Hugh Roy and Lillie Cranz Cullen Distinguished University Professor of Clinical Psychology
Structural, Molecular, and Functional Specialization in Osteocyte Mechanosensing
Structural, Molecular and Functional Specialization in Osteocyte Mechanosensing
MICRODAMAGE AND BONE REMODELING IN STRESS FRACTURE
Diverse effects of somatopause and aging on the skeleton
Diffuse microdamage in bone: Direct repair without remodeling
Ostecocyte Intergrity and Bone Remodeling
Renewed bone remodeling after pausing long-term bisphosphonate use: Does it replace regions of impaired bone quality and restore mechanical integrity?
Poudel SB, Ruff RR, He Z, Dixit M, Yildirim G, Jayarathne H, Manchanayake DH, Basta-Pljakic J, Duran-Ortiz S, Schaffler MB, Kopchick JJ, Sadagurski M, Yakar S
Poudel SB, Ruff RR, He Z, Dixit M, Yildirim G, Jayarathne H, Manchanayake DH, Basta-Pljakic J, Duran-Ortiz S, Schaffler MB, Kopchick JJ, Sadagurski M, Yakar S. The impact of inactivation of the GH/IGF axis during aging on healthspan. Geroscience. 2025 Jun; 47(3):3027-3042.
The impact of inactivation of the GH/IGF axis during aging on healthspan.
Lewis KJ, Boorman-Padgett JF, Castaneda M, Spray DC, Thi MM, Schaffler MB
Journal of visualized experiments : JoVE
Lewis KJ, Boorman-Padgett JF, Castaneda M, Spray DC, Thi MM, Schaffler MB. A Fluorescent Intravital Imaging Approach to Study Load-Induced Calcium Signaling Dynamics in Mouse Osteocytes. J Vis Exp. 2023 02 24; (192).
A Fluorescent Intravital Imaging Approach to Study Load-Induced Calcium Signaling Dynamics in Mouse Osteocytes.
Lewis KJ, Cabahug-Zuckerman P, Boorman-Padgett JF, Basta-Pljakic J, Louie J, Stephen S, Spray DC, Thi MM, Seref-Ferlengez Z, Majeska RJ, Weinbaum S, Schaffler MB
Lewis KJ, Cabahug-Zuckerman P, Boorman-Padgett JF, Basta-Pljakic J, Louie J, Stephen S, Spray DC, Thi MM, Seref-Ferlengez Z, Majeska RJ, Weinbaum S, Schaffler MB. Estrogen depletion on In vivo osteocyte calcium signaling responses to mechanical loading. Bone. 2021 11; 152:116072.
Estrogen depletion on In vivo osteocyte calcium signaling responses to mechanical loading.
Yeni YN, Schaffler MB, Gibson G, Fyhrie DP
Yeni YN, Schaffler MB, Gibson G, Fyhrie DP. Prestress due to dimensional changes caused by demineralization: a potential mechanism for microcracking in bone. Ann Biomed Eng. 2002 Feb; 30(2):217-25.
Prestress due to dimensional changes caused by demineralization: a potential mechanism for microcracking in bone.
Sun HB, Li Y, Fung DT, Majeska RJ, Schaffler MB, Flatow EL
Clinical orthopaedics and related research
Sun HB, Li Y, Fung DT, Majeska RJ, Schaffler MB, Flatow EL. Coordinate regulation of IL-1beta and MMP-13 in rat tendons following subrupture fatigue damage. Clin Orthop Relat Res. 2008 Jul; 466(7):1555-61.
Coordinate regulation of IL-1beta and MMP-13 in rat tendons following subrupture fatigue damage.
Fung DT, Wang VM, Laudier DM, Shine JH, Basta-Pljakic J, Jepsen KJ, Schaffler MB, Flatow EL
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Fung DT, Wang VM, Laudier DM, Shine JH, Basta-Pljakic J, Jepsen KJ, Schaffler MB, Flatow EL. Subrupture tendon fatigue damage. J Orthop Res. 2009 Feb; 27(2):264-273.
Boskey AL, Gelb BD, Pourmand E, Kudrashov V, Doty SB, Spevak L, Schaffler MB
Boskey AL, Gelb BD, Pourmand E, Kudrashov V, Doty SB, Spevak L, Schaffler MB. Ablation of cathepsin k activity in the young mouse causes hypermineralization of long bone and growth plates. Calcif Tissue Int. 2009 Mar; 84(3):229-39.
Ablation of cathepsin k activity in the young mouse causes hypermineralization of long bone and growth plates.
Li W, You L, Schaffler MB, Wang L. The dependency of solute diffusion on molecular weight and shape in intact bone. Bone. 2009 Nov; 45(5):1017-23.
The dependency of solute diffusion on molecular weight and shape in intact bone.
Fung DT, Wang VM, Andarawis-Puri N, Basta-Pljakic J, Li Y, Laudier DM, Sun HB, Jepsen KJ, Schaffler MB, Flatow EL
Fung DT, Wang VM, Andarawis-Puri N, Basta-Pljakic J, Li Y, Laudier DM, Sun HB, Jepsen KJ, Schaffler MB, Flatow EL. Early response to tendon fatigue damage accumulation in a novel in vivo model. J Biomech. 2010 Jan 19; 43(2):274-9.
Early response to tendon fatigue damage accumulation in a novel in vivo model.
Sun Q, Silva EA, Wang A, Fritton JC, Mooney DJ, Schaffler MB, Grossman PM, Rajagopalan S
Sun Q, Silva EA, Wang A, Fritton JC, Mooney DJ, Schaffler MB, Grossman PM, Rajagopalan S. Sustained release of multiple growth factors from injectable polymeric system as a novel therapeutic approach towards angiogenesis. Pharm Res. 2010 Feb; 27(2):264-71.
Sustained release of multiple growth factors from injectable polymeric system as a novel therapeutic approach towards angiogenesis.
