Molecular Cellular and Biomedical Sciences
Methods in molecular biology (Clifton, N.J.)
Williams N, Patel R, Mallikaratchy P. Discovery of Aptamers Against Cell Surface Markers Using Ligand-Guided Selection. Methods Mol Biol. 2023; 2570:13-38.
Discovery of Aptamers Against Cell Surface Markers Using Ligand-Guided Selection.
Freage L, Boykoff N, Mallikaratchy P. Utility of Multivalent Aptamers to Develop Nanoscale DNA Devices against Surface Receptors. ACS Omega. 2021 May 18; 6(19):12382-12391.
Utility of Multivalent Aptamers to Develop Nanoscale DNA Devices against Surface Receptors.
Mallikaratchy P, Liu H, Huang YF, Wang H, Lopez-Colon D, Tan W
Chemical communications (Cambridge, England)
Mallikaratchy P, Liu H, Huang YF, Wang H, Lopez-Colon D, Tan W. Using aptamers evolved from cell-SELEX to engineer a molecular delivery platform. Chem Commun (Camb). 2009 Jun 07; (21):3056-8.
Using aptamers evolved from cell-SELEX to engineer a molecular delivery platform.
Mallikaratchy PR, Ruggiero A, Gardner JR, Kuryavyi V, Maguire WF, Heaney ML, McDevitt MR, Patel DJ, Scheinberg DA
Mallikaratchy PR, Ruggiero A, Gardner JR, Kuryavyi V, Maguire WF, Heaney ML, McDevitt MR, Patel DJ, Scheinberg DA. A multivalent DNA aptamer specific for the B-cell receptor on human lymphoma and leukemia. Nucleic Acids Res. 2011 Mar; 39(6):2458-69.
A multivalent DNA aptamer specific for the B-cell receptor on human lymphoma and leukemia.
Mallikaratchy P, Norman RE, Fronczek FR, Junk T
Acta crystallographica. Section C, Crystal structure communications
Mallikaratchy P, Norman RE, Fronczek FR, Junk T. Tribromo(3,5-dimethyl-2-nitrophenyl-kappa(2)C(1),O)tellurium(IV), bromo(3,5-dimethyl-2-nitrophenyl-kappa(2)C(1),O)tellurium(II) and bromo(3,5-dimethyl-2-nitrosophenyl-kappa(2)C(1),O)tellurium(II). Acta Crystallogr C. 2003 Oct; 59(Pt 10):O571-4.
Tribromo(3,5-dimethyl-2-nitrophenyl-kappa(2)C(1),O)tellurium(IV), bromo(3,5-dimethyl-2-nitrophenyl-kappa(2)C(1),O)tellurium(II) and bromo(3,5-dimethyl-2-nitrosophenyl-kappa(2)C(1),O)tellurium(II).
Shangguan D, Li Y, Tang Z, Cao ZC, Chen HW, Mallikaratchy P, Sefah K, Yang CJ, Tan W
Proceedings of the National Academy of Sciences of the United States of America
Shangguan D, Li Y, Tang Z, Cao ZC, Chen HW, Mallikaratchy P, Sefah K, Yang CJ, Tan W. Aptamers evolved from live cells as effective molecular probes for cancer study. Proc Natl Acad Sci U S A. 2006 Aug 08; 103(32):11838-43.
Aptamers evolved from live cells as effective molecular probes for cancer study.
Mallikaratchy P, Stahelin RV, Cao Z, Cho W, Tan W
Mallikaratchy P, Stahelin RV, Cao Z, Cho W, Tan W. Selection of DNA ligands for protein kinase C-delta. Chem Commun (Camb). 2006 Aug 14; (30):3229-31.
Selection of DNA ligands for protein kinase C-delta.
Tang Z, Mallikaratchy P, Yang R, Kim Y, Zhu Z, Wang H, Tan W
Journal of the American Chemical Society
Tang Z, Mallikaratchy P, Yang R, Kim Y, Zhu Z, Wang H, Tan W. Aptamer switch probe based on intramolecular displacement. J Am Chem Soc. 2008 Aug 27; 130(34):11268-9.
Aptamer switch probe based on intramolecular displacement.
Tang Z, Zhu Z, Mallikaratchy P, Yang R, Sefah K, Tan W
Tang Z, Zhu Z, Mallikaratchy P, Yang R, Sefah K, Tan W. Aptamer-target binding triggered molecular mediation of singlet oxygen generation. Chem Asian J. 2010 Apr 01; 5(4):783-6.
Aptamer-target binding triggered molecular mediation of singlet oxygen generation.
Maio G, Enweronye O, Zumrut HE, Batool S, Van N, Mallikaratchy P
Maio G, Enweronye O, Zumrut HE, Batool S, Van N, Mallikaratchy P. Systematic optimization and modification of a DNA aptamer with 2'-O-methyl RNA analogues. ChemistrySelect. 2017 Mar 01; 2(7):2335-2340.
