatic Osteodystrophy Is a Main Determinant of Low Cortical but Not Trabecular Bone Mass.
PubMed Identifier: 28902430
author list: Liu Z, Han T, Werner H, Rosen CJ, Schaffler MB, Yakar S
published in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
information resource reference: Liu Z, Han T, Werner H, Rosen CJ, Schaffler MB, Yakar S. Reduced Serum IGF-1 Associated With Hepatic Osteodystrophy Is a Main Determinant of Low Cortical but Not Trabecular Bone Mass. J Bone Miner Res. 2018 01; 33(1):123-136.
journal title abbreviation: J Bone Miner Res
publication date: 2017-11-06T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Mitochondrial Function Is Compromised in Cortical Bone Osteocytes of Long-Lived Growth Hormone Receptor Null Mice.
PubMed Identifier: 30216544
author list: Liu Z, Solesio ME, Schaffler MB, Frikha-Benayed D, Rosen CJ, Werner H, Kopchick JJ, Pavlov EV, Abramov AY, Yakar S
published in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
information resource reference: Liu Z, Solesio ME, Schaffler MB, Frikha-Benayed D, Rosen CJ, Werner H, Kopchick JJ, Pavlov EV, Abramov AY, Yakar S. Mitochondrial Function Is Compromised in Cortical Bone Osteocytes of Long-Lived Growth Hormone Receptor Null Mice. J Bone Miner Res. 2019 01; 34(1):106-122.
journal title abbreviation: J Bone Miner Res
publication date: 2018-09-14T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

CITED2 mediates the cross-talk between mechanical loading and IL-4 to promote chondroprotection.
PubMed Identifier: 30891766
author list: He Z, Leong DJ, Xu L, Hardin JA, Majeska RJ, Schaffler MB, Thi MM, Yang L, Goldring MB, Cobelli NJ, Sun HB
published in: Annals of the New York Academy of Sciences
information resource reference: He Z, Leong DJ, Xu L, Hardin JA, Majeska RJ, Schaffler MB, Thi MM, Yang L, Goldring MB, Cobelli NJ, Sun HB. CITED2 mediates the cross-talk between mechanical loading and IL-4 to promote chondroprotection. Ann N Y Acad Sci. 2019 04; 1442(1):128-137.
journal title abbreviation: Ann N Y Acad Sci
publication date: 2019-03-19T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Apoptotic Osteocytes Induce RANKL Production in Bystanders via Purinergic Signaling and Activation of Pannexin Channels.
PubMed Identifier: 31910292
author list: McCutcheon S, Majeska RJ, Spray DC, Schaffler MB, Vazquez M
published in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
information resource reference: McCutcheon S, Majeska RJ, Spray DC, Schaffler MB, Vazquez M. Apoptotic Osteocytes Induce RANKL Production in Bystanders via Purinergic Signaling and Activation of Pannexin Channels. J Bone Miner Res. 2020 05; 35(5):966-977.
journal title abbreviation: J Bone Miner Res
publication date: 2020-02-11T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Primary cilia exist in a small fraction of cells in trabecular bone and marrow.
PubMed Identifier: 25398598
author list: Coughlin TR, Voisin M, Schaffler MB, Niebur GL, McNamara LM
published in: Calcified tissue international
information resource reference: Coughlin TR, Voisin M, Schaffler MB, Niebur GL, McNamara LM. Primary cilia exist in a small fraction of cells in trabecular bone and marrow. Calcif Tissue Int. 2015 Jan; 96(1):65-72.
journal title abbreviation: Calcif Tissue Int
publication date: 2014-11-15T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Changes of elastic constants and anisotropy patterns in trabecular bone during disuse-induced bone loss assessed by poroelastic ultrasound.
PubMed Identifier: 25412022
author list: Cardoso L, Schaffler MB
published in: Journal of biomechanical engineering
information resource reference: Cardoso L, Schaffler MB. Changes of elastic constants and anisotropy patterns in trabecular bone during disuse-induced bone loss assessed by poroelastic ultrasound. J Biomech Eng. 2015 Jan; 137(1).
journal title abbreviation: J Biomech Eng
publication date: 2015-01-01T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Authors response to letter from Plotkin and Bellido.
PubMed Identifier: 25108470
author list: Cheung WY, Kennedy OD, Majeska RJ, Schaffler MB
published in: Calcified tissue international
information resource reference: Cheung WY, Kennedy OD, Majeska RJ, Schaffler MB. Authors response to letter from Plotkin and Bellido. Calcif Tissue Int. 2014 Oct; 95(4):384.
journal title abbreviation: Calcif Tissue Int
publication date: 2014-08-10T00:00:00
year: 2014
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type: Article
type: Document
type: Information Resource

Potential role for a specialized ?3 integrin-based structure on osteocyte processes in bone mechanosensation.
