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Valerie Odero-Marah

TitleProfessor of Biology
Faculty RankProfessor
InstitutionMorgan State University
Address1700 East Cold Spring Lane
McMechen Hall 114
Baltimore MD 21251
Phone(443) 885-2372
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    Other Positions
    TitleAdjunct Associate Professor
    InstitutionGeorgia Institute of Technology

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    Our research interests focus on epithelial-mesenchymal transition (EMT), a process that occurs during normal embryonic development and epithelial tumor progression. Several factors such as Snail transcription factor, are associated with EMT, and contribute to motility, invasion, and tumor progression. Understanding the factors that contribute to EMT and prostate cancer metastasis is crucial for development of cancer therapies. My laboratory focuses on the role of Snail transcription factor in prostate cancer progression and metastasis and antagonizing signaling with natural products.

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    R15CA169899     (ODERO-MARAH, VALERIE)Apr 1, 2013 - Sep 30, 2016
    The Role of Snail Signaling in Prostate Cancer Metastasis
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Liadi Y, Campbell T, Dike P, Harlemon M, Elliott B, Odero-Marah V. Prostate cancer metastasis and health disparities: a systematic review. Prostate Cancer Prostatic Dis. 2023 Apr 12. PMID: 37046071.
      Citations:    Fields:    
    2. Campbell T, Hawsawi O, Henderson V, Dike P, Hwang BJ, Liadi Y, White EZ, Zou J, Wang G, Zhang Q, Bowen N, Scott D, Hinton CV, Odero-Marah V. Novel roles for HMGA2 isoforms in regulating oxidative stress and sensitizing to RSL3-Induced ferroptosis in prostate cancer cells. Heliyon. 2023 Apr; 9(4):e14810. PMID: 37113783.
    3. Sheikhattari P, Shaffer E, Barsha RAA, Silver GB, Elliott B, Delgado C, Purviance P, Odero-Marah V, Bronner Y. Building Capacity for Community-Academia Research Partnerships by Establishing a Physical Infrastructure for Community Engagement: Morgan CARES. Int J Environ Res Public Health. 2022 Sep 30; 19(19). PMID: 36231771.
      Citations:    Fields:    
    4. Burton LJ, Dougan J, Jones J, Smith BN, Randle D, Henderson V, Odero-Marah VA. Correction for Burton et al., "Targeting the Nuclear Cathepsin L CCAAT Displacement Protein/Cut Homeobox Transcription Factor-Epithelial Mesenchymal Transition Pathway in Prostate and Breast Cancer Cells with the Z-FY-CHO Inhibitor". Mol Cell Biol. 2021 Aug 24; 41(9):e0025621. PMID: 34427489.
      Citations:    Fields:    
    5. Sweeney JD, Debeljak M, Riel S, Millena AC, Eshleman JR, Paller CJ, Odero-Marah V. Val16A SOD2 Polymorphism Promotes Epithelial-Mesenchymal Transition Antagonized by Muscadine Grape Skin Extract in Prostate Cancer Cells. Antioxidants (Basel). 2021 Feb 01; 10(2). PMID: 33535682.
    6. Edwards G, Campbell T, Henderson V, Danaher A, Wu D, Srinivasan R, Rezvani K, Odero-Marah VA. SNAIL Transctiption factor in prostate cancer cells promotes neurite outgrowth. Biochimie. 2021 Jan; 180:1-9. PMID: 33132158.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    7. White EZ, Pennant NM, Carter JR, Hawsawi O, Odero-Marah V, Hinton CV. Serum deprivation initiates adaptation and survival to oxidative stress in prostate cancer cells. Sci Rep. 2020 07 27; 10(1):12505. PMID: 32719369.
      Citations: 16     Fields:    Translation:HumansCells
    8. Mor?n-Santiba?ez K, Vasquez AH, Varela-Ramirez A, Henderson V, Sweeney J, Odero-Marah V, Fenelon K, Skouta R. Larrea tridentata Extract Mitigates Oxidative Stress-Induced Cytotoxicity in Human Neuroblastoma SH-SY5Y Cells. Antioxidants (Basel). 2019 Sep 25; 8(10). PMID: 31557847.
    9. Dougan J, Hawsawi O, Burton LJ, Edwards G, Jones K, Zou J, Nagappan P, Wang G, Zhang Q, Danaher A, Bowen N, Hinton C, Odero-Marah VA. Proteomics-Metabolomics Combined Approach Identifies Peroxidasin as a Protector against Metabolic and Oxidative Stress in Prostate Cancer. Int J Mol Sci. 2019 Jun 21; 20(12). PMID: 31234468.