Gu XI, Leong DJ, Guzman F, Mahamud R, Li YH, Majeska RJ, Schaffler MB, Sun HB, Cardoso L
Gu XI, Leong DJ, Guzman F, Mahamud R, Li YH, Majeska RJ, Schaffler MB, Sun HB, Cardoso L. Development and validation of a motion and loading system for a rat knee joint in vivo. Ann Biomed Eng. 2010 Mar; 38(3):621-31.
Development and validation of a motion and loading system for a rat knee joint in vivo.
Fung DT, Sereysky JB, Basta-Pljakic J, Laudier DM, Huq R, Jepsen KJ, Schaffler MB, Flatow EL
Fung DT, Sereysky JB, Basta-Pljakic J, Laudier DM, Huq R, Jepsen KJ, Schaffler MB, Flatow EL. Second harmonic generation imaging and Fourier transform spectral analysis reveal damage in fatigue-loaded tendons. Ann Biomed Eng. 2010 May; 38(5):1741-51.
Second harmonic generation imaging and Fourier transform spectral analysis reveal damage in fatigue-loaded tendons.
Fritton JC, Emerton KB, Sun H, Kawashima Y, Mejia W, Wu Y, Rosen CJ, Panus D, Bouxsein M, Majeska RJ, Schaffler MB, Yakar S
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Fritton JC, Emerton KB, Sun H, Kawashima Y, Mejia W, Wu Y, Rosen CJ, Panus D, Bouxsein M, Majeska RJ, Schaffler MB, Yakar S. Growth hormone protects against ovariectomy-induced bone loss in states of low circulating insulin-like growth factor (IGF-1). J Bone Miner Res. 2010 Feb; 25(2):235-46.
Growth hormone protects against ovariectomy-induced bone loss in states of low circulating insulin-like growth factor (IGF-1).
Zhou Z, Akinbiyi T, Xu L, Ramcharan M, Leong DJ, Ros SJ, Colvin AC, Schaffler MB, Majeska RJ, Flatow EL, Sun HB
Zhou Z, Akinbiyi T, Xu L, Ramcharan M, Leong DJ, Ros SJ, Colvin AC, Schaffler MB, Majeska RJ, Flatow EL, Sun HB. Tendon-derived stem/progenitor cell aging: defective self-renewal and altered fate. Aging Cell. 2010 Oct; 9(5):911-5.
Tendon-derived stem/progenitor cell aging: defective self-renewal and altered fate.
Lynch ME, Main RP, Xu Q, Walsh DJ, Schaffler MB, Wright TM, van der Meulen MC
Journal of applied physiology (Bethesda, Md. : 1985)
Lynch ME, Main RP, Xu Q, Walsh DJ, Schaffler MB, Wright TM, van der Meulen MC. Cancellous bone adaptation to tibial compression is not sex dependent in growing mice. J Appl Physiol (1985). 2010 Sep; 109(3):685-91.
Cancellous bone adaptation to tibial compression is not sex dependent in growing mice.
Sun HB, Andarawis-Puri N, Li Y, Fung DT, Lee JY, Wang VM, Basta-Pljakic J, Leong DJ, Sereysky JB, Ros SJ, Klug RA, Braman J, Schaffler MB, Jepsen KJ, Flatow EL
Sun HB, Andarawis-Puri N, Li Y, Fung DT, Lee JY, Wang VM, Basta-Pljakic J, Leong DJ, Sereysky JB, Ros SJ, Klug RA, Braman J, Schaffler MB, Jepsen KJ, Flatow EL. Cycle-dependent matrix remodeling gene expression response in fatigue-loaded rat patellar tendons. J Orthop Res. 2010 Oct; 28(10):1380-6.
Cycle-dependent matrix remodeling gene expression response in fatigue-loaded rat patellar tendons.
Lee JY, Zhou Z, Taub PJ, Ramcharan M, Li Y, Akinbiyi T, Maharam ER, Leong DJ, Laudier DM, Ruike T, Torina PJ, Zaidi M, Majeska RJ, Schaffler MB, Flatow EL, Sun HB
Lee JY, Zhou Z, Taub PJ, Ramcharan M, Li Y, Akinbiyi T, Maharam ER, Leong DJ, Laudier DM, Ruike T, Torina PJ, Zaidi M, Majeska RJ, Schaffler MB, Flatow EL, Sun HB. BMP-12 treatment of adult mesenchymal stem cells in vitro augments tendon-like tissue formation and defect repair in vivo. PLoS One. 2011 Mar 11; 6(3):e17531.
BMP-12 treatment of adult mesenchymal stem cells in vitro augments tendon-like tissue formation and defect repair in vivo.
Akkus O, Polyakova-Akkus A, Adar F, Schaffler MB
Akkus O, Polyakova-Akkus A, Adar F, Schaffler MB. Aging of microstructural compartments in human compact bone. J Bone Miner Res. 2003 Jun; 18(6):1012-9.
Aging of microstructural compartments in human compact bone.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Schaffler MB. Role of bone turnover in microdamage. Osteoporos Int. 2003 Sep; 14 Suppl 5:S73-7; discussion S77-80.
Verborgt O, Tatton NA, Majeska RJ, Schaffler MB
Verborgt O, Tatton NA, Majeska RJ, Schaffler MB. Spatial distribution of Bax and Bcl-2 in osteocytes after bone fatigue: complementary roles in bone remodeling regulation? J Bone Miner Res. 2002 May; 17(5):907-14.
Spatial distribution of Bax and Bcl-2 in osteocytes after bone fatigue: complementary roles in bone remodeling regulation?
Akkus O, Adar F, Schaffler MB. Age-related changes in physicochemical properties of mineral crystals are related to impaired mechanical function of cortical bone. Bone. 2004 Mar; 34(3):443-53.
Age-related changes in physicochemical properties of mineral crystals are related to impaired mechanical function of cortical bone.