Systematic optimization and modification of a DNA aptamer with 2'-O-methyl RNA analogues.
Mallikaratchy P, Tang Z, Kwame S, Meng L, Shangguan D, Tan W
Mallikaratchy P, Tang Z, Kwame S, Meng L, Shangguan D, Tan W. Aptamer directly evolved from live cells recognizes membrane bound immunoglobin heavy mu chain in Burkitt's lymphoma cells. Mol Cell Proteomics. 2007 Dec; 6(12):2230-8.
Aptamer directly evolved from live cells recognizes membrane bound immunoglobin heavy mu chain in Burkitt's lymphoma cells.
Mallikaratchy P, Tang Z, Tan W. Cell specific aptamer-photosensitizer conjugates as a molecular tool in photodynamic therapy. ChemMedChem. 2008 Mar; 3(3):425-8.
Cell specific aptamer-photosensitizer conjugates as a molecular tool in photodynamic therapy.
Shangguan D, Cao Z, Meng L, Mallikaratchy P, Sefah K, Wang H, Li Y, Tan W
Shangguan D, Cao Z, Meng L, Mallikaratchy P, Sefah K, Wang H, Li Y, Tan W. Cell-specific aptamer probes for membrane protein elucidation in cancer cells. J Proteome Res. 2008 May; 7(5):2133-9.
Cell-specific aptamer probes for membrane protein elucidation in cancer cells.
Zumrut HE, Ara MN, Maio GE, Van NA, Batool S, Mallikaratchy PR
Zumrut HE, Ara MN, Maio GE, Van NA, Batool S, Mallikaratchy PR. Ligand-guided selection of aptamers against T-cell Receptor-cluster of differentiation 3 (TCR-CD3) expressed on Jurkat.E6 cells. Anal Biochem. 2016 11 01; 512:1-7.
Ligand-guided selection of aptamers against T-cell Receptor-cluster of differentiation 3 (TCR-CD3) expressed on Jurkat.E6 cells.
Zumrut HE, Ara MN, Fraile M, Maio G, Mallikaratchy P
Zumrut HE, Ara MN, Fraile M, Maio G, Mallikaratchy P. Ligand-Guided Selection of Target-Specific Aptamers: A Screening Technology for Identifying Specific Aptamers Against Cell-Surface Proteins. Nucleic Acid Ther. 2016 06; 26(3):190-8.
Ligand-Guided Selection of Target-Specific Aptamers: A Screening Technology for Identifying Specific Aptamers Against Cell-Surface Proteins.
Batool S, Bhandari S, George S, Okeoma P, Van N, Z?mr?t HE, Mallikaratchy P
Batool S, Bhandari S, George S, Okeoma P, Van N, Z?mr?t HE, Mallikaratchy P. Engineered Aptamers to Probe Molecular Interactions on the Cell Surface. Biomedicines. 2017 Aug 29; 5(3).
Engineered Aptamers to Probe Molecular Interactions on the Cell Surface.
Mallikaratchy P. Evolution of Complex Target SELEX to Identify Aptamers against Mammalian Cell-Surface Antigens. Molecules. 2017 Jan 30; 22(2).
Evolution of Complex Target SELEX to Identify Aptamers against Mammalian Cell-Surface Antigens.
Zumrut H, Yang Z, Williams N, Arizala J, Batool S, Benner SA, Mallikaratchy P
Zumrut H, Yang Z, Williams N, Arizala J, Batool S, Benner SA, Mallikaratchy P. Ligand-Guided Selection with Artificially Expanded Genetic Information Systems against TCR-CD3e. Biochemistry. 2020 02 04; 59(4):552-562.
Ligand-Guided Selection with Artificially Expanded Genetic Information Systems against TCR-CD3e.
Freage L, Jamal D, Williams NB, Mallikaratchy PR
Freage L, Jamal D, Williams NB, Mallikaratchy PR. A Homodimeric Aptamer Variant Generated from Ligand-Guided Selection Activates the T Cell Receptor Cluster of Differentiation 3 Complex. Mol Ther Nucleic Acids. 2020 Aug 19; 22:167-178.
A Homodimeric Aptamer Variant Generated from Ligand-Guided Selection Activates the T Cell Receptor Cluster of Differentiation 3 Complex.
Mallikaratchy P, Gardner J, Nordstr?m LU, Veomett NJ, McDevitt MR, Heaney ML, Scheinberg DA
Mallikaratchy P, Gardner J, Nordstr?m LU, Veomett NJ, McDevitt MR, Heaney ML, Scheinberg DA. A self-assembling short oligonucleotide duplex suitable for pretargeting. Nucleic Acid Ther. 2013 Aug; 23(4):289-99.