      Citations: 15     Fields:    Translation:HumansCells
    10. Henderson VM, Hawsawi O, Burton LJ, Campbell T, Trice K, Dougan J, Howard SM, Odero-Marah VA. Cancer-bone microenvironmental interactions promotes STAT3 signaling. Mol Carcinog. 2019 08; 58(8):1349-1361. PMID: 31045290.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    11. Burton LJ, Hawsawi O, Sweeney J, Bowen N, Hudson T, Odero-Marah V. CCAAT-displacement protein/cut homeobox transcription factor (CUX1) represses estrogen receptor-alpha (ER-a) in triple-negative breast cancer cells and can be antagonized by muscadine grape skin extract (MSKE). PLoS One. 2019; 14(4):e0214844. PMID: 30964885.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    12. Burton LJ, Hawsawi O, Loyd Q, Henderson V, Howard S, Harlemon M, Ragin C, Roberts R, Bowen N, Gacii A, Odero-Marah V. Association of Epithelial Mesenchymal Transition with prostate and breast health disparities. PLoS One. 2018; 13(9):e0203855. PMID: 30199553.
      Citations: 5     Fields:    Translation:HumansCells
    13. Hawsawi O, Henderson V, Burton LJ, Dougan J, Nagappan P, Odero-Marah V. High mobility group A2 (HMGA2) promotes EMT via MAPK pathway in prostate cancer. Biochem Biophys Res Commun. 2018 09 26; 504(1):196-202. PMID: 30177390.
      Citations: 24     Fields:    Translation:HumansCells
    14. Odero-Marah V, Hawsawi O, Henderson V, Sweeney J. Epithelial-Mesenchymal Transition (EMT) and Prostate Cancer. Adv Exp Med Biol. 2018; 1095:101-110. PMID: 30229551.
      Citations: 76     Fields:    Translation:HumansCells
    15. Burton LJ, Henderson V, Liburd L, Odero-Marah VA. Snail transcription factor NLS and importin ?1 regulate the subcellular localization of Cathepsin L and Cux1. Biochem Biophys Res Commun. 2017 09 09; 491(1):59-64. PMID: 28698143.
      Citations: 7     Fields:    Translation:HumansCells
    16. Burton LJ, Dougan J, Jones J, Smith BN, Randle D, Henderson V, Odero-Marah VA. Targeting the Nuclear Cathepsin L CCAAT Displacement Protein/Cut Homeobox Transcription Factor-Epithelial Mesenchymal Transition Pathway in Prostate and Breast Cancer Cells with the Z-FY-CHO Inhibitor. Mol Cell Biol. 2017 03 01; 37(5). PMID: 27956696.
      Citations: 16     Fields:    Translation:HumansCells
    17. Burton LJ, Rivera M, Hawsawi O, Zou J, Hudson T, Wang G, Zhang Q, Cubano L, Boukli N, Odero-Marah V. Muscadine Grape Skin Extract Induces an Unfolded Protein Response-Mediated Autophagy in Prostate Cancer Cells: A TMT-Based Quantitative Proteomic Analysis. PLoS One. 2016; 11(10):e0164115. PMID: 27755556.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    18. Wilder CL, Walton C, Watson V, Stewart FAA, Johnson J, Peyton SR, Payne CK, Odero-Marah V, Platt MO. Differential cathepsin responses to inhibitor-induced feedback: E-64 and cystatin C elevate active cathepsin S and suppress active cathepsin L in breast cancer cells. Int J Biochem Cell Biol. 2016 10; 79:199-208. PMID: 27592448.
      Citations: 11     Fields:    Translation:HumansCells
    19. Henderson V, Smith B, Burton LJ, Randle D, Morris M, Odero-Marah VA. Snail promotes cell migration through PI3K/AKT-dependent Rac1 activation as well as PI3K/AKT-independent pathways during prostate cancer progression. Cell Adh Migr. 2015; 9(4):255-64. PMID: 26207671.
