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Nathan J Bowen

Faculty RankAssociate Professor
InstitutionClark Atlanta University
DepartmentCCRTD/Biological Sciences
Address223 James P. Brawley Drive, SW
RCST, Room 4029-C
Center for Cancer Research and Therapeutic Development
Atlanta GA 30314
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    Other Positions
    TitleFaculty Member
    InstitutionPanAmerican Bioinformatics Institute

    InstitutionInternational Society of Genetic Genealogy (ISOGG)

    Collapse Affiliation 

    Collapse Biography 
    Collapse awards and honors
    2000 - 2002NIH Postdoctoral IRTA, NICHD
    2002Georgia Cancer Coalition Scholar, UGA

    Collapse Overview 
    Collapse overview
    Areas of interest:
    -Cancer Genomics: Transcriptomes, Somatic Mutations and SNPs Associated with Cancer Risk
    -Biomarker Development
    -Transcriptional Regulatory Networks
    -Chromatin/Epigenetics/Nuclear Architecture

    Affiliated with the following Center for Cancer Research and Therapeutic Development (CCRTD) Facilities:
    -Prostate Cancer Tissue and Fluid Biorepository Core
    -Genomics and Bioinformatics/Next Generation Sequencing Core

    Areas of interest:
    -Cancer Genomics: Transcriptomes, Somatic Mutations and Germline Variation Associated with Cancer Risk
    -Biomarker Development
    -Transcriptional Regulatory Networks
    -Chromatin/Epigenetics/Nuclear Architecture

    Affiliated with the following Center for Cancer Research and Therapeutic Development (CCRTD) Facilities:
    -Prostate Cancer Tissue and Fluid Biorepository Core
    -Genomics and Bioinformatics/Next Generation Sequencing Core