You LD, Weinbaum S, Cowin SC, Schaffler MB
The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology
You LD, Weinbaum S, Cowin SC, Schaffler MB. Ultrastructure of the osteocyte process and its pericellular matrix. Anat Rec A Discov Mol Cell Evol Biol. 2004 Jun; 278(2):505-13.
Ultrastructure of the osteocyte process and its pericellular matrix.
Leong DJ, Choudhury M, Hanstein R, Hirsh DM, Kim SJ, Majeska RJ, Schaffler MB, Hardin JA, Spray DC, Goldring MB, Cobelli NJ, Sun HB
Leong DJ, Choudhury M, Hanstein R, Hirsh DM, Kim SJ, Majeska RJ, Schaffler MB, Hardin JA, Spray DC, Goldring MB, Cobelli NJ, Sun HB. Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse post-traumatic osteoarthritis model. Arthritis Res Ther. 2014 Dec 17; 16(6):508.
Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse post-traumatic osteoarthritis model.
McCreadie BR, Hollister SJ, Schaffler MB, Goldstein SA
McCreadie BR, Hollister SJ, Schaffler MB, Goldstein SA. Osteocyte lacuna size and shape in women with and without osteoporotic fracture. J Biomech. 2004 Apr; 37(4):563-72.
Osteocyte lacuna size and shape in women with and without osteoporotic fracture.
Li CY, Price C, Delisser K, Nasser P, Laudier D, Clement M, Jepsen KJ, Schaffler MB
Li CY, Price C, Delisser K, Nasser P, Laudier D, Clement M, Jepsen KJ, Schaffler MB. Long-term disuse osteoporosis seems less sensitive to bisphosphonate treatment than other osteoporosis. J Bone Miner Res. 2005 Jan; 20(1):117-24.
Long-term disuse osteoporosis seems less sensitive to bisphosphonate treatment than other osteoporosis.
Andarawis-Puri N, Philip A, Laudier D, Schaffler MB, Flatow EL
Andarawis-Puri N, Philip A, Laudier D, Schaffler MB, Flatow EL. Temporal effect of in vivo tendon fatigue loading on the apoptotic response explained in the context of number of fatigue loading cycles and initial damage parameters. J Orthop Res. 2014 Sep; 32(9):1097-103.
Temporal effect of in vivo tendon fatigue loading on the apoptotic response explained in the context of number of fatigue loading cycles and initial damage parameters.
Yang Li C, Majeska RJ, Laudier DM, Mann R, Schaffler MB
Yang Li C, Majeska RJ, Laudier DM, Mann R, Schaffler MB. High-dose risedronate treatment partially preserves cancellous bone mass and microarchitecture during long-term disuse. Bone. 2005 Sep; 37(3):287-95.
High-dose risedronate treatment partially preserves cancellous bone mass and microarchitecture during long-term disuse.
Tommasini SM, Nasser P, Schaffler MB, Jepsen KJ
Tommasini SM, Nasser P, Schaffler MB, Jepsen KJ. Relationship between bone morphology and bone quality in male tibias: implications for stress fracture risk. J Bone Miner Res. 2005 Aug; 20(8):1372-80.
Relationship between bone morphology and bone quality in male tibias: implications for stress fracture risk.
Li CY, Jepsen KJ, Majeska RJ, Zhang J, Ni R, Gelb BD, Schaffler MB
Li CY, Jepsen KJ, Majeska RJ, Zhang J, Ni R, Gelb BD, Schaffler MB. Mice lacking cathepsin K maintain bone remodeling but develop bone fragility despite high bone mass. J Bone Miner Res. 2006 Jun; 21(6):865-75.
Mice lacking cathepsin K maintain bone remodeling but develop bone fragility despite high bone mass.
Wang L, Wang Y, Han Y, Henderson SC, Majeska RJ, Weinbaum S, Schaffler MB
Proceedings of the National Academy of Sciences of the United States of America
Wang L, Wang Y, Han Y, Henderson SC, Majeska RJ, Weinbaum S, Schaffler MB. In situ measurement of solute transport in the bone lacunar-canalicular system. Proc Natl Acad Sci U S A. 2005 Aug 16; 102(33):11911-6.
In situ measurement of solute transport in the bone lacunar-canalicular system.
Xiang Y, Yingling VR, Malique R, Li CY, Schaffler MB, Raphan T
Xiang Y, Yingling VR, Malique R, Li CY, Schaffler MB, Raphan T. Comparative assessment of bone mass and structure using texture-based and histomorphometric analyses. Bone. 2007 Feb; 40(2):544-52.
Comparative assessment of bone mass and structure using texture-based and histomorphometric analyses.
Kawashima Y, Fritton JC, Yakar S, Epstein S, Schaffler MB, Jepsen KJ, LeRoith D
Kawashima Y, Fritton JC, Yakar S, Epstein S, Schaffler MB, Jepsen KJ, LeRoith D. Type 2 diabetic mice demonstrate slender long bones with increased fragility secondary to increased osteoclastogenesis. Bone. 2009 Apr; 44(4):648-55.
Type 2 diabetic mice demonstrate slender long bones with increased fragility secondary to increased osteoclastogenesis.
Wiren KM, Semirale AA, Zhang XW, Woo A, Tommasini SM, Price C, Schaffler MB, Jepsen KJ
Wiren KM, Semirale AA, Zhang XW, Woo A, Tommasini SM, Price C, Schaffler MB, Jepsen KJ. Targeting of androgen receptor in bone reveals a lack of androgen anabolic action and inhibition of osteogenesis: a model for compartment-specific androgen action in the skeleton. Bone. 2008 Sep; 43(3):440-51.
Targeting of androgen receptor in bone reveals a lack of androgen anabolic action and inhibition of osteogenesis: a model for compartment-specific androgen action in the skeleton.
Liu Z, Kennedy OD, Cardoso L, Basta-Pljakic J, Partridge NC, Schaffler MB, Rosen CJ, Yakar S
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Liu Z, Kennedy OD, Cardoso L, Basta-Pljakic J, Partridge NC, Schaffler MB, Rosen CJ, Yakar S. DMP-1-mediated Ghr gene recombination compromises skeletal development and impairs skeletal response to intermittent PTH. FASEB J. 2016 Feb; 30(2):635-52.