      Citations: 34     Fields:    Translation:HumansCells
    20. Burton LJ, Smith BA, Smith BN, Loyd Q, Nagappan P, McKeithen D, Wilder CL, Platt MO, Hudson T, Odero-Marah VA. Muscadine grape skin extract can antagonize Snail-cathepsin L-mediated invasion, migration and osteoclastogenesis in prostate and breast cancer cells. Carcinogenesis. 2015 Sep; 36(9):1019-27. PMID: 26069256.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    21. Goodson WH, Lowe L, Carpenter DO, Gilbertson M, Manaf Ali A, Lopez de Cerain Salsamendi A, Lasfar A, Carnero A, Azqueta A, Amedei A, Charles AK, Collins AR, Ward A, Salzberg AC, Colacci A, Olsen AK, Berg A, Barclay BJ, Zhou BP, Blanco-Aparicio C, Baglole CJ, Dong C, Mondello C, Hsu CW, Naus CC, Yedjou C, Curran CS, Laird DW, Koch DC, Carlin DJ, Felsher DW, Roy D, Brown DG, Ratovitski E, Ryan EP, Corsini E, Rojas E, Moon EY, Laconi E, Marongiu F, Al-Mulla F, Chiaradonna F, Darroudi F, Martin FL, Van Schooten FJ, Goldberg GS, Wagemaker G, Nangami GN, Calaf GM, Williams G, Wolf GT, Koppen G, Brunborg G, Lyerly HK, Krishnan H, Ab Hamid H, Yasaei H, Sone H, Kondoh H, Salem HK, Hsu HY, Park HH, Koturbash I, Miousse IR, Scovassi AI, Klaunig JE, Vondr?cek J, Raju J, Roman J, Wise JP, Whitfield JR, Woodrick J, Christopher JA, Ochieng J, Martinez-Leal JF, Weisz J, Kravchenko J, Sun J, Prudhomme KR, Narayanan KB, Cohen-Solal KA, Moorwood K, Gonzalez L, Soucek L, Jian L, D'Abronzo LS, Lin LT, Li L, Gulliver L, McCawley LJ, Memeo L, Vermeulen L, Leyns L, Zhang L, Valverde M, Khatami M, Romano MF, Chapellier M, Williams MA, Wade M, Manjili MH, Lleonart ME, Xia M, Gonzalez MJ, Karamouzis MV, Kirsch-Volders M, Vaccari M, Kuemmerle NB, Singh N, Cruickshanks N, Kleinstreuer N, van Larebeke N, Ahmed N, Ogunkua O, Krishnakumar PK, Vadgama P, Marignani PA, Ghosh PM, Ostrosky-Wegman P, Thompson PA, Dent P, Heneberg P, Darbre P, Sing Leung P, Nangia-Makker P, Cheng QS, Robey RB, Al-Temaimi R, Roy R, Andrade-Vieira R, Sinha RK, Mehta R, Vento R, Di Fiore R, Ponce-Cusi R, Dornetshuber-Fleiss R, Nahta R, Castellino RC, Palorini R, Abd Hamid R, Langie SA, Eltom SE, Brooks SA, Ryeom S, Wise SS, Bay SN, Harris SA, Papagerakis S, Romano S, Pavanello S, Eriksson S, Forte S, Casey SC, Luanpitpong S, Lee TJ, Otsuki T, Chen T, Massfelder T, Sanderson T, Guarnieri T, Hultman T, Dormoy V, Odero-Marah V, Sabbisetti V, Maguer-Satta V, Rathmell WK, Engstr?m W, Decker WK, Bisson WH, Rojanasakul Y, Luqmani Y, Chen Z, Hu Z. Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead. Carcinogenesis. 2015 Jun; 36 Suppl 1:S254-96. PMID: 26106142.
      Citations: 84     Fields:    Translation:HumansAnimalsPHPublic Health
    22. Ochieng J, Nangami GN, Ogunkua O, Miousse IR, Koturbash I, Odero-Marah V, McCawley LJ, Nangia-Makker P, Ahmed N, Luqmani Y, Chen Z, Papagerakis S, Wolf GT, Dong C, Zhou BP, Brown DG, Colacci AM, Hamid RA, Mondello C, Raju J, Ryan EP, Woodrick J, Scovassi AI, Singh N, Vaccari M, Roy R, Forte S, Memeo L, Salem HK, Amedei A, Al-Temaimi R, Al-Mulla F, Bisson WH, Eltom SE. The impact of low-dose carcinogens and environmental disruptors on tissue invasion and metastasis. Carcinogenesis. 2015 Jun; 36 Suppl 1:S128-59. PMID: 26106135.
