Scott, John
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research areas: Protein Kinase Inhibitors
research areas: MAP Kinase Kinase Kinase 2
research areas: Cell Proliferation
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Williams, Kevin
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Enzyme assay design for high-throughput screening.
PubMed Identifier: 19551359
author list: Williams KP, Scott JE
published in: Methods in molecular biology (Clifton, N.J.)
information resource reference: Williams KP, Scott JE. Enzyme assay design for high-throughput screening. Methods Mol Biol. 2009; 565:107-26.
journal title abbreviation: Methods Mol Biol
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Identification of a Triple Drug Combination That Is Synergistically Cytotoxic for Triple-Negative Breast Cancer Cells Using a Novel Combination Discovery Approach.
PubMed Identifier: 32441190
author list: Ahmad S, He Q, Williams KP, Scott JE
published in: SLAS discovery : advancing life sciences R & D
information resource reference: Ahmad S, He Q, Williams KP, Scott JE. Identification of a Triple Drug Combination That Is Synergistically Cytotoxic for Triple-Negative Breast Cancer Cells Using a Novel Combination Discovery Approach. SLAS Discov. 2020 09; 25(8):923-938.
journal title abbreviation: SLAS Discov
publication date: 2020-05-22T00:00:00
year: 2020
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Small molecule inhibition of Rho GTPase activation to probe signaling cascades
end date: 2016-06-30
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principal investigator name: SONDEK, JOHN E
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Discovery of a Selective Agent that Activates PON1 Enzymatic Activity
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Discovery of a Selective Agent that Activates PON1 Enzymatic Activity
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Authorship 82757
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linked information resource: A universal competitive fluorescence polarization activity assay for S-adenosylmethionine utilizing methyltransferases.

Authorship 84762
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linked information resource: Potential repurposing of known drugs as potent bacterial ?-glucuronidase inhibitors.

Authorship 85189
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linked author: Scott, John
linked information resource: Enzyme assay design for high-throughput screening.

Authorship 85377
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linked author: Scott, John
linked information resource: A homogeneous cell-based assay for measurement of endogenous paraoxonase 1 activity.

Authorship 87243
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linked author: Scott, John
linked information resource: A high throughput proliferation and cytotoxicity assay for co-cultured isogenic cell lines.

Authorship 87818
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linked author: Scott, John
linked information resource: A High Throughput Assay for Discovery of Bacterial ?-Glucuronidase Inhibitors.

Authorship 88025
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linked author: Scott, John
linked information resource: Identification of Inhibitors of Chikungunya virus nsP2 ATPase.

Authorship 88552
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linked author: Scott, John
linked information resource: A high throughput serum paraoxonase assay for discovery of small molecule modulators of PON1 activity.

Authorship 84312
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linked author: Scott, John
linked information resource: Estradiol enhances cell-associated paraoxonase 1 (PON1) activity in vitro without altering PON1 expression.

Authorship 86327
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linked author: Scott, John
linked information resource: Discovery and characterization of an iminocoumarin scaffold as an inhibitor of MEKK2 (MAP3K2).

Authorship 87414
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linked author: Scott, John
linked information resource: CoAsy knockdown in TNBC cell lines resulted in no overt effect on cell proliferation in?vitro.

Authorship 87629
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linked author: Scott, John
linked information resource: Identification of ponatinib and other known kinase inhibitors with?potent MEKK2 inhibitory activity.

Authorship 87736
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linked author: Scott, John
linked information resource: Identification of a Triple Drug Combination That Is Synergistically Cytotoxic for Triple-Negative Breast Cancer Cells Using a Novel Combination Discovery Approach.

Authorship 82556
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linked author: Scott, John
linked information resource: Development and validation of a high-throughput intrinsic ATPase activity assay for the discovery of MEKK2 inhibitors.

Authorship 84483
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linked author: Scott, John
linked information resource: Old drug new use--amoxapine and its metabolites as potent bacterial ?-glucuronidase inhibitors for alleviating cancer drug toxicity.

Authorship 89406
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linked author: Scott, John
linked information resource: Bosutinib reduces the efficacy of Dasatinib in triple-negative breast cancer cell lines.

