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Avrom Caplan

InstitutionCity College, CUNY
Address160 convent ave
Biology MR-526
new york NY 10031
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Muth TR, Caplan AJ. Microbiomes for All. Front Microbiol. 2020; 11:593472. PMID: 33281791.
    2. Karagounis TK, Shaw KS, Caplan A, Lo Sicco K, Femia AN. Acrofacial purpura and necrotic ulcerations in COVID-19: a case series from New York City. Int J Dermatol. 2020 Sep 23. PMID: 32966592.
      Citations:    Fields:    
    3. Sultana R, Theodoraki MA, Caplan AJ. Specificity in the actions of the UBR1 ubiquitin ligase in the degradation of nuclear receptors. FEBS Open Bio. 2013; 3:394-7. PMID: 24251101.
      Citations: 5     Fields:    
    4. Theodoraki MA, Nillegoda NB, Saini J, Caplan AJ. A network of ubiquitin ligases is important for the dynamics of misfolded protein aggregates in yeast. J Biol Chem. 2012 Jul 06; 287(28):23911-22. PMID: 22593585.
      Citations: 31     Fields:    Translation:AnimalsCells
    5. Sultana R, Theodoraki MA, Caplan AJ. UBR1 promotes protein kinase quality control and sensitizes cells to Hsp90 inhibition. Exp Cell Res. 2012 Jan 01; 318(1):53-60. PMID: 21983172.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    6. Theodoraki MA, Caplan AJ. Quality control and fate determination of Hsp90 client proteins. Biochim Biophys Acta. 2012 Mar; 1823(3):683-8. PMID: 21871502.
      Citations: 32     Fields:    Translation:HumansCells
    7. Mandal AK, Theodoraki MA, Nillegoda NB, Caplan AJ. Role of molecular chaperones in biogenesis of the protein kinome. Methods Mol Biol. 2011; 787:75-81. PMID: 21898228.
      Citations: 8     Fields:    Translation:AnimalsCells
    8. Nillegoda NB, Theodoraki MA, Mandal AK, Mayo KJ, Ren HY, Sultana R, Wu K, Johnson J, Cyr DM, Caplan AJ. Ubr1 and Ubr2 function in a quality control pathway for degradation of unfolded cytosolic proteins. Mol Biol Cell. 2010 Jul 01; 21(13):2102-16. PMID: 20462952.
      Citations: 67     Fields:    Translation:AnimalsCells
    9. Mandal AK, Gibney PA, Nillegoda NB, Theodoraki MA, Caplan AJ, Morano KA. Hsp110 chaperones control client fate determination in the hsp70-Hsp90 chaperone system. Mol Biol Cell. 2010 May 01; 21(9):1439-48. PMID: 20237159.
      Citations: 23     Fields:    Translation:Animals
    10. Mandal AK, Nillegoda NB, Chen JA, Caplan AJ. Ydj1 protects nascent protein kinases from degradation and controls the rate of their maturation. Mol Cell Biol. 2008 Jul; 28(13):4434-44. PMID: 18443039.
      Citations: 9     Fields:    Translation:AnimalsCells
    11. Caplan AJ, Ma'ayan A, Willis IM. Multiple kinases and system robustness: a link between Cdc37 and genome integrity. . 2007 Dec 15; 6(24):3145-7. PMID: 18075309.
    12. Theodoraki MA, Kunjappu M, Sternberg DW, Caplan AJ. Akt shows variable sensitivity to an Hsp90 inhibitor depending on cell context. Exp Cell Res. 2007 Nov 01; 313(18):3851-8. PMID: 17643429.
      Citations: 10     Fields:    Translation:AnimalsCells
    13. Ren M, Santhanam A, Lee P, Caplan A, Garrett S. Alteration of the protein kinase binding domain enhances function of the Saccharomyces cerevisiae molecular chaperone Cdc37. Eukaryot Cell. 2007 Aug; 6(8):1363-72. PMID: 17573546.
      Citations: 1     Fields:    Translation:AnimalsCells
    14. Robzyk K, Oen H, Buchanan G, Butler LM, Tilley WD, Mandal AK, Rosen N, Caplan AJ. Uncoupling of hormone-dependence from chaperone-dependence in the L701H mutation of the androgen receptor. Mol Cell Endocrinol. 2007 Mar 30; 268(1-2):67-74. PMID: 17336451.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    15. Mandal AK, Lee P, Chen JA, Nillegoda N, Heller A, DiStasio S, Oen H, Victor J, Nair DM, Brodsky JL, Caplan AJ. Cdc37 has distinct roles in protein kinase quality control that protect nascent chains from degradation and promote posttranslational maturation. J Cell Biol. 2007 Jan 29; 176(3):319-28. PMID: 17242065.