      Citations: 16     Fields:    Translation:HumansAnimalsPHPublic Health
    23. Smith BN, Burton LJ, Henderson V, Randle DD, Morton DJ, Smith BA, Taliaferro-Smith L, Nagappan P, Yates C, Zayzafoon M, Chung LW, Odero-Marah VA. Snail promotes epithelial mesenchymal transition in breast cancer cells in part via activation of nuclear ERK2. PLoS One. 2014; 9(8):e104987. PMID: 25122124.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    24. Muniyan S, Chou YW, Ingersoll MA, Devine A, Morris M, Odero-Marah VA, Khan SA, Chaney WG, Bu XR, Lin MF. Antiproliferative activity of novel imidazopyridine derivatives on castration-resistant human prostate cancer cells. Cancer Lett. 2014 Oct 10; 353(1):59-67. PMID: 25050738.
      Citations: 10     Fields:    Translation:HumansCells
    25. Smith B, Randle D, Mezencev R, Thomas L, Hinton C, Odero-Marah V. Camalexin-induced apoptosis in prostate cancer cells involves alterations of expression and activity of lysosomal protease cathepsin D. Molecules. 2014 Apr 02; 19(4):3988-4005. PMID: 24699144.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    26. Burton LJ, Barnett P, Smith B, Arnold RS, Hudson T, Kundu K, Murthy N, Odero-Marah VA. Muscadine grape skin extract reverts snail-mediated epithelial mesenchymal transition via superoxide species in human prostate cancer cells. BMC Complement Altern Med. 2014 Mar 12; 14:97. PMID: 24617993.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    27. Randle DD, Clarke S, Henderson V, Odero-Marah VA. Snail mediates invasion through uPA/uPAR and the MAPK signaling pathway in prostate cancer cells. Oncol Lett. 2013 Dec; 6(6):1767-1773. PMID: 26889270.
    28. Jones KJ, Chetram MA, Bethea DA, Bryant LK, Odero-Marah V, Hinton CV. Cysteine (C)-X-C Receptor 4 Regulates NADPH Oxidase-2 During Oxidative Stress in Prostate Cancer Cells. Cancer Microenviron. 2013 Sep 28. PMID: 24078461.
    29. Chetram MA, Bethea DA, Odero-Marah VA, Don-Salu-Hewage AS, Jones KJ, Hinton CV. ROS-mediated activation of AKT induces apoptosis via pVHL in prostate cancer cells. Mol Cell Biochem. 2013 Apr; 376(1-2):63-71. PMID: 23315288.
      Citations: 31     Fields:    Translation:HumansCells
    30. Smith BA, Neal CL, Chetram M, Vo B, Mezencev R, Hinton C, Odero-Marah VA. The phytoalexin camalexin mediates cytotoxicity towards aggressive prostate cancer cells via reactive oxygen species. J Nat Med. 2013 Jul; 67(3):607-18. PMID: 23179315.
      Citations: 7     Fields:    Translation:HumansCells
    31. Smith BN, Odero-Marah VA. The role of Snail in prostate cancer. Cell Adh Migr. 2012 Sep-Oct; 6(5):433-41. PMID: 23076049.
      Citations: 49     Fields:    Translation:HumansCells
    32. Neal CL, Henderson V, Smith BN, McKeithen D, Graham T, Vo BT, Odero-Marah VA. Snail transcription factor negatively regulates maspin tumor suppressor in human prostate cancer cells. BMC Cancer. 2012 Aug 02; 12:336. PMID: 22857708.
      Citations: 17     Fields:    Translation:HumansCells
    33. Neal CL, Mckeithen D, Odero-Marah VA. Snail negatively regulates cell adhesion to extracellular matrix and integrin expression via the MAPK pathway in prostate cancer cells. Cell Adh Migr. 2011 May-Jun; 5(3):249-57. PMID: 21478672.
      Citations: 26     Fields:    Translation:HumansCells
    34. Barnett P, Arnold RS, Mezencev R, Chung LW, Zayzafoon M, Odero-Marah V. Snail-mediated regulation of reactive oxygen species in ARCaP human prostate cancer cells. Biochem Biophys Res Commun. 2011 Jan 07; 404(1):34-9. PMID: 21093414.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    35. Chetram MA, Odero-Marah V, Hinton CV. Loss of PTEN permits CXCR4-mediated tumorigenesis through ERK1/2 in prostate cancer cells. Mol Cancer Res. 2011 Jan; 9(1):90-102. PMID: 21076047.
      Citations: 27     Fields:    Translation:HumansCells
    36. McKeithen D, Graham T, Chung LW, Odero-Marah V. Snail transcription factor regulates neuroendocrine differentiation in LNCaP prostate cancer cells. Prostate. 2010 Jun 15; 70(9):982-92. PMID: 20166136.