A self-assembling short oligonucleotide duplex suitable for pretargeting.
Zumrut HE, Mallikaratchy PR. Ligand Guided Selection (LIGS) of Artificial Nucleic Acid Ligands against Cell Surface Targets. ACS Appl Bio Mater. 2020 May 18; 3:2545-2552.
Ligand Guided Selection (LIGS) of Artificial Nucleic Acid Ligands against Cell Surface Targets.
Egbe Vydaline AO, Rozhkov S, Sosa G, Mallikaratchy P
Egbe Vydaline AO, Rozhkov S, Sosa G, Mallikaratchy P. Aptamers as target-specific recognition elements in drug delivery. Adv Drug Deliv Rev. 2025 Nov; 226:115685.
Aptamers as target-specific recognition elements in drug delivery.
Z?mr?t HE, Batool S, Van N, George S, Bhandari S, Mallikaratchy P
Biochimica et biophysica acta. General subjects
Z?mr?t HE, Batool S, Van N, George S, Bhandari S, Mallikaratchy P. Structural optimization of an aptamer generated from Ligand-Guided Selection (LIGS) resulted in high affinity variant toward mIgM expressed on Burkitt's lymphoma cell lines. Biochim Biophys Acta Gen Subj. 2017 Jul; 1861(7):1825-1832.
Structural optimization of an aptamer generated from Ligand-Guided Selection (LIGS) resulted in high affinity variant toward mIgM expressed on Burkitt's lymphoma cell lines.
Boykoff N, Freage L, Lenn J, Mallikaratchy P
Boykoff N, Freage L, Lenn J, Mallikaratchy P. Bispecific Aptamer Sensor toward T-Cell Leukemia Detection in the Tumor Microenvironment. ACS Omega. 2021 Dec 07; 6(48):32563-32570.
Bispecific Aptamer Sensor toward T-Cell Leukemia Detection in the Tumor Microenvironment.
Williams NB, Batool S, Zumrut HE, Patel R, Sosa G, Jamal M, Mallikaratchy P
Williams NB, Batool S, Zumrut HE, Patel R, Sosa G, Jamal M, Mallikaratchy P. An In Vitro Selection Platform to Identify Multiple Aptamers against Multiple Cell-Surface Markers Using Ligand-Guided Selection. Biochemistry. 2022 08 02; 61(15):1600-1613.
An In Vitro Selection Platform to Identify Multiple Aptamers against Multiple Cell-Surface Markers Using Ligand-Guided Selection.
Lingala S, Nordstr?m LU, Mallikaratchy PR
Lingala S, Nordstr?m LU, Mallikaratchy PR. Synthesis of stable azide and alkyne functionalized phosphoramidite nucleosides. Tetrahedron Lett. 2019 Jan 17; 60(3):211-213.
Synthesis of stable azide and alkyne functionalized phosphoramidite nucleosides.
Batool S, Argyropoulos KV, Azad R, Okeoma P, Zumrut H, Bhandari S, Dekhang R, Mallikaratchy PR
Batool S, Argyropoulos KV, Azad R, Okeoma P, Zumrut H, Bhandari S, Dekhang R, Mallikaratchy PR. Dimerization of an aptamer generated from Ligand-guided selection (LIGS) yields a high affinity scaffold against B-cells. Biochim Biophys Acta Gen Subj. 2019 01; 1863(1):232-240.
Dimerization of an aptamer generated from Ligand-guided selection (LIGS) yields a high affinity scaffold against B-cells.
Moccia F, Platella C, Musumeci D, Batool S, Zumrut H, Bradshaw J, Mallikaratchy P, Montesarchio D
International journal of biological macromolecules
Moccia F, Platella C, Musumeci D, Batool S, Zumrut H, Bradshaw J, Mallikaratchy P, Montesarchio D. The role of G-quadruplex structures of LIGS-generated aptamers R1.2 and R1.3 in IgM specific recognition. Int J Biol Macromol. 2019 Jul 15; 133:839-849.
The role of G-quadruplex structures of LIGS-generated aptamers R1.2 and R1.3 in IgM specific recognition.
Zumrut HE, Batool S, Argyropoulos KV, Williams N, Azad R, Mallikaratchy PR
Zumrut HE, Batool S, Argyropoulos KV, Williams N, Azad R, Mallikaratchy PR. Integrating Ligand-Receptor Interactions and In?Vitro Evolution for Streamlined Discovery of Artificial Nucleic Acid Ligands. Mol Ther Nucleic Acids. 2019 Sep 06; 17:150-163.
Integrating Ligand-Receptor Interactions and In?Vitro Evolution for Streamlined Discovery of Artificial Nucleic Acid Ligands.