      Citations: 44     Fields:    Translation:AnimalsCells
    16. Caplan AJ, Mandal AK, Theodoraki MA. Molecular chaperones and protein kinase quality control. Trends Cell Biol. 2007 Feb; 17(2):87-92. PMID: 17184992.
      Citations: 88     Fields:    Translation:HumansAnimalsCells
    17. Shabbir A, DiStasio S, Zhao J, Cardozo CP, Wolff MS, Caplan AJ. Differential effects of the organochlorine pesticide DDT and its metabolite p,p'-DDE on p-glycoprotein activity and expression. Toxicol Appl Pharmacol. 2005 Mar 01; 203(2):91-8. PMID: 15710169.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    18. Caplan A. Teaching resources. Protein kinases. Sci STKE. 2005 Feb 22; 2005(272):tr7. PMID: 15728428.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    19. Fan CY, Ren HY, Lee P, Caplan AJ, Cyr DM. The type I Hsp40 zinc finger-like region is required for Hsp70 to capture non-native polypeptides from Ydj1. J Biol Chem. 2005 Jan 07; 280(1):695-702. PMID: 15496404.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    20. Zhao J, Bauman WA, Huang R, Caplan AJ, Cardozo C. Oxandrolone blocks glucocorticoid signaling in an androgen receptor-dependent manner. Steroids. 2004 May; 69(5):357-66. PMID: 15219414.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    21. Lee P, Shabbir A, Cardozo C, Caplan AJ. Sti1 and Cdc37 can stabilize Hsp90 in chaperone complexes with a protein kinase. Mol Biol Cell. 2004 Apr; 15(4):1785-92. PMID: 14742721.
      Citations: 33     Fields:    Translation:AnimalsCells
    22. Zhao Q, Boschelli F, Caplan AJ, Arndt KT. Identification of a conserved sequence motif that promotes Cdc37 and cyclin D1 binding to Cdk4. J Biol Chem. 2004 Mar 26; 279(13):12560-4. PMID: 14701845.
      Citations: 23     Fields:    Translation:HumansCells
    23. Cardozo CP, Michaud C, Ost MC, Fliss AE, Yang E, Patterson C, Hall SJ, Caplan AJ. C-terminal Hsp-interacting protein slows androgen receptor synthesis and reduces its rate of degradation. Arch Biochem Biophys. 2003 Feb 01; 410(1):134-40. PMID: 12559985.
      Citations: 35     Fields:    Translation:HumansCells
    24. Caplan AJ, Jackson S, Smith D. Hsp90 reaches new heights. Conference on the Hsp90 chaperone machine. . 2003 Feb; 4(2):126-30. PMID: 12612599.
    25. Caplan AJ. What is a co-chaperone? Cell Stress Chaperones. 2003; 8(2):105-7. PMID: 14627194.
      Citations: 24     Fields:    Translation:Cells
    26. Lee P, Rao J, Fliss A, Yang E, Garrett S, Caplan AJ. The Cdc37 protein kinase-binding domain is sufficient for protein kinase activity and cell viability. J Cell Biol. 2002 Dec 23; 159(6):1051-9. PMID: 12499358.
      Citations: 32     Fields:    Translation:AnimalsCells
    27. Goeckeler JL, Stephens A, Lee P, Caplan AJ, Brodsky JL. Overexpression of yeast Hsp110 homolog Sse1p suppresses ydj1-151 thermosensitivity and restores Hsp90-dependent activity. Mol Biol Cell. 2002 Aug; 13(8):2760-70. PMID: 12181344.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    28. Gusarova V, Caplan AJ, Brodsky JL, Fisher EA. Apoprotein B degradation is promoted by the molecular chaperones hsp90 and hsp70. J Biol Chem. 2001 Jul 06; 276(27):24891-900. PMID: 11333259.
      Citations: 41     Fields:    Translation:AnimalsCells
    29. Rao J, Lee P, Benzeno S, Cardozo C, Albertus J, Robins DM, Caplan AJ. Functional interaction of human Cdc37 with the androgen receptor but not with the glucocorticoid receptor. J Biol Chem. 2001 Feb 23; 276(8):5814-20. PMID: 11085988.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    30. Fliss AE, Benzeno S, Rao J, Caplan AJ. Control of estrogen receptor ligand binding by Hsp90. J Steroid Biochem Mol Biol. 2000 Apr; 72(5):223-30. PMID: 10822011.