      Citations: 58     Fields:    Translation:HumansCells
    37. Graham TR, Yacoub R, Taliaferro-Smith L, Osunkoya AO, Odero-Marah VA, Liu T, Kimbro KS, Sharma D, O'Regan RM. Reciprocal regulation of ZEB1 and AR in triple negative breast cancer cells. Breast Cancer Res Treat. 2010 Aug; 123(1):139-47. PMID: 19921427.
      Citations: 45     Fields:    Translation:HumansCells
    38. Graham TR, Odero-Marah VA, Chung LW, Agrawal KC, Davis R, Abdel-Mageed AB. PI3K/Akt-dependent transcriptional regulation and activation of BMP-2-Smad signaling by NF-kappaB in metastatic prostate cancer cells. Prostate. 2009 Feb 01; 69(2):168-80. PMID: 18942118.
      Citations: 23     Fields:    Translation:HumansCells
    39. Odero-Marah VA, Wang R, Chu G, Zayzafoon M, Xu J, Shi C, Marshall FF, Zhau HE, Chung LW. Receptor activator of NF-kappaB Ligand (RANKL) expression is associated with epithelial to mesenchymal transition in human prostate cancer cells. Cell Res. 2008 Aug; 18(8):858-70. PMID: 18645583.
      Citations: 75     Fields:    Translation:HumansAnimalsCells
    40. Zhau HE, Odero-Marah V, Lue HW, Nomura T, Wang R, Chu G, Liu ZR, Zhou BP, Huang WC, Chung LW. Epithelial to mesenchymal transition (EMT) in human prostate cancer: lessons learned from ARCaP model. Clin Exp Metastasis. 2008; 25(6):601-10. PMID: 18535913.
      Citations: 84     Fields:    Translation:HumansCells
    41. Graham TR, Zhau HE, Odero-Marah VA, Osunkoya AO, Kimbro KS, Tighiouart M, Liu T, Simons JW, O'Regan RM. Insulin-like growth factor-I-dependent up-regulation of ZEB1 drives epithelial-to-mesenchymal transition in human prostate cancer cells. Cancer Res. 2008 Apr 01; 68(7):2479-88. PMID: 18381457.
      Citations: 204     Fields:    Translation:HumansCells
    42. Xu J, Wang R, Xie ZH, Odero-Marah V, Pathak S, Multani A, Chung LW, Zhau HE. Prostate cancer metastasis: role of the host microenvironment in promoting epithelial to mesenchymal transition and increased bone and adrenal gland metastasis. Prostate. 2006 Nov 01; 66(15):1664-73. PMID: 16902972.
      Citations: 77     Fields:    Translation:HumansAnimalsCells
    43. Chung LW, Huang WC, Sung SY, Wu D, Odero-Marah V, Nomura T, Shigemura K, Miyagi T, Seo S, Shi C, Molitierno J, Elmore J, Anderson C, Isotani S, Edlund M, Hsieh CL, Wang R, Shehata B, Zhau HE. Stromal-epithelial interaction in prostate cancer progression. Clin Genitourin Cancer. 2006 Sep; 5(2):162-70. PMID: 17026806.
      Citations: 35     Fields:    Translation:HumansCells
    44. Amir S, Margaryan NV, Odero-Marah V, Khalkhali-Ellis Z, Hendrix MJ. Maspin regulates hypoxia-mediated stimulation of uPA/uPAR complex in invasive breast cancer cells. Cancer Biol Ther. 2005 Apr; 4(4):400-6. PMID: 15846059.
      Citations: 7     Fields:    Translation:HumansCells
    45. Odero-Marah VA, Khalkhali-Ellis Z, Chunthapong J, Amir S, Seftor RE, Seftor EA, Hendrix MJ. Maspin regulates different signaling pathways for motility and adhesion in aggressive breast cancer cells. Cancer Biol Ther. 2003 Jul-Aug; 2(4):398-403. PMID: 14508113.
      Citations: 33     Fields:    Translation:HumansCells
    46. Odero-Marah VA, Khalkhali-Ellis Z, Schneider GB, Seftor EA, Seftor RE, Koland JG, Hendrix MJ. Tyrosine phosphorylation of maspin in normal mammary epithelia and breast cancer cells. Biochem Biophys Res Commun. 2002 Jul 26; 295(4):800-5. PMID: 12127964.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
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