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Mark Pezzano

TitleRCMI Program Director
Faculty RankAssociate Professor
InstitutionCity College, CUNY
DepartmentBiology
AddressCity College, CUNY, Marshak Science Building
160 Convent Ave
New York NY 10031
Phone212-650-8577
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    Other Positions
    TitleResearcher
    InstitutionCCNY/MSKCC Partnership


    Collapse Overview 
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    My research is focused on understanding the crosstalk mechanisms and signaling pathways that contribute to the development and maintenance of thymic epithelial microenvironments. Thymic epithelial cells (TECs) are responsible for attracting T cell progenitors from the bone marrow and controlling their subsequent development and selection into a self MHC restricted self-tolerant mature T cell repertoire. We currently have 2 NIH funded research projects in the lab.

    The first is focused on the role of Wnt signaling in the development and maintenance of the thymus. We recently demonstrated that inhibition of Wnt signaling through conditional transgenic expression of DKK in TECs results in a rapid thymic degeneration and a loss to TEC progenitors similar to that observed in the aging thymus. Thee results suggest that Wnt signaling is critical to the maintenance of TEC progenitors and postnatal TEC environments critical for T cell development. Current efforts are focused on utilizing a new TCF-driven H2BGFP Wnt reporter mouse model to identify the specific subsets of TECs that undergo Wnt signaling during developments as well as during thymic regeneration.

    Our second project is focused on identifying TEC stem cell populations capable of reconstituting functional thymic tissue. A Tet- regulated H2BGFP transgenic model is being used to identify label retaining stem cells in the postnatal thymus. Subsets of these cells were shown to be capable of reforming functional thymic tissue when reaggregated and transplanted under the kidney capsule of nude mice. The long term goal of this study is to develop rational therapeutic strategies to enhance thymic recovery in bone marrow transplant patients.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ofili EO, Tchounwou PB, Fernandez-Repollet E, Yanagihara R, Akintobi TH, Lee JE, Malouhi M, Garner ST, Hayes TT, Baker AR, Dent AL, Abdelrahim M, Rollins L, Chang SP, Sy A, Hernandez BY, Bullard PL, Noel RJ, Shiramizu B, Hedges JR, Berry MJ, Bond VC, Lima MF, Mokuau N, Kirken RA, Cruz-Correa M, Sarpong DF, Vadgama J, Yates C, Kahn SA, Soliman KF, Perry G, Pezzano M, Luciano CA, Barnett ME, Oyekan A, Kumar D, Norris KC. The Research Centers in Minority Institutions (RCMI) Translational Research Network: Building and Sustaining Capacity for Multi-Site Basic Biomedical, Clinical and Behavioral Research. Ethn Dis. 2019; 29(Suppl 1):135-144. PMID: 30906162.
      Citations: 1     Fields:    Translation:Humans
    2. Osada M, Singh VJ, Wu K, Sant'Angelo DB, Pezzano M. Label retention identifies a multipotent mesenchymal stem cell-like population in the postnatal thymus. PLoS One. 2013; 8(12):e83024. PMID: 24340075.
      Citations: 7     Fields:    Translation:AnimalsCells
    3. Osada M, Jardine L, Misir R, Andl T, Millar SE, Pezzano M. DKK1 mediated inhibition of Wnt signaling in postnatal mice leads to loss of TEC progenitors and thymic degeneration. PLoS One. 2010 Feb 08; 5(2):e9062. PMID: 20161711.
      Citations: 23     Fields:    Translation:AnimalsCells
    4. Kovalovsky D, Pezzano M, Ortiz BD, Sant'Angelo DB. A novel TCR transgenic model reveals that negative selection involves an immediate, Bim-dependent pathway and a delayed, Bim-independent pathway. PLoS One. 2010 Jan 13; 5(1):e8675. PMID: 20072628.
      Citations: 18     Fields:    Translation:AnimalsCells
    5. Martinez M, Samms M, Hendrix TM, Adeosun O, Pezzano M, Guyden JC. Thymic nurse cell multicellular complexes in HY-TCR transgenic mice demonstrate their association with MHC restriction. Exp Biol Med (Maywood). 2007 Jun; 232(6):780-8. PMID: 17526770.
      Citations: 5     Fields:    Translation:AnimalsCells
    6. Osada M, Ito E, Fermin HA, Vazquez-Cintron E, Venkatesh T, Friedel RH, Pezzano M. The Wnt signaling antagonist Kremen1 is required for development of thymic architecture. Clin Dev Immunol. 2006 Jun-Dec; 13(2-4):299-319. PMID: 17162372.
      Citations: 22     Fields:    Translation:AnimalsCells
    7. Webb O, Kelly F, Benitez J, Li J, Parker M, Martinez M, Samms M, Blake A, Pezzano M, Guyden JC. The identification of thymic nurse cells in vivo and the role of cytoskeletal proteins in thymocyte internalization. Cell Immunol. 2004 Apr; 228(2):119-29. PMID: 15219463.
      Citations: 4     Fields:    Translation:AnimalsCells
    8. Guyden JC, Pezzano M. Thymic nurse cells: a microenvironment for thymocyte development and selection. Int Rev Cytol. 2003; 223:1-37. PMID: 12641209.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
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