      Citations: 27     Fields:    Translation:HumansAnimals
    31. Fliss AE, Rao J, Melville MW, Cheetham ME, Caplan AJ. Domain requirements of DnaJ-like (Hsp40) molecular chaperones in the activation of a steroid hormone receptor. J Biol Chem. 1999 Nov 26; 274(48):34045-52. PMID: 10567371.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    32. Caplan AJ. Hsp90's secrets unfold: new insights from structural and functional studies. Trends Cell Biol. 1999 Jul; 9(7):262-8. PMID: 10370241.
      Citations: 47     Fields:    Translation:AnimalsCells
    33. Brodsky JL, Lawrence JG, Caplan AJ. Mutations in the cytosolic DnaJ homologue, YDJ1, delay and compromise the efficient translation of heterologous proteins in yeast. Biochemistry. 1998 Dec 22; 37(51):18045-55. PMID: 9922173.
      Citations: 15     Fields:    Translation:AnimalsCells
    34. Fang Y, Fliss AE, Rao J, Caplan AJ. SBA1 encodes a yeast hsp90 cochaperone that is homologous to vertebrate p23 proteins. Mol Cell Biol. 1998 Jul; 18(7):3727-34. PMID: 9632755.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    35. Cheetham ME, Caplan AJ. Structure, function and evolution of DnaJ: conservation and adaptation of chaperone function. Cell Stress Chaperones. 1998 Mar; 3(1):28-36. PMID: 9585179.
      Citations: 197     Fields:    Translation:AnimalsCells
    36. Fliss AE, Fang Y, Boschelli F, Caplan AJ. Differential in vivo regulation of steroid hormone receptor activation by Cdc37p. Mol Biol Cell. 1997 Dec; 8(12):2501-9. PMID: 9398671.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    37. Caplan AJ. Yeast molecular chaperones and the mechanism of steroid hormone action. Trends Endocrinol Metab. 1997 Sep; 8(7):271-5. PMID: 18406815.
      Citations: 7     Fields:    
    38. Fang Y, Fliss AE, Robins DM, Caplan AJ. Hsp90 regulates androgen receptor hormone binding affinity in vivo. J Biol Chem. 1996 Nov 08; 271(45):28697-702. PMID: 8910505.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
    39. Dey B, Caplan AJ, Boschelli F. The Ydj1 molecular chaperone facilitates formation of active p60v-src in yeast. Mol Biol Cell. 1996 Jan; 7(1):91-100. PMID: 8741842.
      Citations: 23     Fields:    Translation:Animals
    40. Caplan AJ, Langley E, Wilson EM, Vidal J. Hormone-dependent transactivation by the human androgen receptor is regulated by a dnaJ protein. J Biol Chem. 1995 Mar 10; 270(10):5251-7. PMID: 7890635.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    41. Schwarz E, Westermann B, Caplan AJ, Ludwig G, Neupert W. XDJ1, a gene encoding a novel non-essential DnaJ homologue from Saccharomyces cerevisiae. Gene. 1994 Jul 22; 145(1):121-4. PMID: 8045410.
      Citations: 4     Fields:    Translation:AnimalsCells
    42. Caplan AJ, Cyr DM, Douglas MG. Eukaryotic homologues of Escherichia coli dnaJ: a diverse protein family that functions with hsp70 stress proteins. Mol Biol Cell. 1993 Jun; 4(6):555-63. PMID: 8374166.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    43. Caplan AJ, Cyr DM, Douglas MG. YDJ1p facilitates polypeptide translocation across different intracellular membranes by a conserved mechanism. Cell. 1992 Dec 24; 71(7):1143-55. PMID: 1473150.
      Citations: 92     Fields:    Translation:AnimalsCells
    44. Caplan AJ, Tsai J, Casey PJ, Douglas MG. Farnesylation of YDJ1p is required for function at elevated growth temperatures in Saccharomyces cerevisiae. J Biol Chem. 1992 Sep 15; 267(26):18890-5. PMID: 1527016.
      Citations: 61     Fields:    Translation:Animals
    45. Caplan AJ, Douglas MG. Characterization of YDJ1: a yeast homologue of the bacterial dnaJ protein. J Cell Biol. 1991 Aug; 114(4):609-21. PMID: 1869583.
      Citations: 93     Fields:    Translation:AnimalsCells
    46. McDaniel D, Caplan AJ, Lee MS, Adams CC, Fishel BR, Gross DS, Garrard WT. Basal-level expression of the yeast HSP82 gene requires a heat shock regulatory element. Mol Cell Biol. 1989 Nov; 9(11):4789-98. PMID: 2689867.
      Citations: 31     Fields:    Translation:AnimalsCells
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