DMP-1-mediated Ghr gene recombination compromises skeletal development and impairs skeletal response to intermittent PTH.
Cheung WY, Fritton JC, Morgan SA, Seref-Ferlengez Z, Basta-Pljakic J, Thi MM, Suadicani SO, Spray DC, Majeska RJ, Schaffler MB
Cheung WY, Fritton JC, Morgan SA, Seref-Ferlengez Z, Basta-Pljakic J, Thi MM, Suadicani SO, Spray DC, Majeska RJ, Schaffler MB. Pannexin-1 and P2X7-Receptor Are Required for Apoptotic Osteocytes in Fatigued Bone to Trigger RANKL Production in Neighboring Bystander Osteocytes. J Bone Miner Res. 2016 Apr; 31(4):890-9.
Pannexin-1 and P2X7-Receptor Are Required for Apoptotic Osteocytes in Fatigued Bone to Trigger RANKL Production in Neighboring Bystander Osteocytes.
Leong DJ, Gu XI, Li Y, Lee JY, Laudier DM, Majeska RJ, Schaffler MB, Cardoso L, Sun HB
Matrix biology : journal of the International Society for Matrix Biology
Leong DJ, Gu XI, Li Y, Lee JY, Laudier DM, Majeska RJ, Schaffler MB, Cardoso L, Sun HB. Matrix metalloproteinase-3 in articular cartilage is upregulated by joint immobilization and suppressed by passive joint motion. Matrix Biol. 2010 Jun; 29(5):420-6.
Matrix metalloproteinase-3 in articular cartilage is upregulated by joint immobilization and suppressed by passive joint motion.
Leong DJ, Li YH, Gu XI, Sun L, Zhou Z, Nasser P, Laudier DM, Iqbal J, Majeska RJ, Schaffler MB, Goldring MB, Cardoso L, Zaidi M, Sun HB
Leong DJ, Li YH, Gu XI, Sun L, Zhou Z, Nasser P, Laudier DM, Iqbal J, Majeska RJ, Schaffler MB, Goldring MB, Cardoso L, Zaidi M, Sun HB. Physiological loading of joints prevents cartilage degradation through CITED2. FASEB J. 2011 Jan; 25(1):182-91.
Physiological loading of joints prevents cartilage degradation through CITED2.
Arteaga-Solis E, Sui-Arteaga L, Kim M, Schaffler MB, Jepsen KJ, Pleshko N, Ramirez F
Arteaga-Solis E, Sui-Arteaga L, Kim M, Schaffler MB, Jepsen KJ, Pleshko N, Ramirez F. Material and mechanical properties of bones deficient for fibrillin-1 or fibrillin-2 microfibrils. Matrix Biol. 2011 Apr; 30(3):188-94.
Material and mechanical properties of bones deficient for fibrillin-1 or fibrillin-2 microfibrils.
Lynch ME, Main RP, Xu Q, Schmicker TL, Schaffler MB, Wright TM, van der Meulen MC
Lynch ME, Main RP, Xu Q, Schmicker TL, Schaffler MB, Wright TM, van der Meulen MC. Tibial compression is anabolic in the adult mouse skeleton despite reduced responsiveness with aging. Bone. 2011 Sep; 49(3):439-46.
Tibial compression is anabolic in the adult mouse skeleton despite reduced responsiveness with aging.
Kennedy OD, Herman BC, Laudier DM, Majeska RJ, Sun HB, Schaffler MB
Kennedy OD, Herman BC, Laudier DM, Majeska RJ, Sun HB, Schaffler MB. Activation of resorption in fatigue-loaded bone involves both apoptosis and active pro-osteoclastogenic signaling by distinct osteocyte populations. Bone. 2012 May; 50(5):1115-22.
Activation of resorption in fatigue-loaded bone involves both apoptosis and active pro-osteoclastogenic signaling by distinct osteocyte populations.
Schaffler MB, Kennedy OD. Osteocyte signaling in bone. Curr Osteoporos Rep. 2012 Jun; 10(2):118-25.
The Journal of the American Academy of Orthopaedic Surgeons
Kennedy OD, Schaffler MB. The roles of osteocyte signaling in bone. J Am Acad Orthop Surg. 2012 Oct; 20(10):670-1.
The roles of osteocyte signaling in bone.
Han Y, Cowin SC, Schaffler MB, Weinbaum S
Han Y, Cowin SC, Schaffler MB, Weinbaum S. Mechanotransduction and strain amplification in osteocyte cell processes. Proc Natl Acad Sci U S A. 2004 Nov 23; 101(47):16689-94.
Mechanotransduction and strain amplification in osteocyte cell processes.
Li CY, Schaffler MB, Wolde-Semait HT, Hernandez CJ, Jepsen KJ
Li CY, Schaffler MB, Wolde-Semait HT, Hernandez CJ, Jepsen KJ. Genetic background influences cortical bone response to ovariectomy. J Bone Miner Res. 2005 Dec; 20(12):2150-8.
Genetic background influences cortical bone response to ovariectomy.
Sun L, Peng Y, Sharrow AC, Iqbal J, Zhang Z, Papachristou DJ, Zaidi S, Zhu LL, Yaroslavskiy BB, Zhou H, Zallone A, Sairam MR, Kumar TR, Bo W, Braun J, Cardoso-Landa L, Schaffler MB, Moonga BS, Blair HC, Zaidi M
Sun L, Peng Y, Sharrow AC, Iqbal J, Zhang Z, Papachristou DJ, Zaidi S, Zhu LL, Yaroslavskiy BB, Zhou H, Zallone A, Sairam MR, Kumar TR, Bo W, Braun J, Cardoso-Landa L, Schaffler MB, Moonga BS, Blair HC, Zaidi M. FSH directly regulates bone mass. Cell. 2006 Apr 21; 125(2):247-60.