PubMed Identifier: 29087614
author list: Cabahug-Zuckerman P, Stout RF, Majeska RJ, Thi MM, Spray DC, Weinbaum S, Schaffler MB
published in: Journal of orthopaedic research : official publication of the Orthopaedic Research Society
information resource reference: Cabahug-Zuckerman P, Stout RF, Majeska RJ, Thi MM, Spray DC, Weinbaum S, Schaffler MB. Potential role for a specialized ?3 integrin-based structure on osteocyte processes in bone mechanosensation. J Orthop Res. 2018 02; 36(2):642-652.
journal title abbreviation: J Orthop Res
publication date: 2017-11-28T00:00:00
year: 2017
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type: Document
type: Information Resource

A Bisphosphonate With a Low Hydroxyapatite Binding Affinity Prevents Bone Loss in Mice After Ovariectomy and Reverses Rapidly With Treatment Cessation.
PubMed Identifier: 33869992
author list: Coffman AA, Basta-Pljakic J, Guerra RM, Ebetino FH, Lundy MW, Majeska RJ, Schaffler MB
published in: JBMR plus
information resource reference: Coffman AA, Basta-Pljakic J, Guerra RM, Ebetino FH, Lundy MW, Majeska RJ, Schaffler MB. A Bisphosphonate With a Low Hydroxyapatite Binding Affinity Prevents Bone Loss in Mice After Ovariectomy and Reverses Rapidly With Treatment Cessation. JBMR Plus. 2021 Apr; 5(4):e10476.
journal title abbreviation: JBMR Plus
publication date: 2021-03-03T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Skeletal Response to Insulin in the Naturally Occurring Type 1 Diabetes Mellitus Mouse Model.
PubMed Identifier: 33977201
author list: Dixit M, Liu Z, Poudel SB, Yildirim G, Zhang YZ, Mehta S, Murik O, Altarescu G, Kobayashi Y, Shimizu E, Schaffler MB, Yakar S
published in: JBMR plus
information resource reference: Dixit M, Liu Z, Poudel SB, Yildirim G, Zhang YZ, Mehta S, Murik O, Altarescu G, Kobayashi Y, Shimizu E, Schaffler MB, Yakar S. Skeletal Response to Insulin in the Naturally Occurring Type 1 Diabetes Mellitus Mouse Model. JBMR Plus. 2021 May; 5(5):e10483.
journal title abbreviation: JBMR Plus
publication date: 2021-03-17T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Mechanosensory responses of osteocytes to physiological forces occur along processes and not cell body and require aV?3 integrin.
PubMed Identifier: 24324138
author list: Thi MM, Suadicani SO, Schaffler MB, Weinbaum S, Spray DC
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Thi MM, Suadicani SO, Schaffler MB, Weinbaum S, Spray DC. Mechanosensory responses of osteocytes to physiological forces occur along processes and not cell body and require aV?3 integrin. Proc Natl Acad Sci U S A. 2013 Dec 24; 110(52):21012-7.
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author list: Coffman AA, Basta-Pljakic J, Guerra RM, Ebetino FH, Lundy MW, Majeska RJ, Schaffler MB
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information resource reference: Coffman AA, Basta-Pljakic J, Guerra RM, Ebetino FH, Lundy MW, Majeska RJ, Schaffler MB. Reply to: A Bisphosphonate With a Low Hydroxyapatite Binding Affinity Prevents Bone Loss in Mice After Ovariectomy and Reverses Rapidly With Treatment Cessation. JBMR Plus. 2021 Jul; 5(7):e10492.
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Lactation-Induced Changes in the Volume of Osteocyte Lacunar-Canalicular Space Alter Mechanical Properties in Cortical Bone Tissue.
PubMed Identifier: 27859586
author list: Kaya S, Basta-Pljakic J, Seref-Ferlengez Z, Majeska RJ, Cardoso L, Bromage TG, Zhang Q, Flach CR, Mendelsohn R, Yakar S, Fritton SP, Schaffler MB
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Bone microdamage, remodeling and bone fragility: how much damage is too much damage?
PubMed Identifier: 25848533
author list: Seref-Ferlengez Z, Kennedy OD, Schaffler MB
published in: BoneKEy reports
information resource reference: Seref-Ferlengez Z, Kennedy OD, Schaffler MB. Bone microdamage, remodeling and bone fragility: how much damage is too much damage? Bonekey Rep. 2015; 4:644.
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Osteocyte calcium signals encode strain magnitude and loading frequency in vivo.