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Li X, Chen Y, Bai L, Zhao R, Wu Y, Xie ZR, Wu JM, Bowen NJ, Danaher A, Cook N, Li D, Qui M, Du Y, Fu H, Osunkoya AO, Kucuk O, Wu D. Nicardipine is a putative EED inhibitor and has high selectivity and potency against chemoresistant prostate cancer in preclinical models. Br J Cancer. 2023 09; 129(5):884-894. PMID: 37474721.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Bai L, Li X, Yang Y, Zhao R, White EZ, Danaher A, Bowen NJ, Hinton CV, Cook N, Li D, Wu AY, Qui M, Du Y, Fu H, Kucuk O, Wu D. Bromocriptine monotherapy overcomes prostate cancer chemoresistance in preclinical models. Transl Oncol. 2023 Aug; 34:101707. PMID: 37271121.
    3. Campbell T, Hawsawi O, Henderson V, Dike P, Hwang BJ, Liadi Y, White EZ, Zou J, Wang G, Zhang Q, Bowen N, Scott D, Hinton CV, Odero-Marah V. Novel roles for HMGA2 isoforms in regulating oxidative stress and sensitizing to RSL3-Induced ferroptosis in prostate cancer cells. Heliyon. 2023 Apr; 9(4):e14810. PMID: 37113783.
    4. Hewa Bostanthirige D, Komaragiri SK, Joshi JB, Alzahrani M, Saini I, Jain S, Bowen NJ, Havrda MC, Chaudhary J. The helix-loop-helix transcriptional regulator Id4 is required for terminal differentiation of luminal epithelial cells in the prostate. Oncoscience. 2021; 8:14-30. PMID: 33884281.
    5. Dougan J, Hawsawi O, Burton LJ, Edwards G, Jones K, Zou J, Nagappan P, Wang G, Zhang Q, Danaher A, Bowen N, Hinton C, Odero-Marah VA. Proteomics-Metabolomics Combined Approach Identifies Peroxidasin as a Protector against Metabolic and Oxidative Stress in Prostate Cancer. Int J Mol Sci. 2019 Jun 21; 20(12). PMID: 31234468.
      Citations: 15     Fields:    Translation:HumansCells
    6. Burton LJ, Hawsawi O, Sweeney J, Bowen N, Hudson T, Odero-Marah V. CCAAT-displacement protein/cut homeobox transcription factor (CUX1) represses estrogen receptor-alpha (ER-a) in triple-negative breast cancer cells and can be antagonized by muscadine grape skin extract (MSKE). PLoS One. 2019; 14(4):e0214844. PMID: 30964885.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    7. Elliott B, Millena AC, Matyunina L, Zhang M, Zou J, Wang G, Zhang Q, Bowen N, Eaton V, Webb G, Thompson S, McDonald J, Khan S. Essential role of JunD in cell proliferation is mediated via MYC signaling in prostate cancer cells. Cancer Lett. 2019 04 28; 448:155-167. PMID: 30763715.
      Citations: 27     Fields:    Translation:HumansCells
    8. Burton LJ, Hawsawi O, Loyd Q, Henderson V, Howard S, Harlemon M, Ragin C, Roberts R, Bowen N, Gacii A, Odero-Marah V. Association of Epithelial Mesenchymal Transition with prostate and breast health disparities. PLoS One. 2018; 13(9):e0203855. PMID: 30199553.
      Citations: 5     Fields:    Translation:HumansCells
    9. Ryans K, Omosun Y, McKeithen DN, Simoneaux T, Mills CC, Bowen N, Eko FO, Black CM, Igietseme JU, He Q. The immunoregulatory role of alpha enolase in dendritic cell function during Chlamydia infection. BMC Immunol. 2017 05 19; 18(1):27. PMID: 28525970.
      Citations: 12     Fields:    Translation:AnimalsCells
    10. Sheng X, Bowen N, Wang Z. GLI pathogenesis-related 1 functions as a tumor-suppressor in lung cancer. Mol Cancer. 2016 Mar 18; 15:25. PMID: 26988096.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    11. Du F, Li Y, Zhang W, Kale SP, McFerrin H, Davenport I, Wang G, Skripnikova E, Li XL, Bowen NJ, McDaniels LB, Meng YX, Polk P, Liu YY, Zhang QJ. Highly and moderately aggressive mouse ovarian cancer cell lines exhibit differential gene expression. Tumour Biol. 2016 Aug; 37(8):11147-11162. PMID: 26935058.
      Citations: 6     Fields:    Translation:AnimalsCells
    12. Pannu V, Rida PC, Ogden A, Turaga RC, Donthamsetty S, Bowen NJ, Rudd K, Gupta MV, Reid MD, Cantuaria G, Walczak CE, Aneja R. HSET overexpression fuels tumor progression via centrosome clustering-independent mechanisms in breast cancer patients. Oncotarget. 2015 Mar 20; 6(8):6076-91. PMID: 25788277.
      Citations: 40     Fields:    Translation:HumansCells
    13. Chinaranagari S, Sharma P, Bowen NJ, Chaudhary J. Prostate cancer epigenome. Methods Mol Biol. 2015; 1238:125-40. PMID: 25421658.
      Citations: 4     Fields:    Translation:Humans