Wu D, Schaffler MB, Weinbaum S, Spray DC
Wu D, Schaffler MB, Weinbaum S, Spray DC. Matrix-dependent adhesion mediates network responses to physiological stimulation of the osteocyte cell process. Proc Natl Acad Sci U S A. 2013 Jul 16; 110(29):12096-101.
Matrix-dependent adhesion mediates network responses to physiological stimulation of the osteocyte cell process.
Laudier D, Schaffler MB, Flatow EL, Wang VM
Laudier D, Schaffler MB, Flatow EL, Wang VM. Novel procedure for high-fidelity tendon histology. J Orthop Res. 2007 Mar; 25(3):390-5.
Novel procedure for high-fidelity tendon histology.
Mosig RA, Dowling O, DiFeo A, Ramirez MC, Parker IC, Abe E, Diouri J, Aqeel AA, Wylie JD, Oblander SA, Madri J, Bianco P, Apte SS, Zaidi M, Doty SB, Majeska RJ, Schaffler MB, Martignetti JA
Mosig RA, Dowling O, DiFeo A, Ramirez MC, Parker IC, Abe E, Diouri J, Aqeel AA, Wylie JD, Oblander SA, Madri J, Bianco P, Apte SS, Zaidi M, Doty SB, Majeska RJ, Schaffler MB, Martignetti JA. Loss of MMP-2 disrupts skeletal and craniofacial development and results in decreased bone mineralization, joint erosion and defects in osteoblast and osteoclast growth. Hum Mol Genet. 2007 May 01; 16(9):1113-23.
Loss of MMP-2 disrupts skeletal and craniofacial development and results in decreased bone mineralization, joint erosion and defects in osteoblast and osteoclast growth.
Wang Y, McNamara LM, Schaffler MB, Weinbaum S
Wang Y, McNamara LM, Schaffler MB, Weinbaum S. A model for the role of integrins in flow induced mechanotransduction in osteocytes. Proc Natl Acad Sci U S A. 2007 Oct 02; 104(40):15941-6.
A model for the role of integrins in flow induced mechanotransduction in osteocytes.
Yingling VR, Xiang Y, Raphan T, Schaffler MB, Koser K, Malique R
Yingling VR, Xiang Y, Raphan T, Schaffler MB, Koser K, Malique R. The effect of a short-term delay of puberty on trabecular bone mass and structure in female rats: a texture-based and histomorphometric analysis. Bone. 2007 Feb; 40(2):419-24.
The effect of a short-term delay of puberty on trabecular bone mass and structure in female rats: a texture-based and histomorphometric analysis.
Schaffler MB, Cheung WY, Majeska R, Kennedy O
Schaffler MB, Cheung WY, Majeska R, Kennedy O. Osteocytes: master orchestrators of bone. Calcif Tissue Int. 2014 Jan; 94(1):5-24.
Osteocytes: master orchestrators of bone.
Kennedy OD, Sun H, Wu Y, Courtland HW, Williams GA, Cardoso L, Basta-Pljakic J, Schaffler MB, Yakar S
Kennedy OD, Sun H, Wu Y, Courtland HW, Williams GA, Cardoso L, Basta-Pljakic J, Schaffler MB, Yakar S. Skeletal response of male mice to anabolic hormone therapy in the absence of the Igfals gene. Endocrinology. 2014 Mar; 155(3):987-99.
Skeletal response of male mice to anabolic hormone therapy in the absence of the Igfals gene.
Choi BG, Vilahur G, Zafar MU, Cardoso L, Yadegar D, Ibanez B, Tunstead J, Viles-Gonzalez JF, Schaffler MB, Fuster V, Badimon JJ
Choi BG, Vilahur G, Zafar MU, Cardoso L, Yadegar D, Ibanez B, Tunstead J, Viles-Gonzalez JF, Schaffler MB, Fuster V, Badimon JJ. Selective estrogen receptor modulation influences atherosclerotic plaque composition in a rabbit menopause model. Atherosclerosis. 2008 Nov; 201(1):76-84.
Selective estrogen receptor modulation influences atherosclerotic plaque composition in a rabbit menopause model.
Yakar S, Rosen CJ, Bouxsein ML, Sun H, Mejia W, Kawashima Y, Wu Y, Emerton K, Williams V, Jepsen K, Schaffler MB, Majeska RJ, Gavrilova O, Gutierrez M, Hwang D, Pennisi P, Frystyk J, Boisclair Y, Pintar J, Jasper H, Domene H, Cohen P, Clemmons D, LeRoith D
Yakar S, Rosen CJ, Bouxsein ML, Sun H, Mejia W, Kawashima Y, Wu Y, Emerton K, Williams V, Jepsen K, Schaffler MB, Majeska RJ, Gavrilova O, Gutierrez M, Hwang D, Pennisi P, Frystyk J, Boisclair Y, Pintar J, Jasper H, Domene H, Cohen P, Clemmons D, LeRoith D. Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism. FASEB J. 2009 Mar; 23(3):709-19.
Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism.
Cardoso L, Herman BC, Verborgt O, Laudier D, Majeska RJ, Schaffler MB
Cardoso L, Herman BC, Verborgt O, Laudier D, Majeska RJ, Schaffler MB. Osteocyte apoptosis controls activation of intracortical resorption in response to bone fatigue. J Bone Miner Res. 2009 Apr; 24(4):597-605.
Osteocyte apoptosis controls activation of intracortical resorption in response to bone fatigue.
Courtland HW, Kennedy OD, Wu Y, Gao Y, Sun H, Schaffler MB, Yakar S
Courtland HW, Kennedy OD, Wu Y, Gao Y, Sun H, Schaffler MB, Yakar S. Low levels of plasma IGF-1 inhibit intracortical bone remodeling during aging. Age (Dordr). 2013 Oct; 35(5):1691-703.
Low levels of plasma IGF-1 inhibit intracortical bone remodeling during aging.