PubMed Identifier: 29078317
author list: Lewis KJ, Frikha-Benayed D, Louie J, Stephen S, Spray DC, Thi MM, Seref-Ferlengez Z, Majeska RJ, Weinbaum S, Schaffler MB
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Lewis KJ, Frikha-Benayed D, Louie J, Stephen S, Spray DC, Thi MM, Seref-Ferlengez Z, Majeska RJ, Weinbaum S, Schaffler MB. Osteocyte calcium signals encode strain magnitude and loading frequency in vivo. Proc Natl Acad Sci U S A. 2017 10 31; 114(44):11775-11780.
journal title abbreviation: Proc Natl Acad Sci U S A
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Role of pannexin 1 channels in load-induced skeletal response.
PubMed Identifier: 29952014
author list: Seref-Ferlengez Z, Urban-Maldonado M, Sun HB, Schaffler MB, Suadicani SO, Thi MM
published in: Annals of the New York Academy of Sciences
information resource reference: Seref-Ferlengez Z, Urban-Maldonado M, Sun HB, Schaffler MB, Suadicani SO, Thi MM. Role of pannexin 1 channels in load-induced skeletal response. Ann N Y Acad Sci. 2019 04; 1442(1):79-90.
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Induction of somatopause in adult mice compromises bone morphology and exacerbates bone loss during aging.
PubMed Identifier: 34811875
author list: Dixit M, Duran-Ortiz S, Yildirim G, Poudel SB, Louis LD, Bartke A, Schaffler MB, Kopchick JJ, Yakar S
published in: Aging cell
information resource reference: Dixit M, Duran-Ortiz S, Yildirim G, Poudel SB, Louis LD, Bartke A, Schaffler MB, Kopchick JJ, Yakar S. Induction of somatopause in adult mice compromises bone morphology and exacerbates bone loss during aging. Aging Cell. 2021 12; 20(12):e13505.
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Correction to: Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse posttraumatic osteoarthritis model.
PubMed Identifier: 30606217
author list: Leong DJ, Choudhury M, Hanstein R, Hirsh DM, Kim SJ, Majeska RJ, Schaffler MB, Hardin JA, Spray DC, Goldring MB, Cobelli NJ, Sun HB
published in: Arthritis research & therapy
information resource reference: Leong DJ, Choudhury M, Hanstein R, Hirsh DM, Kim SJ, Majeska RJ, Schaffler MB, Hardin JA, Spray DC, Goldring MB, Cobelli NJ, Sun HB. Correction to: Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse posttraumatic osteoarthritis model. Arthritis Res Ther. 2019 Jan 03; 21(1):1.
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Ablation of Hepatic Production of the Acid-Labile Subunit in Bovine-GH Transgenic Mice: Effects on Organ and Skeletal Growth.
PubMed Identifier: 28475811
author list: Liu Z, Han T, Fishman S, Butler J, Zimmermann T, Tremblay F, Harbison C, Agrawal N, Kopchick JJ, Schaffler MB, Yakar S
published in: Endocrinology
information resource reference: Liu Z, Han T, Fishman S, Butler J, Zimmermann T, Tremblay F, Harbison C, Agrawal N, Kopchick JJ, Schaffler MB, Yakar S. Ablation of Hepatic Production of the Acid-Labile Subunit in Bovine-GH Transgenic Mice: Effects on Organ and Skeletal Growth. Endocrinology. 2017 08 01; 158(8):2556-2571.
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Targeting mitochondrial dysfunction using methylene blue or mitoquinone to improve skeletal aging.
PubMed Identifier: 38535998
author list: Poudel SB, Frikha-Benayed D, Ruff RR, Yildirim G, Dixit M, Korstanje R, Robinson L, Miller RA, Harrison DE, Strong JR, Schaffler MB, Yakar S
published in: Aging
information resource reference: Poudel SB, Frikha-Benayed D, Ruff RR, Yildirim G, Dixit M, Korstanje R, Robinson L, Miller RA, Harrison DE, Strong JR, Schaffler MB, Yakar S. Targeting mitochondrial dysfunction using methylene blue or mitoquinone to improve skeletal aging. Aging (Albany NY). 2024 03 25; 16(6):4948-4964.
journal title abbreviation: Aging (Albany NY)
publication date: 2024-03-25T00:00:00
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A multiscale fluidic device for the study of dendrite-mediated cell to cell communication.
PubMed Identifier: 28791515
author list: McCutcheon S, Majeska R, Schaffler M, Vazquez M
published in: Biomedical microdevices
information resource reference: McCutcheon S, Majeska R, Schaffler M, Vazquez M. A multiscale fluidic device for the study of dendrite-mediated cell to cell communication. Biomed Microdevices. 2017 Aug 08; 19(3):71.
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