A high throughput proliferation and cytotoxicity assay for co-cultured isogenic cell lines.
PubMed Identifier: 36438856
author list: Ahmad S, Wood KC, Scott JE
published in: MethodsX
information resource reference: Ahmad S, Wood KC, Scott JE. A high throughput proliferation and cytotoxicity assay for co-cultured isogenic cell lines. MethodsX. 2022; 9:101927.
journal title abbreviation: MethodsX
publication date: 2022-11-15T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

CoAsy knockdown in TNBC cell lines resulted in no overt effect on cell proliferation in?vitro.
PubMed Identifier: 32828275
author list: Kharabsheh HA, Scott JE
published in: Biochemical and biophysical research communications
information resource reference: Kharabsheh HA, Scott JE. CoAsy knockdown in TNBC cell lines resulted in no overt effect on cell proliferation in?vitro. Biochem Biophys Res Commun. 2020 09 10; 530(1):136-141.
journal title abbreviation: Biochem Biophys Res Commun
publication date: 2020-07-31T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
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A homogeneous cell-based assay for measurement of endogenous paraoxonase 1 activity.
PubMed Identifier: 20096260
author list: Ahmad S, Carter JJ, Scott JE
published in: Analytical biochemistry
information resource reference: Ahmad S, Carter JJ, Scott JE. A homogeneous cell-based assay for measurement of endogenous paraoxonase 1 activity. Anal Biochem. 2010 May 01; 400(1):1-9.
journal title abbreviation: Anal Biochem
publication date: 2010-01-21T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Estradiol enhances cell-associated paraoxonase 1 (PON1) activity in vitro without altering PON1 expression.
PubMed Identifier: 20510879
author list: Ahmad S, Scott JE
published in: Biochemical and biophysical research communications
information resource reference: Ahmad S, Scott JE. Estradiol enhances cell-associated paraoxonase 1 (PON1) activity in vitro without altering PON1 expression. Biochem Biophys Res Commun. 2010 Jul 02; 397(3):441-6.
journal title abbreviation: Biochem Biophys Res Commun
publication date: 2010-05-27T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

A High Throughput Assay for Discovery of Bacterial ?-Glucuronidase Inhibitors.
PubMed Identifier: 21643506
author list: Ahmad S, Hughes MA, Lane KT, Redinbo MR, Yeh LA, Scott JE
published in: Current chemical genomics
information resource reference: Ahmad S, Hughes MA, Lane KT, Redinbo MR, Yeh LA, Scott JE. A High Throughput Assay for Discovery of Bacterial ?-Glucuronidase Inhibitors. Curr Chem Genomics. 2011; 5:13-20.
journal title abbreviation: Curr Chem Genomics
publication date: 2011-04-08T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Potential repurposing of known drugs as potent bacterial ?-glucuronidase inhibitors.
PubMed Identifier: 22535688
author list: Ahmad S, Hughes MA, Yeh LA, Scott JE
published in: Journal of biomolecular screening
information resource reference: Ahmad S, Hughes MA, Yeh LA, Scott JE. Potential repurposing of known drugs as potent bacterial ?-glucuronidase inhibitors. J Biomol Screen. 2012 Aug; 17(7):957-65.
journal title abbreviation: J Biomol Screen
publication date: 2012-04-24T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Identification of Inhibitors of Chikungunya virus nsP2 ATPase.
PubMed Identifier: 39677726
author list: Navarro H, Scott JE, Smith GR, Ghiabi P, Gibson E, Loppnau P, Harding RJ, Hossain MA, Bose MR, Pearce KH, Merten EM, Willson TM, Brown PJ
published in: bioRxiv : the preprint server for biology
information resource reference: Navarro H, Scott JE, Smith GR, Ghiabi P, Gibson E, Loppnau P, Harding RJ, Hossain MA, Bose MR, Pearce KH, Merten EM, Willson TM, Brown PJ. Identification of Inhibitors of Chikungunya virus nsP2 ATPase. bioRxiv. 2025 Jan 14.
journal title abbreviation: bioRxiv
publication date: 2025-01-14T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