Wu Y, Sun H, Basta-Pljakic J, Cardoso L, Kennedy OD, Jasper H, Domen? H, Karabatas L, Guida C, Schaffler MB, Rosen CJ, Yakar S
Wu Y, Sun H, Basta-Pljakic J, Cardoso L, Kennedy OD, Jasper H, Domen? H, Karabatas L, Guida C, Schaffler MB, Rosen CJ, Yakar S. Serum IGF-1 is insufficient to restore skeletal size in the total absence of the growth hormone receptor. J Bone Miner Res. 2013 Jul; 28(7):1575-86.
Serum IGF-1 is insufficient to restore skeletal size in the total absence of the growth hormone receptor.
Seref-Ferlengez Z, Basta-Pljakic J, Kennedy OD, Philemon CJ, Schaffler MB
Seref-Ferlengez Z, Basta-Pljakic J, Kennedy OD, Philemon CJ, Schaffler MB. Structural and mechanical repair of diffuse damage in cortical bone in vivo. J Bone Miner Res. 2014 Dec; 29(12):2537-44.
Structural and mechanical repair of diffuse damage in cortical bone in vivo.
Kennedy OD, Laudier DM, Majeska RJ, Sun HB, Schaffler MB
Kennedy OD, Laudier DM, Majeska RJ, Sun HB, Schaffler MB. Osteocyte apoptosis is required for production of osteoclastogenic signals following bone fatigue in vivo. Bone. 2014 Jul; 64:132-7.
Osteocyte apoptosis is required for production of osteoclastogenic signals following bone fatigue in vivo.
Gong Z, Kennedy O, Sun H, Wu Y, Williams GA, Klein L, Cardoso L, Matheny RW, Hubbard GB, Ikeno Y, Farrar RP, Schaffler MB, Adamo ML, Muzumdar RH, Yakar S
Gong Z, Kennedy O, Sun H, Wu Y, Williams GA, Klein L, Cardoso L, Matheny RW, Hubbard GB, Ikeno Y, Farrar RP, Schaffler MB, Adamo ML, Muzumdar RH, Yakar S. Reductions in serum IGF-1 during aging impair health span. Aging Cell. 2014 Jun; 13(3):408-18.
Reductions in serum IGF-1 during aging impair health span.
Smaldone S, Clayton NP, del Solar M, Pascual G, Cheng SH, Wentworth BM, Schaffler MB, Ramirez F
Smaldone S, Clayton NP, del Solar M, Pascual G, Cheng SH, Wentworth BM, Schaffler MB, Ramirez F. Fibrillin-1 Regulates Skeletal Stem Cell Differentiation by Modulating TGF? Activity Within the Marrow Niche. J Bone Miner Res. 2016 Jan; 31(1):86-97.
Fibrillin-1 Regulates Skeletal Stem Cell Differentiation by Modulating TGF? Activity Within the Marrow Niche.
Dolan EB, Tallon D, Cheung WY, Schaffler MB, Kennedy OD, McNamara LM
Dolan EB, Tallon D, Cheung WY, Schaffler MB, Kennedy OD, McNamara LM. Thermally induced osteocyte damage initiates pro-osteoclastogenic gene expression in vivo. J R Soc Interface. 2016 06; 13(119).
Thermally induced osteocyte damage initiates pro-osteoclastogenic gene expression in vivo.
Frikha-Benayed D, Basta-Pljakic J, Majeska RJ, Schaffler MB
Frikha-Benayed D, Basta-Pljakic J, Majeska RJ, Schaffler MB. Regional differences in oxidative metabolism and mitochondrial activity among cortical bone osteocytes. Bone. 2016 09; 90:15-22.
Regional differences in oxidative metabolism and mitochondrial activity among cortical bone osteocytes.
Kennedy OD, Lendhey M, Mauer P, Philip A, Basta-Pljakic J, Schaffler MB
Kennedy OD, Lendhey M, Mauer P, Philip A, Basta-Pljakic J, Schaffler MB. Microdamage induced by in vivo Reference Point Indentation in mice is repaired by osteocyte-apoptosis mediated remodeling. Bone. 2017 02; 95:192-198.
Microdamage induced by in vivo Reference Point Indentation in mice is repaired by osteocyte-apoptosis mediated remodeling.
Cabahug-Zuckerman P, Frikha-Benayed D, Majeska RJ, Tuthill A, Yakar S, Judex S, Schaffler MB
Cabahug-Zuckerman P, Frikha-Benayed D, Majeska RJ, Tuthill A, Yakar S, Judex S, Schaffler MB. Osteocyte Apoptosis Caused by Hindlimb Unloading is Required to Trigger Osteocyte RANKL Production and Subsequent Resorption of Cortical and Trabecular Bone in Mice Femurs. J Bone Miner Res. 2016 07; 31(7):1356-65.
Osteocyte Apoptosis Caused by Hindlimb Unloading is Required to Trigger Osteocyte RANKL Production and Subsequent Resorption of Cortical and Trabecular Bone in Mice Femurs.
Seref-Ferlengez Z, Maung S, Schaffler MB, Spray DC, Suadicani SO, Thi MM
Seref-Ferlengez Z, Maung S, Schaffler MB, Spray DC, Suadicani SO, Thi MM. P2X7R-Panx1 Complex Impairs Bone Mechanosignaling under High Glucose Levels Associated with Type-1 Diabetes. PLoS One. 2016; 11(5):e0155107.
P2X7R-Panx1 Complex Impairs Bone Mechanosignaling under High Glucose Levels Associated with Type-1 Diabetes.
Dixit M, Louis LD, Basta-Pljakic J, Yildirim G, Poudel SB, Kumararaja F, List EO, Duran SO, Kopchick JJ, Ruff RR, Schaffler MB, Yakar S
Dixit M, Louis LD, Basta-Pljakic J, Yildirim G, Poudel SB, Kumararaja F, List EO, Duran SO, Kopchick JJ, Ruff RR, Schaffler MB, Yakar S. Lifelong Excess in GH Elicits Sexually Dimorphic Effects on Skeletal Morphology and Bone Mechanical Properties. J Bone Miner Res. 2022 11; 37(11):2201-2214.