    14. Patel D, Knowell AE, Korang-Yeboah M, Sharma P, Joshi J, Glymph S, Chinaranagari S, Nagappan P, Palaniappan R, Bowen NJ, Chaudhary J. Inhibitor of differentiation 4 (ID4) inactivation promotes de novo steroidogenesis and castration-resistant prostate cancer. Mol Endocrinol. 2014 Aug; 28(8):1239-53. PMID: 24921661.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    15. Pawar S, Donthamsetty S, Pannu V, Rida P, Ogden A, Bowen N, Osan R, Cantuaria G, Aneja R. KIFCI, a novel putative prognostic biomarker for ovarian adenocarcinomas: delineating protein interaction networks and signaling circuitries. J Ovarian Res. 2014; 7:53. PMID: 25028599.
      Citations: 28     Fields:    Translation:HumansCells
    16. Liu Y, Bowen NJ, Matyunina L, McDonald J, Prausnitz MR. Gene transfection enhanced by ultrasound exposure combined with drug treatment guided by gene chip analysis. Int J Hyperthermia. 2012; 28(4):349-61. PMID: 22621736.
      Citations: 1     Fields:    Translation:HumansCells
    17. Wang L, Mezencev R, Bowen NJ, Matyunina LV, McDonald JF. Isolation and characterization of stem-like cells from a human ovarian cancer cell line. Mol Cell Biochem. 2012 Apr; 363(1-2):257-68. PMID: 22160925.
      Citations: 46     Fields:    Translation:HumansCells
    18. Huda A, Tyagi E, Mari?o-Ram?rez L, Bowen NJ, Jjingo D, Jordan IK. Prediction of transposable element derived enhancers using chromatin modification profiles. PLoS One. 2011; 6(11):e27513. PMID: 22087331.
      Citations: 18     Fields:    Translation:HumansCells
    19. Shahab SW, Matyunina LV, Mezencev R, Walker LD, Bowen NJ, Benigno BB, McDonald JF. Evidence for the complexity of microRNA-mediated regulation in ovarian cancer: a systems approach. PLoS One. 2011; 6(7):e22508. PMID: 21811625.
      Citations: 29     Fields:    Translation:HumansCells
    20. Huda A, Bowen NJ, Conley AB, Jordan IK. Epigenetic regulation of transposable element derived human gene promoters. Gene. 2011 Apr 01; 475(1):39-48. PMID: 21215797.
      Citations: 24     Fields:    Translation:HumansCells
    21. Liu Y, Chen Y, Momin A, Shaner R, Wang E, Bowen NJ, Matyunina LV, Walker LD, McDonald JF, Sullards MC, Merrill AH. Elevation of sulfatides in ovarian cancer: an integrated transcriptomic and lipidomic analysis including tissue-imaging mass spectrometry. Mol Cancer. 2010 Jul 12; 9:186. PMID: 20624317.
      Citations: 51     Fields:    Translation:Humans
    22. Du J, Tian Z, Bowen NJ, Schmutz J, Shoemaker RC, Ma J. Bifurcation and enhancement of autonomous-nonautonomous retrotransposon partnership through LTR Swapping in soybean. Plant Cell. 2010 Jan; 22(1):48-61. PMID: 20081112.
      Citations: 19     Fields:    Translation:AnimalsCells
    23. Bowen NJ, Walker LD, Matyunina LV, Logani S, Totten KA, Benigno BB, McDonald JF. Gene expression profiling supports the hypothesis that human ovarian surface epithelia are multipotent and capable of serving as ovarian cancer initiating cells. BMC Med Genomics. 2009 Dec 29; 2:71. PMID: 20040092.
      Citations: 98     Fields:    Translation:HumansCells
    24. Wang J, Bowen NJ, Mari?o-Ram?rez L, Jordan IK. A c-Myc regulatory subnetwork from human transposable element sequences. Mol Biosyst. 2009 Dec; 5(12):1831-9. PMID: 19763338.
      Citations: 10     Fields:    Translation:HumansCells
    25. Carpenedo RL, Bratt-Leal AM, Marklein RA, Seaman SA, Bowen NJ, McDonald JF, McDevitt TC. Homogeneous and organized differentiation within embryoid bodies induced by microsphere-mediated delivery of small molecules. Biomaterials. 2009 May; 30(13):2507-15. PMID: 19162317.
      Citations: 62     Fields:    Translation:AnimalsCells
    26. K?bel M, Kalloger SE, Boyd N, McKinney S, Mehl E, Palmer C, Leung S, Bowen NJ, Ionescu DN, Rajput A, Prentice LM, Miller D, Santos J, Swenerton K, Gilks CB, Huntsman D. Ovarian carcinoma subtypes are different diseases: implications for biomarker studies. PLoS Med. 2008 Dec 02; 5(12):e232. PMID: 19053170.
      Citations: 329     Fields:    Translation:Humans
    27. Arakaki AK, Mezencev R, Bowen NJ, Huang Y, McDonald JF, Skolnick J. Identification of metabolites with anticancer properties by computational metabolomics. Mol Cancer. 2008 Jun 17; 7:57. PMID: 18559081.
      Citations: 10     Fields:    Translation:HumansCells