A universal competitive fluorescence polarization activity assay for S-adenosylmethionine utilizing methyltransferases.
PubMed Identifier: 18028865
author list: Graves TL, Zhang Y, Scott JE
published in: Analytical biochemistry
information resource reference: Graves TL, Zhang Y, Scott JE. A universal competitive fluorescence polarization activity assay for S-adenosylmethionine utilizing methyltransferases. Anal Biochem. 2008 Feb 15; 373(2):296-306.
journal title abbreviation: Anal Biochem
publication date: 2007-09-29T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
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A high throughput serum paraoxonase assay for discovery of small molecule modulators of PON1 activity.
PubMed Identifier: 20161844
author list: Graves TL, Scott JE
published in: Current chemical genomics
information resource reference: Graves TL, Scott JE. A high throughput serum paraoxonase assay for discovery of small molecule modulators of PON1 activity. Curr Chem Genomics. 2008 Nov 26; 2:51-61.
journal title abbreviation: Curr Chem Genomics
publication date: 2008-11-26T00:00:00
year: 2008
type: Academic Article
type: Article
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Development and validation of a high-throughput intrinsic ATPase activity assay for the discovery of MEKK2 inhibitors.
PubMed Identifier: 23134735
author list: Ahmad S, Hughes MA, Johnson GL, Scott JE
published in: Journal of biomolecular screening
information resource reference: Ahmad S, Hughes MA, Johnson GL, Scott JE. Development and validation of a high-throughput intrinsic ATPase activity assay for the discovery of MEKK2 inhibitors. J Biomol Screen. 2013 Apr; 18(4):388-99.
journal title abbreviation: J Biomol Screen
publication date: 2012-11-07T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Old drug new use--amoxapine and its metabolites as potent bacterial ?-glucuronidase inhibitors for alleviating cancer drug toxicity.
PubMed Identifier: 24780296
author list: Kong R, Liu T, Zhu X, Ahmad S, Williams AL, Phan AT, Zhao H, Scott JE, Yeh LA, Wong ST
published in: Clinical cancer research : an official journal of the American Association for Cancer Research
information resource reference: Kong R, Liu T, Zhu X, Ahmad S, Williams AL, Phan AT, Zhao H, Scott JE, Yeh LA, Wong ST. Old drug new use--amoxapine and its metabolites as potent bacterial ?-glucuronidase inhibitors for alleviating cancer drug toxicity. Clin Cancer Res. 2014 Jul 01; 20(13):3521-30.
journal title abbreviation: Clin Cancer Res
publication date: 2014-04-29T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Identification of ponatinib and other known kinase inhibitors with?potent MEKK2 inhibitory activity.
PubMed Identifier: 26056008
author list: Ahmad S, Johnson GL, Scott JE
published in: Biochemical and biophysical research communications
information resource reference: Ahmad S, Johnson GL, Scott JE. Identification of ponatinib and other known kinase inhibitors with?potent MEKK2 inhibitory activity. Biochem Biophys Res Commun. 2015 Aug 07; 463(4):888-93.
journal title abbreviation: Biochem Biophys Res Commun
publication date: 2015-06-06T00:00:00
year: 2015
type: Academic Article
type: Article
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Discovery and characterization of an iminocoumarin scaffold as an inhibitor of MEKK2 (MAP3K2).
PubMed Identifier: 29309787
author list: Ahmad S, St Hilaire VR, Dandepally SR, Johnson GL, Williams AL, Scott JE
published in: Biochemical and biophysical research communications
information resource reference: Ahmad S, St Hilaire VR, Dandepally SR, Johnson GL, Williams AL, Scott JE. Discovery and characterization of an iminocoumarin scaffold as an inhibitor of MEKK2 (MAP3K2). Biochem Biophys Res Commun. 2018 01 29; 496(1):205-211.
journal title abbreviation: Biochem Biophys Res Commun
publication date: 2018-01-05T00:00:00
year: 2018
type: Academic Article
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Bosutinib reduces the efficacy of Dasatinib in triple-negative breast cancer cell lines.
PubMed Identifier: 24692691
author list: Tarpley M, Abdissa TT, Johnson GL, Scott JE
published in: Anticancer research
information resource reference: Tarpley M, Abdissa TT, Johnson GL, Scott JE. Bosutinib reduces the efficacy of Dasatinib in triple-negative breast cancer cell lines. Anticancer Res. 2014 Apr; 34(4):1629-35.
journal title abbreviation: Anticancer Res
publication date: 2014-04-01T00:00:00
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Drug Evaluation, Preclinical
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University of Hawaii at Manoa
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