Lifelong Excess in GH Elicits Sexually Dimorphic Effects on Skeletal Morphology and Bone Mechanical Properties.
Liu Z, Han T, Werner H, Rosen CJ, Schaffler MB, Yakar S
Liu Z, Han T, Werner H, Rosen CJ, Schaffler MB, Yakar S. Reduced Serum IGF-1 Associated With Hepatic Osteodystrophy Is a Main Determinant of Low Cortical but Not Trabecular Bone Mass. J Bone Miner Res. 2018 01; 33(1):123-136.
Reduced Serum IGF-1 Associated With Hepatic Osteodystrophy Is a Main Determinant of Low Cortical but Not Trabecular Bone Mass.
Liu Z, Solesio ME, Schaffler MB, Frikha-Benayed D, Rosen CJ, Werner H, Kopchick JJ, Pavlov EV, Abramov AY, Yakar S
Liu Z, Solesio ME, Schaffler MB, Frikha-Benayed D, Rosen CJ, Werner H, Kopchick JJ, Pavlov EV, Abramov AY, Yakar S. Mitochondrial Function Is Compromised in Cortical Bone Osteocytes of Long-Lived Growth Hormone Receptor Null Mice. J Bone Miner Res. 2019 01; 34(1):106-122.
Mitochondrial Function Is Compromised in Cortical Bone Osteocytes of Long-Lived Growth Hormone Receptor Null Mice.
He Z, Leong DJ, Xu L, Hardin JA, Majeska RJ, Schaffler MB, Thi MM, Yang L, Goldring MB, Cobelli NJ, Sun HB
Annals of the New York Academy of Sciences
He Z, Leong DJ, Xu L, Hardin JA, Majeska RJ, Schaffler MB, Thi MM, Yang L, Goldring MB, Cobelli NJ, Sun HB. CITED2 mediates the cross-talk between mechanical loading and IL-4 to promote chondroprotection. Ann N Y Acad Sci. 2019 04; 1442(1):128-137.
CITED2 mediates the cross-talk between mechanical loading and IL-4 to promote chondroprotection.
McCutcheon S, Majeska RJ, Spray DC, Schaffler MB, Vazquez M
McCutcheon S, Majeska RJ, Spray DC, Schaffler MB, Vazquez M. Apoptotic Osteocytes Induce RANKL Production in Bystanders via Purinergic Signaling and Activation of Pannexin Channels. J Bone Miner Res. 2020 05; 35(5):966-977.
Apoptotic Osteocytes Induce RANKL Production in Bystanders via Purinergic Signaling and Activation of Pannexin Channels.
Coughlin TR, Voisin M, Schaffler MB, Niebur GL, McNamara LM
Coughlin TR, Voisin M, Schaffler MB, Niebur GL, McNamara LM. Primary cilia exist in a small fraction of cells in trabecular bone and marrow. Calcif Tissue Int. 2015 Jan; 96(1):65-72.
Primary cilia exist in a small fraction of cells in trabecular bone and marrow.
Cardoso L, Schaffler MB. Changes of elastic constants and anisotropy patterns in trabecular bone during disuse-induced bone loss assessed by poroelastic ultrasound. J Biomech Eng. 2015 Jan; 137(1).
Changes of elastic constants and anisotropy patterns in trabecular bone during disuse-induced bone loss assessed by poroelastic ultrasound.
Cheung WY, Kennedy OD, Majeska RJ, Schaffler MB
Cheung WY, Kennedy OD, Majeska RJ, Schaffler MB. Authors response to letter from Plotkin and Bellido. Calcif Tissue Int. 2014 Oct; 95(4):384.
Authors response to letter from Plotkin and Bellido.
Cabahug-Zuckerman P, Stout RF, Majeska RJ, Thi MM, Spray DC, Weinbaum S, Schaffler MB
Cabahug-Zuckerman P, Stout RF, Majeska RJ, Thi MM, Spray DC, Weinbaum S, Schaffler MB. Potential role for a specialized ?3 integrin-based structure on osteocyte processes in bone mechanosensation. J Orthop Res. 2018 02; 36(2):642-652.
Potential role for a specialized ?3 integrin-based structure on osteocyte processes in bone mechanosensation.
Coffman AA, Basta-Pljakic J, Guerra RM, Ebetino FH, Lundy MW, Majeska RJ, Schaffler MB
Coffman AA, Basta-Pljakic J, Guerra RM, Ebetino FH, Lundy MW, Majeska RJ, Schaffler MB. A Bisphosphonate With a Low Hydroxyapatite Binding Affinity Prevents Bone Loss in Mice After Ovariectomy and Reverses Rapidly With Treatment Cessation. JBMR Plus. 2021 Apr; 5(4):e10476.
A Bisphosphonate With a Low Hydroxyapatite Binding Affinity Prevents Bone Loss in Mice After Ovariectomy and Reverses Rapidly With Treatment Cessation.
Dixit M, Liu Z, Poudel SB, Yildirim G, Zhang YZ, Mehta S, Murik O, Altarescu G, Kobayashi Y, Shimizu E, Schaffler MB, Yakar S
Dixit M, Liu Z, Poudel SB, Yildirim G, Zhang YZ, Mehta S, Murik O, Altarescu G, Kobayashi Y, Shimizu E, Schaffler MB, Yakar S. Skeletal Response to Insulin in the Naturally Occurring Type 1 Diabetes Mellitus Mouse Model. JBMR Plus. 2021 May; 5(5):e10483.
Skeletal Response to Insulin in the Naturally Occurring Type 1 Diabetes Mellitus Mouse Model.
Thi MM, Suadicani SO, Schaffler MB, Weinbaum S, Spray DC
Thi MM, Suadicani SO, Schaffler MB, Weinbaum S, Spray DC. Mechanosensory responses of osteocytes to physiological forces occur along processes and not cell body and require aV?3 integrin. Proc Natl Acad Sci U S A. 2013 Dec 24; 110(52):21012-7.