    28. Matyunina LV, Bowen NJ, McDonald JF. LTR retrotransposons and the evolution of dosage compensation in Drosophila. BMC Mol Biol. 2008 Jun 04; 9:55. PMID: 18533037.
      Citations: 9     Fields:    Translation:AnimalsCells
    29. Moreno CS, Matyunina L, Dickerson EB, Schubert N, Bowen NJ, Logani S, Benigno BB, McDonald JF. Evidence that p53-mediated cell-cycle-arrest inhibits chemotherapeutic treatment of ovarian carcinomas. PLoS One. 2007 May 16; 2(5):e441. PMID: 17505532.
      Citations: 20     Fields:    Translation:Humans
    30. Menendez L, Walker D, Matyunina LV, Dickerson EB, Bowen NJ, Polavarapu N, Benigno BB, McDonald JF. Identification of candidate methylation-responsive genes in ovarian cancer. Mol Cancer. 2007 Jan 25; 6:10. PMID: 17254359.
      Citations: 14     Fields:    Translation:HumansCells
    31. Bowen NJ, Jordan IK. Exaptation of protein coding sequences from transposable elements. Genome Dyn. 2007; 3:147-162. PMID: 18753790.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    32. Bowen NJ, Logani S, Dickerson EB, Kapa LB, Akhtar M, Benigno BB, McDonald JF. Emerging roles for PAX8 in ovarian cancer and endosalpingeal development. Gynecol Oncol. 2007 Feb; 104(2):331-7. PMID: 17064757.
      Citations: 82     Fields:    Translation:Humans
    33. Polavarapu N, Bowen NJ, McDonald JF. Newly identified families of human endogenous retroviruses. J Virol. 2006 May; 80(9):4640-2. PMID: 16611924.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    34. Polavarapu N, Bowen NJ, McDonald JF. Identification, characterization and comparative genomics of chimpanzee endogenous retroviruses. Genome Biol. 2006; 7(6):R51. PMID: 16805923.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    35. Bowen NJ, Palmer MB, Wade PA. Chromosomal regulation by MeCP2: structural and enzymatic considerations. Cell Mol Life Sci. 2004 Sep; 61(17):2163-7. PMID: 15338046.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    36. Carney GE, Bowen NJ. p24 proteins, intracellular trafficking, and behavior: Drosophila melanogaster provides insights and opportunities. Biol Cell. 2004 May; 96(4):271-8. PMID: 15145531.
      Citations: 29     Fields:    Translation:AnimalsCells
    37. Bowen NJ, Fujita N, Kajita M, Wade PA. Mi-2/NuRD: multiple complexes for many purposes. Biochim Biophys Acta. 2004 Mar 15; 1677(1-3):52-7. PMID: 15020045.
      Citations: 141     Fields:    Translation:HumansAnimalsCells
    38. Jordan IK, Bowen NJ. Computational analysis of transposable element sequences. Methods Mol Biol. 2004; 260:59-71. PMID: 15020802.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    39. Bowen NJ, Jordan IK, Epstein JA, Wood V, Levin HL. Retrotransposons and their recognition of pol II promoters: a comprehensive survey of the transposable elements from the complete genome sequence of Schizosaccharomyces pombe. Genome Res. 2003 Sep; 13(9):1984-97. PMID: 12952871.
      Citations: 85     Fields:    Translation:AnimalsCells
    40. Arudchandran A, Cerritelli SM, Bowen NJ, Chen X, Krause MW, Crouch RJ. Multiple ribonuclease H-encoding genes in the Caenorhabditis elegans genome contrasts with the two typical ribonuclease H-encoding genes in the human genome. Mol Biol Evol. 2002 Nov; 19(11):1910-9. PMID: 12411600.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    41. Bowen NJ, Jordan IK. Transposable elements and the evolution of eukaryotic complexity. Curr Issues Mol Biol. 2002 Jul; 4(3):65-76. PMID: 12074196.
      Citations: 30     Fields:    Translation:HumansCells
    42. Bowen NJ, McDonald JF. Drosophila euchromatic LTR retrotransposons are much younger than the host species in which they reside. Genome Res. 2001 Sep; 11(9):1527-40. PMID: 11544196.
      Citations: 79     Fields:    Translation:AnimalsCells
    43. Bowen NJ, McDonald JF. Genomic analysis of Caenorhabditis elegans reveals ancient families of retroviral-like elements. Genome Res. 1999 Oct; 9(10):924-35. PMID: 10523521.
      Citations: 39     Fields:    Translation:AnimalsCells
    44. McDonald JF, Matyunina LV, Wilson S, Jordan IK, Bowen NJ, Miller WJ. LTR retrotransposons and the evolution of eukaryotic enhancers. Genetica. 1997; 100(1-3):3-13. PMID: 9440254.
      Citations: 30     Fields:    Translation:AnimalsCells
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