Mechanosensory responses of osteocytes to physiological forces occur along processes and not cell body and require aV?3 integrin.
Coffman AA, Basta-Pljakic J, Guerra RM, Ebetino FH, Lundy MW, Majeska RJ, Schaffler MB. Reply to: A Bisphosphonate With a Low Hydroxyapatite Binding Affinity Prevents Bone Loss in Mice After Ovariectomy and Reverses Rapidly With Treatment Cessation. JBMR Plus. 2021 Jul; 5(7):e10492.
Reply to: A Bisphosphonate With a Low Hydroxyapatite Binding Affinity Prevents Bone Loss in Mice After Ovariectomy and Reverses Rapidly With Treatment Cessation.
Kaya S, Basta-Pljakic J, Seref-Ferlengez Z, Majeska RJ, Cardoso L, Bromage TG, Zhang Q, Flach CR, Mendelsohn R, Yakar S, Fritton SP, Schaffler MB
Kaya S, Basta-Pljakic J, Seref-Ferlengez Z, Majeska RJ, Cardoso L, Bromage TG, Zhang Q, Flach CR, Mendelsohn R, Yakar S, Fritton SP, Schaffler MB. Lactation-Induced Changes in the Volume of Osteocyte Lacunar-Canalicular Space Alter Mechanical Properties in Cortical Bone Tissue. J Bone Miner Res. 2017 04; 32(4):688-697.
Lactation-Induced Changes in the Volume of Osteocyte Lacunar-Canalicular Space Alter Mechanical Properties in Cortical Bone Tissue.
Seref-Ferlengez Z, Kennedy OD, Schaffler MB
Seref-Ferlengez Z, Kennedy OD, Schaffler MB. Bone microdamage, remodeling and bone fragility: how much damage is too much damage? Bonekey Rep. 2015; 4:644.
Bone microdamage, remodeling and bone fragility: how much damage is too much damage?
Lewis KJ, Frikha-Benayed D, Louie J, Stephen S, Spray DC, Thi MM, Seref-Ferlengez Z, Majeska RJ, Weinbaum S, Schaffler MB
Lewis KJ, Frikha-Benayed D, Louie J, Stephen S, Spray DC, Thi MM, Seref-Ferlengez Z, Majeska RJ, Weinbaum S, Schaffler MB. Osteocyte calcium signals encode strain magnitude and loading frequency in vivo. Proc Natl Acad Sci U S A. 2017 10 31; 114(44):11775-11780.
Osteocyte calcium signals encode strain magnitude and loading frequency in vivo.
Seref-Ferlengez Z, Urban-Maldonado M, Sun HB, Schaffler MB, Suadicani SO, Thi MM
Seref-Ferlengez Z, Urban-Maldonado M, Sun HB, Schaffler MB, Suadicani SO, Thi MM. Role of pannexin 1 channels in load-induced skeletal response. Ann N Y Acad Sci. 2019 04; 1442(1):79-90.
Role of pannexin 1 channels in load-induced skeletal response.
Dixit M, Duran-Ortiz S, Yildirim G, Poudel SB, Louis LD, Bartke A, Schaffler MB, Kopchick JJ, Yakar S
Dixit M, Duran-Ortiz S, Yildirim G, Poudel SB, Louis LD, Bartke A, Schaffler MB, Kopchick JJ, Yakar S. Induction of somatopause in adult mice compromises bone morphology and exacerbates bone loss during aging. Aging Cell. 2021 12; 20(12):e13505.
Induction of somatopause in adult mice compromises bone morphology and exacerbates bone loss during aging.
Leong DJ, Choudhury M, Hanstein R, Hirsh DM, Kim SJ, Majeska RJ, Schaffler MB, Hardin JA, Spray DC, Goldring MB, Cobelli NJ, Sun HB. Correction to: Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse posttraumatic osteoarthritis model. Arthritis Res Ther. 2019 Jan 03; 21(1):1.
Correction to: Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse posttraumatic osteoarthritis model.
Liu Z, Han T, Fishman S, Butler J, Zimmermann T, Tremblay F, Harbison C, Agrawal N, Kopchick JJ, Schaffler MB, Yakar S
Liu Z, Han T, Fishman S, Butler J, Zimmermann T, Tremblay F, Harbison C, Agrawal N, Kopchick JJ, Schaffler MB, Yakar S. Ablation of Hepatic Production of the Acid-Labile Subunit in Bovine-GH Transgenic Mice: Effects on Organ and Skeletal Growth. Endocrinology. 2017 08 01; 158(8):2556-2571.
Ablation of Hepatic Production of the Acid-Labile Subunit in Bovine-GH Transgenic Mice: Effects on Organ and Skeletal Growth.
Poudel SB, Frikha-Benayed D, Ruff RR, Yildirim G, Dixit M, Korstanje R, Robinson L, Miller RA, Harrison DE, Strong JR, Schaffler MB, Yakar S
Poudel SB, Frikha-Benayed D, Ruff RR, Yildirim G, Dixit M, Korstanje R, Robinson L, Miller RA, Harrison DE, Strong JR, Schaffler MB, Yakar S. Targeting mitochondrial dysfunction using methylene blue or mitoquinone to improve skeletal aging. Aging (Albany NY). 2024 03 25; 16(6):4948-4964.
Targeting mitochondrial dysfunction using methylene blue or mitoquinone to improve skeletal aging.
McCutcheon S, Majeska R, Schaffler M, Vazquez M
McCutcheon S, Majeska R, Schaffler M, Vazquez M. A multiscale fluidic device for the study of dendrite-mediated cell to cell communication. Biomed Microdevices. 2017 Aug 08; 19(3):71.
A multiscale fluidic device for the study of dendrite-mediated cell to cell communication.
El Seminario Internacional de Cuidadores de personas con Alzheimer